Next Article in Journal
Methyl Jasmonate: An Alternative for Improving the Quality and Health Properties of Fresh Fruits
Next Article in Special Issue
On Topological Indices of Certain Families of Nanostar Dendrimers
Previous Article in Journal
Organocatalyzed Intramolecular Carbonyl-Ene Reactions
Previous Article in Special Issue
Thermoregulated Coacervation, Metal-Encapsulation and Nanoparticle Synthesis in Novel Triazine Dendrimers
Article Menu
Issue 6 (June) cover image

Export Article

Open AccessReview
Molecules 2016, 21(6), 686;

Dendrimer Prodrugs

Laboratory of Design and Synthesis of Chemotherapeutics Potentially Active in Neglected Diseases (LAPEN), Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo—USP, Avenue Professor Lineu Prestes, 580–Building 13, São Paulo SP, 05508-900, Brazil
Author to whom correspondence should be addressed.
Academic Editor: Ashok Kakkar
Received: 7 April 2016 / Revised: 10 May 2016 / Accepted: 17 May 2016 / Published: 31 May 2016
(This article belongs to the Special Issue Functional Dendrimers)
Full-Text   |   PDF [4027 KB, uploaded 31 May 2016]   |  


The main objective of this review is to describe the importance of dendrimer prodrugs in the design of new drugs, presenting numerous applications of these nanocomposites in the pharmaceutical field. Therefore, the use of dendrimer prodrugs as carrier for drug delivery, to improve pharmacokinetic properties of prototype, to promote drug sustained-release, to increase selectivity and, consequently, to decrease toxicity, are just some examples of topics that have been extensively reported in the literature, especially in the last decade. The examples discussed here give a panel of the growing interest dendrimer prodrugs have been evoking in the scientific community. View Full-Text
Keywords: dendrimer; prodrugs; molecular modifications; targeted dendrimer; pharmaceutical applications dendrimer; prodrugs; molecular modifications; targeted dendrimer; pharmaceutical applications

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

da Silva Santos, S.; Igne Ferreira, E.; Giarolla, J. Dendrimer Prodrugs. Molecules 2016, 21, 686.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top