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Molecules 2016, 21(3), 339;

A Peptoid-Based Fluorescent Sensor for Cyanide Detection

College of Pharmacy, Research Institute of Pharmaceutical Sciences, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Korea
Author to whom correspondence should be addressed.
Academic Editor: Scott Reed
Received: 22 January 2016 / Revised: 4 March 2016 / Accepted: 7 March 2016 / Published: 10 March 2016
(This article belongs to the Special Issue Photoactive Molecules)
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Peptoids, N-substituted glycine oligomers, are versatile peptidomimetics with diverse biomedical applications. However, strategies to the development of novel fluorescent peptoids as chemical sensors have not been extensively explored, yet. Here, we synthesized a novel peptoid-based fluorescent probe in which a coumarin moiety was incorporated via copper(I)-catalyzed azide-alkyne cycloaddition reaction. Fluorescence of the newly generated coumarin-peptoid was dramatically quenched upon coordination of the Cu2+ ion, and the resulting peptoid-Cu2+ complex exhibited significant Turn-ON fluorescence following the addition of CN. The rapid and reversible response, combined with cyanide selectivity of the synthesized peptoid, reflects a multistep photo-process and supports its utility as a new type of CN sensor. View Full-Text
Keywords: fluorescence; peptoid; cyanide sensor fluorescence; peptoid; cyanide sensor

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Lim, B.; Lee, J. A Peptoid-Based Fluorescent Sensor for Cyanide Detection. Molecules 2016, 21, 339.

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