An Efficient Chemical Synthesis of Scutellarein: An in Vivo Metabolite of Scutellarin
Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China
Department of Organic Chemistry, China Pharmaceutical University, Nanjing 211198, Jiangsu, China
Authors to whom correspondence should be addressed.
Academic Editors: Derek J. McPhee and Wim Dehaen
Received: 24 January 2016 / Revised: 17 February 2016 / Accepted: 22 February 2016 / Published: 25 February 2016
Scutellarein (2), which is an important in vivo
metabolite of scutellarin (1), was synthesized from 3,4,5-trimethoxyphenol (3) in high yield in four steps. This strategy relies on acetylation, aldolization, cyclization and hydrolysis reactions, respectively.
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MDPI and ACS Style
Dong, Z.-X.; Li, N.-G.; Zhang, P.-X.; Gu, T.; Wu, W.-Y.; Shi, Z.-H. An Efficient Chemical Synthesis of Scutellarein: An in Vivo Metabolite of Scutellarin. Molecules 2016, 21, 263.
Dong Z-X, Li N-G, Zhang P-X, Gu T, Wu W-Y, Shi Z-H. An Efficient Chemical Synthesis of Scutellarein: An in Vivo Metabolite of Scutellarin. Molecules. 2016; 21(3):263.
Dong, Ze-Xi; Li, Nian-Guang; Zhang, Peng-Xuan; Gu, Ting; Wu, Wen-Yu; Shi, Zhi-Hao. 2016. "An Efficient Chemical Synthesis of Scutellarein: An in Vivo Metabolite of Scutellarin." Molecules 21, no. 3: 263.
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