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Molecules 2016, 21(3), 263;

An Efficient Chemical Synthesis of Scutellarein: An in Vivo Metabolite of Scutellarin

Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China
Department of Organic Chemistry, China Pharmaceutical University, Nanjing 211198, Jiangsu, China
Authors to whom correspondence should be addressed.
Academic Editors: Derek J. McPhee and Wim Dehaen
Received: 24 January 2016 / Revised: 17 February 2016 / Accepted: 22 February 2016 / Published: 25 February 2016
(This article belongs to the Section Metabolites)
Full-Text   |   PDF [518 KB, uploaded 25 February 2016]   |  


Scutellarein (2), which is an important in vivo metabolite of scutellarin (1), was synthesized from 3,4,5-trimethoxyphenol (3) in high yield in four steps. This strategy relies on acetylation, aldolization, cyclization and hydrolysis reactions, respectively. View Full-Text
Keywords: scutellarin; scutellarein; metabolite; efficient; synthesis scutellarin; scutellarein; metabolite; efficient; synthesis

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Dong, Z.-X.; Li, N.-G.; Zhang, P.-X.; Gu, T.; Wu, W.-Y.; Shi, Z.-H. An Efficient Chemical Synthesis of Scutellarein: An in Vivo Metabolite of Scutellarin. Molecules 2016, 21, 263.

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