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Molecules 2016, 21(10), 1341;

Resveratrol Ameliorates the Depressive-Like Behaviors and Metabolic Abnormalities Induced by Chronic Corticosterone Injection

College of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China
Authors to whom correspondence should be addressed.
Academic Editor: Thomas J. Schmidt
Received: 14 June 2016 / Revised: 24 September 2016 / Accepted: 6 October 2016 / Published: 13 October 2016
(This article belongs to the Special Issue Improvements for Resveratrol Efficacy)
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Chronic glucocorticoid exposure is known to cause depression and metabolic disorders. It is critical to improve abnormal metabolic status as well as depressive-like behaviors in patients with long-term glucocorticoid therapy. This study aimed to investigate the effects of resveratrol on the depressive-like behaviors and metabolic abnormalities induced by chronic corticosterone injection. Male ICR mice were administrated corticosterone (40 mg/kg) by subcutaneous injection for three weeks. Resveratrol (50 and 100 mg/kg), fluoxetine (20 mg/kg) and pioglitazone (10 mg/kg) were given by oral gavage 30 min prior to corticosterone administration. The behavioral tests showed that resveratrol significantly reversed the depressive-like behaviors induced by corticosterone, including the reduced sucrose preference and increased immobility time in the forced swimming test. Moreover, resveratrol also increased the secretion of insulin, reduced serum level of glucose and improved blood lipid profiles in corticosterone-treated mice without affecting normal mice. However, fluoxetine only reverse depressive-like behaviors, and pioglitazone only prevent the dyslipidemia induced by corticosterone. Furthermore, resveratrol and pioglitazone decreased serum level of glucagon and corticosterone. The present results indicated that resveratrol can ameliorate depressive-like behaviors and metabolic abnormalities induced by corticosterone, which suggested that the multiple effects of resveratrol could be beneficial for patients with depression and/or metabolic syndrome associated with long-term glucocorticoid therapy. View Full-Text
Keywords: resveratrol; corticosterone; depression; metabolic abnormalities resveratrol; corticosterone; depression; metabolic abnormalities

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Li, Y.-C.; Liu, Y.-M.; Shen, J.-D.; Chen, J.-J.; Pei, Y.-Y.; Fang, X.-Y. Resveratrol Ameliorates the Depressive-Like Behaviors and Metabolic Abnormalities Induced by Chronic Corticosterone Injection. Molecules 2016, 21, 1341.

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