Next Article in Journal
Three New Butenolides from the Fungus Aspergillus sp. CBS-P-2
Next Article in Special Issue
Transdermal Permeation and Anti-Inflammation Activities of Novel Sinomenine Derivatives
Previous Article in Journal
Resveratrol Ameliorates the Depressive-Like Behaviors and Metabolic Abnormalities Induced by Chronic Corticosterone Injection
Previous Article in Special Issue
Modulation of Autophagy by a Thioxanthone Decreases the Viability of Melanoma Cells
Open AccessReview

Mitoxantrone-Surfactant Interactions: A Physicochemical Overview

Institute of Physical Chemistry Ilie Murgulescu, Romanian Academy, Splaiul Independentei 202, Bucharest 060021, Romania
Institute of Biology Bucharest, Romanian Academy, Splaiul Independentei 296, Bucharest 060031, Romania
Author to whom correspondence should be addressed.
Academic Editor: Jean Jacques Vanden Eynde
Molecules 2016, 21(10), 1356;
Received: 1 September 2016 / Revised: 29 September 2016 / Accepted: 1 October 2016 / Published: 13 October 2016
Mitoxantrone is a synthetic anticancer drug used clinically in the treatment of different types of cancer. It was developed as a doxorubicin analogue in a program to find drugs with improved antitumor activity and decreased cardiotoxicity compared with the anthracyclines. As the cell membrane is the first barrier encountered by anticancer drugs before reaching the DNA sites inside the cells and as surfactant micelles are known as simple model systems for biological membranes, the drugs-surfactant interaction has been the subject of great research interest. Further, quantitative understanding of the interactions of drugs with biomimicking structures like surfactant micelles may provide helpful information for the control of physicochemical properties and bioactivities of encapsulated drugs in order to design better delivery systems with possible biomedical applications. The present review describes the physicochemical aspects of the interactions between the anticancer drug mitoxantrone and different surfactants. Mitoxantrone-micelle binding constants, partitions coefficient of the drug between aqueous and micellar phases and the corresponding Gibbs free energy for the above processes, and the probable location of drug molecules in the micelles are discussed. View Full-Text
Keywords: mitoxantrone; surfactants; micelles; binding constant; partition coefficient mitoxantrone; surfactants; micelles; binding constant; partition coefficient
Show Figures

Figure 1

MDPI and ACS Style

Enache, M.; Toader, A.M.; Enache, M.I. Mitoxantrone-Surfactant Interactions: A Physicochemical Overview. Molecules 2016, 21, 1356.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop