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Molecules 2015, 20(8), 14833-14848;

Non-Covalent Derivatives: Cocrystals and Eutectics

The Warner Babcock Institute for Green Chemistry, 100 Research Drive, Wilmington, MA 01887, USA
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Kei Saito
Received: 9 June 2015 / Accepted: 5 August 2015 / Published: 14 August 2015
(This article belongs to the Special Issue Frontier in Green Chemistry Approaches)
Full-Text   |   PDF [695 KB, uploaded 14 August 2015]


Non-covalent derivatives (NCDs) are formed by incorporating one (or more) coformer molecule(s) into the matrix of a parent molecule via non-covalent forces. These forces can include ionic forces, Van der Waals forces, hydrogen bonding, lipophilic-lipophilic interactions and pi-pi interactions. NCDs, in both cocrystal and eutectic forms, possess properties that are unique to their supramolecular matrix. These properties include critical product performance factors such as solubility, stability and bioavailability. NCDs have been used to tailor materials for a variety of applications and have the potential to be used in an even broader range of materials and processes. NCDs can be prepared using little or no solvent and none of the reagents typical to synthetic modifications. Thus, NCDs represent a powerfully versatile, environmentally-friendly and cost-effective opportunity. View Full-Text
Keywords: non-covalent derivative; cocrystals; eutectics; green chemistry non-covalent derivative; cocrystals; eutectics; green chemistry
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Stoler, E.; Warner, J.C. Non-Covalent Derivatives: Cocrystals and Eutectics. Molecules 2015, 20, 14833-14848.

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