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Molecules 2015, 20(2), 3050-3066;

New Pregnane Glycosides from Gymnema sylvestre

Institute of Pharmacology and Toxicology, Academy for Military Medical Science, 27 Taiping Road, Haidian District, Beijing 100850, China
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 31 December 2014 / Accepted: 5 February 2015 / Published: 12 February 2015
(This article belongs to the Section Natural Products Chemistry)
Full-Text   |   PDF [859 KB, uploaded 12 February 2015]   |  


Four new pregnane glycosides 14 were isolated from the ethanol extract of the stem of Gymnema sylvestre and named gymsylvestrosides A–D. Hydrolysis of compound 1 under the catalysis of Aspergilus niger β-glucosidase afforded compound 5 (gymsylvestroside E). Their structures were determined by spectroscopic methods such as HRESIMS, 1D and 2D NMR, as well as HMQC-TOCSY experiment. Compounds 14 were screened for Saccharomyces cerevisiae α-glucosidase inhibitory activity. View Full-Text
Keywords: Gymnema sylvestre; Asclepiadaceae; pregnane glycosides; α-glucosidase Gymnema sylvestre; Asclepiadaceae; pregnane glycosides; α-glucosidase

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Xu, R.; Yang, Y.; Zhang, Y.; Ren, F.; Xu, J.; Yu, N.; Zhao, Y. New Pregnane Glycosides from Gymnema sylvestre. Molecules 2015, 20, 3050-3066.

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