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Molecules 2014, 19(6), 7981-7989; https://doi.org/10.3390/molecules19067981

Antidepressant-Like Effects of the Ethyl Acetate Soluble Fraction of the Root Bark of Morus alba on the Immobility Behavior of Rats in the Forced Swim Test

1
Food Resource Research Center, Korea Food Research Institute, Seongnam 463-746, Korea
2
Research Group of Food Functionality, Korea Food Research Institute, Seongnam 463-746, Korea
3
Graduate School of Biotechnology and Research Institute of Life Sciences & Resources, Kyung Hee University, Yongin 446-701, Korea
These authors contributed equally in this work.
*
Author to whom correspondence should be addressed.
Received: 23 April 2014 / Revised: 5 June 2014 / Accepted: 10 June 2014 / Published: 12 June 2014
(This article belongs to the Section Natural Products Chemistry)
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Abstract

In this study, the antidepressant-like effects of Morus alba fractions in rats were investigated in the forced swim test (FST). Male Wistar rats (9-week-old) were administered orally the M. alba ethyl acetate (EtOAc 30 and 100 mg/kg) and M. alba n-butanol fractions (n-BuOH 30 and 100 mg/kg) every day for 7 consecutive days. On day 7, 1 h after the final administration of the fractions, the rats were exposed to the FST. M. alba EtOAc fraction at the dose of 100 mg/kg induced a decrease in immobility behavior (p < 0.01) with a concomitant increase in both climbing (p < 0.05) and swimming (p < 0.05) behaviors when compared with the control group, and M. alba EtOAc fraction at the dose of 100 mg/kg decreased the hypothalamic-pituitary-adrenal (HPA) axis response to the stress, as indicated by an attenuated corticosterone response and decreased c-fos immunoreactivity in the hippocampal and hypothalamic paraventricular nucleus (PVN) region. These findings demonstrated that M. alba EtOAc fraction have beneficial effects on depressive behaviors and restore both altered c-fos expression and HPA activity. View Full-Text
Keywords: Morus alba; antistress; antidepressant activity; forced swimming test Morus alba; antistress; antidepressant activity; forced swimming test
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Lim, D.W.; Kim, Y.T.; Park, J.-H.; Baek, N.-I.; Han, D. Antidepressant-Like Effects of the Ethyl Acetate Soluble Fraction of the Root Bark of Morus alba on the Immobility Behavior of Rats in the Forced Swim Test. Molecules 2014, 19, 7981-7989.

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