Synthesis of Novel Highly Functionalized 4-Thiazolidinone Derivatives from 4-Phenyl-3-thiosemicarbazones
Abstract
:1. Introduction
2. Results and Discussion
Carbonyl compound | Product | Product number | Reaction time (h) | Yield (%) |
---|---|---|---|---|
4a | 1 | 70 | ||
4b | 3 | 90 | ||
4c | 2 | 93 | ||
4d | 1 | 90 | ||
4e | 1 | 91 | ||
4f | 2 | 89 | ||
4g | 2 | 91 | ||
4h | 1 | 89 |
Compound | Product | Product number | Reaction time (h) | Yield (%) |
---|---|---|---|---|
4a | 6a | 1 | 91 | |
4b | 6b | 3 | 68 | |
4c | 6c | 3 | 82 | |
4d | 6d | 2 | 86 | |
4e | 6e | 2 | 80 | |
4f | 6f | 3 | 89 | |
4g | 6g | 3 | 90 | |
4h | 6h | 2 | 88 |
Compound | Product | Product number | Yield (%) |
---|---|---|---|
4a | 8a | 73 | |
4b | 8b | 70 | |
4c | 8c | 76 | |
4d | 8d | 74 | |
4e | 8e | 73 | |
4f | 8f | 75 | |
4g | 8g | 70 | |
4h | 8h | 71 |
3. Experimental
3.1. General
3.2. General Procedure for the Preparation of Compounds 4a–h
3.3. General Procedure for the Preparation of Compounds 6a–h
3.4. General Procedure for the Preparation of Compounds 8a–h
4. Conclusions
Acknowledgments
Author Contributions
Conflictts of Interest
References and Notes
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- CCDC contains the supplementary crystallographic data of compound 8b for this paper. These data can be obtained free of charge from The Cambridge Crystallographic Data Centre via http://www.ccdc.cam.ac.uk/data_request/cif.
- CCDC contains the supplementary crystallographic data of compound 8g for this paper. These data can be obtained free of charge from The Cambridge Crystallographic Data Centre via http://www.ccdc.cam.ac.uk/data_request/cif.
- Sample Availability: Samples of the compounds 4a–h, 6a–h and 8a–h are available from the authors.
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Benmohammed, A.; Khoumeri, O.; Djafri, A.; Terme, T.; Vanelle, P. Synthesis of Novel Highly Functionalized 4-Thiazolidinone Derivatives from 4-Phenyl-3-thiosemicarbazones. Molecules 2014, 19, 3068-3083. https://doi.org/10.3390/molecules19033068
Benmohammed A, Khoumeri O, Djafri A, Terme T, Vanelle P. Synthesis of Novel Highly Functionalized 4-Thiazolidinone Derivatives from 4-Phenyl-3-thiosemicarbazones. Molecules. 2014; 19(3):3068-3083. https://doi.org/10.3390/molecules19033068
Chicago/Turabian StyleBenmohammed, Abdelmadjid, Omar Khoumeri, Ayada Djafri, Thierry Terme, and Patrice Vanelle. 2014. "Synthesis of Novel Highly Functionalized 4-Thiazolidinone Derivatives from 4-Phenyl-3-thiosemicarbazones" Molecules 19, no. 3: 3068-3083. https://doi.org/10.3390/molecules19033068