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Molecules 2012, 17(8), 8928-8937;

Anti-Platelet Aggregation and Vasorelaxing Effects of the Constituents of the Rhizomes of Zingiber officinale

Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan
Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
Department of Biotechnology, Southern Taiwan University, Tainan 710, Taiwan
Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan
Department of Pharmacy, China Medical University, Taichung 404, Taiwan
Chinese Medicinal Research and Development Center, China Medical University and Hospital, Taichung 404, Taiwan
Author to whom correspondence should be addressed.
Received: 10 May 2012 / Revised: 13 July 2012 / Accepted: 21 July 2012 / Published: 26 July 2012
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In the present study, the chemical investigation of the bioactive fractions of the rhizomes of Zingiber officinale has resulted in the identification of twenty-nine compounds including one new compound, O-methyldehydrogingerol (1). Some of the isolates were subjected into the evaluation of their antiplatelet aggregation and vasorelaxing bioactivities. Among the tested compounds, [6]-gingerol (13) and [6]-shogaol (17) exhibited potent anti-platelet aggregation bioactivity. In addition, [10]-gingerol (15) inhibited the Ca2+-dependent contractions in high K+ medium. According to the results in the present research, the bioactivity of ginger could be related to the anti-platelet aggregation and vasorelaxing mechanism. View Full-Text
Keywords: anti-platelet aggregation; vasorelaxing; Zingiberaceae; gingerol; shogaol anti-platelet aggregation; vasorelaxing; Zingiberaceae; gingerol; shogaol

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Liao, Y.-R.; Leu, Y.-L.; Chan, Y.-Y.; Kuo, P.-C.; Wu, T.-S. Anti-Platelet Aggregation and Vasorelaxing Effects of the Constituents of the Rhizomes of Zingiber officinale. Molecules 2012, 17, 8928-8937.

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