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Open AccessArticle

Inhibitory Effects of Resveratrol Analogs on Mushroom Tyrosinase Activity

1
NIQUA, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais 36036-900, Brazil
2
Department of Chemistry, I.C.E., Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-900, Brazil
*
Authors to whom correspondence should be addressed.
Molecules 2012, 17(10), 11816-11825; https://doi.org/10.3390/molecules171011816
Received: 26 July 2012 / Revised: 28 September 2012 / Accepted: 30 September 2012 / Published: 9 October 2012
(This article belongs to the Special Issue Antioxidants 2012)
Skin pigmentation disorders typically involve an overproduction or uneven distribution of melanin, which results in skin spots. Resveratrol can inhibit tyrosinase, the active enzyme in the synthesis of melanin, but it does not inhibit the synthesis of melanin to an extent that enables its use alone as a skin whitening agent in pharmaceutical formulations, so its use as a coadjuvant in treatment of hyperpigmentation is suggested. Six resveratrol analogs were tested for tyrosinase inhibitory activity in vitro. Among the analogs tested, compound D was the most powerful tyrosinase inhibitor (IC50 = 28.66 µg/mL), two times more active than resveratrol (IC50 = 57.05 µg/mL), followed by the analogs A, E, B, F and C, respectively. This demonstrated that the hydroxylation at C4' on the phenolic ring was the molecular modification with most importance for the observed activity. View Full-Text
Keywords: chemical synthesis; mushroom tyrosinase activity; structure-activity; tyrosinase; activity in vitro chemical synthesis; mushroom tyrosinase activity; structure-activity; tyrosinase; activity in vitro
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Zimmermann Franco, D.C.; Gonçalves de Carvalho, G.S.; Rocha, P.R.; Da Silva Teixeira, R.; Da Silva, A.D.; Barbosa Raposo, N.R. Inhibitory Effects of Resveratrol Analogs on Mushroom Tyrosinase Activity. Molecules 2012, 17, 11816-11825.

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