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Molecules 2012, 17(1), 1103-1112;

The Newly Isolated Endophytic Fungus Paraconiothyrium sp. LK1 Produces Ascotoxin

School of Applied Biosciences, College of Agriculture and Life Sciences, Kyungpook National University, Daegu 702-701, Korea
Department of Plant Sciences, Kohat University of Science and Technology, Kohat 26000, Pakistan
Department of Botany, Abdul Wali Khan University, Mardan 23300, Pakistan
Department of Biological Sciences and Chemistry, College of Arts & Sciences, University of Nizwa, Nizwa 33, Oman
Author to whom correspondence should be addressed.
Received: 19 December 2011 / Revised: 6 January 2012 / Accepted: 11 January 2012 / Published: 20 January 2012
(This article belongs to the Section Natural Products Chemistry)
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We have isolated five endophytic fungi from the roots of Capsicum annuum, Cucumis sativus and Glycine max. The culture filtrates (CF) of these endophytes were screened on dwarf mutant rice (Waito-C) and normal rice (Dongjin-byeo). Endophyte CAC-1A significantly inhibited the growth of Waito-C and Dongjin-byeo. Endophyte CAC-1A was identified as Paraconiothyrium sp. by sequencing the ITS rDNA region and phylogenetic analysis. The ethyl acetate fraction of Paraconiothyrium sp. suppressed the germination of Lactuca sativa and Echinochloa crus-galli seeds. The ethyl acetate fraction of the endophyte was subjected to bioassay-guided isolation and we obtained the phytotoxic compound ascotoxin (1) which was characterized through NMR and GC/MS techniques. Ascotoxin revealed 100% inhibitory effects on seed germination of Echinochloa crus-galli. Compound (1) was isolated for the first time from Paraconiothyrium sp. View Full-Text
Keywords: Paraconiothyrium sp.; ascotoxin; growth inhibitory effect; endophytic fungi Paraconiothyrium sp.; ascotoxin; growth inhibitory effect; endophytic fungi

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Khan, A.L.; Hamayun, M.; Hussain, J.; Kang, S.-M.; Lee, I.-J. The Newly Isolated Endophytic Fungus Paraconiothyrium sp. LK1 Produces Ascotoxin. Molecules 2012, 17, 1103-1112.

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