A New Cytotoxic Friedelane Acid – Pluricostatic Acid – and Other Compounds from the Leaves of Marila pluricostata
Abstract
:Introduction
Results and Discussion
Biological activity
GI50 (μg/mL) | |||
---|---|---|---|
MCF-7 | H-460 | SF-268 | |
dichloromethane extract | 5.9 | 6.2 | 4.6 |
methanolic fraction defatted | 8.3 | 7.8 | 5.5 |
neutral fraction | 1.6 | 1.5 | 0.7 |
acid fraction | 2.4 | 2.7 | 2.2 |
1 | 3.0 | 1.2 | 3.3 |
8 | 6.3 | 5.1 | 4.6 |
9 | 7.8 | 7.2 | > 10 |
10 | 7.2 | 5.3 | 6.5 |
11 | 5.0 | 3.6 | 5.1 |
Adriamycin | 0.37 | 0.42 | 0.50 |
Experimental
General
Plant Material
Extraction, Isolation and Identification
Components | Retention time (Rt) (min.) | Relative (%) | M+ m/z |
---|---|---|---|
fraction A | |||
α-copaene | 17.33 | 2.6 | 220 |
β-caryophyllene | 20.01 | 29.9 | 204 |
zingiberene | 20.83 | 1.1 | 204 |
germacrene-d | 21.84 | 0.6 | 204 |
α-amorphene | 23.02 | 11.7 | 204 |
β-selinene | 23.19 | 3.8 | 204 |
calarene | 23.71 | 4.1 | 204 |
α-muurolene | 24.17 | 3.6 | 204 |
χ-cadinene | 24.87 | 7.7 | 204 |
calamenene | 25.01 | 1.6 | 204 |
δ-cadinene | 25.42 | 3.6 | 204 |
α-cadinene | 26.09 | 3.0 | 204 |
calacorene | 26.85 | 1.3 | 200 |
α-caryophyllene oxide | 27.90 | 10.9 | 220 |
Total compounds identified | 85.5 | ||
fraction B | |||
α-copaene | 17.37 | 36.0 | 220 |
β-elemene | 18.41 | 0.9 | 204 |
β-caryophyllene | 20.03 | 13.4 | 204 |
β-cubenene | 20.25 | 3.0 | 204 |
α-humulene | 21.18 | 0.8 | 204 |
α-amorphene | 23.05 | 11.7 | 204 |
α-aromadendrene | 23.11 | 3.8 | 204 |
Total compounds identified | 69.6 | ||
fraction C | |||
α-cubebene | 16.06 | 5.1 | 204 |
α-copaene | 17.35 | 38.2 | 220 |
β-bourbonene | 17.76 | 7.6 | 204 |
β-cubenene | 20.25 | 11.3 | 204 |
α-aromadendrene | 23.13 | 0.7 | 204 |
β-sesquiphellandrene | 25.34 | 0.9 | 204 |
Total compounds identified | 36.4 | ||
fraction D | |||
β-farnesene | 16.48 | 2.8 | 204 |
α-curcumene | 16.92 | 1.8 | 202 |
β-bisabolene | 17.72 | 1.9 | 204 |
Squalene | 42.40 | 89.9 | 410 |
Total compounds identified | 96.4 |
Test for in vitro Antineoplastic Cytotoxicity
Molecular Modeling
Acknowledgment
References
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Olmedo, D.A.; López-Pérez, J.L.; Del Olmo, E.; Vásquez, Y.; San Feliciano, A.; Gupta, M.P. A New Cytotoxic Friedelane Acid – Pluricostatic Acid – and Other Compounds from the Leaves of Marila pluricostata. Molecules 2008, 13, 2915-2924. https://doi.org/10.3390/molecules13112915
Olmedo DA, López-Pérez JL, Del Olmo E, Vásquez Y, San Feliciano A, Gupta MP. A New Cytotoxic Friedelane Acid – Pluricostatic Acid – and Other Compounds from the Leaves of Marila pluricostata. Molecules. 2008; 13(11):2915-2924. https://doi.org/10.3390/molecules13112915
Chicago/Turabian StyleOlmedo, Dionisio A., José L. López-Pérez, Esther Del Olmo, Yelkaira Vásquez, Arturo San Feliciano, and Mahabir P. Gupta. 2008. "A New Cytotoxic Friedelane Acid – Pluricostatic Acid – and Other Compounds from the Leaves of Marila pluricostata" Molecules 13, no. 11: 2915-2924. https://doi.org/10.3390/molecules13112915