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Molecules 2008, 13(11), 2915-2924;

A New Cytotoxic Friedelane Acid – Pluricostatic Acid – and Other Compounds from the Leaves of Marila pluricostata

Centro de Investigaciones Farmacognósticas de la Flora Panameña (CIFLORPAN), Facultad de Farmacia, Universidad de Panamá, Apartado 0824-00172,Panama
Departamento de Química Farmacéutica, Facultad de Farmacia, CIETUS, Universidad de Salamanca, Campus Miguel de Unamuno, E-37007, Salamanca, Spain
Author to whom correspondence should be addressed.
Received: 16 October 2008 / Revised: 14 November 2008 / Accepted: 18 November 2008 / Published: 25 November 2008
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Bioassay-guided fractionation of the dichloromethane extract of the leaves of Marila pluricostata led to the isolation of 2α,3β-dihydroxy-D:A-friedoolean-28-oic acid (pluricostatic acid), a new friedelane triterpenoid, (1), ten known triterpenoids and three sterols. Their chemical structures were elucidated through spectroscopic analysis. The less polar fractions, on GC/MS analysis and comparison with a MS library, resulted in the identification of twenty four sesquiterpenoids. The new triterpenoid acid 1 showed cytotoxicity against the MCF-7, H-460, and SF-268 human cancer cell lines with GI50 values from 1.2 to 3.3 μg/mL. View Full-Text
Keywords: Marila pluricostata; Clusiaceae; Triterpenoids; Cytotoxicity; 2α; 3β- dihydroxy-D:A-friedoolean-28-oic acid Marila pluricostata; Clusiaceae; Triterpenoids; Cytotoxicity; ; 3β- dihydroxy-D:A-friedoolean-28-oic acid

Figure 1

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Olmedo, D.A.; López-Pérez, J.L.; Del Olmo, E.; Vásquez, Y.; San Feliciano, A.; Gupta, M.P. A New Cytotoxic Friedelane Acid – Pluricostatic Acid – and Other Compounds from the Leaves of Marila pluricostata. Molecules 2008, 13, 2915-2924.

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