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Article

Fluctuation of Information Entropy Measures in Cell Image

The Biophysical Interdisciplinary Schottenstein Center for the Research and Technology of the Cellome, Physics Department, Bar Ilan University, Ramat-Gan 5290002, Israel
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Entropy 2017, 19(10), 565; https://doi.org/10.3390/e19100565
Received: 31 July 2017 / Revised: 10 September 2017 / Accepted: 18 October 2017 / Published: 23 October 2017
A simple, label-free cytometry technique is introduced. It is based on the analysis of the fluctuation of image Gray Level Information Entropy (GLIE) which is shown to reflect intracellular biophysical properties like generalized entropy. In this study, the analytical relations between cellular thermodynamic generalized entropy and diffusivity and GLIE fluctuation measures are explored for the first time. The standard deviation (SD) of GLIE is shown by experiments, simulation and theoretical analysis to be indifferent to microscope system “noise”. Then, the ability of GLIE fluctuation measures to reflect basic cellular entropy conditions of early death and malignancy is demonstrated in a cell model of human, healthy-donor lymphocytes, malignant Jurkat cells, as well as dead lymphocytes and Jurkat cells. Utilization of GLIE-based fluctuation measures seems to have the advantage of displaying biophysical characterization of the tested cells, like diffusivity and entropy, in a novel, unique, simple and illustrative way. View Full-Text
Keywords: image analysis; information entropy; label-free; cytometry; cellular entropy; cellular malignancy image analysis; information entropy; label-free; cytometry; cellular entropy; cellular malignancy
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MDPI and ACS Style

Wohl, I.; Zurgil, N.; Hakuk, Y.; Sobolev, M.; Deutsch, M. Fluctuation of Information Entropy Measures in Cell Image. Entropy 2017, 19, 565. https://doi.org/10.3390/e19100565

AMA Style

Wohl I, Zurgil N, Hakuk Y, Sobolev M, Deutsch M. Fluctuation of Information Entropy Measures in Cell Image. Entropy. 2017; 19(10):565. https://doi.org/10.3390/e19100565

Chicago/Turabian Style

Wohl, Ishay, Naomi Zurgil, Yaron Hakuk, Maria Sobolev, and Mordechai Deutsch. 2017. "Fluctuation of Information Entropy Measures in Cell Image" Entropy 19, no. 10: 565. https://doi.org/10.3390/e19100565

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