Omics Technologies and Other Quality and Safety Methodologies in Nutrition and Health

Topic Information

Dear Colleagues,

Good health and wellbeing rank third in the sustainable development goals of the United Nations, and it would seem that helping ten billion people to live nutritionally and healthily in the future is an exceptional challenge. How can make the best use of research outcomes to pursue this goal? We have organized the following topic to help. This topic, entitled “Omics Technologies and Other Quality and Safety Methodologies in Nutrition and Health", offers rapid publication of original research papers and up-to-date reviews, placing an emphasis on new discoveries and trends. It also attempts to highlight the issues of food nutrition or safety, biomedical or pharmaceutical analysis, emerging environment contaminants, authentication and origin traceability, as well as multi-omics analysis. The major aim of this multidisciplinary topic is to bridge the gap between research outcomes and human wellness.

Dr. Xianjiang Li
Dr. Wen Ma
Topic Editors

Keywords

Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Foods foods	4.7	7.4	2012	14.5 Days	CHF 2900	Submit
Molecules molecules	4.2	7.4	1996	15.1 Days	CHF 2700	Submit
Nutrients nutrients	4.8	9.2	2009	13.5 Days	CHF 2900	Submit
Metabolites metabolites	3.5	5.7	2011	16.1 Days	CHF 2700	Submit

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Published Papers (4 papers)

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All Foods Molecules Nutrients Metabolites

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Open AccessArticle

From Tea to Functional Foods: Exploring Caryopteris mongolica Bunge for Anti-Rheumatoid Arthritis and Unraveling Its Potential Mechanisms

by Xin Dong, Zhi Wang, Yao Fu, Yuxin Tian, Peifeng Xue, Yuewu Wang, Feiyun Yang, Guojing Li and Ruigang Wang

Nutrients 2024, 16(24), 4311; https://doi.org/10.3390/nu16244311 - 13 Dec 2024

Viewed by 1081

Abstract

Background: Caryopteris mongolica Bunge (CM) shows promising potential for managing rheumatoid arthritis (RA) and digestive disorders, attributed to its rich content of bioactive compounds such as polyphenols and flavonoids. Despite its common use in herbal tea, the specific mechanisms underlying CM’s anti-inflammatory and [...] Read more.

Background: Caryopteris mongolica Bunge (CM) shows promising potential for managing rheumatoid arthritis (RA) and digestive disorders, attributed to its rich content of bioactive compounds such as polyphenols and flavonoids. Despite its common use in herbal tea, the specific mechanisms underlying CM’s anti-inflammatory and joint-protective effects remain unclear, limiting its development as a functional food. This study investigated the effects of aqueous CM extract on RA in collagen-induced arthritis (CIA) rats and explored the underlying mechanisms. Methods: Forty-eight female Sprague-Dawley rats were randomly assigned to six groups (n = 8): normal control, CIA model, methotrexate (MTX), and CM high-, middle-, and low-dose groups. Anti-inflammatory and joint-protective effects were evaluated using biochemical and histological analyses. To elucidate the mechanisms, we applied metabolomics, network pharmacology, and transcriptomics approaches. Results: The results demonstrated that CM extract effectively suppressed synovial inflammation in CIA rats, reducing joint degradation. CM’s anti-inflammatory effects were mediated through the TNF signaling pathway, modulating glycerophospholipid and amino acid metabolism, including reduced levels of tryptophan, LysoPC, and asparagine. Molecular docking identified scutellarin and apigenin as key bioactive compounds. Additionally, immunofluorescence analysis revealed CM’s therapeutic effects via TNF signaling inhibition and suppression of M1 macrophage polarization. Conclusions: These findings highlight the therapeutic potential of CM for RA and support its development as a functional food or pharmaceutical product. Full article

(This article belongs to the Topic Omics Technologies and Other Quality and Safety Methodologies in Nutrition and Health)

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13 pages, 2161 KiB  

Open AccessArticle

The Accurate and Exclusive Quantification of Somatic Cells in Raw Milk with an OPD-Cu²⁺ System-Based Colorimetric Method

by Menghui Xie, Meng Wang, Siyuan Liu, Yingying Liu, Ziquan Wang, Guoping Zhou and Zhiwei Sui

Foods 2024, 13(18), 2890; https://doi.org/10.3390/foods13182890 - 12 Sep 2024

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Abstract

The somatic cell count (SCC) refers to the number of somatic cells present in each milliliter of raw milk and serves as a crucial indicator of dairy cow udder health and raw milk quality. Traditional SCC detection methods are often time-consuming, expensive, and [...] Read more.

The somatic cell count (SCC) refers to the number of somatic cells present in each milliliter of raw milk and serves as a crucial indicator of dairy cow udder health and raw milk quality. Traditional SCC detection methods are often time-consuming, expensive, and susceptible to bacterial interference, rendering them unsuitable for the rapid and unbiased assessment of raw milk quality. Consequently, there is an urgent need for a low-cost, accurate, and user-friendly SCC quantification method. Here, a method based on an OPD-Cu²⁺ system for SCC quantification was developed. It was found that OPD oxidation signals exhibited a linear correlation with SCC. Following optimization, the detection system was established with a Cu²⁺ concentration of 25 μM, an OPD concentration of 2 mM, and an incubation time of 15 min. Furthermore, the method demonstrated significant resistance to bacterial interference, though it produced weaker signals in response to bacteria. The somatic cell recovery rate in milk after pretreatment was 88.9%, and SCC was quantified accurately within 45 min, with a linear range of 10⁴–10⁶ cells/mL. In summary, the method developed is cost-effective, straightforward, and facilitates precise somatic cell quantification, offering significant practical value and a new approach for SCC detection in raw milk. Full article

(This article belongs to the Topic Omics Technologies and Other Quality and Safety Methodologies in Nutrition and Health)

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18 pages, 3939 KiB  

Open AccessArticle

Structural Characterization and Abundance of Sialylated Milk Oligosaccharides in Holstein Cows during Early Lactation

by Lisa Isernhagen, Christina E. Galuska, Andreas Vernunft and Sebastian P. Galuska

Foods 2024, 13(16), 2484; https://doi.org/10.3390/foods13162484 - 7 Aug 2024

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Abstract

Among other bioactive molecules, milk contains high amounts of sialylated milk oligosaccharides (MOs) that influence numerous processes in the offspring. For instance, sialylated MOs inhibit the invasion of pathogens and positively influence the gut microbiome to support the optimal development of the offspring. [...] Read more.

Among other bioactive molecules, milk contains high amounts of sialylated milk oligosaccharides (MOs) that influence numerous processes in the offspring. For instance, sialylated MOs inhibit the invasion of pathogens and positively influence the gut microbiome to support the optimal development of the offspring. For these reasons, sialylated MOs are also used in infant formula as well as food supplements and are potential therapeutic substances for humans and animals. Because of the high interest in sialylated bovine MOs (bMOs), we used several analytical approaches, such as gas and liquid chromatography in combination with mass spectrometry, to investigate in detail the profile of sialylated bMOs in the milk of Holstein Friesian cows during early lactation. Most of the 40 MOs identified in this study were sialylated, and a rapid decrease in all detected sialylated bMOs took place during the first day of lactation. Remarkably, we observed a high variance within the sialylation level during the first two days after calving. Therefore, our results suggest that the content of sialylated MOs might be an additional quality marker for the bioactivity of colostrum and transitional milk to ensure its optimized application for the production of milk replacer and food supplements. Full article

(This article belongs to the Topic Omics Technologies and Other Quality and Safety Methodologies in Nutrition and Health)

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20 pages, 9899 KiB  

Open AccessArticle

Anti-Type II Diabetic Effects of Coix Seed Prolamin Hydrolysates: Physiological and Transcriptomic Analyses

by Guifang Zhang, Zhiming Li, Shu Zhang, Lu Bai, Hangqing Zhou and Dongjie Zhang

Foods 2024, 13(14), 2203; https://doi.org/10.3390/foods13142203 - 12 Jul 2024

Cited by 1 | Viewed by 1625

Abstract

Previous studies have demonstrated that enzymatically prepared coix seed prolamin hydrolysates (CHPs) contain several bioactive peptides that efficiently inhibit the activity of target enzymes (α-glucosidase and dipeptidyl kinase-IV) in type 2 diabetes mellitus (T2DM). However, the anti-T2DM effects and potential mechanisms of CHPs [...] Read more.

Previous studies have demonstrated that enzymatically prepared coix seed prolamin hydrolysates (CHPs) contain several bioactive peptides that efficiently inhibit the activity of target enzymes (α-glucosidase and dipeptidyl kinase-IV) in type 2 diabetes mellitus (T2DM). However, the anti-T2DM effects and potential mechanisms of CHPs as a whole in vivo have not yet been systematically explored. Therefore, we evaluated the preventive, therapeutic, and modifying effects of CHPs on T2DM by combining physiological and liver transcriptomics with a T2DM mouse model. The results showed that sustained high-fructose intake led to prediabetic symptoms in mice, with abnormal fluctuations in blood glucose and blood lipid levels. Intervention with CPHs effectively prevented weight loss; regulated abnormal changes in blood glucose; improved impaired glucose tolerance; inhibited the abnormal expression of total cholesterol, triglycerides, and low-density lipoproteins; alleviated insulin resistance; and restored pancreatic islet tissue function in mice fed a high-fructose diet. In addition, we found that CHPs also play a palliative role in the loss of liver function and protect various organ tissues (including the liver, kidneys, pancreas, and heart), and are effective in preventing damage to the liver and pancreatic islet cells. We also found that the intake of CHPs reversed the abnormally altered hepatic gene profile in model mice and identified 381 differentially expressed genes that could serve as key genes for preventing the development of T2DM, which are highly correlated with multiple glycolipid metabolic pathways. We demonstrated that CHPs play a positive role in the normal functioning of the insulin signalling pathway dominated by the IRS-1/PI3K/AKT (insulin receptor substrates-1/phosphoinositide 3-kinase/protein kinase B) pathway. In summary, CHPs can be used as effective food-borne glucose-modifying components of healthy foods. Full article

(This article belongs to the Topic Omics Technologies and Other Quality and Safety Methodologies in Nutrition and Health)

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