Nanotechnology Therapies for Cancers

Topic Information

Dear Colleagues,

This Topic, focused on the use of nanotechnology for cancer therapies, explores the potential of nanomaterials for targeted drug delivery, enhancing efficacy and reducing side effects, with the aim of revolutionizing cancer treatment. We welcome original research articles, reviews, and perspectives on a wide range of topics related to nanotechnology-based cancer therapy, including (but not limited to) the following:

• Current advances in nanomedicine;
• The design, synthesis and characterization of novel nanoparticles;
• Nanotechnology and bacterial engineering;
• Nanotechnology and noncoding RNA;
• Nanotechnology in drug resistance management;
• Nanobiotics against antimicrobial resistance;
• Multifunctional nanostructures for cancer therapy;
• Nanotechnology in enhanced drug delivery;
• Nanotechnology in targeted therapies;
• Improving cancer immunotherapy through nanotechnology;
• Improving therapeutic efficacy with nanocarriers;
• Nanotechnology and immunoengineering;
• Nano-immunoengineering in CAR-T cell therapy against tumor microenvironments;
• Nanotechnology in advancements of combination cancer therapies;
• Nanotechnology in early cancer detection and diagnosis;
• Challenges regarding the clinical translation of nanostructures and future directions.

Dr. Deepak Parashar
Dr. Vivek K. Kashyap
Topic Editors

Keywords

Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Applied Nano applnano	-	5.9	2020	18.6 Days	CHF 1000	Submit
Cancers cancers	4.8	9.0	2009	17.5 Days	CHF 2900	Submit
International Journal of Molecular Sciences ijms	5.6	10.0	2000	17.5 Days	CHF 2900	Submit
Journal of Functional Biomaterials jfb	5.9	9.7	2010	15.1 Days	CHF 2700	Submit
Nanomaterials nanomaterials	4.8	10.3	2010	12.5 Days	CHF 2400	Submit

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Published Papers (2 papers)

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All Cancers IJMS Applied Nano JFB Nanomaterials

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17 pages, 3186 KB  

Open AccessArticle

Amine-Functionalized and Gold-Decorated Amine-Functionalized TiO₂ Nanoparticles Modulate Breast Cancer Cell Viability

by Juan P. Muñoz, Kiamara Muñoz-Jaime, Diego Soto-Jiménez, Nachimuthu Venkatesh, Néstor Novoa and Krishnamoorthy Shanmugaraj

Int. J. Mol. Sci. 2026, 27(12), 5475; https://doi.org/10.3390/ijms27125475 - 17 Jun 2026

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Abstract

Surface engineering is a key strategy for modulating the biological behavior of TiO₂-based nanomaterials, with potential relevance for future localized or adjuvant approaches targeting residual cancer cells. This study evaluated whether amine functionalization and subsequent gold decoration modify the effects of [...] Read more.

Surface engineering is a key strategy for modulating the biological behavior of TiO₂-based nanomaterials, with potential relevance for future localized or adjuvant approaches targeting residual cancer cells. This study evaluated whether amine functionalization and subsequent gold decoration modify the effects of TiO₂ nanoparticles (TiO₂NPs) on MCF7 and MDA-MB-231 breast cancer cells. The synthesized materials preserved the anatase TiO₂ framework, while surface modification altered their physicochemical and optical properties. After 24 h of exposure, pristine TiO₂NPs produced minimal changes in cell viability, whereas NH₂-functionalized TiO₂NPs (TiO₂NPs-NH₂) and gold-decorated NH₂-functionalized TiO₂NPs (Au@TiO₂NPs-NH₂) reduced viability in a concentration-dependent and cell line-dependent manner. These effects were more evident in the MTT assay than in Trypan Blue exclusion counting, suggesting changes in metabolic activity before extensive membrane integrity loss. Overall, the findings indicate that surface modification, rather than the TiO₂ core alone, is a major determinant of the cellular response to these nanomaterials. These results provide an initial in vitro basis for further mechanistic studies evaluating surface-engineered TiO₂NPs as candidate platforms for future adjuvant breast cancer strategies. Full article

(This article belongs to the Topic Nanotechnology Therapies for Cancers)

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13 pages, 2306 KB  

Open AccessArticle

Development, Characterization, and Biological Evaluation of Clove Essential Oil Microemulsions

by José Nabor Haro-González, Jorge Alejandro Barbosa-Nuñez, Moisés Martínez-Velázquez and Hugo Espinosa-Andrews

Appl. Nano 2026, 7(2), 13; https://doi.org/10.3390/applnano7020013 - 31 May 2026

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Abstract

Clove essential oils (CEOs) are widely studied because of their biological potential; however, their applications are limited because of their water immiscibility. Microemulsions (MEs) can protect, deliver, and enhance the biological activities of CEOs, including their antioxidant and cytotoxic activities. In this research, [...] Read more.

Clove essential oils (CEOs) are widely studied because of their biological potential; however, their applications are limited because of their water immiscibility. Microemulsions (MEs) can protect, deliver, and enhance the biological activities of CEOs, including their antioxidant and cytotoxic activities. In this research, the effects of ethanol as a cosurfactant and the polysorbate 80:cosurfactant mixture (S_mix = 1:0, 9:1, 7:1, 5:1, 3:1, and 1:1) on the formation of CEO-MEs were evaluated via a pseudo-ternary phase diagram. After 35 days, all the systems produced clear, monodisperse, and thermodynamically stable MEs, characterized by average sizes below 25.6 nm and low polydispersity index values (<0.21). The S_mix dose–response experiments without CEO revealed that the S_mix ratios of 1:1 and 3:1 resulted in the lowest cytotoxicity to HT-29 (colorectal adenocarcinoma) cells. The antioxidant capacity of the CEO-ME was greater than that of the CEO. Finally, the CEO-MEs enhanced the in vitro cytotoxic activity of the CEO against Caco-2, HT-29, HeLa, PC-3, and A549 cancer cells. These findings provide valuable information for the development of low-energy clove essential oil MEs for potential incorporation into functional foods and pharmaceutical products. Full article

(This article belongs to the Topic Nanotechnology Therapies for Cancers)

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