Recent Advances in Biochemistry, Immunology, and Diagnosis of Infectious Disease

Dear Colleagues,

This thematic Topic seeks to showcase cutting-edge advances at the convergence of biochemistry, immunology, and diagnostic innovation in infectious diseases. In an era marked by emerging pathogens, antimicrobial resistance, and rapidly evolving variants, there is a critical need to deepen our molecular understanding and translate these insights into effective clinical tools.

We invite contributions that elucidate the biochemical foundations of pathogen biology, including metabolic pathways, structural dynamics, and host–pathogen interactions that drive virulence, persistence, and therapeutic response. Emphasis is also placed on immunological breakthroughs, spanning innate sensing mechanisms, antibody and T-cell immunity, mucosal responses, immune evasion strategies, and next-generation vaccine design.

Equally important are advances in diagnostics that enable rapid, sensitive, and accessible detection. Topics of interest include molecular and serological assays, biosensor technologies, multi-omics platforms, artificial intelligence-assisted diagnostics, and biomarker discovery for early and precise disease identification.

This Topic welcomes original research, comprehensive reviews, and methodological studies that bridge basic science and clinical application. By integrating biochemical insights, immune profiling, and innovative therapeutic and diagnostic approaches, this collection aims to accelerate translational research and support improved surveillance, prevention, and management of infectious diseases globally.

Prof. Dr. Salvatore G. De-Simone
Dr. Herbert Leonel M.Mattos de Matos-Guedes
Topic Editors