Topic Editors

Head, Department of Molecular Biology and Cell Pathology, Third Faculty of Medicine, Charles University, Prague, Czech Republic
Dr. Katerina Kotlabova
Department of Molecular Biology and Cell Pathology, Third Faculty of Medicine, Charles University, 14700 Prague, Czech Republic

Pathogenesis of Pregnancy-Related Complications 2.0

Abstract submission deadline
31 May 2024
Manuscript submission deadline
31 August 2024
Viewed by
10477

Topic Information

Dear Colleagues,

Preeclampsia, HELLP syndrome, fetal growth restriction, gestational diabetes mellitus, preterm birth (preterm prelabor rupture of membranes and spontaneous preterm labor), and an invasive placenta are major complications responsible for maternal and perinatal morbidity and mortality. The elucidation of the pathogenetic mechanisms related to the initiation and onset of severe pregnancy-related complications enables the identification of potential biomarkers for the early stratification of at-risk patients. Additionally, pregnancy-related complications induce long-term metabolic and vascular abnormalities that might increase the overall risk of metabolic, cardiovascular, cerebrovascular, kidney, and other diseases later in life in mothers and their offspring. This Topic aims to provide an overview of the latest research on the mechanisms associated with pregnancy-related complications as well as on the contributions of pregnancy-related complications to the later development of various diseases. This will include the underlying mechanisms, diagnostics/prognostics, and treatment strategies associated with pregnancy-related complications, and will be of interest to scientists and clinicians working in this quickly expanding area.

Topics will include (but are not limited to) the following:

  • Pathogenesis of pregnancy-related complications;
  • Diagnosis and prognosis of pregnancy-related complications;
  • Short-term and long-term follow-up after pregnancy-related complications (mothers and offspring);
  • Novel treatment modalities of pregnancy-related complications and their short-term as well as long-term consequences.

Prof. Dr. Ilona Hromadnikova
Dr. Katerina Kotlabova
Topic Editors

Keywords

  • gestational hypertension
  • preeclampsia
  • HELLP syndrome
  • fetal growth restriction
  • gestational diabetes mellitus
  • preterm birth
  • invasive placenta

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
Biomedicines
biomedicines
4.7 3.7 2013 15.4 Days CHF 2600 Submit
Current Issues in Molecular Biology
cimb
3.1 2.4 1999 13.5 Days CHF 2200 Submit
Endocrines
endocrines
- - 2020 27.2 Days CHF 1000 Submit
International Journal of Molecular Sciences
ijms
5.6 7.8 2000 16.3 Days CHF 2900 Submit
Journal of Molecular Pathology
jmp
- - 2020 24.9 Days CHF 1000 Submit
Life
life
3.2 2.7 2011 17.5 Days CHF 2600 Submit
Reproductive Medicine
reprodmed
- - 2020 29.2 Days CHF 1000 Submit

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Published Papers (4 papers)

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20 pages, 1583 KiB  
Article
Simple and Fast Prediction of Gestational Diabetes Mellitus Based on Machine Learning and Near-Infrared Spectra of Serum: A Proof of Concept Study at Different Stages of Pregnancy
by Daniela Mennickent, Lucas Romero-Albornoz, Sebastián Gutiérrez-Vega, Claudio Aguayo, Federico Marini, Enrique Guzmán-Gutiérrez and Juan Araya
Biomedicines 2024, 12(6), 1142; https://doi.org/10.3390/biomedicines12061142 - 21 May 2024
Viewed by 447
Abstract
Gestational diabetes mellitus (GDM) is a hyperglycemic state that is typically diagnosed by an oral glucose tolerance test (OGTT), which is unpleasant, time-consuming, has low reproducibility, and results are tardy. The machine learning (ML) predictive models that have been proposed to improve GDM [...] Read more.
Gestational diabetes mellitus (GDM) is a hyperglycemic state that is typically diagnosed by an oral glucose tolerance test (OGTT), which is unpleasant, time-consuming, has low reproducibility, and results are tardy. The machine learning (ML) predictive models that have been proposed to improve GDM diagnosis are usually based on instrumental methods that take hours to produce a result. Near-infrared (NIR) spectroscopy is a simple, fast, and low-cost analytical technique that has never been assessed for the prediction of GDM. This study aims to develop ML predictive models for GDM based on NIR spectroscopy, and to evaluate their potential as early detection or alternative screening tools according to their predictive power and duration of analysis. Serum samples from the first trimester (before GDM diagnosis) and the second trimester (at the time of GDM diagnosis) of pregnancy were analyzed by NIR spectroscopy. Four spectral ranges were considered, and 80 mathematical pretreatments were tested for each. NIR data-based models were built with single- and multi-block ML techniques. Every model was subjected to double cross-validation. The best models for first and second trimester achieved areas under the receiver operating characteristic curve of 0.5768 ± 0.0635 and 0.8836 ± 0.0259, respectively. This is the first study reporting NIR-spectroscopy-based methods for the prediction of GDM. The developed methods allow for prediction of GDM from 10 µL of serum in only 32 min. They are simple, fast, and have a great potential for application in clinical practice, especially as alternative screening tools to the OGTT for GDM diagnosis. Full article
(This article belongs to the Topic Pathogenesis of Pregnancy-Related Complications 2.0)
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12 pages, 470 KiB  
Review
Maternal Influenza and Offspring Neurodevelopment
by Marya Egorova, Vladimir Egorov and Yana Zabrodskaya
Curr. Issues Mol. Biol. 2024, 46(1), 355-366; https://doi.org/10.3390/cimb46010023 - 2 Jan 2024
Viewed by 1298
Abstract
This review examines the complex interactions between maternal influenza infection, the immune system, and the neurodevelopment of the offspring. It highlights the importance of high-quality studies to clarify the association between maternal exposure to the virus and neuropsychiatric disorders in the offspring. Additionally, [...] Read more.
This review examines the complex interactions between maternal influenza infection, the immune system, and the neurodevelopment of the offspring. It highlights the importance of high-quality studies to clarify the association between maternal exposure to the virus and neuropsychiatric disorders in the offspring. Additionally, it emphasizes that the development of accurate animal models is vital for studying the impact of infectious diseases during pregnancy and identifying potential therapeutic targets. By drawing attention to the complex nature of these interactions, this review underscores the need for ongoing research to improve the understanding and outcomes for pregnant women and their offspring. Full article
(This article belongs to the Topic Pathogenesis of Pregnancy-Related Complications 2.0)
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17 pages, 1523 KiB  
Review
Regulation of SIRT1 in Ovarian Function: PCOS Treatment
by Xinrong Li, Yuxu He, Shuang Wu, Peiwen Zhang, Mailin Gan, Lei Chen, Ye Zhao, Lili Niu, Shunhua Zhang, Yanzhi Jiang, Zongyi Guo, Jinyong Wang, Linyuan Shen and Li Zhu
Curr. Issues Mol. Biol. 2023, 45(3), 2073-2089; https://doi.org/10.3390/cimb45030133 - 2 Mar 2023
Cited by 4 | Viewed by 2445
Abstract
The sirtuin family, a group of NAD+-dependent class 3 histone deacetylases (HDACs), was extensively studied initially as a group of longevity genes that are activated in caloric restriction and act in concert with nicotinamide adenine dinucleotides to extend the lifespan. Subsequent studies have [...] Read more.
The sirtuin family, a group of NAD+-dependent class 3 histone deacetylases (HDACs), was extensively studied initially as a group of longevity genes that are activated in caloric restriction and act in concert with nicotinamide adenine dinucleotides to extend the lifespan. Subsequent studies have found that sirtuins are involved in various physiological processes, including cell proliferation, apoptosis, cell cycle progression, and insulin signaling, and they have been extensively studied as cancer genes. In recent years, it has been found that caloric restriction increases ovarian reserves, suggesting that sirtuins may play a regulatory role in reproductive capacity, and interest in the sirtuin family has continued to increase. The purpose of this paper is to summarize the existing studies and analyze the role and mechanism of SIRT1, a member of the sirtuin family, in regulating ovarian function. Research and review on the positive regulation of SIRT1 in ovarian function and its therapeutic effect on PCOS syndrome. Full article
(This article belongs to the Topic Pathogenesis of Pregnancy-Related Complications 2.0)
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15 pages, 566 KiB  
Review
Difficulties in Adaptation of the Mother and Newborn via Cesarean Section versus Natural Birth—A Narrative Review
by Vasile Valeriu Lupu, Ingrith Crenguta Miron, Anca Adam Raileanu, Iuliana Magdalena Starcea, Ancuta Lupu, Elena Tarca, Adriana Mocanu, Ana Maria Laura Buga, Valeriu Lupu and Silvia Fotea
Life 2023, 13(2), 300; https://doi.org/10.3390/life13020300 - 21 Jan 2023
Cited by 19 | Viewed by 4542
Abstract
Birth is a physiological act that is part of the morpho-functional economy of the maternal body. Each stage in the act of birth has a predetermined pathway that is neurohormonally induced and morpho-functionally established through specific and characteristic adaptations. Like maternity, childbirth also [...] Read more.
Birth is a physiological act that is part of the morpho-functional economy of the maternal body. Each stage in the act of birth has a predetermined pathway that is neurohormonally induced and morpho-functionally established through specific and characteristic adaptations. Like maternity, childbirth also has an important impact on the maternal body as a biological structure and psycho-emotional behavior. Cesarean section performed at the request of the mother with no medical underlying conditions besides the prolonged hospitalization risk can also cause breathing problems in children, delayed breastfeeding, and possible complications in a future pregnancy. Vaginal birth remains the path of choice for a physiological evolution pregnancy. Although erroneously considered safe and easy today, cesarean section delivery must remain an emergency procedure or a procedure recommended for pregnancies where birth is a risk to the mother and to the child, as cesarean section itself is a risk factor for negative outcomes for both mother and baby. This review summarizes the impact that both cesarean section and natural birth have on mother and newborn in their attempt to adapt to postpartum events and extrauterine life. Full article
(This article belongs to the Topic Pathogenesis of Pregnancy-Related Complications 2.0)
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