Topic Editors

Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15224, USA
Dr. Yingmei Feng
Beijing Youan Hospital, Capital Medical University, Beijing, China
Dr. Zhiyong Lei
University Medical Center Utrecht, Utrecht, The Netherlands

Tissue-Specific, Disease-Signatured Macrophages in Control of Redox and Antioxidation in Metabolic Diseases

Abstract submission deadline
5 May 2025
Manuscript submission deadline
5 July 2025
Viewed by
2856

Topic Information

Dear Colleagues,

Reactive oxygen species (ROS) compose a complicated network signaling system, known as redox regulation, which is critical for maintenance of the homeostasis and metabolism of the human body. The imbalance of oxidation and anti-oxidation causes metabolic disorders, leading to many prevalent diseases, such as cancer, cardiovascular diseases, neurodegenerative diseases and diabetes. Macrophages play a pivotal role in immunity and nearly all physiological and pathological processes, during which macrophages act not only as one of the major target cells of oxidants, but also as important effector cells of inducible endogenous antioxidants. Accumulating evidence has demonstrated a pattern that macrophages dynamically adjust their activation profile toward a steadily changing microenvironment that requires altering their phenotype, a process known as macrophage polarization. Recent studies have shown that macrophage polarization is far more complicated than the classically catalogized proinflammatory M1 and anti-inflammatory M2, but more likely into a wide spectrum of phenotypes that do not fit rigidly into the definition of M1 or M2. To this end, studies on the tissue-specific, disease-signatured macrophage phenotypes appeared to be important for improving our understanding on the crosstalk between macrophages and microenvironment to regulate redox, metabolism, inflammation and immunity. After the outbreak of COVID-19, a notion arises that macrophages-associated regulation of ROS and immunity is altered by the viral infection and contributes to the disease progression and aggravation. The goal of this research topic aims to provide a scientific forum for the latest and innovative research for better understanding the role of macrophages as well as their specific polarization in the control of microenvironmental oxidative status that governs the initiation and progression of cancer, cardiovascular diseases, neurodegenerative diseases, diabetes and other related metabolic disorders. The scope of this research topic issue preferentially covers the latest and advanced results with innovative findings on the roles of macrophages, especially the specific phenotypic alteration of macrophages, in the control of microenvironmental oxidative status that governs the initiation and progression of cancer, cardiovascular diseases, neurodegenerative diseases, diabetes and other related metabolic disorders. Both research and review articles are welcome except case reports.

Dr. Xiangwei Xiao
Dr. Yingmei Feng
Dr. Zhiyong Lei
Topic Editors

Keywords

  • oxidants
  • antioxidants
  • ROS
  • metabolism
  • macrophages
  • macrophage polarization
  • inflammation
  • microenvironment
  • immune crosstalk
  • cell interactions
  • metabolic diseases
  • cancer
  • cardiovascular diseases
  • neurodegenerative diseases
  • diabetes

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
Antioxidants
antioxidants
6.0 10.6 2012 13.9 Days CHF 2900 Submit
Biomolecules
biomolecules
4.8 9.4 2011 16.9 Days CHF 2700 Submit
Journal of Cardiovascular Development and Disease
jcdd
2.4 2.6 2014 20.3 Days CHF 2700 Submit
Metabolites
metabolites
3.4 5.7 2011 13.2 Days CHF 2700 Submit
Neurology International
neurolint
3.2 3.7 2009 23.3 Days CHF 1600 Submit
Pharmaceutics
pharmaceutics
4.9 7.9 2009 14.2 Days CHF 2900 Submit

Preprints.org is a multidiscipline platform providing preprint service that is dedicated to sharing your research from the start and empowering your research journey.

MDPI Topics is cooperating with Preprints.org and has built a direct connection between MDPI journals and Preprints.org. Authors are encouraged to enjoy the benefits by posting a preprint at Preprints.org prior to publication:

  1. Immediately share your ideas ahead of publication and establish your research priority;
  2. Protect your idea from being stolen with this time-stamped preprint article;
  3. Enhance the exposure and impact of your research;
  4. Receive feedback from your peers in advance;
  5. Have it indexed in Web of Science (Preprint Citation Index), Google Scholar, Crossref, SHARE, PrePubMed, Scilit and Europe PMC.

Published Papers (1 paper)

Order results
Result details
Journals
Select all
Export citation of selected articles as:
28 pages, 26521 KiB  
Article
Lactiplantibacillus plantarum and Saussurea costus as Therapeutic Agents against a Diabetic Rat Model—Approaches to Investigate Pharmacophore Modeling of Human IkB Kinase and Molecular Interaction with Dehydrocostus Lactone of Saussurea costus
by Metab A. AlGeffari, Dina Mansour, Omar Ahmed-Farid, Einas Mohamed Yousef, Shereen A. Mohamed, Mahmoud M. A. Moustafa, Hassan Barakat and Khalid Abd El Ghany
Metabolites 2023, 13(6), 764; https://doi.org/10.3390/metabo13060764 - 19 Jun 2023
Viewed by 1604
Abstract
Lactic acid bacteria is well-known as a vital strategy to alleviate or prevent diabetes. Similarly, the plant Saussurea costus (Falc) Lipsch is a preventive power against diabetes. Here, we aimed to determine whether lactic acid bacteria or Saussurea costus is more effective in [...] Read more.
Lactic acid bacteria is well-known as a vital strategy to alleviate or prevent diabetes. Similarly, the plant Saussurea costus (Falc) Lipsch is a preventive power against diabetes. Here, we aimed to determine whether lactic acid bacteria or Saussurea costus is more effective in treating a diabetic rat model in a comparative study manner. An in vivo experiment was conducted to test the therapeutic activity of Lactiplantibacillus plantarum (MW719476.1) and S. costus plants against an alloxan-induced diabetic rat model. Molecular, biochemical, and histological analyses were investigated to evaluate the therapeutic characteristics of different treatments. The high dose of S. costus revealed the best downregulated expression for the IKBKB, IKBKG, NfkB1, IL-17A, IL-6, IL-17F, IL-1β, TNF-α, TRAF6, and MAPK genes compared to Lactiplantibacillus plantarum and the control groups. The downregulation of IKBKB by S. costus could be attributed to dehydrocostus lactone as an active compound with proposed antidiabetic activity. So, we performed another pharmacophore modeling analysis to test the possible interaction between human IkB kinase beta protein and dehydrocostus lactone as an antidiabetic drug. Molecular docking and MD simulation data confirmed the interaction between human IkB kinase beta protein and dehydrocostus lactone as a possible drug. The target genes are important in regulating type 2 diabetes mellitus signaling, lipid and atherosclerosis signaling, NF-κB signaling, and IL-17 signaling pathways. In conclusion, the S. costus plant could be a promising source of novel therapeutic agents for treating diabetes and its complications. Dehydrocostus lactone caused the ameliorative effect of S. costus by its interaction with human IkB kinase beta protein. Further, future studies could be conducted to find the clinical efficacy of dehydrocostus lactone. Full article
Show Figures

Figure 1

Back to TopTop