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Microorganisms
Special Issues
Advances in Mechanisms of Multidrug-Resistant Bacteria
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Advances in Mechanisms of Multidrug-Resistant Bacteria

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Antimicrobial Agents and Resistance".

Deadline for manuscript submissions: 31 October 2026 | Viewed by 895

Editor

Dr. Yongxin Jin

E-Mail Website
Guest Editor
State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China
Interests: gene regulation; antibiotic resistance; virulence factor; molecular mechanisms

Special Issue Information

Dear Colleagues,

The Special Issue entitled "Advances in Mechanisms of Multidrug-Resistant Bacteria" aims to present recent research on any aspect of the novel mechanisms of antibacterial resistance. Some of its focal points include, but are not limited to, the following:

  1. Novel resistance mechanisms in bacteria
  2. Innovative drug development for AMR bacteria
  3. Evolution of bacterial drug resistance

Reviews, original research, and communications will be welcome.

Dr. Yongxin Jin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial resistance
  • antimicrobial resistance evolution
  • multidrug-resistant bacteria
  • resistance mechanisms
  • innovative drug development

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

20 pages, 8855 KB  
Article
Synergistic Inhibition of Acinetobacter baumannii Biofilm Formation and Reduction of Lung Inflammation In Vivo by Combination of α-Pinene and Meropenem
by Shengqiang Yang, Yongqi Mu, Lin Wang and Hong Zeng
Microorganisms 2026, 14(5), 968; https://doi.org/10.3390/microorganisms14050968 - 25 Apr 2026
Viewed by 597
Abstract
Acinetobacter baumannii, a prominent opportunistic pathogen in healthcare settings, causes severe infections and poses significant challenges for clinical treatment. This study investigates the synergistic effects of α-pinene combined with meropenem (MEM) on A. baumannii biofilm formation and lung injury in mice, aiming [...] Read more.
Acinetobacter baumannii, a prominent opportunistic pathogen in healthcare settings, causes severe infections and poses significant challenges for clinical treatment. This study investigates the synergistic effects of α-pinene combined with meropenem (MEM) on A. baumannii biofilm formation and lung injury in mice, aiming to develop new strategies to combat persistent infections and antibiotic resistance. α-pinene combined with MEM exhibited strong synergistic antibacterial activity against carbapenem-resistant A. baumannii (CRAB 5E9). The combination significantly inhibited biofilm formation, extracellular polymer production, surface motility, and quorum sensing. The expression of key genes such as ompA, bfmR, bap, csuAB, abaI, and abaR was reduced by up to 61%. In vivo, the treatment alleviated weight loss, decreased the bacterial load in lung tissue, and reduced lung inflammation. Furthermore, it significantly suppressed proteins involved in the inflammatory response and the MAPK pathway, including TLR4, NF-κB, NLRP3, TRAF6, ERK2, p38 MAPK, JNK, and TNF-α. The combination of α-pinene and MEM synergistically inhibits A. baumannii biofilm formation and alleviates the inflammatory response in a mouse model, offering a potential therapeutic approach for combating A. baumannii infections. Full article
(This article belongs to the Special Issue Advances in Mechanisms of Multidrug-Resistant Bacteria)
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