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Compounds
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Organic Compounds with Biological Activity (2nd Edition)
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Organic Compounds with Biological Activity (2nd Edition)

A special issue of Compounds (ISSN 2673-6918).

Deadline for manuscript submissions: 31 October 2026 | Viewed by 2662

Editors

Dr. Małgorzata Anna Marć

E-Mail Website
Guest Editor
Cell Engineering Laboratory, La Paz University Hospital Health Research Institute (IdiPAZ), 28046 Madrid, Spain
Interests: ADMETox; pharmacology; anticancer research; multidrug resistance; efflux pumps; cytotoxicity; apoptosis; antibacterial assays; pharmaceutical biotechnology; drug discovery and development; selenocompounds; small molecules; probiotics
Special Issues, Collections and Topics in MDPI journals
Dr. Enrique Domínguez-Álvarez

E-Mail Website
Guest Editor
Instituto de Química Orgánica General, Consejo Superior de Investigaciones Científicas (IQOG-CSIC), Juan de la Cierva 3, 28006 Madrid, Spain
Interests: selenium; anticancer research; antibacterial activity; cancer multidrug resistance; bacterial multidrug resistance; efflux pumps; medicinal chemistry; organic synthesis; selenium chemistry; antifungal activity; antibiotics; biofilms; selenium nanoparticles
Special Issues, Collections and Topics in MDPI journals
Dr. Alcides Pinto Simao

E-Mail Website
Guest Editor Assistant
Fakultät für Chemie und Biochemie, Ruhr University Bochum, Universitatstraße 150, 44801 Bochum, Germany
Interests: polyaromatic hydrocarbons (PAH); trace amines; amino acids; sugars; matrix-isolation; Fourier-transform infrared spectroscopy (FTIR); quantum cascade laser-infrared-vibrational circular dichroism spectroscopy (QCL-IR-VCD); resonance-enhanced multiphoton ionization spectroscopy (REMPI); ion-dip spectroscopy; Fourier-transform microwave spectroscopy (FTMW); chirp-pulsed Fourier-transform microwave spectroscopy CP-FTMW; instrument design; analysis algorithms

Special Issue Information

Dear Colleagues,

Recently (2023–2025), we launched a successful first edition of this Special Issue, and here we launch a second edition, wishing to further develop on its success.

We live in a society that needs new developments to advance and to solve the problems of the daily life. In this context, chemistry can help through the identification of novel compounds that show biological activities and can be used to treat human and animal diseases, to improve the quality and properties of the food and beverages, to disinfect surfaces and to increase the production in agriculture and livestock.

These novel compounds can be chemically synthesized or isolated and purified from natural sources; and can have novel promising applications against the treatment of diseases, the management of plagues in agriculture and veterinary, or the disinfection of tools, spaces or surfaces, among other uses. In this Special Issue, we welcome works that report initial the synthesis, isolation, preparation, characterization and biological activities of chemical compounds that can serve to future applications in biology, medicine, pharmacy, medicinal chemistry, agriculture, veterinary and public health.

Dr. Małgorzata Anna Marć
Dr. Enrique Domínguez-Álvarez
Guest Editors

Dr. Alcides Pinto Simao
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Compounds is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biological activity
  • medicinal chemistry
  • chemical compounds
  • active compounds
  • organic chemistry
  • synthesis
  • biological applications
  • compounds in veterinary
  • compounds in agriculture

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

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19 pages, 1523 KB  
Article
Integrated Chemometric Assessment, Antioxidant Potential, and Phytochemical Fingerprinting of Selected Stachys and Betonica Plants
by Anna Hawrył, Mirosław Hawrył, Mykhaylo Chernetskyy, Wiktor Wojciech Winiarski and Anna Oniszczuk
Compounds 2026, 6(1), 14; https://doi.org/10.3390/compounds6010014 - 4 Feb 2026
Cited by 1 | Viewed by 742
Abstract
The aim of this study was to evaluate, on a preliminary basis, the ability of multivariate techniques to predict the antioxidant activity of selected Stachys and Betonica species, based on chromatographic data. The methanol extracts of six Stachys species and ten Betonica species [...] Read more.
The aim of this study was to evaluate, on a preliminary basis, the ability of multivariate techniques to predict the antioxidant activity of selected Stachys and Betonica species, based on chromatographic data. The methanol extracts of six Stachys species and ten Betonica species were analyzed using reversed-phase high-performance liquid chromatography (RP-HPLC) to obtain their chromatographic profiles. The phytochemical similarity of the samples was assessed using a selected chemometric method (principal component analysis (PCA) and hierarchical cluster analysis (HCA)). The antioxidant activity of the studied extracts (DPPH with 2,2-diphenyl-1-picrylhydrazyl reagent and FRAP—ferric reducing antioxidant power) was determined using a spectrophotometric technique. A multivariate PLS model was then used to predict the antioxidant activity of the methanolic extracts of Stachys and Betonica species based on their RP-HPLC fingerprints. The two obtained PLS models proved useful for predicting the biological activity of the tested extracts. High correlation coefficients (DPPH: R2 = 0.9963; FRAP: R2 = 0.9895) confirmed the reliability of the PLS prediction model. The results confirmed the effectiveness of combining qualitative and quantitative chromatographic fingerprinting methods with antioxidant activity testing and chemometric analysis, demonstrating that extracts from Stachys and Betonica are a rich source of bioactive substances with antioxidant properties. Full article
(This article belongs to the Special Issue Organic Compounds with Biological Activity (2nd Edition))
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14 pages, 547 KB  
Article
Efficient Recovery of Biologically Active Substances from Currant Pomace—Pre-Drying Effects on Supercritical CO2 Extracts
by Filip Herzyk, Małgorzata Korzeniowska and Tomasz Krusiński
Compounds 2025, 5(4), 48; https://doi.org/10.3390/compounds5040048 - 6 Nov 2025
Cited by 2 | Viewed by 1123
Abstract
Currant pomaces were valorised using food-grade supercritical CO2 to examine how pre-drying (convective vs. freeze-drying) and species (black vs. red currant) shape extract composition and antioxidant readouts. Total phenolics (TPCs), DPPH capacity, tocopherols and fatty acids were determined; statistics employed included the [...] Read more.
Currant pomaces were valorised using food-grade supercritical CO2 to examine how pre-drying (convective vs. freeze-drying) and species (black vs. red currant) shape extract composition and antioxidant readouts. Total phenolics (TPCs), DPPH capacity, tocopherols and fatty acids were determined; statistics employed included the Welch test with Holm adjustment and one-way ANOVA. Blackcurrant showed consistently higher TPCs than redcurrant, whereas DPPH responses were maximised in freeze-dried redcurrant. Freeze-drying increased PUFAs and concomitantly lowered SFAs within both species, with MUFAs varying within a narrower band and tending to be higher in blackcurrant. Tocopherol profiles in residues displayed homologue- and species-specific redistribution (e.g., α higher after convective drying in blackcurrant; γ/δ preferentially retained after freeze-drying), consistent with microstructure-dependent mass transfer and homologue-specific partitioning during SFE. Collectively, pre-drying emerged as the principal lever to tailor lipid class balance and antioxidant performance under fixed extraction conditions. Practically, freeze-drying is suited to PUFA-rich, antioxidant-active fractions, whereas convective drying favours more oxidation-resilient profiles. These results support process-informed ingredient design for clean-label applications and motivate yield-normalised mass balances and scale-up studies. Full article
(This article belongs to the Special Issue Organic Compounds with Biological Activity (2nd Edition))
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Review

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25 pages, 906 KB  
Review
Redox Biology of Capsaicin: ROS Signaling, Mitochondrial Regulation, and Ferroptosis
by Lenka Kuželová and Hana Ďúranová
Compounds 2026, 6(3), 41; https://doi.org/10.3390/compounds6030041 - 8 Jul 2026
Abstract
Capsaicin, the main pungent capsaicinoid of Capsicum species, is often described as either an antioxidant or a pro-oxidant compound. This binary view is useful but does not fully explain its effects on cellular redox homeostasis. The response to capsaicin depends on dose, exposure [...] Read more.
Capsaicin, the main pungent capsaicinoid of Capsicum species, is often described as either an antioxidant or a pro-oxidant compound. This binary view is useful but does not fully explain its effects on cellular redox homeostasis. The response to capsaicin depends on dose, exposure time, cell type, metabolic state, mitochondrial function, antioxidant capacity, and TRPV1 expression. Capsaicin can modulate reactive oxygen species (ROS) production through TRPV1-dependent calcium signaling, but also through TRPV1-independent effects on plasma and mitochondrial membranes. These mechanisms influence mitochondrial bioenergetics, membrane potential, lipid peroxidation, and redox-sensitive signaling. Moderate ROS formation may support adaptive responses, including Nrf2 activation, mitochondrial quality control, and cellular stress tolerance. In contrast, persistent or excessive ROS accumulation may promote mitochondrial dysfunction, apoptosis, and oxidative cell death. Evidence for capsaicin-associated ferroptosis is emerging, particularly through changes in lipid peroxidation, glutathione availability, GPX4 activity, and SLC7A11 expression or activity, but remains incomplete in many models. This review summarizes current evidence on capsaicin-mediated ROS regulation, mitochondrial stress, TRPV1-dependent and TRPV1-independent mechanisms, ferroptosis-related pathways, and methodological challenges in oxidative stress assessment. Full article
(This article belongs to the Special Issue Organic Compounds with Biological Activity (2nd Edition))
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