Organic Compounds with Biological Activity (2nd Edition)

A special issue of Compounds (ISSN 2673-6918).

Deadline for manuscript submissions: 31 October 2026 | Viewed by 898

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Guest Editor
Cell Engineering Laboratory, La Paz University Hospital Health Research Institute (IdiPAZ), 28046 Madrid, Spain
Interests: ADMETox; pharmacology; anticancer research; multidrug resistance; efflux pumps; cytotoxicity; apoptosis; antibacterial assays; pharmaceutical biotechnology; drug discovery & development; selenocompounds; small molecules; probiotics
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Instituto de Química Orgánica General, Consejo Superior de Investigaciones Científicas (IQOG-CSIC), Juan de la Cierva 3, 28006 Madrid, Spain
Interests: selenium; anticancer research; antibacterial activity; cancer multidrug resistance; bacterial multidrug resistance; efflux pumps; medicinal chemistry; organic synthesis; selenium chemistry; antifungal activity; antibiotics; biofilms; selenium nanoparticles
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Guest Editor Assistant
Fakultät für Chemie und Biochemie, Ruhr University Bochum, Universitatstraße 150, 44801 Bochum, Germany
Interests: polyaromatic hydrocarbons (PAH); trace amines; amino acids; sugars; matrix-isolation; Fourier-transform infrared spectroscopy (FTIR); quantum cascade laser-infrared-vibrational circular dichroism spectroscopy (QCL-IR-VCD); resonance-enhanced multiphoton ionization spectroscopy (REMPI); ion-dip spectroscopy; Fourier-transform microwave spectroscopy (FTMW); chirp-pulsed Fourier-transform microwave spectroscopy CP-FTMW; instrument design; analysis algorithms

Special Issue Information

Dear Colleagues,

Recently (2023–2025), we launched a successful first edition of this Special Issue, and here we launch a second edition, wishing to further develop on its success.

We live in a society that needs new developments to advance and to solve the problems of the daily life. In this context, chemistry can help through the identification of novel compounds that show biological activities and can be used to treat human and animal diseases, to improve the quality and properties of the food and beverages, to disinfect surfaces and to increase the production in agriculture and livestock.

These novel compounds can be chemically synthesized or isolated and purified from natural sources; and can have novel promising applications against the treatment of diseases, the management of plagues in agriculture and veterinary, or the disinfection of tools, spaces or surfaces, among other uses. In this Special Issue, we welcome works that report initial the synthesis, isolation, preparation, characterization and biological activities of chemical compounds that can serve to future applications in biology, medicine, pharmacy, medicinal chemistry, agriculture, veterinary and public health.

Dr. Małgorzata Anna Marć
Dr. Enrique Domínguez-Álvarez
Guest Editors

Dr. Alcides Pinto Simao
Guest Editor Assistant

Manuscript Submission Information

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Keywords

  • biological activity
  • medicinal chemistry
  • chemical compounds
  • active compounds
  • organic chemistry
  • synthesis
  • biological applications
  • compounds in veterinary
  • compounds in agriculture

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Published Papers (1 paper)

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14 pages, 547 KB  
Article
Efficient Recovery of Biologically Active Substances from Currant Pomace—Pre-Drying Effects on Supercritical CO2 Extracts
by Filip Herzyk, Małgorzata Korzeniowska and Tomasz Krusiński
Compounds 2025, 5(4), 48; https://doi.org/10.3390/compounds5040048 - 6 Nov 2025
Cited by 1 | Viewed by 598
Abstract
Currant pomaces were valorised using food-grade supercritical CO2 to examine how pre-drying (convective vs. freeze-drying) and species (black vs. red currant) shape extract composition and antioxidant readouts. Total phenolics (TPCs), DPPH capacity, tocopherols and fatty acids were determined; statistics employed included the [...] Read more.
Currant pomaces were valorised using food-grade supercritical CO2 to examine how pre-drying (convective vs. freeze-drying) and species (black vs. red currant) shape extract composition and antioxidant readouts. Total phenolics (TPCs), DPPH capacity, tocopherols and fatty acids were determined; statistics employed included the Welch test with Holm adjustment and one-way ANOVA. Blackcurrant showed consistently higher TPCs than redcurrant, whereas DPPH responses were maximised in freeze-dried redcurrant. Freeze-drying increased PUFAs and concomitantly lowered SFAs within both species, with MUFAs varying within a narrower band and tending to be higher in blackcurrant. Tocopherol profiles in residues displayed homologue- and species-specific redistribution (e.g., α higher after convective drying in blackcurrant; γ/δ preferentially retained after freeze-drying), consistent with microstructure-dependent mass transfer and homologue-specific partitioning during SFE. Collectively, pre-drying emerged as the principal lever to tailor lipid class balance and antioxidant performance under fixed extraction conditions. Practically, freeze-drying is suited to PUFA-rich, antioxidant-active fractions, whereas convective drying favours more oxidation-resilient profiles. These results support process-informed ingredient design for clean-label applications and motivate yield-normalised mass balances and scale-up studies. Full article
(This article belongs to the Special Issue Organic Compounds with Biological Activity (2nd Edition))
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