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Molecular Biology and the Genetic Breeding of Aquatic Animals: Breakthroughs and Challenges (2nd Edition)

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 20 April 2026 | Viewed by 230

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Guest Editor
Integrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City & College of Fisheries, Southwest University, Chongqing 402460, China
Interests: molecular biology and genetic breeding of aquatic animals; biodiversity and conservation of aquatic animals; sustainable development of fishery
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Special Issue Information

Dear Colleagues,

Aquatic animals are important for ensuring the aquatic product supply in terms of high levels of proteins, unsaturated fatty acids, vitamins, and microelements. Recently, the increasing demands for aquatic products have resulted in the rapid depletion of fishery stocks all over the world. With decreasing water resources, it has become urgent to improve the aquaculture industry’s efficiency and sustainability. Thus, to obtain new breeds with desirable traits such as a rapid growth, a high meat quality, and stress resistance, a variety of technologies have been developed by the molecular biology and genetic breeding fields. The present Special Issue will focus on aquaculture industry improvements in molecular biology, such as genomic sequencing and gene-editing technologies, as well as genetic breeding, such as markers’ assistant selective, integration, and modification breeding. We welcome original research article and review submissions that contribute to progress in molecular biology and the genetic breeding of aquatic animals.

Prof. Dr. Hongyan Xu
Guest Editor

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Keywords

  • transgenic
  • genetic breeding
  • omics
  • gene expression and regulation
  • aquatic animals

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Published Papers (1 paper)

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Research

35 pages, 18788 KB  
Article
Crustacean Protein Kinases A and C: Bioinformatic Characterization in Decapods and Other Non-Model Organisms
by Talia B. Head, Jorge L. Pérez-Moreno, Laura E. Antizzo, David S. Durica and Donald L. Mykles
Int. J. Mol. Sci. 2025, 26(21), 10585; https://doi.org/10.3390/ijms262110585 - 30 Oct 2025
Abstract
The AGC kinases constitute a large and ancient gene superfamily with origins that coincided with the appearance of multicellularity. Three AGC kinase families—protein kinase A (PKA), protein kinase G (PKG), and protein kinase C (PKC)—mediate the actions of neuropeptide hormones, biogenic amines, and [...] Read more.
The AGC kinases constitute a large and ancient gene superfamily with origins that coincided with the appearance of multicellularity. Three AGC kinase families—protein kinase A (PKA), protein kinase G (PKG), and protein kinase C (PKC)—mediate the actions of neuropeptide hormones, biogenic amines, and other ligands on various physiological processes in metazoans. Metazoans express two PKG types. Jawed vertebrates express three PKA catalytic (C) subunits, four regulatory (R) subunits, and twelve PKCs, organized into conventional, novel delta-like, novel epsilon-like, atypical, and protein kinase N (PKN) subfamilies. By contrast, invertebrate PKA and PKC sequences are not well characterized. Consequently, limited database resources can result in misidentification or mischaracterization of proteins and can lead to misinterpretation of experimental data. A broad phylogenetic and sequence analysis of CrusTome transcriptome and GenBank databases was used to characterize 640 PKA-C sequences, 1122 PKA-R sequences, and 1844 PKC sequences distributed among the Annelida, Arthropoda, Chordata, Cnidaria, Nematoda, Mollusca, Echinodermata, Porifera, Platyhelminthes, and Tardigrada. Phylogenetic analysis and multiple sequence alignments revealed conservation of certain PKA-C, PKA-R and PKC isoforms across metazoans, as well as diversification of additional taxon-specific isoforms. Decapods expressed four PKA-C isoforms, designated PKA-C1, -CD1, -CGLY1, and -CGLY2; five PKA-R isoforms, designated PKA-RI1, -RID1, -RIIGLY, and -RIID1; and five PKC isoforms, designated PKND1-3, conventional cPKCD1, novel nPKCD1δ and nPKCD1ε, and atypical aPKCD1. PKA-CGLY1, -CGLY2, and -RIIGLY had glycine-rich N-terminal sequences that were unique to crustaceans. These data suggest lineage-specific diversification that retained the core catalytic function of each kinase, while regions outside of the kinase domain may provide specialized regulatory mechanisms and/or spatiotemporal subcellular localization in invertebrate tissues. Full article
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