Nutraceuticals: Current Approaches in Their Metabolism, Biological Activity and Preservation

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 2927

Special Issue Editors


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Guest Editor
CONACyT—Benemérita Universidad Autónoma de Puebla, Puebla, Mexico
Interests: nutraceuticals; metabolic engineering; metabolomics; transcriptomics; functional genomics

E-Mail Website
Guest Editor
Centro de Investigación y de Estudios Avanzados del IPN, Unidad Irapuato, Km 9.6 Carretera Irapuato-León, 36824 Irapuato, Guanajuato, Mexico
Interests: biotechnology; natural plant products; flavonoids; terpnoids; microalgae; molecular biology; biochem

Special Issue Information

Dear Colleagues,

The term nutraceutical involves natural substances able to improve human health. These substances are mainly biosynthesized and accumulated by plants, algae, fungi and other organisms in the form of secondary or even primary metabolites. In the character of nutraceuticals, these compounds need to be orally consumed to exert their benefits. Knowing the biological activity of nutraceuticals from edible sources may help to understand the natural ability of foods, especially native foods for controlling the inflammatory and oxidative process derived from unbalanced diets which promote the prevalence of obesity, type 2 diabetes mellitus, hypertension, dyslipidemias and neurodegenerative diseases. This volume aims to compile and disseminate recent efforts regarding the discovery of new sources of nutraceuticals supported by cutting-edge analytical techniques and novel biological or in silico protocols which led to elucidating their therapeutic effects. In addition, reports on new biotechnological platforms to scale the production of molecules with proven nutraceutical activity are also welcome. Authors are invited to submit potential contributions considering the following points:

  1. Qualitative and quantitative analytical studies for determining the accumulation of single or combined nutraceuticals in novel or overlooked edible sources.
  2. Metabolomics profiling to understand the synthesis and accumulation of primary and secondary metabolites in edible sources under diverse experimental conditions.
  3. In vitro, in vivo and in silico approaches to clarify the nutraceutical activity of single or combined substances.
  4. Biosynthesis, metabolic engineering, tissue culture and elicitation for the sustainable production of nutraceuticals.
  5. New methods to preserve nutraceuticals in foods.
  6. Comprehensive reviews on the status of molecules with nutraceutical activity.

Potential contributions may be focused on one of the first five points or cover more than one requirement.

Dr. Nemesio Villa-Ruano
Dr. Edmundo Lozoya-Gloria
Guest Editors

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Keywords

  • nutraceuticals
  • new sources
  • metabolism
  • accumulation
  • instrumental analysis
  • biological tests
  • metabolic engineering
  • tissue culture

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Published Papers (1 paper)

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Research

11 pages, 1013 KiB  
Article
Anti-Inflammatory Potential of Pteropodine in Rodents
by Rogelio Paniagua-Pérez, Laura Sánchez-Chapul, Eduardo Madrigal-Bujaidar, Isela Álvarez-González, Eduardo Madrigal-Santillán, Lidia Cruz-Hernández, Carlos Martínez-Canseco, Celia Reyes-Legorreta, Lidia Ruiz-Rosano, Cecilia Hernández-Flores, Rene Valdez-Mijares and Alejandra Quintana-Armenta
Metabolites 2023, 13(8), 907; https://doi.org/10.3390/metabo13080907 - 3 Aug 2023
Cited by 2 | Viewed by 1599
Abstract
Pteropodine (PT) is a component of some plants with potentially useful pharmacological activities for humans. This compound has biomedical properties related to the modulation of the immune system, nervous system, and inflammatory processes. This study addresses the anti-inflammatory and antioxidant capacity of pteropodin [...] Read more.
Pteropodine (PT) is a component of some plants with potentially useful pharmacological activities for humans. This compound has biomedical properties related to the modulation of the immune system, nervous system, and inflammatory processes. This study addresses the anti-inflammatory and antioxidant capacity of pteropodin in a murine model of arthritis and induced edema of the mouse ear. To evaluate the anti-inflammatory activity, we used the reversed passive Arthus reaction (RPAR), which includes the rat paw edema test, the rat pleurisy test, and a mouse ear edema model. The antioxidant effect of PT was evaluated by determining the myeloperoxidase enzyme activity. PT showed an anti-inflammatory effect in the different specific and non-specific tests. We found a 51, 66 and 70% inhibitory effect of 10, 20 and 40 mg/kg of PT, respectively, in the rat paw edema test. In the pleurisy assay, 40 mg/kg of PT induced a low neutrophil count (up to 36%) when compared to the negative control group, and 20 mg/kg of PT increased the content of lymphocytes by up to 28% and the pleural exudate volume decreased by 52% when compared to the negative control group, respectively. We also found an 81.4% inflammatory inhibition of the edema ear with 0.04 mg/ear of PT, and a significant myeloperoxidase enzyme inhibition by the three doses of PT tested. We conclude that PT exerted a potent anti-inflammatory effect in the acute inflammation model in rodents. Full article
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