Search Results (3,106)

Background/Objectives: Professional quality of life influences patient care, staff well-being, and organizational efficacy. The COVID-19 pandemic placed pressure on healthcare professionals, disrupting their professional quality of life and imposing a psychological burden. In Greece, these issues were intensified by a decade of economic crisis, marked by constrained healthcare budget, personnel shortages, and insufficient resources. This study investigates the pandemic’s impact on the professional quality of life of Greek healthcare professionals to support targeted interventions. Methods: A cross-sectional study was conducted using descriptive statistics. The participants were a convenience sample of 246 healthcare professionals from a Greek regional university hospital with at least one year of experience and who had worked with COVID-19-positive or potentially exposed but asymptomatic patients. Data were collected between March and June 2021 using the Professional Quality of Life Scale (version 5). Results: Of the 246 participants, 81.3% were women and 33.8% were aged 50 or older. Moderate concern and fear regarding COVID-19 were reported, with 34.6% extremely afraid of transmitting the virus to family or friends and 22.8% to patients or their families. Overall professional quality of life was moderate: compassion satisfaction was moderate to high, while burnout and secondary traumatic stress were moderate to low. Higher compassion satisfaction was linked to holding a position of responsibility. Burnout was associated with having children, permanent employment, years of experience, and increased pandemic-related fear. Higher secondary traumatic stress was associated with older age, more years of experience, and greater pandemic-related fear. Conclusions: These findings support international research and highlight that the moderate levels observed indicate intrinsic motivation based on professionalism in patient care, providing evidence of resilience and coping mechanisms that reduce psychological consequences on well-being due to the pandemic. Full article

This study considers citrus rootstocks as autonomous biological entities and examines whether, and to what extent, they differently regulate plant–water relations and biomass allocation as well as how such physiological variations translate into differences in vegetative vigor. To address these questions, four citrus genotypes—Sour Orange (SO), Volkamer Lemon (VL), Swingle Citrumelo (CTR), and Troyer Citrange (TC)—were compared with respect to their morphological traits, biomass distribution, and hydraulic properties. These four rootstocks were selected as they represent contrasting genetic backgrounds and well-documented differences in vigor, stress tolerance, and hydraulic behavior, providing an effective model for assessing intrinsic physiological variability. The findings reveal pronounced rootstock-specific differences in water acquisition, transport, and utilization, with direct implications for the hydraulic architecture, leaf water status, and partitioning of biomass between above- and belowground organs. CTR exhibited a highly integrated hydraulic strategy, characterized by elevated conductance across both aerial and root systems and accompanied by greater biomass allocation to the canopy and absorptive roots, resulting in an enhanced overall vigor. SO and VL displayed an intermediate physiological performance, whereas TC demonstrated a restricted hydraulic transport capacity, which is associated with lower biomass allocation, reduced leaf water potential, and diminished vigor. By assessing rootstocks independently of scion influences, this work demonstrates that variations between citrus rootstocks cannot be explained solely by morphological traits but instead reflect contrasting physiological strategies governing the coordinated management of water and carbon resources. These results highlight the rootstock as a central determinant of hydraulic functioning, biomass partitioning, and plant vigor and provide a conceptual basis for selecting rootstocks that are better suited to water-limited environments. Full article

This review highlights the anti-inflammatory and antioxidant effects of probiotics and their complex health-related impacts. The main health areas targeted are gastrointestinal inflammation, neuroinflammation, systemic metabolic disorders, and liver conditions. Probiotics work mechanistically to regulate key inflammatory pathways by suppressing nuclear factor (NF-κb) and mitogen-activated protein kinase (MAPK) pathways and activating antioxidant defenses through nuclear erythroid 2-related factor (Nrf2). They stimulate anti-inflammatory cytokines (including interleukin 10 (IL-10) and inhibit pro-inflammatory mediators such as tumor necrosis factor-α (TNF-α), partly through the regulation of T cells. Probiotics also produce antioxidant metabolites (e.g., exopolysaccharides and short-chain fatty acids), which enhance the host’s resistance to oxidative stress. Supplementation with probiotics improves intestinal inflammation and oxidative injury in gut disorders. Clinical trials suggest that probiotic supplements may reduce neuroinflammation and oxidative stress, while improving cognitive or behavioral outcomes in neurodegenerative disorders. Overall, this review underscores that probiotics have potent anti-inflammatory and antioxidant effects within the gut–brain axis and across various organ systems, supporting their use as valuable adjunctive therapies for inflammatory and oxidative stress-related conditions. It further emphasizes that additional mechanistic research and controlled clinical trials are essential to translate these findings into the most effective therapeutic strategies. Full article

Background/Objectives: Veterinarians are among the most stressed of all professional groups. Their work is characterised by long working hours, high emotional demands and an increased risk of anxiety, depression, suicide and burnout. The aim of this cross-sectional study that examines retrospective records of experienced violence was to analyse the frequency of violent acts and their connection to certain factors (age, gender, place of work, and specialist area according to animal species). Methods: This nationwide, cross-sectional, online survey of veterinarians in Germany was conducted between July 2021 and February 2023. A total of 1053 veterinarians were included in the analysis, which was conducted according to the respondents’ age, (<35 years, 35–45 years and >45 years), gender, workplace and veterinary specialisation. Sociodemographic and work-related data were collected, as were responses to questions regarding experiences of violence, which were differentiated between verbal abuse and physical violence. The data were analysed using descriptive statistics and non-parametric group comparisons (Kruskal–Wallis test with Bonferroni correction, Mann–Whitney U test and Pearson’s chi-squared test). Results: Overall, 52.7% of veterinarians reported experiencing verbal abuse or physical violence at the hands of animal owners. Verbal abuse occurred, on average, more than three times per month, whereas physical violence was rare. Physical violence occurred significantly more frequently among middle-aged veterinarians (p < 0.001). The highest prevalence of verbal abuse or violence (72.5%, p < 0.001) was reported by veterinarians working in public authorities, while the lowest was reported by those working in laboratories. Conclusions: Workplace violence against veterinarians is a frequent occupational burden in Germany and highlights the urgent need for targeted prevention, de-escalation training and organisational support across veterinary settings. Full article

The purpose of this study is to examine how employees’ artificial intelligence awareness (AIA) influences adaptive performance in the workplace through the mediating roles of eustress and task crafting within the Job Demands–Resources (JD-R) Theory. Data were collected from 372 full-time employees working in five-star hotels and analyzed using PLS-SEM with WarpPLS. The findings reveal that employees’ AI awareness significantly enhances adaptive performance both directly and indirectly. AI awareness also positively predicts eustress and task crafting, suggesting that informed employees experience motivating stress and actively reshape their tasks to optimize work processes. Moreover, both eustress and task crafting serve as significant mediators, amplifying the effect of AI awareness on adaptive performance. These results underscore the value of cultivating AI knowledge among employees to foster proactive behaviors and positive stress responses, ultimately supporting adaptability in dynamic work environments. The study contributes to JD-R Theory by integrating AI-related awareness as a personal resource driving employee adaptation. Full article

A major danger that significantly raises the possibility of deep coal mining accidents is the delayed water influx from the bottom plate, which is brought on by the activation of tiny faults brought on by mining at the working face of the restricted aquifer. This study develops 17 numerical models utilizing FLAC3D simulation software 6.00.69 to clarify the activation and water inburst mechanisms of minor faults influenced by various parameters, incorporating fluid–solid coupling effects in coal seam mining. The developmental patterns of the stress field, displacement field, plastic zone, and seepage field of the floor rock layer were systematically examined in relation to four primary factors: aquifer water pressure, minor fault angle, fracture zone width, and the distance from the coal seam to the aquifer. The results of the study show that the upper and lower plates of the minor fault experience discontinuous deformation as a result of mining operations. The continuity of the rock layers below is broken by the higher plate’s deformation, which is significantly larger than that of the lower plate. The activation and water flow into small faults are influenced by many elements in diverse ways. Increasing the distance between the coal seam and the aquifer will make the water conduction pathway more resilient. This will reduce the amount of water that flows in. On the other hand, higher aquifer water pressure, a larger fracture zone, and a fault that is tilted will all help smaller faults become active and create channels for water to flow into. The gray relational analysis method was used to find out how sensitive something is. The sensitivities of each factor to water influence were ranked from high to low as follows: distance between the aquifer and coal seam (correlation coefficient 0.766), aquifer water pressure (0.756), width of the fracture zone (0.710), and angle of the minor fault (0.673). This study statistically elucidates the inherent mechanism of delayed water instillation in minor faults influenced by many circumstances, offering a theoretical foundation for the accurate prediction and targeted mitigation of mine water hazards. Full article

The APETALA2/Ethylene Response Factor (AP2/ERF) family of transcription factors (TF) is characterized by their participation in various biological processes related to growth, development, and response to stress. ERFs are ideal candidates for crop improvement because they regulate defense genes like JERF1, JERF3, LeERF2, NtERF5, and Tsil which confer tolerance to drought, salinity, osmotic stress, and pathogen attack, respectively. The ERF subfamily includes the TF Pti4, whose activity is regulated by different signaling pathways, thus providing tolerance response to multiple factors such as drought, salinity, cold, and pathogen attack in tomato. In this work we evaluated the effect of overexpression of TF SlPti4 from Solanum lycopersicum in transgenic tobacco plants when subjected to saline, osmotic, and drought stress. Our results from this study demonstrated that transgenic lines overexpressing Pti4 tolerate abiotic stress during germination and in plants. The transgenic lines showed improvements in photoinhibition, electron transport rate, chlorophyll content, and biomass, as well as a reduction in malondialdehyde content. Full article

Brain-derived growth factor, BDNF, has critical roles in a wide variety of neuronal aspects, including cell survival, differentiation, and synaptic function after their maturation. TrkB, a high-affinity receptor for BDNF, is a major contributor in these neuronal aspects, and its functions are exerted via stimulating intracellular signaling pathways including the mitogen-activated protein kinase (MAPK) pathways. As a family of MAPKs, the functions of ERK1/2, p38MAPK, and JNKs have been extensively studied using in vivo and in vitro neuronal systems. ERK 1/2, a major serine-threonine kinase and belonging to the MAPK family, also works as a downstream molecule after activation of the BDNF/TrkB system. Interestingly, growing evidence has demonstrated that ERK1/2 signaling exerts a positive or negative influence on neurons in both healthy and pathological conditions in the central nervous system (CNS). Indeed, activation of ERK 1/2 stimulated by the BDNF/TrkB system is involved in the regulation of synaptic plasticity. On the other hand, overactivation of ERK1/2 signaling under pathological conditions is closely related to neurodegeneration. Furthermore, cell stress activates p38MAPKs and JNK signaling, contributing to the progression of neurodegeneration. In this review, we show how MAPK pathway signaling affects neuronal fate, including cell survival or cell death, in the CNS. Moreover, we discuss the involvement of overactivation of MAPK signaling in the neurodegeneration observed in Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD). Full article

Short-range internal timing supports coordinated movement, attention, and physiological regulation, yet distortions of time experience are frequently reported across clinical and high-arousal states. Patients with anxiety or acute stress often describe an apparent acceleration of time, whereas depressive states are more commonly associated with a slowing of subjective time. Neurological conditions, including Parkinson’s disease and epilepsy, further demonstrate alterations in temporal processing that cannot be reduced to a single mechanism. This narrative review synthesizes evidence from experimental timing paradigms, subjective passage-of-time judgments, and chronobiological approaches to examine how internal timing varies across biological states. In this study, we highlight the distinction between experiential time distortion and performance-based interval timing and discuss how task characteristics, arousal level, and neural context contribute to heterogeneous findings. Historical and methodological foundations are reviewed, including early chronobiological work linking subjective time estimation to biological rhythms. The reviewed evidence suggests that many timing distortions observed in stress-related, affective, and neurological conditions reflect state-dependent reconfiguration rather than irreversible dysfunction. Framing timing variability as a potential marker of internal state may help reconcile inconsistent results across paradigms and inform future clinical and translational research on temporal processing. Full article

Background/Objectives: Nurses are susceptible to compassion fatigue due to the nature of their professional responsibilities. Factors contributing to this vulnerability include daily patient interactions and organizational elements within their work environment, as well as work-related stress and sociodemographic characteristics, including age, marital status, years of professional experience, and, notably, gender. This research investigates the relationship between compassion fatigue and the levels of anxiety and depression, as well as the professional quality of life among nurses providing care to dementia patients in Greece. Methods: A cross-sectional survey was carried out with 115 nurses working in dementia care centers in Greece. The Hospital Anxiety and Depression Scale (HADS), the Professional Quality of Life Scale (ProQOL-5), and the participants’ personal, demographic, and professional information were all included in an electronic questionnaire. Multiple regression analysis was used. Results: A total of 42.6% of nurses rated their working environment as favorable. Additionally, 23.5% of the sample exhibited high levels of compassion satisfaction, whereas 46.1% demonstrated low levels of burnout. Female gender (p = 0.022) and a higher family income (p = 0.046) was positively associated with compassion satisfaction. Regression analysis indicated that elevated symptoms of anxiety and depression were found to correlate with decreased compassion satisfaction, increased burnout, and heightened secondary post-traumatic stress. Conclusions: Engaging in the care of patients with dementia, particularly throughout the pandemic period, has underscored a pronounced susceptibility to compassion fatigue, physical fatigue, pain, psychological stress, and a reduced quality of life. These results highlight the importance for nursing management to adopt specific organizational measures, including proper staffing levels, balancing workloads, and conducting routine mental health assessments. Full article

High-arch dams are usually built in high-ground stress distribution areas. The deformation and stability of the abutment slope are directly related to the safety of the construction and operation of these dams. At present, there are few studies on deformation monitoring and analysis of ultra-high-arch dam abutment slopes. In this study, the surface displacement, anchor stress, and anchor cable’s anchoring force of the dam abutment slope of Wudongde Hydropower Station before and after impounding were monitored, and the safety and deformation mechanism of the dam abutment slope were analyzed, focusing on its change amplitude and change trends. Our results indicate that surface displacement and rock mass deformation at the abutment slopes on both banks are minimal, with stability being maintained following excavation and support works and no abnormal deformation occurring during impoundment. Most anchor bolt stresses remained below 50 MPa, with stable readings exceeding 200 MPa at monitored points. The loss rates of the anchor cable’s anchorage force generally fell within ±15%, with variations primarily occurring prior to excavation and support works. Minimal changes were observed before and after impoundment, indicating overall slope stability. The deformation and stress of the dam abutment slope did not exhibit abnormal changes before or after impounding, and the entire slope is in a stable state. These research results provide a reference for the safe operation of Wudongde Hydropower Station. Full article

Cell morphology and its mechanical properties are crucial factors in cancer development, affecting migration, invasiveness, and the potential risk of metastasis. However, most studies address these aspects separately, limiting the understanding of how morphological complexity relates to cellular mechanics. This work presents an integrated approach that simultaneously quantifies morphology and viscoelasticity in the human osteosarcoma cell line MG-63. Stress–relaxation experiments and optical imaging of the same cells were performed using a custom-built system that couples Atomic Force Microscopy (AFM) with an inverted optical microscope. Morphometric parameters were extracted from cell contours, while viscoelastic properties were obtained by fitting AFM data to the Fractional Kelvin (FK) and Fractional Zener (FZ) models. Among the morphological descriptors, the Shape Complexity (SC) was proposed. It is derived from the Lobe Contribution Elliptical Fourier Analysis (LOCO-EFA), which captures fine-scale contour features overlooked by conventional metrics. Experimental results show that, in MG-63 cells, higher SC values are associated with greater stiffness, indicating a correlation between cell shape complexity and cell stiffness. Furthermore, loading-rate analysis shows that the FZ model captures strain-rate-dependent stiffening more effectively than the FK model. This methodology provides a first approach to jointly analyzing quantitative morphological parameters and mechanical properties, underlining the importance of combined studies to achieve a comprehensive understanding of cell behavior. Full article

Background: This study investigated the relationships between hematological and bone metabolism variables in 35 elite female trail runners, focusing on identifying key hematological correlates of bone health. Methods: Forty-four hematological variables, including biochemical, hormonal, metabolic, liver enzyme, and iron profiles, as well as complete blood count and platelet indices, were analyzed. Bone mineral density (BMD) and bone mineral content (BMC) were assessed at multiple skeletal regions via dual-energy X-ray absorptiometry (DXA). A cross-sectional design was employed, utilizing descriptive statistics, correlation analyses, and multiple linear regression to analyze the associations between hematological markers and BMC and BMD. Results: Significant but moderate associations were identified: magnesium consistently emerged as a negatively associated factor, particularly associated with BMC and BMD in the lumbar spine (L1–L4) and whole-body, potentially reflecting hypothesized mineral mobilization during chronic physical stress. Follicle-stimulating hormone showed positive associations with BMD, suggesting a potential protective association in bone turnover regulation. Additionally, calcium and thyroid hormones were linked to regional bone properties, highlighting site-specific skeletal vulnerabilities. Conclusions: These findings suggest a complex interplay between mineral homeostasis and hormonal balance that may be related to skeletal integrity in elite female trail runners. This work provides a foundation for developing evidence-based guidelines to support the health and performance of female endurance athletes. Further research is warranted to confirm these results through longitudinal evaluations. Full article

Fatty liver in fish is characterized by excessive lipid accumulation, driven by factors such as inflammation, oxidative stress, and the overexpression of lipid-related genes. This condition can lead to metabolic dysfunction and reduced disease resistance, resulting in growth disorders and even mortality. Increasing incidence of fatty liver is closely linked to environmental conditions and feeding practices, posing significant challenges to the aquaculture industry. This paper offers a comprehensive overview of hepatic steatosis, with a particular emphasis on fish species. Through a detailed review of various scholarly works, this paper seeks to identify common patterns, emerging trends, and measurable correlations, highlighting the critical importance of understanding this complex relationship. The study of fatty liver is conducted across three dimensions: influencing factors, underlying mechanisms, and potential solutions. Currently, numerous factors contribute to the development of fatty liver, such as feed composition and environmental temperature. On a mechanistic level, the research explores lipid accumulation, inflammation, oxidative stress, and related processes. Furthermore, the paper suggests various solutions and preventive strategies, including considering environmental adaptability during animal migration, employing genetic enhancement techniques, modifying feeding practices, investigating the Nrf2 pathway, and utilizing rapamycin. These findings have significant implications for fisheries management and aquaculture practices, providing valuable insights to enhance sustainability in the industry. Full article

Emotional dysregulation (ED) reflects a heightened reactivity to stimuli, characterized by excessive negative affect and impulsive behaviors. This study aimed to evaluate ED in workers seeking care for occupational stress and to examine its associations with sociodemographic characteristics, occupational stress, and the severity of anxiety and depressive symptoms. Eighty-seven workers referred for work-related stress were assessed using the Psychological Stress Measure (PSM) and the Job Content Questionnaire (JCQ) for stress, the Beck Depression Inventory-II (BDI-II) and the Self-Rating Anxiety Scale (SAS) for psychopathology, and the RIPoSt-40 for ED. Group comparisons and correlation analyses were conducted using parametric or non-parametric tests, as appropriate. Forty-six percent of participants met criteria for Adjustment Disorders and 54% for Major Depressive Disorder. No significant differences between diagnostic groups emerged for ED or symptom severity. Women reported higher perceived stress and anxiety than men. Negative ED domains—affective instability, negative emotionality, and emotional impulsivity—showed moderate-to-strong positive correlations with stress, anxiety, and depressive symptoms. Affective instability was also related to job stress dimensions, correlating negatively with decision latitude and positively with job demands. Negative emotional dysregulation appears to be a transdiagnostic vulnerability factor for stress-related psychopathology. Screening for ED may support early detection and targeted preventive interventions in occupational settings. Full article