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Keywords = wheel-running training

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19 pages, 6569 KiB  
Article
The Long-Term Inspection and Monitoring of Transition Zones with a Sudden Change in Railway Track Stiffness
by Stanislav Hodas, Jana Izvoltova and Erik Vrchovsky
Infrastructures 2025, 10(5), 109; https://doi.org/10.3390/infrastructures10050109 - 28 Apr 2025
Viewed by 628
Abstract
Transition zones are located at points on a track where there has been a change in the main composition of the railway infrastructure; as such, there are many sections that undergo a sudden change in the stiffness of the structures built. When trains [...] Read more.
Transition zones are located at points on a track where there has been a change in the main composition of the railway infrastructure; as such, there are many sections that undergo a sudden change in the stiffness of the structures built. When trains are running, a longitudinal shockwave is created by the wheels, hitting these building objects with a greater stiffness and deforming the surroundings of these zones. The greatest amount of attention should be paid to the transition points from the fixed track to the classic track with a track bed, including objects of the railway substructure, such as bridges and portals of tunnels. As part of the research on the main corridor lines, long-term inspection and monitoring studies were carried out using a trolley with a continuous measurement system; height changes in the deflections of rails are evidence of their behaviour. The measurements took place on a fixed track and a track with ballast. The changes in the height jumps between the fixed railway track and the track with a gravel bed are significant. These height deflections allow designers to develop new, more durable construction designs. Full article
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21 pages, 24767 KiB  
Article
Dynamic Characteristic Analysis of Bogie Gearbox Bearings Under Typical Wheel-Rail Excitation
by Meiling Wang, Qi Yang, Xinyu Liu, Zhihao Zan, Baogang Wen and Jingyu Zhai
Lubricants 2025, 13(4), 144; https://doi.org/10.3390/lubricants13040144 - 25 Mar 2025
Viewed by 551
Abstract
The bogie gearbox bearing is one of the critical components in the running gear of trains, and its dynamic characteristics significantly influence the safety and stability of the entire system. In addition to internal excitations within the gearbox, during actual operation, the system [...] Read more.
The bogie gearbox bearing is one of the critical components in the running gear of trains, and its dynamic characteristics significantly influence the safety and stability of the entire system. In addition to internal excitations within the gearbox, during actual operation, the system is notably affected by wheel-rail disturbances, such as wheel tread wear and track irregularities. As train operating speeds increase, these impacts become more complex and pronounced. This study focuses on the cylindrical roller bearings at the input end of the bogie gearbox. A dynamic model accounting for the effects of centrifugal force and lubrication was proposed by analyzing the force characteristics of the rolling elements, inner and outer rings, and the cage, respectively. The model was verified through the velocity characteristics of the internal components. Furthermore, a method for obtaining wheel-rail excitation based on a coupled dynamic model of the bogie and wheel-rail system was proposed. Based on this, a comparative analysis was conducted on the internal contact load characteristics and the vibration characteristics of each component of the bogie gearbox bearings under different wheel polygonal excitation amplitudes and orders, as well as under the combined influence of track irregularities and wheel polygons. The results indicate that wheel polygonal excitation and track irregularity excitation have significant effects on bearing vibration and contact load. An increase in the polygonal order and amplitude intensifies the contact load between the rolling elements and the outer ring, thereby increasing bearing vibration. Additionally, a higher polygonal order leads to more frequent impacts between the rolling elements and the outer ring. The coupling effect of wheel-rail excitations further amplifies bearing vibration and contact load. Full article
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19 pages, 15598 KiB  
Article
Research on the Dynamic Response Characteristics of a Railway Vehicle Under Curved Braking Conditions
by Chunguang Zhao, Zhiyong Fan, Peixuan Li, Micheale Yihdego Gebreyohanes, Zhiwei Wang and Jiliang Mo
Vehicles 2025, 7(1), 18; https://doi.org/10.3390/vehicles7010018 - 15 Feb 2025
Viewed by 950
Abstract
When a railway train runs along a curved track with braking, the dynamic behaviors of the vehicle are extremely complex and difficult to accurately reveal due to the coupling effects between the wheel–rail interactions and the disc–pad frictions. Therefore, a rigid–flexible coupled trailer [...] Read more.
When a railway train runs along a curved track with braking, the dynamic behaviors of the vehicle are extremely complex and difficult to accurately reveal due to the coupling effects between the wheel–rail interactions and the disc–pad frictions. Therefore, a rigid–flexible coupled trailer car dynamics model of a railway train is established. In this model, the brake systems and vehicle system are dynamically coupled via the frictions within the braking interface, wheel–rail relationships and suspension systems. Furthermore, the effectiveness of the established model is validated by a comparison with the field test data. Based on this, the dynamic response characteristics of vehicle under curve and straight braking conditions are analyzed and compared, and the influence of the curve geometric parameters on vehicle vibration and operation safety is explored. The results show that braking on a curve track directly affects the vibration characteristics of the vehicle and reduces its operation safety. When the vehicle is braking on a curve track, the lateral vibration of the bogie frame significantly increases compared to the vehicle braking on a straight track, and the vibration intensifies as the curve radius decreases. When the curved track maintains equilibrium superelevation, the differences in primary suspension force, wheel–rail vertical force, and wheel axle lateral force between the inner and outer sides of the first and second wheelsets are relatively minor under both straight and curved braking conditions. Additionally, under these circumstances, the derailment coefficient is minimized. However, when the curve radius is 7000 m, with a superelevation of 40 mm, the maximum dynamic wheel load reduction rate of the inner wheel of the second wheelset is 0.54, which reaches 90% of the allowable limit value of 0.6 for the safety index, and impacts the vehicle running safety. Therefore, it is necessary to focus on the operation safety of railway trains when braking on curved tracks. Full article
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16 pages, 3165 KiB  
Article
Efficient Wheel-Rail Stick-Slip Numerical Modeling for Railway Traction Vehicles
by Razvan Andrei Oprea, Cristina Mihaela Tudorache and Marius Adrian Spiroiu
Appl. Sci. 2024, 14(23), 11164; https://doi.org/10.3390/app142311164 - 29 Nov 2024
Viewed by 979
Abstract
Motor railway vehicles necessitate enhanced control of wheel-rail contact mechanics to ensure optimal adhesion. During train running, driving wheelsets exhibit torsional vibrations that compromise adhesion and potentially lead to axle damage. Consequently, the development of dynamic models for analyzing driving wheelset stick-slip phenomena [...] Read more.
Motor railway vehicles necessitate enhanced control of wheel-rail contact mechanics to ensure optimal adhesion. During train running, driving wheelsets exhibit torsional vibrations that compromise adhesion and potentially lead to axle damage. Consequently, the development of dynamic models for analyzing driving wheelset stick-slip phenomena and control strategies is an area of significant research interest for traction control, studies on rail corrugation, and locomotive drivetrain design. Despite their application in various railway vehicle problems, non-smooth models have not been explored as an alternative for analyzing stick-slip, and existing research has focused on extensive computations based on Kalker’s theory or simplified models using constitutive friction laws. This work demonstrates the efficacy of non-smooth models in studying motor wheelset stick-slip. The non-smooth approach is suited for control systems, prioritizes simplicity while capturing the essential friction characteristics, and enables efficient dynamic simulations. The proposed model incorporates a set-valued friction law, and the equations of motion are formulated as a switch model. Numerical integration is achieved through an event-driven algorithm. The paper showcases application examples for the model. A direct comparison with an equivalent model using a constitutive friction law shows that the non-smooth integration is an order of magnitude more efficient in the stick phase. Full article
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19 pages, 14911 KiB  
Article
Transverse-Direction Post-Seismic Running Safety of Longitudinally Connected Ballastless Track–Continuous Girder Bridge Systems Considering Earthquake Damage State
by Yulin Feng, Shenglin Xu, Bitao Wu, Wangbao Zhou, Xiang Liu, Liangqin Wu, Junhuan Rao, Ping Xiang and Zhongzhao Guo
Buildings 2024, 14(12), 3803; https://doi.org/10.3390/buildings14123803 - 28 Nov 2024
Cited by 1 | Viewed by 824
Abstract
The transverse-direction post-seismic running safety of a longitudinally connected ballastless track-continuous girder bridge (LCBTCGB) system considering earthquake damage state (EDS) was studied. In this study, a simulation model of an LCBTCGB was established, and the post-earthquake damage law of the LCBTCGB was analyzed [...] Read more.
The transverse-direction post-seismic running safety of a longitudinally connected ballastless track-continuous girder bridge (LCBTCGB) system considering earthquake damage state (EDS) was studied. In this study, a simulation model of an LCBTCGB was established, and the post-earthquake damage law of the LCBTCGB was analyzed by selecting the ground motion that had the greatest influence from within the existing studies. The EDS of key interlayer components and the residual deformation law of each layer structure of the LCBTCGB system were defined. Subsequently, the residual deformations and EDS from the simulation model were imported into a coupled dynamic model of the train, track, and bridge. Evaluation of running safety evaluation after an earthquake was carried out with and without considering EDS, and a running safety guidance diagram for after an earthquake is provided. The results revealed that under conditions of rare earthquakes, without considering EDS, the running safety judgment after the earthquake were underestimated, and the risk increased by 13.6%. Following the designed earthquake, the running safety risk after the earthquake increased by 18.7% if EDS was not considered. The risk of the running safety index exceeding the limit did not increase linearly with earthquake intensity with and without considering EDS. When the EDS was considered, derailment coefficients and wheel axle lateral forces exceeded the safety limit value at an earthquake intensity of 0.2 g, whereas these limit values were only exceeded at an earthquake intensity of 0.3 g when EDS is ignored. When the earthquake intensity reached 0.5 g, the influence on the derailment coefficient was greater but the difference in the wheel axle lateral forces was not significant with or without considering EDS. It is suggested that EDS should be considered when post-seismic running safety of LCBTCGBs are analyzed; otherwise, it will lead to misjudgment of running safety after an earthquake. Full article
(This article belongs to the Section Building Structures)
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19 pages, 5984 KiB  
Article
A Rapid Prediction of Suppressed Vibration in Composite Bridges Equipped with Constrained Layer Damping
by Quanmin Liu, Weiwang Fu, Lizhong Song, Kui Gao and Peipei Xu
Buildings 2024, 14(11), 3621; https://doi.org/10.3390/buildings14113621 - 14 Nov 2024
Viewed by 725
Abstract
The vibration characteristics of a composite bridge with constrained layer damping (CLD) were investigated using the wave and finite element method (WFEM), and the effects of the material and geometrical parameters of the CLD on the vibration reduction in the bridge were analyzed. [...] Read more.
The vibration characteristics of a composite bridge with constrained layer damping (CLD) were investigated using the wave and finite element method (WFEM), and the effects of the material and geometrical parameters of the CLD on the vibration reduction in the bridge were analyzed. Firstly, a numerical model for the dynamic response of a composite steel–concrete bridge using WFEM. The calculated acceleration of the bridge under the wheel–rail force obtained using this model was in good agreement with that obtained using the conventional finite element method and field measurements. Second, a segment model of the bridge with a CLD was established. The equation of motion based on the WFEM was solved to determine the dynamic response of the bridge induced by running trains. Finally, the effects of the covering area and CLD parameters on the vibration mitigation of steel–concrete bridges were analyzed. The results show that a reduction of 5–10 dB of the acceleration level of steel members in the full frequency range can be achieved by installing the CLD. A lower shear modulus of the viscoelastic core is beneficial for low-frequency vibration reduction in the bridge. However, a higher shear modulus of the damping layer is required for vibration mitigation in the high-frequency range. The vibration reduction in the composite bridge was more sensitive to the thickness of the constraining layer than to that of the damping layer. Full article
(This article belongs to the Section Building Structures)
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18 pages, 3921 KiB  
Article
8-Week Kaempferia parviflora Extract Administration Improves Submaximal Exercise Capacity in Mice by Enhancing Skeletal Muscle Antioxidant Gene Expression and Plasma Antioxidant Capacity
by Jiapeng Huang, Yishan Tong, Shuo Wang, Takashi Tagawa, Yasuhiro Seki, Sihui Ma, Ziwei Zhang, Tiehan Cao, Haruki Kobori and Katsuhiko Suzuki
Antioxidants 2024, 13(9), 1147; https://doi.org/10.3390/antiox13091147 - 23 Sep 2024
Cited by 1 | Viewed by 2263
Abstract
Black ginger (Kaempferia parviflora) extract (KPE) is extracted from a ginger family plant grown in Thailand. The polyphenolic components have potential antioxidant effects and have been reported to enhance exercise performance. However, the impact of long-term KPE administration combined with long-term [...] Read more.
Black ginger (Kaempferia parviflora) extract (KPE) is extracted from a ginger family plant grown in Thailand. The polyphenolic components have potential antioxidant effects and have been reported to enhance exercise performance. However, the impact of long-term KPE administration combined with long-term training on the endurance exercise performance of healthy individuals has not been fully studied. In this study, a healthy mouse model was used to investigate the effects of 8 weeks KPE administration and voluntary wheel running on the submaximal endurance exercise capacity and its mechanism. The results showed that 8 weeks of KPE administration significantly enhanced the submaximal endurance exercise capacity of mice and extended the daily voluntary wheel running distance. By measuring oxidative stress markers in plasma and the mRNA expression of antioxidant genes in skeletal muscle, we found that KPE significantly increased plasma antioxidant levels and activated the Nrf2 (Nuclear factor erythroid 2-related factor 2)/ARE (Antioxidant Response Element) pathway and its downstream antioxidant genes expression in skeletal muscle. These results suggest that KPE may enhance the antioxidant capacity of plasma and skeletal muscle by activating the Nrf2-ARE-centered antioxidant pathway, thereby increasing the daily running distance and improving the submaximal endurance exercise capacity of mice. Full article
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16 pages, 4241 KiB  
Article
Vibration-Based Detection of Axlebox Bearing Considering Inner and Outer Ring Raceway Defects
by Chuang Liu, Xinwen Zhang, Ruichen Wang, Qiang Guo and Junguo Li
Lubricants 2024, 12(5), 142; https://doi.org/10.3390/lubricants12050142 - 23 Apr 2024
Cited by 4 | Viewed by 1782
Abstract
The occurrence of an axlebox bearing ring raceway defect is an inevitable and commonly observed phenomenon in railway wheels. It not only leads to surface damage but also poses the potential threat of further damage and degradation, thereby increasing the risks associated with [...] Read more.
The occurrence of an axlebox bearing ring raceway defect is an inevitable and commonly observed phenomenon in railway wheels. It not only leads to surface damage but also poses the potential threat of further damage and degradation, thereby increasing the risks associated with running safety and maintenance costs. Hence, it becomes imperative to detect raceway defects at an early stage to mitigate safety hazards and reduce maintenance efforts. In this study, the focus lies in investigating the effectiveness of vibration-based detection techniques for identifying raceway defects in high-speed train axlebox bearing systems. To achieve this, a dynamic model that accurately represents the coupling dynamics between the vehicle and the track is developed. This model incorporates various dynamic factors, such as traction transmission, gear transmission, and track geometry irregularities. By using the comprehensive dynamic model, the dynamic responses of the axlebox can be accurately calculated. The proposed methodology primarily revolves around analysing the vertical vibrations of the axlebox caused by raceway defects in both the time and frequency domains. Additionally, an envelope analysis using a developed band-pass filter is also employed. The results obtained from this study clearly demonstrate the successful detection of raceway defects in a more realistic vehicle model, thereby providing an efficient approach for the detection of axlebox bearing raceway defects. Consequently, this research contributes significantly to the field of high-speed train systems and paves the way for enhanced safety and maintenance practices. Full article
(This article belongs to the Special Issue Condition Monitoring and Simulation Analysis of Bearings)
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16 pages, 3703 KiB  
Article
Link Protein 1 Is Involved in the Activity-Dependent Modulation of Perineuronal Nets in the Spinal Cord
by Judith Sánchez-Ventura, Natalia Lago, Clara Penas, Xavier Navarro and Esther Udina
Int. J. Mol. Sci. 2024, 25(8), 4267; https://doi.org/10.3390/ijms25084267 - 12 Apr 2024
Viewed by 1605
Abstract
One of the challenges of the mature nervous system is to maintain the stability of neural networks while providing a degree of plasticity to generate experience-dependent modifications. This plasticity–stability dynamism is regulated by perineuronal nets (PNNs) and is crucial for the proper functioning [...] Read more.
One of the challenges of the mature nervous system is to maintain the stability of neural networks while providing a degree of plasticity to generate experience-dependent modifications. This plasticity–stability dynamism is regulated by perineuronal nets (PNNs) and is crucial for the proper functioning of the system. Previously, we found a relation between spinal PNNs reduction and maladaptive plasticity after spinal cord injury (SCI), which was attenuated by maintaining PNNs with activity-dependent therapies. Moreover, transgenic mice lacking the cartilage link protein 1 (Crtl1 KO mice) showed aberrant spinal PNNs and increased spinal plasticity. Therefore, the aim of this study is to evaluate the role of link protein 1 in the activity-dependent modulation of spinal PNNs surrounding motoneurons and its impact on the maladaptive plasticity observed following SCI. We first studied the activity-dependent modulation of spinal PNNs using a voluntary wheel-running protocol. This training protocol increased spinal PNNs in WT mice but did not modify PNN components in Crtl1 KO mice, suggesting that link protein 1 mediates the activity-dependent modulation of PNNs. Secondly, a thoracic SCI was performed, and functional outcomes were evaluated for 35 days. Interestingly, hyperreflexia and hyperalgesia found at the end of the experiment in WT-injured mice were already present at basal levels in Crtl1 KO mice and remained unchanged after the injury. These findings demonstrated that link protein 1 plays a dual role in the correct formation and in activity-dependent modulation of PNNs, turning it into an essential element for the proper function of PNN in spinal circuits. Full article
(This article belongs to the Special Issue Plasticity of the Nervous System after Injury: 2nd Edition)
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25 pages, 2122 KiB  
Article
Railway Bridge Runability Safety Analysis in a Vessel Collision Event
by Lorenzo Bernardini, Andrea Collina and Gianluca Soldavini
Vibration 2024, 7(2), 326-350; https://doi.org/10.3390/vibration7020016 - 25 Mar 2024
Cited by 1 | Viewed by 2093
Abstract
Bridges connecting islands close to the coast and crossing the sea have been attracting the attention of several researchers working in the field of train–bridge interactions. A runability analysis of a bridge during the event of a ship impact with a pier is [...] Read more.
Bridges connecting islands close to the coast and crossing the sea have been attracting the attention of several researchers working in the field of train–bridge interactions. A runability analysis of a bridge during the event of a ship impact with a pier is one of the most interesting and challenging scenarios to simulate. The objective of the present paper is to study the impact on the running safety of a train crossing a sea bridge as a function of different operational factors, such as the train travelling speed, the type of impacting ship, and the impact force magnitude. Considering train–bridge interactions, a focus is also placed on wheel–rail geometrical contact profiles, considering new and worn wheel–rail profiles. This work is developed considering a representative continuous deck bridge with pier foundations located on the sea bed composed of six spans of 80 m. Time-domain simulations of trains running on the bridge during ship impact events were carried out to quantify the effect of different operating parameters on the train running safety. For this purpose, derailment and unloading coefficients, according to railway standards, were calculated from wheel–rail vertical and lateral contact forces. Maps of the safety coefficients were finally built to assess the combined effect of the impact force magnitude and train speed. The present investigation also showed that new wheel–rail contact geometrical profiles represent the most critical case compared to moderately worn wheel–rail profiles. Full article
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21 pages, 10444 KiB  
Article
Analysis of Asymmetric Wear of Brake Pads on Freight Wagons despite Full Contact between Pad Surface and Wheel
by Sergii Panchenko, Juraj Gerlici, Alyona Lovska, Vasyl Ravlyuk, Ján Dižo and Miroslav Blatnický
Symmetry 2024, 16(3), 346; https://doi.org/10.3390/sym16030346 - 13 Mar 2024
Cited by 4 | Viewed by 2695
Abstract
This article presents the results of a study focused on identifying the main causes of the asymmetric (clinodual) wear of composite brake pads on freight wagons. A new scientific approach to determining the clinodual wear of composite brake pads on freight wagons is [...] Read more.
This article presents the results of a study focused on identifying the main causes of the asymmetric (clinodual) wear of composite brake pads on freight wagons. A new scientific approach to determining the clinodual wear of composite brake pads on freight wagons is proposed. It is established that the harmful abrasion of the pad occurs during the movement of the freight train due to an imperfection in the bogie-brake lever transmission. The causes of the non-normative frictional wear of composite brake pads were investigated. This kind of wear leads to the tilting and abutting of the upper end of the brake pads against the rotating wheel during train running. The results of geometric and kinetostatic studies of the “pad–wheel” tribotechnical pair are provided to establish the causes and consequences of the accelerated clinodual frictional wear of composite brake pads on pendulum suspension in the bogies of freight wagons. The conditions of rotation of the wheels during braking “for” and “against” the clockwise direction depending on the direction of the train are considered. A new approach to brake-pad-wear prediction depending on the mileage of wagons under operational conditions is proposed. The research conducted in this study contributes to the development of the mechanical parts of freight-wagon brakes, increasing the efficiency of brake operation and improving the safety of train traffic. Full article
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22 pages, 6605 KiB  
Article
Multiagent Reinforcement Learning for Active Guidance Control of Railway Vehicles with Independently Rotating Wheels
by Juyao Wei, Zhenggang Lu, Zheng Yin and Zhipeng Jing
Appl. Sci. 2024, 14(4), 1677; https://doi.org/10.3390/app14041677 - 19 Feb 2024
Cited by 3 | Viewed by 1526
Abstract
This paper presents a novel data-driven multiagent reinforcement learning (MARL) controller for enhancing the running stability of independently rotating wheels (IRW) and reducing wheel–rail wear. We base our active guidance controller on the multiagent deep deterministic policy gradient (MADDPG) algorithm. In this framework, [...] Read more.
This paper presents a novel data-driven multiagent reinforcement learning (MARL) controller for enhancing the running stability of independently rotating wheels (IRW) and reducing wheel–rail wear. We base our active guidance controller on the multiagent deep deterministic policy gradient (MADDPG) algorithm. In this framework, each IRW controller is treated as an independent agent, facilitating localized control of individual wheelsets and reducing the complexity of the required observations. Furthermore, we enhance the MADDPG algorithm with prioritized experience replay (PER), resulting in the PER-MADDPG algorithm, which optimizes training convergence and stability by prioritizing informative experience samples. In this paper, we compare the PER-MADDPG algorithm against existing controllers, demonstrating the superior simulation performance of the proposed algorithm, particularly in terms of self-centering capability and curve-negotiation behavior, effectively reducing the wear number. We also develop a scaled IRW vehicle for active guidance experiments. The experimental results validate the enhanced running performance of IRW vehicles using our proposed controller. Full article
(This article belongs to the Special Issue Automation and Intelligent Control Systems)
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16 pages, 4473 KiB  
Article
Remaining Useful Life Estimation of Hollow Worn Railway Vehicle Wheels via On-Board Random Vibration-Based Wheel Tread Depth Estimation
by Ilias A. Iliopoulos and John S. Sakellariou
Sensors 2024, 24(2), 375; https://doi.org/10.3390/s24020375 - 8 Jan 2024
Cited by 2 | Viewed by 1661
Abstract
The problem of remaining useful life estimation (RULE) of hollow worn railway vehicle wheels in terms of remaining mileage via wheel tread depth estimation using on-board vibration signals from a single accelerometer on the bogie frame is presently investigated. This is achieved based [...] Read more.
The problem of remaining useful life estimation (RULE) of hollow worn railway vehicle wheels in terms of remaining mileage via wheel tread depth estimation using on-board vibration signals from a single accelerometer on the bogie frame is presently investigated. This is achieved based on the introduction of a statistical time series method that employs: (i) advanced data-driven stochastic Functionally Pooled models for the modeling of the vehicle dynamics under different wheel tread depths in a range of interest until a critical limit, as well as tread depth estimation through a proper optimization procedure, and (ii) a wheel tread depth evolution function with respect to the vehicle running mileage that interconnects the estimated hollow wear with the remaining useful mileage. The method’s RULE performance is investigated via hundreds of Simpack-based Monte Carlo simulations with an Attiko Metro S.A. vehicle and many hollow worn wheels scenarios which are not used for the method’s training. The obtained results indicate the accurate estimation of the wheels tread depth with a mean absolute error of ∼0.07 mm that leads to a corresponding small error of ∼3% with respect to the wheels remaining useful mileage. In addition, the comparison with a recently introduced Multiple Model (MM)-based multi-health state classification method for RULE, demonstrates the better performance of the postulated method that achieves 81.17% True Positive Rate (TPR) which is significantly higher than the 45.44% of the MM method. Full article
(This article belongs to the Special Issue Feature Papers in Fault Diagnosis & Sensors 2023)
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18 pages, 3066 KiB  
Article
Endurance Exercise Training Mitigates Diastolic Dysfunction in Diabetic Mice Independent of Phosphorylation of Ulk1 at S555
by Yuntian Guan, Mei Zhang, Christie Lacy, Soham Shah, Frederick H. Epstein and Zhen Yan
Int. J. Mol. Sci. 2024, 25(1), 633; https://doi.org/10.3390/ijms25010633 - 3 Jan 2024
Cited by 2 | Viewed by 2993
Abstract
Millions of diabetic patients suffer from cardiovascular complications. One of the earliest signs of diabetic complications in the heart is diastolic dysfunction. Regular exercise is a highly effective preventive/therapeutic intervention against diastolic dysfunction in diabetes, but the underlying mechanism(s) remain poorly understood. Studies [...] Read more.
Millions of diabetic patients suffer from cardiovascular complications. One of the earliest signs of diabetic complications in the heart is diastolic dysfunction. Regular exercise is a highly effective preventive/therapeutic intervention against diastolic dysfunction in diabetes, but the underlying mechanism(s) remain poorly understood. Studies have shown that the accumulation of damaged or dysfunctional mitochondria in the myocardium is at the center of this pathology. Here, we employed a mouse model of diabetes to test the hypothesis that endurance exercise training mitigates diastolic dysfunction by promoting cardiac mitophagy (the clearance of mitochondria via autophagy) via S555 phosphorylation of Ulk1. High-fat diet (HFD) feeding and streptozotocin (STZ) injection in mice led to reduced endurance capacity, impaired diastolic function, increased myocardial oxidative stress, and compromised mitochondrial structure and function, which were all ameliorated by 6 weeks of voluntary wheel running. Using CRISPR/Cas9-mediated gene editing, we generated non-phosphorylatable Ulk1 (S555A) mutant mice and showed the requirement of p-Ulk1at S555 for exercise-induced mitophagy in the myocardium. However, diabetic Ulk1 (S555A) mice retained the benefits of exercise intervention. We conclude that endurance exercise training mitigates diabetes-induced diastolic dysfunction independent of Ulk1 phosphorylation at S555. Full article
(This article belongs to the Special Issue Molecular Insights into the Role of Exercise in Disease and Health)
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16 pages, 7118 KiB  
Article
Research on Environmental Vibration Induced by High-Speed Maglev Transportation
by Ziping Han, Guofeng Zeng and Feng Ye
Appl. Sci. 2024, 14(1), 413; https://doi.org/10.3390/app14010413 - 2 Jan 2024
Cited by 2 | Viewed by 1932
Abstract
As a novel form of railway transportation, maglev transportation has the advantages of a better curve negotiation ability and grade ability and lower noise and vibration than traditional urban wheel–rail transportation. Thus, it is suitable for use in urban public transportation. However, the [...] Read more.
As a novel form of railway transportation, maglev transportation has the advantages of a better curve negotiation ability and grade ability and lower noise and vibration than traditional urban wheel–rail transportation. Thus, it is suitable for use in urban public transportation. However, the levitation of the widely utilized electromagnet suspension (EMS) system relies on continuously active suspension force adjustment, which gives it vehicle–track-coupled vibration characteristics different to those of the traditional wheel–track transportation system. Despite many research studies focusing on maglev vehicle–track coupling vibration, the environmental vibration influences associated with the running of maglev trains are still unclear. When the vibration propagates to the surroundings beyond certain thresholds, it may lead to various vibration serviceability problems. Practical test results on the environmental vibration induced by maglev transportation are still not enough to generate convincing vibration propagation and attenuation laws. In this research, a series of in situ tests were carried out around the Shanghai maglev line; the results show that the viaduct bridge is helpful in reducing environmental vibration, and an empirical formula was proposed to predict the effect of viaduct column height. Due to the ground wave superposition, a vibration-amplifying zone was also found about 10 m away from the maglev line, in which the vibration magnitude was strong enough to be perceived by the surrounding occupants. Full article
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