Search Results (5,542)

The emergence of SARS-CoV-2 variants highlights the urgent need for novel therapeutic strategies, particularly entry inhibitors that could efficiently prevent viral infection. Medicinal herbs and herbal combination formulas have long been recognized for their effects in treating infectious diseases and their antiviral properties, thus providing abundant resources for the discovery of antiviral candidates. While many candidates have been suggested to have antiviral activity against SARS-CoV-2 infection, few have been validated for their mechanisms, including possible effects on viral entry. This study aimed to identify SARS-CoV-2 entry inhibitors from medicinal herbs and herbal formulas that are known for heat-clearing and detoxifying properties and/or antiviral activities. A SARS-CoV-2 pseudoparticle (SARS-CoV-2pp) system was used to assess mechanism-specific entry inhibition. Our results showed that the methanol extract of Anemarrhena asphodeloides rhizome, as well as the water extracts of Cimicifuga foetida rhizome, Xiao Chai Hu Tang (XCHT), and Sheng Ma Ge Gen Tang (SMGGT), have substantial inhibitory effects on the entry of SARS-CoV-2pps into host cells. Given the observation that Cimicifuga foetida exhibited the most potent inhibition and is a constituent of SMGGT, we further investigated the major compounds of the herb and identified caffeic acid as a bioactive component for blocking SARS-CoV-2pp entry. Entry inhibition of Cimicifuga foetida and caffeic acid was validated on both wild-type and the currently dominant JN.1 strain SARS-CoV-2pp systems. Moreover, caffeic acid was able to both inactivate the pseudoparticles and prevent their entry into pretreated host cells. The results support the traditional use of these herbal medicines and underscore their potential as valuable resources for identifying active compounds and developing therapeutic entry inhibitors for the management of COVID-19. Full article

The rapid advancement of underwater wireless communication technologies is critical to unlocking the full potential of marine resource exploration and environmental monitoring. This paper reviews recent progress in three primary modalities: underwater acoustic communication, radio frequency (RF) communication, and underwater optical wireless communication (UWOC), each designed to address specific challenges posed by complex underwater environments. Acoustic communication, while effective for long-range transmission, is constrained by ambient noise and high latency; recent innovations in noise reduction and data rate enhancement have notably improved its reliability. RF communication offers high-speed, short-range capabilities in shallow waters, but still faces challenges in hardware miniaturization and accurate channel modeling. UWOC has emerged as a promising solution, enabling multi-gigabit data rates over medium distances through advanced modulation techniques and turbulence mitigation. Additionally, bio-inspired approaches such as electric field communication provide energy-efficient and robust alternatives under turbid conditions. This paper further examines the practical integration of these technologies in underwater platforms, including autonomous underwater vehicles (AUVs), highlighting trade-offs between energy efficiency, system complexity, and communication performance. By synthesizing recent advancements, this review outlines the advantages and limitations of current underwater communication methods and their real-world applications, offering insights to guide the future development of underwater communication systems for robotic and vehicular platforms. Full article

Environmental monitoring plays a key role in understanding and mitigating the effects of climate change, pollution, and resource mismanagement. The growth of printed sensor technologies offers an innovative approach to addressing these challenges due to their low cost, flexibility, and scalability. Printed sensors enable the real-time monitoring of air, water, soil, and climate, providing significant data for data-driven decision-making technologies and policy development to improve the quality of the environment. The development of new materials, such as graphene, conductive polymers, and biodegradable substrates, has significantly enhanced the environmental applications of printed sensors by improving sensitivity, enabling flexible designs, and supporting eco-friendly and disposable solutions. The development of inkjet, screen, and roll-to-roll printing technologies has also contributed to the achievement of mass production without sacrificing quality or performance. This review presents the current progress in printed sensors for environmental applications, with a focus on technological advances, challenges, applications, and future directions. Moreover, the paper also discusses the challenges that still exist due to several issues, e.g., sensitivity, stability, power supply, and environmental sustainability. Printed sensors have the potential to revolutionize ecological monitoring, as evidenced by recent innovations such as Internet of Things (IoT) integration, self-powered designs, and AI-enhanced data analytics. By addressing these issues, printed sensors can develop a better understanding of environmental systems and help promote the UN sustainable development goals. Full article

Effective water infrastructure planning and management is key to sustainable water supply globally. This research assesses water infrastructure planning and management in Gauteng, South Africa, amid growing challenges from rapid urbanisation, high water demand, climate change, and resource scarcity. These challenges threaten the achievement of Sustainable Development Goals 6 and 11; hence, an integrated approach is required for water sustainability. The study responds to a gap in the literature, which often treats planning and management separately, by adopting an integrated, multi-institutional approach across the water value chain. A mixed-methods triangulation strategy was employed for data collection whereby surveys provided quantitative data, while two sets of structured interviews were conducted: the first round to determine causal relationships among the critical success factors and the second round to validate the proposed framework. The findings reveal a misalignment between infrastructure planning and implementation, contributing to infrastructure backlogs and a short- to medium-term focus. Infrastructure management is further constrained by inadequate system redundancy, leading to ineffective maintenance. External factors such as delayed adoption of 4IR technologies, lack of climate resilient strategies, and fragmented institutional coordination exacerbate these issues. Using Decision-Making Trial and Evaluation Laboratory (DEMATEL) analysis, the study identified Strategic Alignment and a Value-Driven Approach as the most influential critical success factors in water asset management. The research concludes by proposing an integrated water infrastructure and planning framework that supports sustainable water supply. Full article

Flocculants are indispensable in water and wastewater treatment, enabling the aggregation and removal of suspended particles, colloids, and emulsions. However, the conventional development and application of flocculants rely heavily on empirical methods, which are time-consuming, resource-intensive, and environmentally problematic due to issues such as sludge production and chemical residues. Recent advances in machine learning (ML) have opened transformative avenues for the design, optimization, and intelligent application of flocculants. This review systematically examines the integration of ML into flocculant research, covering algorithmic approaches, data-driven structure–property modeling, high-throughput formulation screening, and smart process control. ML models—including random forests, neural networks, and Gaussian processes—have successfully predicted flocculation performance, guided synthesis optimization, and enabled real-time dosing control. Applications extend to both synthetic and bioflocculants, with ML facilitating strain engineering, fermentation yield prediction, and polymer degradability assessments. Furthermore, the convergence of ML with IoT, digital twins, and life cycle assessment tools has accelerated the transition toward sustainable, adaptive, and low-impact treatment technologies. Despite its potential, challenges remain in data standardization, model interpretability, and real-world implementation. This review concludes by outlining strategic pathways for future research, including the development of open datasets, hybrid physics–ML frameworks, and interdisciplinary collaborations. By leveraging ML, the next generation of flocculant systems can be more effective, environmentally benign, and intelligently controlled, contributing to global water sustainability goals. Full article

The ongoing advancement of urbanization has significantly amplified its impacts on the water environment. Understanding the coupling relationships between urbanization and the water environment (UAWE) is crucial for Chinese policymakers aiming to promote sustainable urban development. In this study, a comprehensive UAWE evaluation model was developed to examine the development trajectories in Neijiang City from 2012 to 2022. Methodologically, a comprehensive evaluation approach was applied to assess urbanization and water resource trends over this period, followed by the development of a Coupling Coordination Degree Model (CCDM) to quantify their synergistic relationship. The results showed that the coupling between the comprehensive urbanization index and the water environment system evolved over time, as reflected in the following key findings: (1) Neijiang underwent three distinct stages from 2012 to 2022 in terms of coupling and coordination between urbanization and the water environment: Basic Coordination (2012–2015), Good Coordination (2016–2020), and Excellent Coordination (2020–2022). (2) Urbanization exerted varying impacts on subsystems of the water environment, with the pressure-response subsystems exhibiting marked volatility from 2012 to 2022. The impact intensity followed the order spatial urbanization > economic urbanization > social urbanization > population urbanization. These findings offer valuable theoretical and practical insights for aligning urban sustainability goals with effective water environment protection measures. This study provides essential guidance for policymakers in Neijiang and similar regions, enabling the development of tailored strategies for sustainable urbanization and enhanced water management. Full article

Urban infrastructure, such as water supply networks, sewage systems, and electricity networks, is essential for the functioning of cities and, consequently, for the well-being of citizens. Despite its essentiality, the distribution of infrastructure in urban areas is not homogeneous, especially in cities in developing countries. Socially vulnerable areas often face significant deficiencies in sewage and road paving, exacerbating urban inequalities. In this regard, urban planners must consider the multiple elements of urban infrastructure and assess the compensation levels between them to reduce inequality effectively. In particular, the complexity of the problem necessitates considering the multidimensionality and heterogeneity of urban infrastructure. This complexity qualifies the operational framework of composite indicators as the natural solution to the problem. This study develops a new weighting system for the balanced expansion of urban infrastructures through composite indicators constructed by the Ordered Weighted Average operator. Implementing these weighting systems provides an opportunity to analyze urban infrastructure from different perspectives, offering transparency regarding the weaknesses and strengths of each perspective. This prevents unreliable representations from being used in decision-making and provides a solid basis for allocating investments in urban infrastructure. In particular, the study suggests that adopting weighting systems that prioritize intermediate values and avoid extreme values can lead to better resource allocation, helping to identify areas with deficient infrastructure and promoting more equitable urban development. Full article

Promoting the sustainable development of virtual water trade is of great significance to safeguarding China’s water resource security and balanced regional economic growth. This study analyzes the virtual water trade network among 31 Chinese provinces based on multi-regional input–output tables from 2012, 2015, and 2017, using total trade decomposition, social network analysis, and exponential random graph models. The key findings are as follows: (1) The total virtual water trade volume remains stable, with Xinjiang, Jiangsu, and Guangdong as the core regions, while remote areas such as Shaanxi and Gansu have lower trade volumes. The primary industry dominates, and it is driven by simple value chains. (2) Provinces such as Xinjiang, Heilongjiang, and Jiangsu form the network’s core. Network density and symmetry increased from 2012 to 2015 but declined slightly in 2017, with efficiency peaking and then dropping, and the clustering coefficient decreased annually. Four economic sectors exhibit distinct interactions: frequent two-way flows in Sector 1, significant inflows in Sector 2, prominent net spillovers in Sector 3, and key brokers in Sector 4. (3) The network evolved from a core-periphery structure with weak ties to a stable, heterogeneous, and resilient system. (4) Influencing factors, such asper capita water resources, economic development, and population, significantly impact trade. Similarities in economic levels, population, and water endowments promote trade, while spatial distance has a limited effect, with geographic proximity showing a significant negative impact on long-distance trade. Full article

Optimizing irrigation and the targeted use of plant growth regulators are key strategies to improve productivity in citrus systems under water-limited conditions. This study evaluated the effects of three irrigation levels (4.44, 5.18, and 7.77 mm day⁻¹) combined with variable doses of naphthaleneacetic acid (NAA) and gibberellic acid (GA₃) on physiological and productive responses in Citrus aurantiifolia. The treatment with 7.77 mm irrigation and moderate doses of NAA (100 mg L⁻¹) and GA₃ (80 mg L⁻¹) increased yield by 38% (6.2 kg/plant), and it enhanced photosystem II photochemical efficiency (F_v/F_m = 0.82), chlorophyll index (SPAD = 62), and fruit weight by 15%. In contrast, high hormone doses under water deficit reduced leaf water potential and impaired physiological performance, leading to lower productivity. These findings support the combined use of regulated deficit irrigation and hormonal biostimulation as a sustainable strategy to enhance key lime yield and resource efficiency in semi-arid environments. Full article

Groundwater is one of the main water sources for consumption, domestic use, agriculture, and tourism in coastal communities. However, high total dissolved solids (TDS) levels in the water (700–2000 mg L⁻¹ TDS) and electrical conductivity (3000–5000 µS cm⁻¹) threaten the health and economic growth opportunities for residents. This research aims to evaluate the performance of a laboratory-scale electrodialysis system as a technology for desalinating brackish water. For this purpose, water samples were collected from real groundwater sources. Batch experiments were conducted with varying operational parameters, such as voltage (2–10 V), feed volume (100–1600 mL), recovery rate (50–80%), and cros-flow velocity (1.3–5.1 cm s⁻¹) to determine the electrodialysis system setup that meets the requirements for drinking water in terms of TDS and energy efficiency. A total specific energy consumption of 1.65 kWh m⁻³, including pumping energy, was achieved at a laboratory scale. The conditions were as follows: flow velocity of 5.14 cm s⁻¹, applied voltage of 6 V, feed volume of 1.6 L, and a water recovery of 66%. Furthermore, increasing the flow velocity and the applied voltage enhanced the desalination kinetics and salt removal. Additionally, the system presented opportunities for scalability. This research aims to evaluate a sustainable membrane-based treatment technology for meeting the growing demand for water resources in coastal communities, particularly in developing countries in South America. Full article

Multistage centrifugal pumps, owing to their high head characteristics, are commonly applied in domains like subsea resource exploitation and groundwater extraction. However, the wear of flow passage components caused by solid particles in the fluid severely threatens equipment lifespan and system safety. To investigate the influence of solid-liquid two-phase flow on pump performance and wear, this study conducted numerical simulations of the solid-liquid two-phase flow within multistage centrifugal pumps based on the Euler–Lagrange approach and the Tabakoff wear model. The simulation results showed good agreement with experimental data. Under the design operating condition, compared to the clear water condition, the efficiency under the solid-liquid two-phase flow condition decreased by 1.64%, and the head coefficient decreased by 0.13. As the flow rate increases, particle momentum increases, the particle Stokes number increases, inertial forces are enhanced, and the coupling effect with the fluid weakens, leading to an increased impact intensity on flow passage components. This results in a gradual increase in the wear area of the impeller front shroud, back shroud, pressure side, and the peripheral casing. Under the same flow rate condition, when particles enter the pump chamber of a subsequent stage from a preceding stage, the fluid, after being rectified by the return guide vane, exhibits a more uniform flow pattern and reduced turbulence intensity. The particle Stokes number in the subsequent stage is smaller than that in the preceding stage, weakening inertial effects and enhancing the coupling effect with the fluid. This leads to a reduced impact intensity on flow passage components, resulting in a smaller wear area of these components in the subsequent stage compared to the preceding stage. This research offers critical theoretical foundations and practical guidelines for developing wear-resistant multistage centrifugal pumps in solid-liquid two-phase flow applications, with direct implications for extending service life and optimizing hydraulic performance. Full article

The Mediterranean region, identified by scientists as a ‘climate hot spot’, is experiencing warmer and drier conditions, along with an increase in the intensity and frequency of extreme weather events. One such extreme phenomena is droughts. The recent wildfires in this region are a concerning consequence of this phenomenon, causing severe environmental damage and transforming natural landscapes. However, droughts involve a two-way interaction: On the one hand, climate change and various human activities, such as urbanization and deforestation, influence the development and severity of droughts. On the other hand, droughts have a significant impact on various sectors, including ecology, agriculture, and the local economy. This study investigates drought dynamics in four Mediterranean countries, Greece, France, Italy, and Spain, each of which has experienced severe wildfire events in recent years. Using satellite-based Earth observation data, we monitored drought conditions across these regions over a five-year period that includes the dates of major wildfires. To support this analysis, we derived and assessed key indices: the Normalized Difference Vegetation Index (NDVI), Normalized Difference Water Index (NDWI), and Normalized Difference Drought Index (NDDI). High-resolution satellite imagery processed within the Google Earth Engine (GEE) platform enabled the spatial and temporal analysis of these indicators. Our findings reveal that, in all four study areas, peak drought conditions, as reflected in elevated NDDI values, were observed in the months leading up to wildfire outbreaks. This pattern underscores the potential of satellite-derived indices for identifying regional drought patterns and providing early signals of heightened fire risk. The application of GEE offered significant advantages, as it allows efficient handling of long-term and large-scale datasets and facilitates comprehensive spatial analysis. Our methodological framework contributes to a deeper understanding of regional drought variability and its links to extreme events; thus, it could be a valuable tool for supporting the development of adaptive management strategies. Ultimately, such approaches are vital for enhancing resilience, guiding water resource planning, and implementing early warning systems in fire-prone Mediterranean landscapes. Full article

The transition to sustainable agriculture is a critical challenge for the U.S. food system. A sustainable food system must support the production of healthy and nutritious food while ensuring economic sustainability for farmers and ranchers. It should also reduce negative environmental impacts on soil, water, biodiversity, and climate, and promote equitable and inclusive access to land, farming resources, and food. This narrative review synthesizes U.S. social science literature to identify the key factors that support or impede the adoption of sustainable agricultural practices in the U.S. Our analysis reveals seven overarching factors that influence producer decision-making: awareness and knowledge, social factors, psychological factors, technologies and tools, economic factors, implementation capacity, and policies and regulations. The review highlights the critical role of social science in navigating complexity and uncertainty. Key priorities emerging from the literature include developing measurable, outcome-based programs; ensuring credible communication through trusted intermediaries; and designing tailored interventions. The findings demonstrate that initiatives will succeed when they emphasize measurable benefits, address uncertainties, and develop programs that capitalize on identified opportunities while overcoming existing barriers. Full article

For effective groundwater resource management, it is essential to model the dynamic behaviour of aquifers in response to rainfall. Here, a methodological approach using a recurrent neural network, specifically a Long Short-Term Memory (LSTM) network, is used to model groundwater levels of the shallow porous aquifer in Southern Italy. This aquifer is recharged by local rainfall, which exhibits minimal variation across the catchment in terms of volume and temporal distribution. To gain a deeper understanding of the complex interactions between precipitation and groundwater levels within the aquifer, we used water level data from six wells. Although these wells were not directly correlated in terms of individual measurements, they were geographically located within the same shallow aquifer and exhibited a similar hydrogeological response. The trained model uses two variables, rainfall and groundwater levels, which are usually easily available. This approach allowed the model, during the training phase, to capture the general relationships and common dynamics present across the different time series of wells. This methodology was employed despite the geographical distinctions between the wells within the aquifer and the variable duration of their observed time series (ranging from 27 to 45 years). The results obtained were significant: the global model, trained with the simultaneous integration of data from all six wells, not only led to superior performance metrics but also highlighted its remarkable generalization capability in representing the hydrogeological system. Full article

While water conservancy projects continuously enhance flood control and resource allocation capabilities, the adverse impacts on basin systems, particularly the structural disruption of surface water–groundwater continuity, have become increasingly pronounced. Therefore, establishing quantitative assessment of water system connectivity as a critical foundation for optimizing spatial water distribution, maintaining ecohydrological equilibrium, and enhancing flood–drought regulation efficacy is important. Focusing on the regulated reaches of the Panjiakou, Daheiting, and Taolinkou reservoirs in the Luan River Basin, this study established and integrated a three-dimensional assessment framework that synthesizes hydrological processes, hydraulic structural effects, and human activities as three fundamental drivers, and employed the Analytic Hierarchy Process (AHP) to develop a quantitative connectivity evaluation system. Results indicate that water conservancy projects significantly altered basin connectivity: surface water connectivity decreased by 0.40, while groundwater connectivity experienced a minor reduction (0.25) primarily through reservoir seepage. Consequently, the integrated surface–groundwater system declined by 0.39. Critically, project scale governs surface connectivity attenuation intensity, which substantially exceeds impacts on groundwater systems. The comprehensive assessment system developed in this study provides theoretical and methodological support for diagnosing river connectivity, formulating ecological restoration strategies, and protecting basin ecosystems. Full article