Search Results (343)

Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disorder characterized by persistent airflow limitation and chronic airway inflammation. Current therapeutic strategies primarily offer symptomatic relief and are often limited by systemic side effects, inadequate lung deposition, and poor patient compliance. Naringin (NAR), a natural flavonoid with strong antioxidant, anti-inflammatory, and anti-fibrotic activities, has demonstrated potential in mitigating COPD-associated pathophysiology. However, its therapeutic application is restricted by poor water solubility, low bioavailability, and rapid metabolism. Nanotechnology-based drug delivery systems, particularly poly(lactic-co-glycolic acid) (PLGA) nanoparticles, provide an effective approach for lung-targeted therapy. Their nanoscale size promotes deep lung deposition, enhanced cellular uptake, reduced lung clearance, improved therapeutic efficacy, and reduced systemic side effects. The present study aimed to develop NAR-loaded PLGA nanoparticles (NAR PLGA NP) for enhanced cell-targeting in inflammatory lung conditions. NAR PLGA NP were prepared using the emulsion solvent evaporation method, with PLGA in the organic phase and soya lecithin (SL) with poly(vinyl alcohol) (PVA) as surfactants in the aqueous phase. A face-centered central composite design was employed to optimize the formulation. The optimized nanoparticles were characterized for size distribution by dynamic light scattering, entrapment efficiency, Transmission Electron Microscopy (TEM), Fourier Transform Infrared (FTIR), Differential Scanning Calorimetry (DSC), X-Ray Diffraction (XRD), and in vitro drug release. The safety of PLGA and lecithin-coated PLGA nanoparticles (LC PLGA NP) was assessed using an MTT assay on lung epithelial cells, followed by cellular uptake studies, angiogenesis by chick Yolk Sac Membrane (YSM) assay, and in vitro evaluation of reactive oxidative stress (ROS) and anti-inflammatory activity. The optimized PLGA formulation showed a hydrodynamic diameter of 201 ± 1 nm with PDI 0.20 ± 0.03 and EE of 76.11 ± 2.1%, and 81.7 ± 4.9% drug release at 72 h, whereas LC PLGA NP showed a hydrodynamic diameter of 308 ± 3 nm, PDI of 0.21 ± 0.05, entrapment efficiency of 82.45 ± 4.8%, and 71.4 ± 3.2% drug release at 72 h. Both PLGA NP and LC PLGA NP demonstrated good cytocompatibility with lung epithelial cells, efficient cellular uptake, and a significant reduction in intracellular reactive oxygen species (ROS) levels (**** p value < 0.0001). Moreover, the formulations markedly suppressed pro-inflammatory cytokines, including TNF-α, IL-6, and IL-1β, indicating anti-inflammatory activity. The angiogenesis assay further suggested their ability for lung tissue repair and remodeling. These findings support the potential of LC PLGA NP as a promising cell-specific targeting system for naringin in inflammatory lung conditions. Full article

Vapor Pressure Deficit (VPD) is a critical determinant of atmospheric evaporative demand and plant water stress in tropical agricultural systems. This study applied a Gaussian Mixture Model (GMM) and K-Means clustering to 36,528 hourly meteorological observations collected from Eastern Thailand between August 2021 and September 2025, with the objective of identifying distinct atmospheric moisture regimes relevant to precision irrigation management in durian cultivation. Two input configurations were evaluated: a multivariate feature space comprising air temperature, relative humidity, wind speed, solar radiation, and VPD; and a univariate input consisting of VPD alone. Model selection for GMM was guided by the Akaike Information Criterion (AIC) and Bayesian Information Criterion (BIC), while K-Means performance was assessed using the Elbow method, Silhouette Coefficient, Calinski–Harabasz Index, and Davies–Bouldin Index. For the multivariate input, GMM identified K = 7 as the optimal number of clusters, supported by the largest single-step reduction in both AIC and BIC at this transition point. For the univariate VPD input, K = 5 was selected as the most parsimonious and agriculturally interpretable solution. The seven clusters derived from the multivariate GMM were organized into four atmospheric moisture regimes, such as very low, moderate, high, and very high evaporative demand, capturing the full spectrum of diurnal and seasonal VPD variability characteristic of Eastern Thailand. The results demonstrate that GMM-based probabilistic clustering applied to multivariate meteorological inputs provides a more comprehensive characterization of atmospheric moisture dynamics than univariate or geometric clustering approaches, offering a practical framework for tiered irrigation scheduling and drought stress early warning systems in tropical fruit cultivation. Full article

Actual evapotranspiration is a primary pathway for crop water consumption in irrigation districts, including the Shijin irrigation district, where understanding the impacts of irrigation is crucial for managing water resources in this large-scale, water-scarce region. However, existing studies on evapotranspiration driving mechanisms often overlook irrigation activities and lack an analysis of synergistic effects among different environmental factors, with such research remaining particularly limited for this area. This study investigates the synergistic impact mechanisms of multiple drivers on evapotranspiration. Using data from 2003 to 2017, a projection pursuit model was employed to quantitatively assess the contributions of meteorological factors, Leaf Area Index, and irrigation to evapotranspiration evolution. The results indicate a significant structural shift in evapotranspiration, and the reduction in soil evaporation plays an important role in driving the variation of total evapotranspiration. Among the various factors, Leaf Area Index and irrigation exhibited the highest contribution rates to evapotranspiration. Furthermore, irrigation primarily acts in synergy with crop growth to enhance evapotranspiration. This study provides critical scientific insights for evidence-based water resource management and policy optimization in the Shijin irrigation district. Full article

The formation of stereocomplex (SC) crystallites in poly(L-lactide) (PLLA)/poly(D-lactide) (PDLA) blends has attracted significant attention due to its potential to enhance the performance of biodegradable polymer films. In this study, the effect of solvent evaporation kinetics on the crystallization behavior, microstructure, and functional properties of PLLA/PDLA blend films was systematically investigated. Films with various blend ratios were prepared under open-lid (fast evaporation) and closed-lid (slow evaporation) conditions. Differential scanning calorimetry (DSC), wide-angle X-ray diffraction (WAXD), and small-angle X-ray scattering (SAXS) analyses revealed that slow solvent evaporation significantly promotes stereocomplex formation, particularly at the equimolar (50:50) composition, resulting in a higher degree of crystallinity and a more compact structure compared to fast evaporation conditions. These structural changes were directly correlated with improved functional properties. The optimized PLLA/PDLA (50:50) films exhibited a substantial reduction in water vapor permeability from 22.7 to 3.11 g·mm/m²·day·kPa (~86% decrease) and a marked decrease in microbial growth, as evidenced by reduced total plate count (TPC) values compared to neat polymers. The enhanced barrier performance and reduced microbial proliferation were attributed to the reduced free volume and increased tortuosity associated with densely packed stereocomplex crystallites, as supported by DSC and WAXD results. These findings demonstrate the importance of solvent evaporation kinetics in tailoring structure–property relationships to control stereocomplex formation and multiscale structural organization, providing a practical strategy for biodegradable packaging films. Full article

Epidermal barrier dysfunction, driven by disorganization and altered composition of the stratum corneum (SC) lipid matrix, underlies multiple inflammatory dermatoses, namely atopic dermatitis (AD). The lipid fraction derived from Black Soldier Fly larvae (BSFL) biomass has emerged as a promising biomaterial for skin health applications, particularly for restoring barrier function. Following previous work on the development of solid lipid nanoparticles (SLNs) incorporating BSFL lipid extract, the present study focused on the mechanistic evaluation of the occlusive, moisturizing and skin reinforcement potential of these nanoformulations (NFs), by exploring both in vitro and in vivo models. The compatibility assays showed no adverse effects after patch testing on healthy or atopic individuals, nor alterations on skin hydration, transepidermal water loss (TEWL), or redness. In vitro studies confirmed the ability of these NFs to form an occlusive lipid film, hampering moisture loss, with 39% reduction of water loss compared to the control. Efficacy assays in human volunteers revealed a statistically significant improvement in epidermal conditions at treated sites, evidenced by enhanced SC hydration. The plastic occlusion stress test (POST) revealed a trend toward a reduced evaporation half-life, suggesting a modulation of the epidermal water dynamics, although the effect did not reach statistical significance. Overall, BSFL-based lipid nanoparticles emerge as emollient agents with broad potential for incorporation into next-generation cosmetic and pharmaceutical products for the management of AD. Full article

This study proposes a comprehensive methodology for the design and performance assessment of infiltration ponds integrated within hybrid grey–green urban drainage systems. The scope of the ponds is twofold: (i) increase infiltration of rainwater, and hence groundwater recharge, and (ii) decrease pluvial discharge downstream. The framework is applied to the Rome Technopole district, which serves as a pilot case for testing and demonstrating the procedure. Through 30-year continuous simulations performed with the EPA Storm Water Management Model and forced with a 5 min historical rainfall, the approach enables a performance-based evaluation that captures the full hydrological variability and the hydraulic performances of urban drainage systems. The methodology relies on physically based models for both the grey stormwater drainage network and the infiltration ponds, combined with a long-term simulation and functional analysis under transient conditions. The approach explicitly represents the main hydrological processes, including runoff generation, flow routing, storage dynamics, infiltration, and soil moisture variability, enabling a quantitative evaluation of peak-flow attenuation, infiltration efficiency, groundwater recharge volumes, seasonal variability, and wet–dry cycle behaviour. The latter is used to assess the long-term evolution of pond performance and its implications for maintenance activities, including clogging development and removal. Scenario analyses explore the influence of pond geometry and storage volumes, highlighting the trade-offs between hydrological efficiency, evaporation losses, and drawdown times. Beyond the specific application to the Rome Technopole developed in this study, we propose a generalizable, practitioner-oriented design procedure suited to contexts where infiltration-based solutions are desirable but regulatory guidance is fragmented. The proposed design workflow identifies critical parameters for both the hydraulic design and the operational management of infiltration ponds, enabling a statistical evaluation of their performance. The analysis of peak-flow reduction, infiltrated volumes, and the timing and frequency of wet–dry cycles provides a robust technical basis for the proper sizing, integration, and long-term assessment of infiltration ponds within urban drainage planning. Full article

This study investigates the development of mixed matrix membranes based on polyethersulfone incorporated with attapulgite for gas separation applications, addressing the existing gap regarding the use of this mineral in dense membranes obtained exclusively by solvent evaporation and its combined effects on microstructure and transport. The membranes were prepared by phase inversion via solvent evaporation, using solvent/polymer ratios of 75/25 and 80/20 and a thickness of 0.25 mm. The solutions were evaluated in terms of viscosity, and the membranes were characterized by structural techniques such as X-ray diffraction (XRD), atomic force microscope (AFM), contact angle, mechanical properties (tensile testing), and water vapor permeation. The results showed that attapulgite incorporation promoted a reduction in surface roughness (up to ~40%) and a decrease in contact angle (from ~89° to ~68°), indicating increased hydrophilicity. In addition, water vapor permeability was influenced in a non-linear manner, with optimized performance observed at 3 wt% filler loading. Solution viscosities remained within ranges suitable for processing. Structural analyses indicated compatibility between the phases, while morphology changes dependent on filler content were decisive for transport behavior. It is concluded that attapulgite is a promising additive for fine-tuning membrane properties, enabling optimization of the sorption–diffusion balance and improvement of membrane performance in separation applications. Full article

Coastal aquifers are essential freshwater sources for domestic, agricultural, and industrial use, particularly in regions where surface water is limited. However, these systems face growing stress from saltwater intrusion, climate-driven reductions in recharge, sea level rise, and intensified groundwater extraction. This review synthesizes recent research on coastal aquifer responses to these pressures, highlighting the interplay between natural hydrogeologic conditions and human-induced demand. Across deltaic and sedimentary systems, studies consistently show declining groundwater levels, the landward migration of saline interfaces, and reduced aquifer buffering capacity, especially in areas with high evaporation and limited recharge. The review also evaluates emerging strategies to preserve coastal groundwater security. Integrated hydrological models, managed aquifer recharge (MAR), optimized abstraction schemes, and remote sensing-based monitoring are advancing adaptive management capabilities. In parallel, policy and nature-based interventions—such as aquifer protection zoning, wetland rehabilitation, and dune system restoration—support long-term resilience by enhancing natural recharge and reducing vulnerability. The overall findings reveal the need for climate-informed and locally tailored groundwater management. Future efforts should prioritize coupling high-resolution climate projections with aquifer system models, evaluating MAR viability in saline-prone environments, and strengthening collaborative governance frameworks to ensure sustainable and equitable use of coastal aquifers. Full article

Dry rooms used in battery and semiconductor research facilities require ultra-low dew-point environments, which demand significant thermal energy for desiccant rotor regeneration. In steam-regenerated systems, condensate discharged through steam traps partially evaporates due to pressure reduction, generating flash steam that is typically released into the atmosphere, resulting in substantial energy losses. This study investigates the generation and recovery potential of flash steam in dry room HVAC systems. Field measurements were conducted for 18 steam-regenerated desiccant air handling units installed in a medium-scale research facility (total floor area: 43,000 m²) in southern Gyeonggi Province, Korea. Boiler operation data—including feedwater flow rate, pressure, and operating time—were analyzed over a six-month period from March to August 2025. The results showed that the average flash steam generation rate was approximately 1.16 ton/h, corresponding to 8.56% of the average feedwater flow rate. Two recovery methods were evaluated: a steam jet thermocompressor (SJT) and an exhaust vapor condenser (EVC). The analysis revealed that the EVC system provides a more practical solution for medium-scale dry rooms because it does not require high-pressure primary steam. By recovering flash steam using three EVC units, an average heat recovery of 724 kW was achieved. The recovered heat can produce 86 °C hot water, which can be utilized as a driving heat source for an absorption chiller, generating approximately 507 kW of cooling capacity. This configuration partially offsets the cooling load of existing centrifugal chillers, thereby reducing electrical energy consumption. In addition, the proposed system eliminates atmospheric discharge of flash steam, mitigating the visible white plume phenomenon commonly observed in industrial facilities. The results demonstrate the technical feasibility of integrating flash steam recovery with absorption cooling to enhance energy efficiency in medium-scale dry room HVAC systems. Full article

Given South Korea’s acute land constraints and ambitious renewable energy targets, floating solar farms (FSFs) on multi-purpose dam reservoirs offer a sustainable land-sparing solution for advancing the water-energy nexus and climate adaptation. This study estimates households’ willingness to pay (WTP) for a tariff premium supporting FSFs on multi-purpose dam reservoirs—a bundled sustainability attribute encompassing land-sparing deployment, water-energy nexus synergies (90% evaporation reduction, hydropower complementarity), and avoided land-use conflicts—relative to equivalent electricity from land-based solar farms (LSFs). The valuation scenario explicitly frames FSFs as an integrated policy package, not an isolated engineering characteristic, with balanced disclosure of location-specific trade-offs. The study highlights the sustainability value of land-sparing water-energy nexus solutions in South Korea. The analysis draws on a nationwide contingent valuation survey of 1000 households conducted from mid-April to mid-May 2025. Employing the one-and-one-half-bound dichotomous choice format with a spike model to handle zero WTP responses, we estimate a mean tariff premium of KRW 26.8 (USc 1.9) per kWh—17% of the residential rate. This exceeds the current FSF-LSF levelized cost differential (KRW 19 per kWh), despite 49% zero bids largely from protest responses. Socioeconomic factors (education, income, female gender, metropolitan residence, policy awareness) significantly shape acceptance probabilities. These findings affirm meaningful support for FSF deployment, contributing to long-term sustainability by integrating renewable energy with water resource management and reducing land-use conflicts. They also inform sustainable energy transition policies by showing that consumers are willing to fund multifunctional infrastructure synergies. Full article

The multi-cycle high-rate injection and production operations in Underground Gas Storage (UGS) facilities converted from depleted fracture-pore carbonate gas reservoirs induce complex rock–fluid interactions that threaten long-term integrity and performance. This study experimentally investigates the petrophysical responses of the Xiangguosi (XGS) UGS carbonate reservoirs in China using multi-cycle stress sensitivity tests, fines migration experiments, and water evaporation–salt precipitation analyses. SEM observations distinguish the contributions of crack closure and matrix compression to permeability evolution. Results show a sharp contrast in mechanical damage: high-quality rocks present negligible permanent deformation (<8% Young’s modulus reduction), whereas poor-quality rocks suffer catastrophic deterioration (>60%). Fines migration exhibits a three-stage behavior under cyclic flow, with water saturation significantly aggravating permeability impairment. A critical salinity threshold (220,000 ppm) is identified for the transition between drying-enhanced storage and salt plugging. Permeability declines sharply despite a slight porosity increase due to selective salt clogging of key pore throats, revealing a clear porosity–permeability decoupling. Salt deposition under movable water conditions can reduce UGS capacity by up to 1.45%. Reservoir heterogeneity, microfractures, karst structures, and initial petrophysical properties dominate the storage and flow space evolution. This work provides a predictive framework for optimizing injection–production strategies and improving the performance of complex carbonate UGS. Full article

The urban heat island effect is strongly linked to the use of dense mineral pavements with high thermal inertia and lacking passive heat dissipation mechanisms. This article evaluates the potential of evaporatively cooled concrete pavers, based on capillary action and evaporation by incorporating recycled, bio-based, and lightweight materials to develop functional porosity. Ten paver formulations were developed using natural or recycled sand, hemp fibers and shives, and lightweight aggregates. Compressive strength, density, capillary absorption, and thermal behavior were characterized. Tests were conducted outdoors in full sunlight over 48 h in comparison with reference urban materials. The results show that capillary action alone is insufficient to induce effective cooling. The raw recycled sand formulation exhibits high capillary absorption but reaches maximum temperatures of 43–44 °C, which may be due to its low interconnected porosity that limits evaporation. Conversely, formulations incorporating bio-based materials or lightweight aggregates showed a more favorable balance between water availability, reduced density, and surface cooling performance. Hemp-based pavers reach maximum temperatures of 38–40 °C, while those incorporating expanded clay range between 37 and 39 °C, representing a reduction of 7 to 13 °C compared to bitumen and maintaining mechanical strengths suitable for pedestrian use. The results suggest that effective evaporative cooling is associated with sufficient capillary absorption, efficient water transfer toward the surface, and moderate density limiting heat storage. This study demonstrates that high capillary absorption alone does not ensure effective evaporative cooling. By systematically comparing recycled, bio-based and lightweight aggregates, the results reveal that evaporative cooling efficiency probably depends on the functional connectivity of the pore network and on a moderate material density limiting heat storage. Full article

Mineral substrates for indoor horticulture systems critically determine plant water availability and irrigation demand. However, integrative assessments linking pore structure, water retention, and evaporation dynamics of commonly used mineral growing media remain scarce. A total of nine distinct mineral substrates were investigated: expanded clay, expanded slate, pumice, perlite, zeolite, vermiculite, lava granules, brick chips, and clay granules. To assess the impact of granulometry, pumice was tested in three different grain sizes (1–3 mm, 4–7 mm, 7–14 mm), resulting in a total of 11 experimental samples. Samples were characterized using scanning electron microscopy (SEM), suction experiments, and evaporation tests at 30%, 50%, and 70% relative humidity (RH) at 23 °C. Bulk density ranged from <0.12 g·cm⁻³ (perlite, vermiculite) to >0.99 g·cm⁻³ (zeolite, brick chips), while volumetric water content varied from 11.0 vol.% (expanded clay) to 46.6 vol.% (vermiculite). Plant-available water content (AWC) ranged from 2.7 vol.% (expanded clay) to 30.9 vol.% (clay granules). These results demonstrate that pore interconnectivity, rather than total porosity, is the decisive driver of hydraulic performance. Finer pumice fractions increased water retention by ~16% compared to coarser fractions. All substrates exhibited a two-phase evaporation profile, with initial rates ranging from 1.9 to 5.6 g·h⁻¹ at 30% RH. Clay granules showed the most temporally stable evaporation, with only a 37% rate reduction over 48 h, compared to 66% for perlite. While conducted under controlled laboratory conditions, these findings provide a quantitative basis for targeted substrate selection and blending to optimize root-zone hydration, irrigation efficiency, and hygrothermal performance in permanent indoor horticulture systems. Full article

The study focuses on the attempt to produce structural concrete, class C25/30 with exposure class XC3, using recycled aggregates derived from Excavation, Construction and Demolition Waste (ECDW) management. All the necessary properties of the recycled aggregates used were determined and four concrete mix compositions were made with recycled aggregate percentages ranging from 25% to 100%, while two more mix compositions were made with natural aggregates (NAs) to compare the results. A total of 78 cubic specimens, 13 from each mix, were obtained and their compressive strength, dynamic modulus of elasticity, rebound number, maximum deformation and maximum mass loss due to evaporation were determined at ages of 3, 7, 14, 28 and 90 days. The results show that 25–50% replacement with mixed recycled aggregates can satisfy the C25/30 strength class, whereas 100% replacement leads to significant strength and stiffness reductions. Overall, the study demonstrates that structural-grade recycled aggregate concrete is feasible up to moderate replacement levels, provided that the high water absorption and increased deformability associated with recycled aggregates are explicitly accounted for in mix design, curing and serviceability checks. Full article

Rising temperatures and increasing evaporative demand accelerate soil moisture loss (SML) during the sowing-to-emergence phase of cotton (Gossypium hirsutum L.), constraining crop establishment under water-limited Mediterranean conditions. Conventional tillage (CT) involves intensive tillage operations with higher fuel and energy requirements, whereas strip tillage (ST) limits tillage to the crop row while preserving inter-row residues. This study evaluated ST and CT across two consecutive growing seasons (2024 and 2025) under a wheat–cotton rotation system. A field experiment was conducted using a replicated design (n = 8), in which emergence parameters, SML (0–10 cm), yield, and fuel-derived energy use and CO₂ emissions were quantified. SML was significantly lower under ST than CT (43% in 2024 and 52% in 2025; p < 0.001), leading to earlier emergence (0.98–1.17 days) and higher emergence rate index (ERI) values. Cotton yield was slightly higher under CT (3–4%); however, this difference, although statistically significant (p = 0.001), remained limited and consistent across years. In contrast, ST resulted in a 66–69% reduction in operational fuel use, with proportional reductions in energy use and CO₂ emissions on an area basis. Yield-scaled indicators, defined as energy use (MJ kg⁻¹) and CO₂ emissions (kg CO₂ kg⁻¹) per unit yield, further revealed substantially greater resource-use efficiency under ST compared with CT. These findings demonstrate that strip tillage enhances hydrothermal conditions during crop establishment while markedly reducing energy demand and carbon intensity, providing a resource-efficient mechanization strategy for cotton production under increasing climatic stress. Full article