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Keywords = two-photon lithography

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36 pages, 3145 KB  
Review
From Lithography to Nanoimprint: Physics-Based, Data-Driven, and Hybrid Frameworks for Defect Prediction in Advanced Patterning Technologies
by Jean Chien and Eric Lee
Electronics 2026, 15(15), 3355; https://doi.org/10.3390/electronics15153355 - 29 Jul 2026
Abstract
Advanced patterning technologies have evolved from direct optical image transfer into predictive manufacturing frameworks in which defects are shaped by imaging physics, material response, process variation, and computational correction. Starting from the development of resolution enhancement techniques (RET) and optical proximity correction (OPC), [...] Read more.
Advanced patterning technologies have evolved from direct optical image transfer into predictive manufacturing frameworks in which defects are shaped by imaging physics, material response, process variation, and computational correction. Starting from the development of resolution enhancement techniques (RET) and optical proximity correction (OPC), this review traces how conventional optical lithography became the foundation of modern computational lithography. The discussion then extends to extreme ultraviolet lithography (EUVL) and nanoimprint lithography (NIL), where defect mechanisms no longer follow the same geometry-driven correction logic. EUVL introduces stochastic resist response, photon-limited variability, and mask 3D effects, while NIL shifts the dominant defect origins toward resist filling, residual layer variation, template interaction, viscoelastic deformation, and demolding. This review focuses on two major modeling paradigms for defect prediction from an OPC-centric view: physics-based frameworks that provide mechanism-level interpretability, and data-driven frameworks that enable rapid pattern recognition, hotspot detection, layout-to-image prediction, and uncertainty-aware screening. Recent advances also point to hybrid physics–machine learning (ML) frameworks as a promising way forward by synergistically combining physical constraints, simulation-derived knowledge, and data-driven inference. In summary, this review emphasizes the transition from contour correction to physically grounded, data-efficient, and uncertainty-aware defect prediction in optical lithography, EUVL, and NIL. Full article
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29 pages, 7765 KB  
Review
Nanosphere Self-Assembly Imaging Systems and Defect Detection Algorithms for Self-Assembled Structures: A Review
by Qihang Liu, Yuang Chen, Qingwei Zhou, Jinbao Jiang, Fang Luo, Fan Wu, Chucai Guo, Zhihong Zhu and Dan Chen
Nanomaterials 2026, 16(14), 890; https://doi.org/10.3390/nano16140890 - 20 Jul 2026
Viewed by 247
Abstract
Self-assembled nanosphere structures are widely used as bottom-up platforms for ordered micro- and nanostructures, with applications in photonic crystals, sensing platforms, functional coatings, drug delivery, and nanosphere lithography. Their performance and reproducibility depend on structural order, packing density, interparticle spacing, and defect density [...] Read more.
Self-assembled nanosphere structures are widely used as bottom-up platforms for ordered micro- and nanostructures, with applications in photonic crystals, sensing platforms, functional coatings, drug delivery, and nanosphere lithography. Their performance and reproducibility depend on structural order, packing density, interparticle spacing, and defect density and distribution. Thus, reliable imaging and quantitative defect detection are needed for quality evaluation and process optimization. This review provides an overview of defect characteristics, imaging systems, and defect detection algorithms for self-assembled nanosphere structures. It first introduces representative zero-, one-, two-, and three-dimensional assemblies, followed by a summary of common defects, including vacancies, interstitial particles, dislocations, grain boundaries, stacking faults, voids, and cracks. Optical microscopy, electron microscopy, atomic force microscopy, scanning near-field optical microscopy, and correlative techniques are compared in terms of resolution, field of view, temporal resolution, contrast mechanism, in situ capability, and compatibility with feedback control. Algorithmic approaches are also reviewed, encompassing classical image processing, machine learning, and deep learning, along with their applications in segmentation, localization, classification, and high-throughput analysis. Overall, reliable defect inspection requires integrated workflows. These workflows should combine appropriate imaging systems, image quality control, transferable algorithms, standardized datasets, and closed-loop feedback. Full article
(This article belongs to the Section Synthesis, Interfaces and Nanostructures)
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28 pages, 6202 KB  
Review
Freeform Micro-Optical Elements—Recent Production Techniques, Opportunities and Challenges
by Tomasz Blachowicz, Guido Ehrmann, Johannes Fiedler, Reinhard Kaschuba and Andrea Ehrmann
Micro 2026, 6(2), 35; https://doi.org/10.3390/micro6020035 - 11 May 2026
Viewed by 1092
Abstract
Freeform optics belong to the increasingly important elements in optical research and industry, which pose several challenges regarding design and highly precise manufacturing. First being used in cameras and for focusing, nowadays freeform optics are used in a broad range of applications, from [...] Read more.
Freeform optics belong to the increasingly important elements in optical research and industry, which pose several challenges regarding design and highly precise manufacturing. First being used in cameras and for focusing, nowadays freeform optics are used in a broad range of applications, from lighting to LiDAR, from endoscopy to photovoltaics, and from astronomical instruments to quantum cryptography. Designing freeform optics can be based on different theories and methods. Fabrication is possible by mechanical methods, such as diamond turning or high-precision milling, often followed by different polishing techniques, as well as laser-based techniques, mainly applying different lithographic techniques. Here, we give an overview of recent design and optimization methods, production methods used during the last years, and applications of freeform optics, including the possibility to combine freeform optics with tunability for different applications. We describe the opportunities of new applications as well as common problems and give an outlook towards future directions of research and development. Full article
(This article belongs to the Section Analysis Methods and Instruments)
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14 pages, 2689 KB  
Article
Construction of Atomically Thin Boron Films on Si Heterojunctions Using a First Principles Approach
by Piet Xiaowen Fang, Stoyan Nihtianov and Changming Fang
Materials 2026, 19(5), 952; https://doi.org/10.3390/ma19050952 - 28 Feb 2026
Viewed by 493
Abstract
Deposition of amorphous boron (a-B) onto Si substrates via chemical decomposition of B2H6 molecules produces a-B/Si, heterojunctions which are the core parts of photodetectors used in vacuum ultraviolet (VUV) and potentially in extreme ultraviolet (EUV) lithography. However, fundamental questions regarding [...] Read more.
Deposition of amorphous boron (a-B) onto Si substrates via chemical decomposition of B2H6 molecules produces a-B/Si, heterojunctions which are the core parts of photodetectors used in vacuum ultraviolet (VUV) and potentially in extreme ultraviolet (EUV) lithography. However, fundamental questions regarding the limit on the thickness of the deposited a-B thin films and the intrinsic electronic nature of the B atoms adjacent to the Si substrate remain unanswered. Here we investigated the local structural and electronic properties of atomic-thin a-B layers at the Si{001} substrates using ab initio molecular dynamics (AIMD) techniques. The investigation revealed a rich variety of local chemical bonding and consequently interfacial electronic properties. For thin a-B layer(s)/Si systems, most of the a-B atoms at the interface formed (-B-Si-B-Si-) chains on the Si{001} surface. These B atoms were found to occupy the positions of the missing Si atoms and were bonded to the surficial Si atoms. The surficial Si atoms predominantly have two B neighbors. Localized defect states at the Fermi level for the interfacial Si and B atoms were found in the pseudo-gap. These states have a major influence on the electrical properties of the device. The predicted minimum thickness of the a-B films is about 1 to 2 nm, a useful metric for the manufacturing of a-B/Si devices. The information obtained here further helps us to understand the working mechanisms of a-B/Si interfaces for photon detection and constructing new core devices for potential applications in the field of metal/semiconductor heterojunctions for photon detection, photovoltaics, Schottky diodes and semiconductor devices. Full article
(This article belongs to the Section Thin Films and Interfaces)
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9 pages, 3340 KB  
Communication
Broadband Trilayer Adiabatic Edge Coupler on Thin-Film Lithium Tantalate for NIR Light
by Shiqing Gao, Xinke Xing, Shuai Chen and Kaixuan Chen
Photonics 2026, 13(1), 41; https://doi.org/10.3390/photonics13010041 - 31 Dec 2025
Viewed by 919
Abstract
This work addresses the challenge of realizing broadband, low-loss fiber-to-waveguide coupling in the short-wavelength near-infrared range (700–1050 nm), where the required fine structural dimensions and taper tips approach or even exceed current fabrication limits, resulting in tight fabrication tolerances and degraded coupling efficiency. [...] Read more.
This work addresses the challenge of realizing broadband, low-loss fiber-to-waveguide coupling in the short-wavelength near-infrared range (700–1050 nm), where the required fine structural dimensions and taper tips approach or even exceed current fabrication limits, resulting in tight fabrication tolerances and degraded coupling efficiency. We propose a broadband trilayer adiabatic edge coupler on a thin-film lithium tantalate platform that requires only two standard lithography and etching steps. The design integrates a crossed bilayer taper and a dual-core mode converter to achieve adiabatic mode transformation from a ridge to a thin strip waveguide, ensuring excellent fabrication tolerance and process simplicity. Simulations predict a minimum coupling loss of 0.57 dB at 850 nm, which includes the transmission through the complete edge-coupler structure, along with a 0.5-dB bandwidth exceeding 140 nm. The proposed structure provides a broadband, low-loss, and fabrication-tolerant interface for short-wavelength photonic systems such as quantum photonics, biosensing, and visible-light communications. Full article
(This article belongs to the Special Issue Advanced Photonic Integration Technology and Devices)
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62 pages, 5074 KB  
Review
Advancements in Two-Photon Polymerization (2PP) for Micro and Nanoscale Fabrication
by Prithvi Basu
Nanomanufacturing 2026, 6(1), 1; https://doi.org/10.3390/nanomanufacturing6010001 - 23 Dec 2025
Cited by 3 | Viewed by 5762
Abstract
Two-photon polymerization (2PP) is revolutionizing micro- and nanoscale manufacturing by enabling true 3D fabrication with feature sizes far below the diffraction limit—capabilities that traditional lithography cannot match. By using ultrafast femtosecond laser pulses and nonlinear absorption, 2PP initiates polymerization only at the laser’s [...] Read more.
Two-photon polymerization (2PP) is revolutionizing micro- and nanoscale manufacturing by enabling true 3D fabrication with feature sizes far below the diffraction limit—capabilities that traditional lithography cannot match. By using ultrafast femtosecond laser pulses and nonlinear absorption, 2PP initiates polymerization only at the laser’s focal point, offering unmatched spatial precision. This paper highlights key advancements driving the field forward: the development of new materials engineered for 2PP with improved sensitivity, mechanical strength, and the introduction of high-speed, parallelized fabrication strategies that significantly enhance throughput. These innovations are shifting 2PP from a prototyping tool to a viable method for scalable production. Applications now range from custom biomedical scaffolds to complex photonic and metamaterial structures, demonstrating their growing real-world impact. We also address persistent challenges—including slow writing speeds and limited material options—and explore future directions to overcome these barriers. With continued progress in materials and hardware, 2PP is well positioned to become a cornerstone of next-generation additive manufacturing. Full article
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14 pages, 2211 KB  
Communication
Large-Area Nanostructure Fabrication with a 75 nm Half-Pitch Using Deep-UV Flat-Top Laser Interference Lithography
by Kexin Jiang, Mingliang Xie, Zhe Tang, Xiren Zhang and Dongxu Yang
Sensors 2025, 25(18), 5906; https://doi.org/10.3390/s25185906 - 21 Sep 2025
Cited by 4 | Viewed by 1958
Abstract
Micro- and nanopatterning is crucial for advanced photonic, electronic, and sensing devices. Yet achieving large-area periodic nanostructures with a 75 nm half-pitch on low-cost laboratory systems remains difficult, because conventional near-ultraviolet laser interference lithography (LIL) suffers from Gaussian-beam non-uniformity and a narrow exposure [...] Read more.
Micro- and nanopatterning is crucial for advanced photonic, electronic, and sensing devices. Yet achieving large-area periodic nanostructures with a 75 nm half-pitch on low-cost laboratory systems remains difficult, because conventional near-ultraviolet laser interference lithography (LIL) suffers from Gaussian-beam non-uniformity and a narrow exposure latitude. Here, we report a cost-effective deep-ultraviolet (DUV) dual-beam LIL system based on a 266 nm laser and diffractive flat-top beam shaping, enabling large-area patterning of periodical nanostructures. At this wavelength, a moderate half-angle can be chosen to preserve a large beam-overlap region while still delivering 150 nm period (75 nm half-pitch) structures. By independently tuning the incident angle and beam uniformity, we pattern one-dimensional (1D) gratings and two-dimensional (2D) arrays over a Ø 1.0 cm field with critical-dimension variation < 5 nm (1σ), smooth edges, and near-vertical sidewalls. As a proof of concept, we transfer a 2D pattern into Si to create non-metal-coated nanodot arrays that serve as surface-enhanced Raman spectroscopy (SERS) substrates. The arrays deliver an average enhancement factor of ~1.12 × 104 with 11% intensity relative standard deviation (RSD) over 65 sampling points, a performance near the upper limit of all-dielectric SERS substrates. The proposed method overcomes the uneven hotspot distribution and complex fabrication procedures in conventional SERS substrates, enabling reliable and large-area chemical sensing. Compared to electron-beam lithography, the flat-top DUV-LIL approach offers orders-of-magnitude higher throughput at a fraction of the cost, while its centimeter-scale uniformity can be scaled to full wafers with larger beam-shaping optics. These attributes position the method as a versatile and economical route to large-area photonic metasurfaces and sensing devices. Full article
(This article belongs to the Section Nanosensors)
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10 pages, 14631 KB  
Article
Robust On-Chip Polymer Coupler for All-Optical Ultrasound Detection
by Chao Zhao, Peijian Li and Chonglei Zhang
Photonics 2025, 12(9), 869; https://doi.org/10.3390/photonics12090869 - 28 Aug 2025
Viewed by 1195
Abstract
Fiber-chip couplers play an important role in the field of on-chip all-optical ultrasound detection; however, they have received limited attention in research. Here, we present an on-chip photoresin coupler fabricated via two-photon lithography, combining the benefits of compact size, wide bandwidth, low loss, [...] Read more.
Fiber-chip couplers play an important role in the field of on-chip all-optical ultrasound detection; however, they have received limited attention in research. Here, we present an on-chip photoresin coupler fabricated via two-photon lithography, combining the benefits of compact size, wide bandwidth, low loss, and robust coupling. Utilizing a high-refractive-index photoresin medium, we achieved transmission efficiencies better than −1.3 dB in water environments within a 1528–1567 nm bandwidth. Alignment errors were constrained to ±2.5 μm laterally and 20 μm axially, with angular deviations exceeding ±3° at a −1 dB loss. Its sturdy structure facilitates 5–30 MHz ultrasound detection in liquid environments through phase-shifted Bragg grating. Full article
(This article belongs to the Section Lasers, Light Sources and Sensors)
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45 pages, 5794 KB  
Review
Nanophotonic Materials and Devices: Recent Advances and Emerging Applications
by Yuan-Fong Chou Chau
Micromachines 2025, 16(8), 933; https://doi.org/10.3390/mi16080933 - 13 Aug 2025
Cited by 28 | Viewed by 8311
Abstract
Nanophotonics, the study of light–matter interactions at the nanometer scale, has emerged as a transformative field that bridges photonics and nanotechnology. Using engineered nanomaterials—including plasmonic metals, high-index dielectrics, two-dimensional (2D) materials, and hybrid systems—nanophotonics enables light manipulation beyond the diffraction limit, unlocking novel [...] Read more.
Nanophotonics, the study of light–matter interactions at the nanometer scale, has emerged as a transformative field that bridges photonics and nanotechnology. Using engineered nanomaterials—including plasmonic metals, high-index dielectrics, two-dimensional (2D) materials, and hybrid systems—nanophotonics enables light manipulation beyond the diffraction limit, unlocking novel applications in sensing, imaging, and quantum technologies. This review provides a comprehensive overview of recent advances (post-2020) in nanophotonic materials, fabrication methods, and their cutting-edge applications. We first discuss the fundamental principles governing nanophotonic phenomena, such as localized surface plasmon resonances (LSPRs), Mie resonances, and exciton–polariton coupling, highlighting their roles in enhancing light–matter interactions. Next, we examine state-of-the-art fabrication techniques, including top-down (e.g., electron beam lithography and nanoimprinting) and bottom-up (e.g., chemical vapor deposition and colloidal synthesis) approaches, as well as hybrid strategies that combine scalability with nanoscale precision. We then explore emerging applications across diverse domains: quantum photonics (single-photon sources, entangled light generation), biosensing (ultrasensitive detection of viruses and biomarkers), nonlinear optics (high-harmonic generation and wave mixing), and integrated photonic circuits. Special attention is given to active and tunable nanophotonic systems, such as reconfigurable metasurfaces and hybrid graphene–dielectric devices. Despite rapid progress, challenges remain, including optical losses, thermal management, and scalable integration. We conclude by outlining future directions, such as machine learning-assisted design, programmable photonics, and quantum-enhanced sensing, and offering insights into the next generation of nanophotonic technologies. This review serves as a timely resource for researchers in photonics, materials science, and nanotechnology. Full article
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12 pages, 7558 KB  
Article
High Resolution Imaging Using Micro-Objectives Fabricated by 2-Photon-Polymerization
by Fabian Thiemicke, Mostafa Agour, Ralf B. Bergmann and Claas Falldorf
Appl. Sci. 2025, 15(15), 8756; https://doi.org/10.3390/app15158756 - 7 Aug 2025
Cited by 1 | Viewed by 1657
Abstract
We experimentally demonstrate high-resolution imaging using micro-objectives fabricated by two-photon polymerization (2PP) lithography, highlighting its potential as a flexible and precise fabrication method. The 2PP manufacturing process offers the ability to develop micro-optics with customized geometries and material properties, including tailored refractive indices. [...] Read more.
We experimentally demonstrate high-resolution imaging using micro-objectives fabricated by two-photon polymerization (2PP) lithography, highlighting its potential as a flexible and precise fabrication method. The 2PP manufacturing process offers the ability to develop micro-optics with customized geometries and material properties, including tailored refractive indices. This flexibility introduces new degrees of freedom in optical system design and expands the applicability of micro-optics to advanced imaging tasks where other materials and fabrication methods are insufficient. For our study, bi-convex micro-optics with different geometries with radii of curvature of <15 μm and minimized contact areas (<1 μm2) to ensure easy release from the substrate were fabricated with 2PP and investigated for their optical performance. With these micro-optics, the tracks with a pitch of 320 nm and the pits and lands as small as 130 nm were successfully resolved on a BluRay disc surface, demonstrating for the first time the high-resolution imaging capabilities of bi-convex spherical micro lenses. Full article
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20 pages, 5319 KB  
Article
Multiscale 2PP and LCD 3D Printing for High-Resolution Membrane-Integrated Microfluidic Chips
by Julia K. Hoskins, Patrick M. Pysz, Julie A. Stenken and Min Zou
Nanomanufacturing 2025, 5(3), 11; https://doi.org/10.3390/nanomanufacturing5030011 - 12 Jul 2025
Cited by 3 | Viewed by 3001
Abstract
This study presents a microfluidic chip platform designed using a multiscale 3D printing strategy for fabricating microfluidic chips with integrated, high-resolution, and customizable membrane structures. By combining two-photon polymerization (2PP) for submicron membrane fabrication with liquid crystal display printing for rapid production of [...] Read more.
This study presents a microfluidic chip platform designed using a multiscale 3D printing strategy for fabricating microfluidic chips with integrated, high-resolution, and customizable membrane structures. By combining two-photon polymerization (2PP) for submicron membrane fabrication with liquid crystal display printing for rapid production of larger components, this approach addresses key challenges in membrane integration, including sealing reliability and the use of transparent materials. Compared to fully 2PP-based fabrication, the multiscale method achieved a 56-fold reduction in production time, reducing total fabrication time to approximately 7.2 h per chip and offering a highly efficient solution for integrating complex structures into fluidic chips. The fabricated chips demonstrated excellent mechanical integrity. Burst pressure testing showed that all samples withstood internal pressures averaging 1.27 ± 0.099 MPa, with some reaching up to 1.4 MPa. Flow testing from ~35 μL/min to ~345 μL/min confirmed stable operation in 75 μm square channels, with no leakage and minimal flow resistance up to ~175 μL/min without deviation from the predicted behavior in the 75 μm. Membrane-integrated chips exhibited outlet flow asymmetries greater than 10%, indicating active fluid transfer across the membrane and highlighting flow-dependent permeability. Overall, this multiscale 3D printing approach offers a scalable and versatile solution for microfluidic device manufacturing. The method’s ability to integrate precise membrane structures enable advanced functionalities such as diffusion-driven particle sorting and molecular filtration, supporting a wide range of biomedical, environmental, and industrial lab-on-a-chip applications. Full article
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24 pages, 10324 KB  
Article
A Versatile Platform for Designing and Fabricating Multi-Material Perfusable 3D Microvasculatures
by Nathaniel Harris, Charles Miller and Min Zou
Micromachines 2025, 16(6), 691; https://doi.org/10.3390/mi16060691 - 8 Jun 2025
Cited by 2 | Viewed by 3201
Abstract
Perfusable microvasculature is critical for advancing in vitro tissue models, particularly for neural applications where limited diffusion impairs organoid growth and fails to replicate neurovascular function. This study presents a versatile fabrication platform that integrates mesh-driven design, two-photon lithography (TPL), and modular interfacing [...] Read more.
Perfusable microvasculature is critical for advancing in vitro tissue models, particularly for neural applications where limited diffusion impairs organoid growth and fails to replicate neurovascular function. This study presents a versatile fabrication platform that integrates mesh-driven design, two-photon lithography (TPL), and modular interfacing to create multi-material, perfusable 3D microvasculatures. Various 2D and 3D capillary paths were test-printed using both polygonal and lattice support strategies. A double-layered capillary scaffold based on the Hilbert curve was used for comparative materials testing. Methods for printing rigid (OrmoComp), moderately stiff hydrogel (polyethylene glycol diacrylate, PEGDA 700), and soft elastomeric (photocurable polydimethylsiloxane, PDMS) materials were developed and evaluated. Cone support structures enabled high-fidelity printing of the softer materials. A compact heat-shrink tubing interface provided leak-free perfusion without bulky fittings. Physiologically relevant flow velocities and Dextran diffusion through the scaffold were successfully demonstrated. Cytocompatibility assays confirmed that all TPL-printed scaffold materials supported human neural stem cell viability. Among peripheral components, lids fabricated via fused deposition modeling designed to hold microfluidic needle adapters exhibited good biocompatibility, while those made using liquid crystal display-based photopolymerization showed significant cytotoxicity despite indirect exposure. Overall, this platform enables creation of multi-material microvascular systems facilitated by TPL technology for complex, 3D neurovascular modeling, blood–brain barrier studies, and integration into vascularized organ-on-chip applications. Full article
(This article belongs to the Special Issue Microfluidic Chips for Biomedical Applications)
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19 pages, 5079 KB  
Review
Advances in Design and Fabrication of Micro-Structured Solid Targets for High-Power Laser-Matter Interaction
by Florin Jipa, Laura Ionel and Marian Zamfirescu
Photonics 2024, 11(11), 1008; https://doi.org/10.3390/photonics11111008 - 25 Oct 2024
Cited by 3 | Viewed by 2827
Abstract
Accelerated particles have multiple applications in materials research, medicine, and the space industry. In contrast to classical particle accelerators, laser-driven acceleration at intensities greater than 1018 W/cm2, currently achieved at TW and PW laser facilities, allow for much larger electric [...] Read more.
Accelerated particles have multiple applications in materials research, medicine, and the space industry. In contrast to classical particle accelerators, laser-driven acceleration at intensities greater than 1018 W/cm2, currently achieved at TW and PW laser facilities, allow for much larger electric field gradients at the laser focus point, several orders of magnitude higher than those found in conventional kilometer-sized accelerators. It has been demonstrated that target design becomes an important factor to consider in ultra-intense laser experiments. The energetic and spatial distribution of the accelerated particles strongly depends on the target configuration. Therefore, target engineering is one of the key approaches to optimizing energy transfer from the laser to the accelerated particles. This paper provides an overview of recent progress in 2D and 3D micro-structured solid targets, with an emphasis on fabrication procedures based on laser material processing. Recently, 3D laser lithography, which involves Two-Photon Absorption (TPA) effects in photopolymers, has been proposed as a technique for the high-resolution fabrication of 3D micro-structured targets. Additionally, laser surface nano-patterning followed by the replication of the patterns through molding, has been proposed and could become a cost-effective and reliable solution for intense laser experiments at high repetition rates. Recent works on numerical simulations have also been presented. Using particle-in-cell (PIC) simulation software, the importance of structured micro-target design in the energy absorption process of intense laser pulses—producing localized extreme temperatures and pressures—was demonstrated. Besides PIC simulations, the Finite-Difference Time-Domain (FDTD) numerical method offers the possibility to generate the specific data necessary for defining solid target material properties and designing their optical geometries with high accuracy. The prospects for the design and technological fabrication of 3D targets for ultra-intense laser facilities are also highlighted. Full article
(This article belongs to the Special Issue High-Power Ultrafast Lasers: Development and Applications)
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36 pages, 3550 KB  
Review
Advanced Laser Techniques for the Development of Nature-Inspired Biomimetic Surfaces Applied in the Medical Field
by Anita Ioana Visan and Gianina Florentina Popescu-Pelin
Coatings 2024, 14(10), 1290; https://doi.org/10.3390/coatings14101290 - 9 Oct 2024
Cited by 16 | Viewed by 5314
Abstract
This review focuses on the innovative use of laser techniques in developing and functionalizing biomimetic surfaces, emphasizing their potential applications in the medical and biological fields. Drawing inspiration from the remarkable properties of various natural systems, such as the water-repellent lotus leaf, the [...] Read more.
This review focuses on the innovative use of laser techniques in developing and functionalizing biomimetic surfaces, emphasizing their potential applications in the medical and biological fields. Drawing inspiration from the remarkable properties of various natural systems, such as the water-repellent lotus leaf, the adhesive gecko foot, the strong yet lightweight spider silk, and the unique optical structures of insect wings, we explore the potential for replicating these features through advanced laser surface modifications. Depending on the nature and architecture of the surface, particular techniques have been designed and developed. We present an in-depth analysis of various methodologies, including laser ablation/evaporation techniques, such as Pulsed Laser Deposition and Matrix-Assisted Pulsed Laser Evaporation, and approaches for laser surface structuring, including two-photon lithography, direct laser interference patterning, laser-induced periodic surface structures, direct laser writing, laser-induced forward transfer, and femtosecond laser ablation of metals in organic solvents. Additionally, specific applications are highlighted with the aim of synthesizing this knowledge and outlining future directions for research that further explore the intersection of laser techniques and biomimetic surfaces, paving the way for advancements in biomedical applications. Full article
(This article belongs to the Special Issue Biomimetic Approaches in Coatings Synthesis)
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18 pages, 7591 KB  
Article
3D Printing of High-Porosity Membranes with Submicron Pores for Microfluidics
by Julia K. Hoskins and Min Zou
Nanomanufacturing 2024, 4(3), 120-137; https://doi.org/10.3390/nanomanufacturing4030009 - 27 Jun 2024
Cited by 8 | Viewed by 4185
Abstract
In this study, we investigate the potential of two-photon lithography (2PL) as a solution to the challenges encountered in conventional membrane fabrication techniques, aiming to fabricate tailor-made membranes with high-resolution submicron pore structures suitable for advanced applications. This approach led to the development [...] Read more.
In this study, we investigate the potential of two-photon lithography (2PL) as a solution to the challenges encountered in conventional membrane fabrication techniques, aiming to fabricate tailor-made membranes with high-resolution submicron pore structures suitable for advanced applications. This approach led to the development of fabrication techniques and printed membranes that can be adapted to various lab-on-a-chip (LOC) devices. Membranes were fabricated with pore diameters as small as 0.57 µm and porosities of 4.5%, as well as with larger pores of approximately 3.73 µm in diameter and very high porosities that reached up to 60%. Direct 3D printing of membranes offers a pathway for fabricating structures tailored to specific applications in microfluidics, enabling more efficient separation processes at miniature scales. This research represents a significant step towards bridging the gap between membrane technology and microfluidics, promising enhanced capabilities for a wide array of applications in biotechnology, chemical analysis, and beyond. Full article
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