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40 pages, 10781 KiB  
Review
Recent Developments in Additively Manufactured Crash Boxes: Geometric Design Innovations, Material Behavior, and Manufacturing Techniques
by Ahmed Saber, A. M. Amer, A. I. Shehata, H. A. El-Gamal and A. Abd_Elsalam
Appl. Sci. 2025, 15(13), 7080; https://doi.org/10.3390/app15137080 - 24 Jun 2025
Cited by 2 | Viewed by 732
Abstract
Crash boxes play a vital role in improving vehicle safety by absorbing collision energy and reducing the forces transmitted to occupants. Additive manufacturing (AM) has become a powerful method for developing advanced crash boxes by enabling complex geometries. This review provides a comprehensive [...] Read more.
Crash boxes play a vital role in improving vehicle safety by absorbing collision energy and reducing the forces transmitted to occupants. Additive manufacturing (AM) has become a powerful method for developing advanced crash boxes by enabling complex geometries. This review provides a comprehensive examination of recent progress in AM crash boxes, with a focus on three key aspects: geometric design innovations, material behavior, and manufacturing techniques. The review investigates the influence of various AM-enabled structural configurations, including tubular, origami-inspired, lattice, and bio-inspired designs, on crashworthiness performance. Among these, bio-inspired structures exhibit superior energy absorption characteristics, achieving a mean specific energy absorption (SEA) of 21.51 J/g. Material selection is also explored, covering polymers, fiber-reinforced polymers, metals, and multi-material structures. Metallic AM crash boxes demonstrate the highest energy absorption capacity, with a mean SEA of 28.65 J/g. In addition, the performance of different AM technologies is evaluated, including Stereolithography (SLA), Material Jetting (MJT), Selective Laser Melting (SLM), Selective Laser Sintering (SLS), Fused Deposition Modeling (FDM), and hybrid manufacturing techniques. Among these, crash boxes produced by SLM show the most favorable energy absorption performance, with a mean SEA of 16.50 J/g. The findings presented in this review offer critical insights to guide future research and development in the design and manufacturing of next-generation AM crash boxes intended to enhance vehicle safety. Full article
(This article belongs to the Section Additive Manufacturing Technologies)
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14 pages, 2220 KiB  
Article
Numerical Simulation Analysis of Concrete-Filled Circular CFRP–Steel Middle Long Columns
by Chuheng Zhong, Shuai Wang, Jun Leng and Jinzhi Zhou
Appl. Sci. 2025, 15(11), 6311; https://doi.org/10.3390/app15116311 - 4 Jun 2025
Viewed by 429
Abstract
Based on the research on concrete-filled circular steel tubular columns, the influence of carbon-fiber-reinforced polymers (CFRPs) on the ultimate bearing capacity of concrete-filled steel tubes (CFSTs) was further explored in this paper. Ten different concrete-filled circular CFRP–steel middle long columns were made for [...] Read more.
Based on the research on concrete-filled circular steel tubular columns, the influence of carbon-fiber-reinforced polymers (CFRPs) on the ultimate bearing capacity of concrete-filled steel tubes (CFSTs) was further explored in this paper. Ten different concrete-filled circular CFRP–steel middle long columns were made for an axial compression test, and the influence of the CFRP layers, the concrete strength grades, the steel tube wall thickness, and the slenderness ratio on the ultimate bearing capacity was discussed. Combined with theoretical analysis, the calculation method of ultimate bearing capacity of it was found. The load midspan deflection diagram was obtained by numerical simulation with finite element analysis software ANSYS2021R1, and the test results were compared. The results demonstrate that CFRP layers significantly enhance the ultimate bearing capacity of circular steel tube–CFRP confined concrete columns, with one to three layers increasing the capacity by 42.5%, 69.4%, and 88.4%, respectively, under identical conditions. In comparison, the concrete strength, the steel tube thickness, and the slenderness ratio showed lesser effects (<20% improvement), providing critical support for engineering applications of CFRP-confined circular steel tubular columns. Moreover, the error of ANSYS calculation results is small, which is in line with the test. This is of great significance to verify the correctness of the test of concrete-filled circular CFRP–steel middle long columns. Full article
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20 pages, 5087 KiB  
Article
Modified Energy-Based Design Method of the Precast Partially Steel-Reinforced Concrete Beam–CFST Column Eccentrically Braced Frame
by Fugui Hou, Weiguang Chong, Yu Lin, Xijun He and Guanglei Zhang
Buildings 2025, 15(11), 1797; https://doi.org/10.3390/buildings15111797 - 24 May 2025
Viewed by 427
Abstract
The eccentrically braced frame (EBF) is a typical structural system used in high-rise buildings. Current related design methods focus on the concrete and steel structures rather than on the complex composite structure. In addition, they tend to overlook the contribution of the energy-dissipation [...] Read more.
The eccentrically braced frame (EBF) is a typical structural system used in high-rise buildings. Current related design methods focus on the concrete and steel structures rather than on the complex composite structure. In addition, they tend to overlook the contribution of the energy-dissipation unit and its corresponding additional influence on the structure. In this study, a precast composite EBF structure is selected as a case study, including the partially steel-reinforced concrete (PSRC) beam and the concrete-filled steel tubular (CFST) column. A modified energy-based design method is proposed to leverage the excellent seismic performance of the precast composite EBF structure. The multi-stage energy-dissipation mechanism and the additional influence of the eccentric braces are systematically considered through the energy distribution coefficient and the layout of dampers. A case study of a 12-floor, three-bay precast composite EBF structure is conducted using a series of nonlinear time-history analyses. Critical seismic responses, including the maximum inter-story drift ratio, residual inter-story drift ratio, and peak acceleration, are systematically analyzed to evaluate the effectiveness of the proposed design theory. The distribution coefficient is recommended to range from 0.70 to 0.80 to balance the energy-dissipation contribution between the frame and the eccentric braces. In terms of the damper layout, the energy-dissipation contribution of the eccentric brace should differ among the lower, middle, and upper floors. Full article
(This article belongs to the Special Issue Advances in Novel Precast Concrete Structures)
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20 pages, 7848 KiB  
Article
Experimental and FEM Analysis of Slab Structures Reinforced with Tubular Reinforcement
by Tae-Hee Lee, Gun Jung, Taehoon Han and Jang-Ho Jay Kim
Materials 2025, 18(10), 2369; https://doi.org/10.3390/ma18102369 - 20 May 2025
Viewed by 318
Abstract
This study investigates the structural behavior of reinforced concrete slabs and culverts using newly developed tubular rebars as a replacement for conventional deformed rebars. Tubular rebars, which are approximately 50% lighter and exhibit twice the tensile strength of standard deformed rebars, were evaluated [...] Read more.
This study investigates the structural behavior of reinforced concrete slabs and culverts using newly developed tubular rebars as a replacement for conventional deformed rebars. Tubular rebars, which are approximately 50% lighter and exhibit twice the tensile strength of standard deformed rebars, were evaluated through experimental tests and finite element analysis (FEA). Results showed that tubular rebars achieved up to 44.46% higher yield strength and up to 25.31% higher ultimate strength in statically determinate slabs compared to conventional rebars, though with reduced ductility. In statically indeterminate configurations such as fixed slabs and box culverts, the ductility performance improved significantly, with ductility index differences reduced to less than 3%. Hybrid reinforcement combining tubular and deformed rebars also enhanced performance, especially in compression zones. These findings demonstrate that tubular rebars can be a sustainable and structurally efficient alternative to conventional reinforcement when deflection control is ensured. Full article
(This article belongs to the Section Materials Simulation and Design)
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15 pages, 16118 KiB  
Article
Axial Tensile Experiment of the Lap-Type Asymmetric K-Shaped Square Tubular Joints with Built-In Stiffeners
by Zhihua Zhong, Peiyu Peng, Zheweng Zhu, Xiang Ao, Shiwei Xiong, Jinkun Huang, Lihong Zhou and Xiaochuan Bai
Buildings 2025, 15(10), 1634; https://doi.org/10.3390/buildings15101634 - 13 May 2025
Viewed by 322
Abstract
To study the mechanical properties of asymmetric K-shaped square tubular joints with built-in stiffening rib lap joints, axial tensile tests were carried out on one K-shaped joint without built-in stiffening ribs and four K-shaped joints with built-in stiffening ribs using an electro-hydraulic servo [...] Read more.
To study the mechanical properties of asymmetric K-shaped square tubular joints with built-in stiffening rib lap joints, axial tensile tests were carried out on one K-shaped joint without built-in stiffening ribs and four K-shaped joints with built-in stiffening ribs using an electro-hydraulic servo structural testing system. The effects of the addition of stiffening ribs and the welding method of the stiffening ribs on the mechanical properties were studied comparatively. The failure mode of the K-shaped joint was obtained, and the strain distribution and peak displacement reaction force in the nodal region were analyzed. A finite element analysis of the K-shaped joint was carried out, and the finite element results were compared with the experimental results. The results showed that the addition of transverse reinforcement ribs and more complete welds shared the squeezing effect of the brace on the chord. Arranging more reinforcing ribs in the fittings makes the chord more uniformly stressed and absorbs more energy while increasing the flexural load capacity of the fittings’ side plates. The presence of a weld gives a short-lived temperature increase in the area around the crack, and the buckling of the structure causes the surface temperature in the buckling area to continue to increase for some time. The temperature change successfully localized where the structure was deforming and creating cracks. The addition of the reinforcing ribs resulted in a change in the deformation pattern of the model, and the difference occurred because the flexural capacity of the brace with the added reinforcing ribs was greater than that of the side plate buckling. Full article
(This article belongs to the Special Issue Application of Experiment and Simulation Techniques in Engineering)
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16 pages, 3292 KiB  
Article
Topology Optimization of Additively Manufactured Adherends for Increased Adhesive Bond Strength
by Michael Ascher and Ralf Späth
Materials 2025, 18(10), 2170; https://doi.org/10.3390/ma18102170 - 8 May 2025
Viewed by 483
Abstract
The limited build space of additive manufacturing (AM) machines constrains the maximum size of AM components, while manufacturing costs rise with geometric complexity. To enhance value and overcome size limitations, it can be more efficient to join non-AM and AM components to meet [...] Read more.
The limited build space of additive manufacturing (AM) machines constrains the maximum size of AM components, while manufacturing costs rise with geometric complexity. To enhance value and overcome size limitations, it can be more efficient to join non-AM and AM components to meet the requirements by means of a hybrid structure. Adhesive bonding is particularly suitable for such joints, as it imposes no constraints on the joining surface’s geometry or the adherend’s material. To ensure structural integrity, it is conceivable to exploit the design freedom underlying AM processes by optimizing the topology of the AM component to stress the adhesive layer homogeneously. This study explores the feasibility of this concept using the example of an axially loaded single-lap tubular joint between a carbon fiber-reinforced composite tube and an additively manufactured laser-based powder-bed-fusion aluminum alloy sleeve. The sleeve topology was optimized using the finite element method, achieving a 75 %P reduction in adhesive stress increase compared to a non-optimized sleeve. Due to the pronounced ductility of the two-component epoxy-based adhesive, the static bond strength remained unaffected, whereas fatigue life significantly improved. The findings demonstrate the feasibility of leveraging AM design freedom to enhance adhesive joint performance, providing a promising approach for hybrid structures in lightweight applications. Full article
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8 pages, 4501 KiB  
Proceeding Paper
Parametric Investigation of Fatigue-Cracked Tubular T-Joint Repair Using Composite Reinforcement
by Muhammad Hazim, Saravanan Karuppanan and Mohsin Iqbal
Eng. Proc. 2025, 87(1), 38; https://doi.org/10.3390/engproc2025087038 - 8 Apr 2025
Viewed by 251
Abstract
Circular hollow sections (CHSs) are widely used in offshore jacket structures due to their excellent compressive strength, torsional resistance, and direction-independent stiffness. However, CHS joints are prone to fatigue-induced cracking caused by complex geometries, environmental loading, and aging. Fatigue crack propagation, governed by [...] Read more.
Circular hollow sections (CHSs) are widely used in offshore jacket structures due to their excellent compressive strength, torsional resistance, and direction-independent stiffness. However, CHS joints are prone to fatigue-induced cracking caused by complex geometries, environmental loading, and aging. Fatigue crack propagation, governed by the stress intensity factor (SIF), threatens structural integrity if the SIF exceeds fracture toughness. Composite reinforcement has emerged as a promising solution for mitigating crack propagation and enhancing joint performance. This study presents a numerical parametric investigation of fatigue-cracked tubular T-joints, focusing on the effects of crack size, crack location, and composite reinforcement on the SIF under various loading conditions. The highest SIF was consistently observed at the saddle point in T-joints under axial and out-of-plane bending (OPB) loads. However, in T-joints subjected to in-plane bending (IPB) loads, the highest SIF was found between the crown and saddle points. The SIF increased with the size and diameter of the cracks. The application of CFRP wrapping was found to reduce the SIF by more than 50% across all loading conditions, with the most significant reductions observed when the reinforcement was oriented along the chord axis. Full article
(This article belongs to the Proceedings of The 5th International Electronic Conference on Applied Sciences)
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20 pages, 2598 KiB  
Article
Recycling Fiber-Reinforced Polyamide Waste from the Automotive Industry: Life Cycle Assessment (LCA) of an Advanced Pyrolysis Process to Reclaim Glass Fibers and Valuable Chemicals
by Blanca María Caballero, Alexander Lopez-Urionabarrenechea, Jean Paul Gonzalez-Arcos, Borja Benjamín Perez-Martinez, Esther Acha, Maider Iturrondobeitia, Julen Ibarretxe, Aritz Esnaola and Maider Baskaran
Materials 2025, 18(7), 1594; https://doi.org/10.3390/ma18071594 - 1 Apr 2025
Viewed by 737
Abstract
The generation of pyrolysis liquids and gases with poor quality is a limiting factor for the development of the recycling process of fiber-reinforced plastic waste. In this article, the life cycle assessment (LCA) of an advanced two-step pyrolysis process to recycle glass fiber-reinforced [...] Read more.
The generation of pyrolysis liquids and gases with poor quality is a limiting factor for the development of the recycling process of fiber-reinforced plastic waste. In this article, the life cycle assessment (LCA) of an advanced two-step pyrolysis process to recycle glass fiber-reinforced polyamide waste is presented. First, the solid waste is pyrolyzed by heating up at 3 °C/min to 500 °C in a tank reactor. The generated volatiles are subsequently thermally cracked at 900 °C in a tubular packed bed reactor. The process is able to reclaim the glass fibers similarly to the conventional one reactor pyrolysis, while producing liquids and gases with better properties. The large quantity of oxygenated pyrolysis oils generated in the conventional pyrolysis are cracked into gaseous hydrocarbons, CO, CO2 and a minor aqueous liquid. The pyrolysis gases become the main product of the process, presenting an interesting composition of hydrogen (39.9 vol.%), methane (22.5 vol.%), carbon monoxide (19.5 vol.%) and ethylene (10.8 vol.%). The LCA shows that advanced pyrolysis demonstrates better environmental performance than conventional pyrolysis, avoiding fossil resource scarcity and reducing global warming by half and human carcinogenic toxicity by one third. Full article
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15 pages, 3531 KiB  
Article
VMP1 Constitutive Expression in Mice Dampens Pancreatic and Systemic Histopathological Damage in an Experimental Model of Severe Acute Pancreatitis
by Veronica Boggio, Claudio Daniel Gonzalez, Elsa Zotta, Alejandro Ropolo and Maria Ines Vaccaro
Int. J. Mol. Sci. 2025, 26(7), 3196; https://doi.org/10.3390/ijms26073196 - 29 Mar 2025
Viewed by 541
Abstract
Acute pancreatitis (AP) an inflammatory condition caused by the premature activation of pancreatic proteases, leads to organ damage, systemic inflammation, and multi-organ failure. Severe acute pancreatitis (SAP) has high morbidity and mortality, affecting the liver, kidneys, and lungs. Autophagy maintains pancreatic homeostasis, with [...] Read more.
Acute pancreatitis (AP) an inflammatory condition caused by the premature activation of pancreatic proteases, leads to organ damage, systemic inflammation, and multi-organ failure. Severe acute pancreatitis (SAP) has high morbidity and mortality, affecting the liver, kidneys, and lungs. Autophagy maintains pancreatic homeostasis, with VMP1-mediated selective autophagy (zymophagy) preventing intracellular zymogen activation and acinar cell death. This study examines the protective role of VMP1 (Vacuole Membrane Protein 1)-induced autophagy using ElaI-VMP1 transgenic mice in a necrohemorrhagic SAP model (Hartwig’s model). ElaI-VMP1 mice show significantly reduced pancreatic injury, including lower necrosis, edema, and inflammation, compared to wild-type (WT) mice. Biochemical markers (lactate dehydrogenase-LDH-, amylase, and lipase) and histopathology confirm that VMP1 expression mitigates pancreatic damage. Increased zymophagy negatively correlates with acinar necrosis, reinforcing its protective role. Beyond the pancreas, ElaI-VMP1 mice exhibit preserved liver, kidney, and lung histology, indicating reduced systemic organ damage. The liver maintains normal architecture, kidneys show minimal tubular necrosis, and lung inflammation features are reduced compared to WT mice. Our results confirm that zymophagy functions as a protective pathophysiological mechanism against pancreatic and extrapancreatic tissue injury in SAP. Further studies on the mechanism of VMP1-mediated selective autophagy in AP are necessary to determine its relevance and possible modulation to prevent the severity of AP. Full article
(This article belongs to the Special Issue Pancreatic Diseases: Molecular Pathology and Therapeutics)
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26 pages, 7700 KiB  
Article
Assessment of Structural Integrity Through On-Site Decision-Making Analysis for a Jacket-Type Offshore Platform
by Rodrigo Daniel Álvarez Bello Martínez, Juan Antonio Álvarez-Arellano and Youness El Hamzaoui
Appl. Sci. 2025, 15(7), 3418; https://doi.org/10.3390/app15073418 - 21 Mar 2025
Viewed by 1349
Abstract
This paper presents a comprehensive on-site decision-making framework for assessing the structural integrity of a jacket-type offshore platform in the Gulf of Mexico, installed at a water depth of 50 m. Six critical analyses—(i) static operation and storm, (ii) dynamic storm, (iii) strength-level [...] Read more.
This paper presents a comprehensive on-site decision-making framework for assessing the structural integrity of a jacket-type offshore platform in the Gulf of Mexico, installed at a water depth of 50 m. Six critical analyses—(i) static operation and storm, (ii) dynamic storm, (iii) strength-level seismic, (iv) seismic ductility (pushover), (v) maximum wave resistance (pushover), and (vi) spectral fatigue—are performed using SACS V16 software to capture both linear and nonlinear interactions among the soil, piles, and superstructure. The environmental conditions include multi-directional wind, waves, currents, and seismic loads. In the static linear analyses (i, ii, and iii), the overall results confirm that the unity checks (UCs) for structural members, tubular joints, and piles remain below allowable thresholds (UC < 1.0), thus meeting API RP 2A-WSD, AISC, IMCA, and Pemex P.2.0130.01-2015 standards for different load demands. However, these three analyses also show hydrostatic collapse due to water pressure on submerged elements, which is mitigated by installing stiffening rings in the tubular components. The dynamic analyses (ii and iii) reveal how generalized mass and mass participation factors influence structural behavior by generating various vibration modes with different periods. They also include a load comparison under different damping values, selecting the most unfavorable scenario. The nonlinear analyses (iv and v) provide collapse factors (Cr = 8.53 and RSR = 2.68) that exceed the minimum requirements; these analyses pinpoint the onset of plasticization in specific elements, identify their collapse mechanism, and illustrate corresponding load–displacement curves. Finally, spectral fatigue assessments indicate that most tubular joints meet or exceed their design life, except for one joint (node 370). This joint’s service life extends from 9.3 years to 27.0 years by applying a burr grinding weld-profiling technique, making it compliant with the fatigue criteria. By systematically combining linear, nonlinear, and fatigue-based analyses, the proposed framework enables robust multi-hazard verification of marine platforms. It provides operators and engineers with clear strategies for reinforcing existing structures and guiding future developments to ensure safe long-term performance. Full article
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7 pages, 1013 KiB  
Proceeding Paper
Modeling of Stress Concentration Factors in CFRP-Reinforced Circular Hollow Section KT-Joints Under Axial Compression
by Mohsin Iqbal, Saravanan Karuppanan, Veeradasan Perumal, Mark Ovinis, Muhammad Iqbal and Adnan Rasul
Eng. Proc. 2025, 87(1), 19; https://doi.org/10.3390/engproc2025087019 - 17 Mar 2025
Cited by 1 | Viewed by 413
Abstract
Tubular structures are critical in renewable energy and offshore industries but face significant loads over time, leading to joint degradation. Carbon fiber-reinforced polymers (CFRPs) offer promising rehabilitation solutions, yet existing studies often overlook stress concentration factors (SCFs) along the weld toe. This study [...] Read more.
Tubular structures are critical in renewable energy and offshore industries but face significant loads over time, leading to joint degradation. Carbon fiber-reinforced polymers (CFRPs) offer promising rehabilitation solutions, yet existing studies often overlook stress concentration factors (SCFs) along the weld toe. This study examines SCFs at 24 weld toe positions in CFRP-reinforced KT-joints under axial compression. Using 5429 simulations and artificial neural networks, precise estimations of CFRPs’ impact on SCFs were achieved, with <10% error. These findings demonstrate CFRPs’ potential to reduce SCFs and improve fatigue life prediction for tubular joints under axial compression. Full article
(This article belongs to the Proceedings of The 5th International Electronic Conference on Applied Sciences)
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12 pages, 3907 KiB  
Article
A Bioartificial Device for the Encapsulation of Pancreatic β-Cells Using a Semipermeable Biocompatible Porous Membrane
by Nicola Cuscino, Salvatore Castelbuono, Claudio Centi, Rosaria Tinnirello, Maura Cimino, Giovanni Zito, Andrea Orlando, Massimo Pinzani, Pier Giulio Conaldi, Alessandro Mattina and Vitale Miceli
J. Clin. Med. 2025, 14(5), 1631; https://doi.org/10.3390/jcm14051631 - 27 Feb 2025
Viewed by 1211
Abstract
Background/Objectives: Type 1 diabetes (T1D) is a chronic autoimmune condition characterized by the destruction of pancreatic β-cells, leading to insulin deficiency. Current therapies, such as islet transplantation, face significant challenges, including limited donor availability and the need for lifelong immunosuppression. Encapsulation technologies [...] Read more.
Background/Objectives: Type 1 diabetes (T1D) is a chronic autoimmune condition characterized by the destruction of pancreatic β-cells, leading to insulin deficiency. Current therapies, such as islet transplantation, face significant challenges, including limited donor availability and the need for lifelong immunosuppression. Encapsulation technologies offer a promising alternative, providing immune protection and maintaining β-cell viability. In this study, we propose an encapsulation device featuring a spiral tubular semipermeable polyethersulfone (PES) membrane reinforced with a rigid biocompatible resin scaffold. Methods: The PES membrane was engineered with a tailored porosity of 0.5 µm, enabling efficient nutrient and oxygen exchange while preventing immune cell infiltration. Using INS-1E insulin-secreting cells aggregated into size-controlled islet-like spheroids (ILSs), we evaluated the device’s performance. Results: The device achieved high ILS viability and insulin secretion over 48 h at therapeutic densities, maintaining functionality comparable to free-floating ILSs (control). The PES membrane, with its mechanical stability and biocompatibility, ensured durability without compromising diffusion dynamics, overcoming a critical limitation of other encapsulation approaches. Importantly, the device geometry allowed for the encapsulation of up to 356,000 islet equivalents (IEQs) in a single capillary fiber, reaching therapeutic thresholds for T1D patients. Conclusions: this device, with its innovative design, enables high-density encapsulation while preserving ILS functionality and scalability, making it a potential platform for clinical application. This work highlights the potential of PES-based encapsulation devices to overcome key barriers in T1D treatment, paving the way for personalized, long-term solutions to restore insulin independence. Full article
(This article belongs to the Section Endocrinology & Metabolism)
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20 pages, 3077 KiB  
Article
Colorectal Adenoma Subtypes Exhibit Signature Molecular Profiles: Unique Insights into the Microenvironment of Advanced Precancerous Lesions for Early Detection Applications
by Francesco Mattia Mancuso, Juan Carlos Higareda-Almaraz, Pol Canal-Noguer, Arianna Bertossi, Alexandre Perera-Lluna, Michael Herbert Alexander Roehrl and Kristi Kruusmaa
Cancers 2025, 17(4), 654; https://doi.org/10.3390/cancers17040654 - 14 Feb 2025
Viewed by 1296
Abstract
Background: Colorectal cancer (CRC) is characterized by the uncontrolled growth of malignant colonic or rectal crypt epithelium. About 85% of CRCs evolve through a stepwise progression from advanced precancerous adenoma lesions. A better understanding of the evolution from adenoma to carcinoma can [...] Read more.
Background: Colorectal cancer (CRC) is characterized by the uncontrolled growth of malignant colonic or rectal crypt epithelium. About 85% of CRCs evolve through a stepwise progression from advanced precancerous adenoma lesions. A better understanding of the evolution from adenoma to carcinoma can provide a window of opportunity not only for early detection and therapeutic intervention but potentially also for cancer prevention strategies. Methods: This study investigates the heterogeneous methylation, copy-number alteration (CNA), and mutation signals of histological adenoma subtypes in the context of progression from normal colon to advanced precancerous lesions (APLs) and early-stage CRC. Results: Differential methylation analysis revealed 2321 significantly altered regions among APLs: 137 hypermethylated regions in serrated vs. tubular, 2093 in serrated vs. tubulovillous, and 91 in tubular vs. tubulovillous adenoma subtypes. The most differentiating pathways for serrated adenomas belonged to cAMP signaling and the regulation of pluripotency of stem cells, while regions separating tubular and tubulovillous subtypes were enriched for WNT signaling. CNA events were mostly present in tubular or tubulovillous adenomas, with the most frequent signals being seen in chromosomes 7, 12, 19, and 20. In contrast, early-stage CRC exhibited signals in chromosomes 7, 8, and 20, indicating different processes between APL and early-stage CRC. Mutations reinforce subtype-level differences, showing specific alterations in each subtype. Conclusions: These findings are especially important for developing early detection or cancer prevention tests trying to capture adenoma signatures. Full article
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13 pages, 5830 KiB  
Article
Shear Capacity of Hollow High-Performance Concrete Beams with Cross-Wound Carbon Fiber-Reinforced Polymer Reinforcement
by Tomáš Vlach, Jakub Řepka, Jakub Hájek, Jan Pošta, Richard Fürst and Petr Hájek
Polymers 2025, 17(1), 75; https://doi.org/10.3390/polym17010075 - 30 Dec 2024
Viewed by 1059
Abstract
This paper introduces cross-wound CFRP shear reinforcement of hollow HPC beams. The CFRP reinforcement was manufactured in the form of a square tubular mesh from carbon rovings oriented at ±45° from the longitudinal axis. The shear reinforcement was made in two variants from [...] Read more.
This paper introduces cross-wound CFRP shear reinforcement of hollow HPC beams. The CFRP reinforcement was manufactured in the form of a square tubular mesh from carbon rovings oriented at ±45° from the longitudinal axis. The shear reinforcement was made in two variants from carbon yarns with linear densities of 1600 and 3700 tex. Tensile reinforcement made of BFRP bars was positioned directly around the hollow core and was used as a platform for manual winding of the shear reinforcement. The hollow beams were subjected to a three-point bending test with four configurations of the tensile BFRP reinforcement for better evaluation of the effect of the shear reinforcement under different conditions. The 1600 tex shear reinforcement increased the ultimate flexural strength by at least 89% compared to specimens without any shear reinforcement. The 3700 tex shear reinforcement yielded slightly better results in most cases but was not utilized to its full shear capacity as these specimens always failed in shear due to the delamination of the concrete matrix from the shear reinforcement. There was too much reinforcement in the beam cross-section. Full article
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15 pages, 5826 KiB  
Article
Effect of Heat-Shrinkable Tape Application on the Mechanical Performance of CFRP Components Obtained by a Filament Winding Process
by Iacopo Bianchi, Archimede Forcellese, Tommaso Mancia, Chiara Mignanelli, Michela Simoncini and Tommaso Verdini
J. Compos. Sci. 2024, 8(12), 535; https://doi.org/10.3390/jcs8120535 - 16 Dec 2024
Cited by 1 | Viewed by 1177
Abstract
Carbon Fiber Reinforced Polymers (CFRPs) are widely used in aerospace, automotive, and other sectors for their high strength-to-weight ratio and adaptability. In order to reach high mechanical performance and quality for CFRP components in which a thermosetting resin is used, the curing process [...] Read more.
Carbon Fiber Reinforced Polymers (CFRPs) are widely used in aerospace, automotive, and other sectors for their high strength-to-weight ratio and adaptability. In order to reach high mechanical performance and quality for CFRP components in which a thermosetting resin is used, the curing process plays a key role, and the optimal conditions have to be identified. In this context, the present study aims to study the effect of heat-shrinkable tape application on the mechanical performance of CFRP tubular components obtained by a filament winding process. To this purpose, CFRP hoop-wound components were realized with a laboratorial filament winding machine. Half of them were directly cured in a muffle oven, while the other half were cured after the application of heat-shrinkable tape around the external surface of the component. To evaluate the effect of the heat-shrinkable tape use on the mechanical properties of the CFRP wound parts, ring specimens, obtained by the tubular components according to the ASTM D2290 standard, were subjected to ring tensile tests. The thickness uniformity and void content of the components were evaluated by means of X-ray computed tomography, whilst the fracture surfaces were observed using scanning electron microscopy. It was demonstrated that the heat-shrinkable tape application around the external surface of the CFRP tubular components allows for improved mechanical performance of the wound parts due to the enhanced material compaction, resulting in stronger and more cohesive structures characterized by a uniform thickness and reduced void content. Full article
(This article belongs to the Special Issue Carbon Fiber Composites, Volume III)
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