Search Results (814)

The transition toward a sustainable agri-food system, aligned with agricultural and environmental policy objectives, has increased interest in aromatic plants as non-synthetic pesticide alternatives. This study focused on evaluating the antifungal potential of five specific aromatic plant species, particularly Lavandula dentata, Origanum vulgare, Thymus vulgaris, Salvia officinalis and Rosmarinus officinalis, against the phytopathogenic soil-borne fungi Fusarium oxysporum f.sp. radicis-lycopersici and Verticillium dahliae. During screening, L. dentata and T. vulgaris extracts exhibited strong in vitro fungicidal activity. Bioactive compounds previously detected in both lavender and thyme were identified in their extracts using a triple quadrupole/linear ion trap mass spectrometer. Assessment of in vitro phytoprotective action of L. dentata extract in solid and liquid growth media demonstrated inhibitory effects against F. oxysporum f.sp. radicis-lycopersici at concentrations above 1% v/v, with inhibitory effects of L. dentata extract being observed at concentrations equal to or above 2% v/v. T. vulgaris extract inhibited V. dahliae growth on solid media at concentrations at 1% v/v or above, while inhibitory effects were observed in broth media containing 2% v/v thyme extract. Seed germination tests of both L. dentata and T. vulgaris revealed a concentration-dependent reduction in their germination index (GI) at concentrations equal or above 2% v/v, apart from the effect of lavender extract on cress, where inhibition occurred at dose application above 5% v/v. In planta experiments demonstrated the complete phytoprotective action of lavender extract against F. oxysporum f.sp. radicis-lycopersici, while a marginal improvement in plant survival was observed during application of T. vulgaris extract. Full article

Porous, crystalline gamma-Al₂O₃ coatings with a thickness of (6 ± 0.5) μm and a uniform distribution of rare earth (RE) dopants are synthesized by plasma electrolytic oxidation of aluminum at a current density of 150 mA/cm² in a boric acid and borax (BB) solution containing added RE oxide particles (Ho₂O₃, Tb₄O₇, and Pr₆O₁₁) at concentrations of 1, 2, and 4 g/L. The concentration of RE oxide particles in the BB solution determines the amount of RE elements incorporated into the coatings but does not significantly affect their surface morphology, crystal structure, or light absorption properties. The coatings exhibit high absorption in the middle/near-ultraviolet region, characteristic of Al₂O₃. Typical 4f-4f transitions of Ho³⁺, Tb³⁺, and Pr³⁺ are observed in the photoluminescence spectra. Photocatalytic evaluations using methyl orange degradation under simulated solar irradiation show that RE doping significantly enhances photocatalytic efficiency. Peak degradation efficiencies are achieved at a concentration of 4 g/L for all RE oxides. After 8 h of irradiation, maximum degradation reaches 88%, 92%, and 85% with pseudo-first-order rate constants (k_app) of about 0.274 h⁻¹, 0.339 h⁻¹, and 0.232 h⁻¹ for coatings synthesized in BB with 4 g/L Ho₂O₃, Tb₄O₇, or Pr₆O₁₁, respectively. In comparison, the pristine Al₂O₃ coating achieves only about 50% degradation (k_app ≈ 0.087 h⁻¹). Photoluminescence indicates that RE³⁺ ions serve as effective charge-carrier traps, suppressing electron–hole pair recombination. RE-doped Al₂O₃ coatings demonstrate exceptional structural stability and reusability over six cycles, highlighting their potential for sustainable wastewater remediation. Full article

In Na- through Ca-like ions of Fe, rather low-lying 3d levels feature level lifetimes in the range from picoseconds to many seconds. This lifetime range is somewhat wider than that of the 3p resonance levels of the same ions. When trying to measure such level lifetimes, the width of the range exceeds the capabilities of a single measurement scheme. However, there also is the fundamental problem of multi-exponential decay curves and the reliability of their analysis. This problem has arisen afresh for the analysis of long-lived 3p levels in the ground configurations of many isoelectronic sequences that are replenished by cascades from long-lived 3d levels that have no $E1$ decay channels, but consequently feature lifetimes of the same order of magnitude as those in the ground configuration. This tutorial addresses the measurement situation for lifetimes of 3d levels in a number of ions of Fe and nearby elements. Full article

Alcohol-induced liver damage (AILD), characterized by oxidative stress and inflammation, is a major health concern. While black ginseng extract (BGE) exhibits diverse pharmacological activities, its protective effects against AILD and underlying molecular mechanisms remain unclear. This study evaluated the protective effects of BGE against AILD using in vivo, in vitro, and in silico models. In mice, daily oral administration of 25% ethanol (5 g/kg) for 2 weeks induced liver injury. BGE (100–500 mg/kg) significantly reduced serum alanine aminotransferase (AST) and aspartate aminotransferase (ALT)levels while increasing catalase (CAT) and superoxide dismutase (SOD) activities. In ethanol-treated HepG2 cells, BGE inhibited nitric oxide (NO) production and suppressed cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) expression while increasing heme oxygenase-1 (HO-1)expression. Ginsenoside Rh1, quantified at 4.7 mg/g via quadrupole linear ion trap tandem mass spectrometry coupled with UPLC (UPLC-Q-TRAP-MS/MS), was identified as a key bioactive compound. Network pharmacology and molecular docking analyses revealed key inflammatory signaling pathways and core hub genes associated with ginsenoside Rh1. Integrated analyses suggest that ginsenoside Rh1 contributes to the multi-target effects of BGE by modulating inflammatory signaling pathways. Collectively, BGE is a potential therapeutic candidate for the prevention and treatment of AILD, with ginsenoside Rh1 serving as a key bioactive constituent and quality control marker. Full article

In the present work, the blackening process of Panax quinquefolius L. (PQ) was systematically investigated at temperatures of 70–90 °C, relative humidities (RHs) of 70–85%, and treatment times of 0–14 days. Ginsenoside compositions and transformation pathways were analyzed by high-performance liquid chromatography (HPLC) and liquid chromatography coupled with ion trap time-of-flight tandem mass spectrometry (LC-IT-TOF-MS/MS). The results demonstrated that blackening treatment significantly increased total saponin content from 2.72% to 5.73% after being treated at 80 °C and 70% RH for 12 days, accompanied by the highest conversion efficiencies for newly generated ginsenosides Rk1 (8.89 mg/g) and Rg5 (17.69 mg/g). Furthermore, compared with untreated PQ saponins (PQS), the blackened PQ saponins treated under optimal conditions (BPQS) exhibited superior 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) cation (ABTS⁺) radical scavenging activities, with IC₅₀ values of 0.2999 mg/mL and 0.2640 mg/mL, respectively, as well as stronger reducing power. Meanwhile, BPQS exhibited higher cytotoxicity toward HepG2 cells and effectively inhibited cell survival and proliferation by promoting the expression of apoptosis-related proteins, including caspase 3 and caspase 9. Our findings indicate that BPQS may be a functional ingredient suitable for use in dietary supplements and disease chemoprevention. Full article

Photo-Fenton technology is considered an effective method for removing organic pollutants from water. In this work, a novel Mn-doped FeWO₄ (Mn-FeWO₄) photocatalyst was synthesized via a one-step hydrothermal method and applied for the photo-Fenton degradation of tetracycline (TC). The optimal Mn-FeWO₄-0.05 achieved 100% removal of TC within 60 min under visible light irradiation with a degradation rate constant of 0.0793 min⁻¹, which is 4.5 times higher than that of pristine FeWO₄. Systematic characterization revealed that Mn²⁺ ions were successfully incorporated into the FeWO₄ lattice, inducing lattice expansion and narrowing the bandgap from 2.37 eV to 2.25 eV, while also adjusting the conduction and valence band positions. This modulation significantly enhanced visible light absorption and promoted the separation and migration of photogenerated electron–hole pairs. In addition, the Mn²⁺/Mn³⁺ and Fe²⁺/Fe³⁺ dual redox cycles ensure the continuous generation of reactive oxygen species. Radical trapping experiments and electron paramagnetic resonance (EPR) spectroscopy demonstrated that superoxide radicals (•O₂⁻) and photogenerated holes (h⁺) were the dominant reactive species, while singlet oxygen (¹O₂) and hydroxyl radicals (•OH) played auxiliary roles. Moreover, Mn-FeWO₄-0.05 exhibited excellent stability, strong anti-interference ability against common anions, and high degradation efficiency toward various pollutants. Full article

The progressive miniaturization of devices devoted to energy manipulation and storage calls for extending thermodynamic concepts towards regimes where quantum effects become unavoidable. In this context, quantum thermodynamics provides the proper framework for understanding and exploiting non-classical effects for energy applications. Within this framework, we present a comprehensive review of the role played by spin systems as versatile platforms for quantum energy technologies, focusing on their dual role as Quantum Thermal Machines and Quantum Batteries. We discuss how the combination of discrete spectra, engineered interactions and long coherence times enables the realization of high-performance quantum devices. We then highlight how genuinely quantum features can be exploited to achieve performance beyond classical limits. Beyond theoretical developments, we review the rapid experimental progress across leading spin platforms, including nuclear magnetic resonance systems, trapped ions, nitrogen-vacancy centers in diamond and superconducting circuits, which are bringing quantum energy devices from conceptual proposals to actual realizations. By presenting a unified spin-based framework that integrates energy conversion and storage, this review outlines the foundations of the emerging field of quantum energy and identifies key challenges and future directions for scalable quantum energy technologies. Full article

Secondary electrospray ionization mass spectrometry (SESI-MS) has emerged as a powerful technique for the real-time, non-invasive analysis of volatile organic compounds (VOCs) in complex matrices, such as exhaled breath and microbial volatilomes. However, its transition to routine application is hindered by significant challenges in absolute quantification, unambiguous identification, and standardization. This review provides a comprehensive overview of these limitations and the emerging solutions proposed to overcome them. Matrix effects, including gas-phase ion suppression and C-trap competition, are examined alongside mitigation strategies such as spectral stitching and standard addition. To enhance quantification stability, advanced standard delivery systems and dynamic quality control protocols are evaluated. The identification bottleneck—stemming from the absence of chromatographic separation—is addressed through the use of curated databases and advanced fragmentation techniques, such as incremental quadrupole acquisition to resolve overlapping spectra (IQAROS), to resolve isobaric interferences. Furthermore, the role of chemometrics in extracting biological fingerprints is discussed. Finally, the need for harmonized reporting standards and multicenter validation is emphasized to ensure cross-study reproducibility. Resolving these methodological gaps is essential for the clinical and industrial translation of SESI-MS. Full article

Highly polar M-mol-X (M = alkali metal, mol = molecule, X = halogen) insertion complexes have been predicted to offer potential practical applications, including molecular interactions with light, ion-pair induced isomerization, etc. In the present work, the insertion complexes of the seven-membered, fused bicyclic norcaradiene and its monocyclic isomer trapped in Li-I, Na-I, and K-I counterion pairs were investigated using ab initio methods. The structures, stability, polarities, and simulated infrared spectra are analyzed and the effects of the insertion on the norcaradiene to cycloheptatriene isomerization process are examined. Furthermore, an uncommon bond between iodine and a fully substituted carbon atom is reported upon and hypothesized to be catalyzed by the presence of the cation in the insertion complexes. Full article

The push for higher energy density in electric vehicles has resulted in large-sized lithium-ion batteries, but their geometric upscaling exacts a heavy thermal price. Under high-rate discharge, these massive cells become heat traps, risking thermal runaway. To tame this instability, this paper engineered a hybrid management strategy fusing liquid cooling, Phase Change Materials (PCMs), and flow deflectors. With a primary focus on the structural optimization of the cooling channel, a three-dimensional numerical model, calibrated using experimentally determined thermophysical properties, was developed to overcome the thermal bottlenecks of conventional cooling architectures. Results indicated that the initial channel optimization effectively reduced the maximum temperature to 327.7 K, but it still remained near the safety threshold. Integrating PCM radically altered the thermal landscape, slashing the outlet temperature differential by 41.67% (from 2.76 K to 1.61 K) compared to pure liquid cooling and blunting peak thermal spikes. Furthermore, to overcome laminar stagnation, strategic deflector baffles were introduced to agitate the coolant, enhancing heat dissipation. Specifically, the optimal half-coverage (L = 1/2) baffle configuration successfully lowered the maximum temperature to 322.42 K while substantially reducing the system pressure drop from 948.16 Pa to 627.57 Pa, achieving a 33.33% reduction compared to the full-coverage scheme. Finally, a multi-variable sensitivity analysis confirmed the extraordinary engineering robustness of the optimized configuration, demonstrating a negligible maximum temperature fluctuation of less than 0.5% despite ±10% operational and material uncertainties. This synergistic system actively stabilizes the thermal envelope, offering a robust engineering blueprint for next-generation high-power battery packs. Full article

The development of efficient, stable, and sustainably fabricated photocatalysts for solar-driven hydrogen evolution remains a critical challenge in the field. Herein, we report a novel green coprecipitation strategy to synthesize calcium-doped zinc oxide (Ca-ZnO) nanosheets, utilizing cactus juice as a natural, multifunctional medium for the coprecipitation process. This method enables the in situ, tunable incorporation of 3–7% Ca²⁺ ions into the wurtzite ZnO lattice without the use of harsh chemical reagents. Comprehensive characterization confirms that Ca²⁺ substitutionally replaces Zn²⁺, which preserves the intrinsic crystal structure of ZnO well while inducing the formation of uniform nanosheet morphology. This doping strategy effectively modulates the electronic band structure, progressively narrowing the bandgap from 3.19 eV to 2.90 eV and significantly enhancing visible-light absorption. Crucially, the incorporation of Ca²⁺ also generates oxygen vacancies, which serve as efficient electron traps to suppress photogenerated charge carrier recombination. The optimized 5%Ca-ZnO photocatalyst demonstrates a favorable hydrogen evolution rate of 889 μmol·g⁻¹·h⁻¹ under full-spectrum irradiation, with stability, retaining 94.8% of its activity after four cycles. This work not only provides a high-performance material but also establishes a generalizable, sustainable paradigm for the design of advanced semiconductor photocatalysts. Full article

Background: Polygonatum sibiricum (PS), a perennial herbaceous plant belonging to the Liliaceae family, is widely distributed in China and other East Asian countries. PS has been used as food and medicine for thousands of years, and its rhizomes are rich in Polygonatum sibiricum polysaccharides (PSP), which exhibit various bioactivities, yet their structural features and therapeutic mechanisms against ulcerative colitis (UC) remain unclear. Methods: A homogeneous polysaccharide, PSP-1b (57.45 kDa), was isolated from the rhizomes of PS via ion-exchange and gel filtration chromatography and structurally characterized using chromatographic and spectroscopic methods. In vivo, its effects were evaluated in a dextran sulfate sodium (DSS)-induced mouse model of UC, while in vitro mechanisms were explored using macrophages stimulated with lipopolysaccharide (LPS) and neutrophil extracellular traps (NETs). Results: PSP-1b was identified as a neutral polysaccharide with minimal branching. Its primary structural backbone was largely composed of →4)-β-D-Galp-(1→ residues. A portion of these backbone residues was substituted at the O-6 position by side chains primarily composed of β-D-Galp-(1→ units. In vivo, PSP-1b significantly alleviated DSS-induced colitis by reducing inflammatory cytokine secretion, suppressing colonic macrophage infiltration, and reversing neutrophil extracellular traps (NETs) deposition. In vitro, PSP-1b directly interacted with TLR4, inhibited the MAPK/NF-κB signaling pathway, and attenuated LPS- and NET-induced macrophage polarization and inflammation. Conclusions: PSP-1b as a promising candidate for functional foods or therapeutic agents targeting inflammatory bowel disease. Full article

Synchronously enhancing the light response range and electron–hole separation efficiency is essential to improve photocatalytic activity. Herein, we synthesized a Cu-doped ZnIn₂S₄ (ZIS) catalyst with S-vacancy (Cu_n-VZIS) via hydrothermal synthesis, incorporating sulfur vacancies and directionally substituting copper ions for zinc ions. The experimental results elucidate the synergistically photocatalytic mechanism associated with the two types of defects. Both the sulfur vacancies within the structure and the copper doping sites lead to a reduction in the size of the ZnIn₂S₄ unit cell. The sulfur vacancy traps electrons, thereby mitigating the recombination of photogenerated carriers. Meanwhile, the copper ions optimize the carrier migration pathways, enhancing the overall carrier separation efficiency. Consequently, Cu_1.5-VZIS demonstrates a stable and markedly enhanced photocatalytic hydrogen production activity, achieving a performance that is 7.5 times greater than that of pristine ZIS. Our study elucidates the effect of vacancy defects and ion doping on the photogenerated charge dynamics in ZIS, and paves a novel pathway for optimizing carrier dynamics through the concurrent utilization of both types of defects. Full article

Atmospheric aerosols modulate Earth’s radiation balance through direct effects and through their role as cloud condensation nuclei (CCN), contributing to variability in near-surface temperature (NST). Galactic cosmic rays (GCRs) further influence aerosol–cloud interactions by enhancing particle formation and growth, but combined aerosol optical depth (AOD)–GCR effects on NST remain poorly constrained across climates. Using satellite and reanalysis data, we examine joint influences on NST anomalies at three neutron-monitoring stations, Oulu, Newark, and Hermanus, during 2000–2022. The sites share similar geomagnetic cutoffs but contrasting climates, enabling separation of ionization from geomagnetic shielding. Multiple linear regression (MLR) captures AOD effects and their modulation by GCR flux. Adding an interaction term (AOD × GCR) improves fit, raising adjusted R² from 0.22→0.31 (Oulu), 0.37→0.52 (Newark), and 0.69→0.78 (Hermanus). ECMWF reanalysis shows hydrophilic organic matter aerosol (OMA) dominates (0.19, 0.29, 0.41 µg kg⁻¹ at Oulu, Newark and Hermanus), with sulphate elevated at Oulu/Newark and coarse sea salt at Hermanus. Elevated OMA and sulphate at Oulu/Newark imply GCR-enhanced fine CCN and cooling, whereas humid, sea-salt-rich Hermanus favors ion-mediated growth of larger hygroscopic particles that increase longwave trapping and warming. Findings provide site-specific evidence that GCR ionization modulates aerosol processes and contributes to regional NST variability, informing improved parameterizations in climate models. Full article

A novel catalyst, Tm₂FeSbO₇, was synthesized by employing the solid-phase high-temperature sintering method, and, for the first time, it was utilized to create a Z-type heterojunction with BiYO₃. A direct Z-scheme Tm₂FeSbO₇/BiYO₃ heterojunction photocatalyst (TBHP) was successfully produced by employing the ball-milling technique. X-ray diffraction analysis results indicated that Tm₂FeSbO₇ crystallized in a cubic pyrochlorestructure which owned the Fd-3m space group, with a unit cell parameter of 10.1769 Å, whereas BiYO₃ displayed a fluorite structure in the Fm-3m space group, with a unit cell parameter of 5.4222 Å. The Mossbauer spectrum of Tm₂FeSbO₇ showed that Fe³⁺ ions might locate at octahedral sites. The measured bandgap widths for the TBHP, Tm₂FeSbO_7, and BiYO₃ were 2.14 eV, 2.21 eV, and 2.30 eV, respectively. Multiple experimental results demonstrated that the TBHP exhibited a higher valence band ionization potential, a narrower band gap width, and a higher removal efficiency of the sulfamethoxazole (SMX) compared with the Dy₂TmSbO₇/BiHoO₃ heterojunction photocatalyst. Under visible-light irradiation (VISLI) of 115 min, the TBHP showcased exceptional photocatalytic elimination performance; therefore, the elimination rate of the SMX and the total organic carbon (TOC) mineralization rate reached 99.51% and 98.10%, respectively. In contrast to single-component Tm₂FeSbO₇, BiYO_3, or conventional nitrogen-doped titanium dioxide (N-TiO₂) catalyst, the TBHP exhibited removal efficiency enhancement for degrading the SMX by 1.17 times, 1.31 times, or 4.06 times. Simultaneously, the matching mineralization rate for removing the TOC density by employing the TBHP was 1.20 times, 1.34 times, or 4.73 times higher than that by employing Tm₂FeSbO₇, BiYO₃, or conventional N-TiO₂. Above experimental results indicated that the mineralization efficiency for removing TOC density by employing the TBHP was higher than that by employing Tm₂FeSbO₇, BiYO₃, or N-TiO₂. Radicals trapping experiments and the electron paramagnetic resonance spectroscopy results revealed that hydroxyl radicals, superoxide anions, and photoinduced holes were the primary active species during the catalytic elimination course of the SMX by employing the TBHP under VISLI. The results demonstrated that the direct Z-scheme TBHP, which was developed in this study, exhibited the maximal removal efficiency for degrading the SMX in contrast to Tm₂FeSbO₇, BiYO₃, or N-TiO₂. Additionally, the possible elimination routes and elimination mechanisms of the SMX were proposed. Therefore, an important scientific foundation for developing high-performance heterojunction catalysts was established. Full article