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Search Results (299)

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Keywords = topological defects

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14 pages, 3808 KiB  
Article
Defect-Engineered Elastic CNC/Chitosan-Based Carbon Aerogel with Wideband Microwave Absorption
by Weikai Zhan, Yijie Hu, Liangjun Li, Yonggang Jiang, Junzong Feng and Jian Feng
Nanomaterials 2025, 15(16), 1233; https://doi.org/10.3390/nano15161233 - 13 Aug 2025
Viewed by 264
Abstract
The burgeoning electromagnetic pollution from 5G/6G technologies demands lightweight, broadband, and mechanically robust electromagnetic microwave absorbers (EMWAs). Conventional carbon aerogels suffer from structural fragility and inadequate electromagnetic dissipation. Herein, we propose a defect-engineering strategy through precise optimization of the chitosan (CS)/cellulose nanocrystal (CNC) [...] Read more.
The burgeoning electromagnetic pollution from 5G/6G technologies demands lightweight, broadband, and mechanically robust electromagnetic microwave absorbers (EMWAs). Conventional carbon aerogels suffer from structural fragility and inadequate electromagnetic dissipation. Herein, we propose a defect-engineering strategy through precise optimization of the chitosan (CS)/cellulose nanocrystal (CNC) ratio to fabricate elastic boron nitride nanosheet (BNNS)-embedded carbon aerogels. By fixing BNNS content for optimal impedance matching and modulating the CS/CNC ratio of the aerogel, we achieve synergistic control over hierarchical microstructure, defect topology, and electromagnetic response. The aerogel exhibits a wide effective absorption bandwidth (EAB) of 8.3 GHz at a thickness of 3.6 mm and an excellent reflection loss of −52.79 dB (>99.999% attenuation), surpassing most biomass-derived EMWAs. The performance stems from CNC-derived topological defects enabling novel polarization pathways and BNNS-triggered interfacial polarization, while optimal graphitization (ID/IG = 1.08) balances conductive loss. Simultaneously, the optimal CS/CNC ratio facilitates the formation of a stable and flexible framework. The long-range ordered micro-arch lamellar structure endows the aerogel with promising elasticity, which retains 82% height after 1000 cyclic compression at 50% strain. This work paves the way for biomass-derived carbon aerogels as next-generation wearable and conformal EMWAs with broadband absorption. Full article
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13 pages, 3292 KiB  
Article
Topological Large-Area Waveguide States Based on THz Photonic Crystals
by Yulin Zhao, Feng Liang, Jingsen Li, Jianfei Han, Jiangyu Chen, Haihua Hu, Ke Zhang and Yuanjie Yang
Photonics 2025, 12(8), 791; https://doi.org/10.3390/photonics12080791 - 5 Aug 2025
Viewed by 277
Abstract
Terahertz (THz) has attracted substantial attention owing to its unique advantages in high-speed communications. However, conventional THz waveguide systems are inherently constrained by high transmission losses, stringent fabrication precision requirements, and extreme sensitivity to structural defects. Topological edge states with topological protection have [...] Read more.
Terahertz (THz) has attracted substantial attention owing to its unique advantages in high-speed communications. However, conventional THz waveguide systems are inherently constrained by high transmission losses, stringent fabrication precision requirements, and extreme sensitivity to structural defects. Topological edge states with topological protection have driven significant advancements in THz wave manipulation. Nevertheless, the width of the topological waveguide based on edge states remains restricted. In this work, we put forward a type of spin photonic crystal with three-layer heterostructures, where large-area topological waveguide states are demonstrated. The results show that these topological waveguide states are localized within the region of Dirac photonic crystals. They also display spin-momentum-locking characteristics and maintain strong robustness against defects and sharp bends. Furthermore, a THz beam splitter and a topological beam modulator are implemented. The designed heterostructures expand the applications of multi-functional topological devices and provide a prospective pathway for overcoming the waveguide bottleneck in THz applications. Full article
(This article belongs to the Section Optoelectronics and Optical Materials)
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17 pages, 2008 KiB  
Article
The Comprehensive Benefit Evaluation of Urban Drainage Culverts and Pipes Based on Combination Weighting
by Weimin Geng and Zhixuan Cheng
Water 2025, 17(15), 2233; https://doi.org/10.3390/w17152233 - 26 Jul 2025
Viewed by 340
Abstract
The urban drainage system is a significant lifeline for ensuring the safe operation of a city. In recent years, defects and diseases in drainage pipes and their ancillary facilities have occurred frequently. Aiming to provide decision-makers with comprehensive benefit evaluation support, we chose [...] Read more.
The urban drainage system is a significant lifeline for ensuring the safe operation of a city. In recent years, defects and diseases in drainage pipes and their ancillary facilities have occurred frequently. Aiming to provide decision-makers with comprehensive benefit evaluation support, we chose to evaluate the security, environmental, social, and economic benefits of urban drainage culverts and pipes (UDCPs). An index system of 14 first-level indicators in four dimensions was established, and the indicators contain 28 influencing factors. The index weight was obtained by combining the analytical hierarchy process and entropy weight method, and the weights assigned to the security, environmental, social, and economic benefits were 0.448, 0.222, 0.202, and 0.128, respectively. The evaluation system was developed on the basis of a geographic information system (GIS), and the topological analysis of the GIS was applied in the calculation. To process the questionnaire results, this study adopted the automatic questionnaire analysis and scoring method combining natural language processing and optical character recognition technology. The method was applied in the study area in southern China, which contains 9 catchment areas and 1356 pipes. The results show that about 5% of the pipelines need to be included in the renewal plan. For UDCP renewal, the findings provide a decision-making tool of the comprehensive analysis for the selection of engineering technologies and the evaluation of the implementation effects. Full article
(This article belongs to the Special Issue Urban Drainage Systems and Stormwater Management)
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18 pages, 1657 KiB  
Review
Alkaline Amino Acids for Salt Reduction in Surimi: A Review
by Tong Shi, Guxia Wang, Yu Xie, Wengang Jin, Xin Wang, Mengzhe Li, Yuanxiu Liu and Li Yuan
Foods 2025, 14(14), 2545; https://doi.org/10.3390/foods14142545 - 21 Jul 2025
Viewed by 428
Abstract
Surimi products are popular due to their high protein and low fat content. However, traditional processing methods rely on high concentrations of salt (2–3%) to maintain texture and stability, contributing to excessive sodium intake. As global health trends advance, developing green and low-salt [...] Read more.
Surimi products are popular due to their high protein and low fat content. However, traditional processing methods rely on high concentrations of salt (2–3%) to maintain texture and stability, contributing to excessive sodium intake. As global health trends advance, developing green and low-salt technologies while maintaining product quality has become a research focus. Alkaline amino acids regulate protein conformation and intermolecular interactions through charge shielding, hydrogen bond topology, metal chelation, and hydration to compensate for the defects of solubility, gelation, and emulsification stability in the low-salt system. This article systematically reviews the mechanisms and applications of alkaline amino acids in reducing salt and maintaining quality in surimi. Research indicates that alkaline amino acids regulate the conformational changes of myofibrillar proteins through electrostatic shielding, hydrogen bond topology construction, and metal chelation, significantly improving gel strength, water retention, and emulsion stability in low-salt systems, with the results comparable to those in high-salt systems. Future research should optimize addition strategies using computational simulations technologies and establish a quality and safety evaluation system to promote industrial application. This review provides a theoretical basis for the green processing and functional enhancement of surimi products, which could have significant academic and industrial value. Full article
(This article belongs to the Special Issue Innovative Technology of Aquatic Product Processing)
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20 pages, 2267 KiB  
Review
Multiscale Simulation of Nanowear-Resistant Coatings
by Xiaoming Liu, Kun Gao, Peng Chen, Lijun Yin and Jing Yang
Materials 2025, 18(14), 3334; https://doi.org/10.3390/ma18143334 - 16 Jul 2025
Viewed by 442
Abstract
Nanowear-resistant coatings are critical for extending the service life of mechanical components, yet their performance optimization remains challenging due to the complex interplay between atomic-scale defects and macroscopic wear behavior. While experimental characterization struggles to resolve transient interfacial phenomena, multiscale simulations, integrating ab [...] Read more.
Nanowear-resistant coatings are critical for extending the service life of mechanical components, yet their performance optimization remains challenging due to the complex interplay between atomic-scale defects and macroscopic wear behavior. While experimental characterization struggles to resolve transient interfacial phenomena, multiscale simulations, integrating ab initio calculations, molecular dynamics, and continuum mechanics, have emerged as a powerful tool to decode structure–property relationships. This review systematically compares mainstream computational methods and analyzes their coupling strategies. Through case studies on metal alloy nanocoatings, we demonstrate how machine learning-accelerated simulations enable the targeted design of layered architectures with 30% improved wear resistance. Finally, we propose a protocol combining high-throughput simulation and topology optimization to guide future coating development. Full article
(This article belongs to the Section Thin Films and Interfaces)
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26 pages, 48882 KiB  
Article
TiO2 Nanoparticles Obtained by Laser Sintering When Added to Methacrylate Photopolymer Resin Improve Its Physicochemical Characteristics and Impart Antibacterial Properties
by Aleksandr V. Simakin, Dmitriy E. Burmistrov, Ilya V. Baimler, Ann V. Gritsaeva, Dmitriy A. Serov, Maxim E. Astashev, Pavel Chapala, Shamil Z. Validov, Fatikh M. Yanbaev and Sergey V. Gudkov
Inorganics 2025, 13(7), 233; https://doi.org/10.3390/inorganics13070233 - 10 Jul 2025
Viewed by 575
Abstract
In this paper, titanium oxide nanoparticles (TiO2-NPs) with complex surface topologies were obtained for the first time using simple procedures applied in laser sintering. Based on the obtained nanoparticles and polymethyl methacrylate-like photopolymer resin, a composite material (MPR/TiO2-NPs) for [...] Read more.
In this paper, titanium oxide nanoparticles (TiO2-NPs) with complex surface topologies were obtained for the first time using simple procedures applied in laser sintering. Based on the obtained nanoparticles and polymethyl methacrylate-like photopolymer resin, a composite material (MPR/TiO2-NPs) for 3D printing was created using the MSLA technology. Products made of the material containing from 0.001 to 0.1% wt. TiO2-NPs didn’t contain internal defects and were less brittle than the resin without nanoparticles. Products made of the MPR/TiO2-NPs material were well polished; after polishing, areas with a variation in the surface profile height of less than 10 nm were found on the surfaces. Nanoparticles in the volume of products made of the material are apparently unevenly distributed; there are alternating areas of micrometer sizes with slightly higher and slightly lower concentrations of nanoparticles. Spectroscopy showed that adding the developed nanoparticles promoted better polymerization of the MPR resin. The addition of nanoparticles to the material slightly increased its ability to generate active forms of oxygen and damage biomacromolecules. At the same time, the resulting material exhibits significant antibacterial properties and doen’t affect the growth and reproduction of animal cells. The created material can be a very effective basis for the additive manufacturing of products with improved physical and chemical properties and balanced biological activity. Full article
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38 pages, 3052 KiB  
Review
Recent Advancements in Understanding Hot Carrier Dynamics in Perovskite Solar Cells
by Muhammad Mujahid, Jonas Gradauskas, Algirdas Sužiedėlis, Edmundas Širmulis and Steponas Ašmontas
Energies 2025, 18(13), 3543; https://doi.org/10.3390/en18133543 - 4 Jul 2025
Viewed by 646
Abstract
A potential field of study for improving the efficiency of next-generation photovoltaic devices hot carriers in perovskite solar cells is investigated in this review paper. Considering their relevance to hot carrier dynamics, the paper thoroughly studies metal halide perovskites’ essential characteristics and topologies. [...] Read more.
A potential field of study for improving the efficiency of next-generation photovoltaic devices hot carriers in perovskite solar cells is investigated in this review paper. Considering their relevance to hot carrier dynamics, the paper thoroughly studies metal halide perovskites’ essential characteristics and topologies. We review important aspects like carrier excitation, exciton binding energy, phonon coupling, carrier excitation, thermalization, and hot hole and hot electron dynamics. We investigate, in particular, the significance of relaxation mechanisms, including thermalization and the Auger heating effect. Moreover, the bottleneck effect and defect management are discussed with an eye on their impact on device performance and carrier behaviour. A review of experimental methods for their use in investigating hot carrier dynamics, primarily transient photovoltage measurements, is included. Utilizing this thorough investigation, we hope to provide an insightful analysis of the difficulties and techniques for reducing the effect of hot carriers in perovskite solar cells and optimizing their performance. Full article
(This article belongs to the Special Issue Perovskite Solar Cells and Tandem Photovoltaics)
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19 pages, 6386 KiB  
Article
Process–Structure Co-Optimization of Glass Fiber-Reinforced Polymer Automotive Front-End Module
by Ziming Chen, Pengcheng Guo, Longjian Tan, Tuo Ye and Luoxing Li
Materials 2025, 18(13), 3121; https://doi.org/10.3390/ma18133121 - 1 Jul 2025
Viewed by 402
Abstract
For automotive GFRP structural components, beyond structural design, the warpage, residual stress/strain, and fiber orientation inevitably induced during the injection molding process significantly compromise their service performance. These factors also diminish the reliability of performance assessments. Thus, it is imperative to develop a [...] Read more.
For automotive GFRP structural components, beyond structural design, the warpage, residual stress/strain, and fiber orientation inevitably induced during the injection molding process significantly compromise their service performance. These factors also diminish the reliability of performance assessments. Thus, it is imperative to develop a process–structure co-optimization approach for GFRP components. In this paper, the performance of a front-end module is evaluated through topological structure design, injection molding process optimization, and simulation with mapped injection molding history, followed by experimental validation and analysis. Under ±1000 N loading, the initial design shows excessive displacement at the latch mounting points (2.254 mm vs. <2.0 mm limit), which is reduced to 1.609 mm after topology optimization. By employing a sequential valve control system, the controls of the melt line and fiber orientation are is superior to thatose of conventional gating systems. The optimal process parameter combination is determined through orthogonal experiments, reducing the warpage to 1.498 mm with a 41.5% reduction compared to the average warpage of the orthogonal tests. The simulation results incorporating injection molding data mapping (fiber orientation, residual stress–strain) show closer agreement with experimental measurements. When the measured displacement exceeded 0.65 mm, the average relative error Er, range R, and variance s2 between the experimental results and mapped simulations were 11.78%, 14%, and 0.002462, respectively, validating the engineering applicability of this method. The methodology and workflow can provide methodological support for the design and performance assessment of GFRP automotive body structures, which enhances structural rigidity, improves control over injection molding process defects, and elevates the reliability of performance evaluation. Full article
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42 pages, 23380 KiB  
Review
A Review of Recent Research on Flow and Heat Transfer Analysis in Additively Manufactured Transpiration Cooling for Gas Turbines
by Kirttayoth Yeranee and Yu Rao
Energies 2025, 18(13), 3282; https://doi.org/10.3390/en18133282 - 23 Jun 2025
Viewed by 1235
Abstract
Advanced gas turbine cooling technologies are required to bridge the gap between turbine inlet temperatures and component thermal limits. Transpiration cooling has emerged as a promising method, leveraging porous structures to enhance cooling effectiveness. Recent advancements in additive manufacturing (AM) enable precise fabrication [...] Read more.
Advanced gas turbine cooling technologies are required to bridge the gap between turbine inlet temperatures and component thermal limits. Transpiration cooling has emerged as a promising method, leveraging porous structures to enhance cooling effectiveness. Recent advancements in additive manufacturing (AM) enable precise fabrication of complex transpiration cooling architectures, such as triply periodic minimal surface (TPMS) and biomimetic designs. This review analyzes AM-enabled transpiration cooling for gas turbines, elucidating key parameters, heat transfer mechanisms, and flow characteristics of AM-fabricated designs through experimental and numerical studies. Previous research has concluded that well-designed transpiration cooling achieves cooling effectiveness up to five times higher than the traditional film cooling methods, minimizes jet lift-off, improves temperature uniformity, and reduces coolant requirements. Optimized coolant controls, graded porosity designs, complex topologies, and hybrid cooling architectures further enhance the flow uniformity and cooling effectiveness in AM transpiration cooling. However, challenges remain, including 4–77% porosity shrinkage in perforated transpiration cooling for 0.5–0.06 mm holes, 15% permeability loss from defects, and 10% strength reduction in AM models. Emerging solutions include experimental validations using advanced diagnostics, high-fidelity multiphysics simulations, AI-driven and topology optimizations, and novel AM techniques, which aim at revolutionizing transpiration cooling for next-generation gas turbines operating under extreme conditions. Full article
(This article belongs to the Special Issue Heat Transfer Analysis: Recent Challenges and Applications)
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19 pages, 2327 KiB  
Article
Analytical Investigation of Dynamic Response in Cracked Structure Subjected to Moving Load
by Shuirong Gui, Hongwei Zeng, Zhisheng Gui, Mingjun Tan, Zhongzhao Guo, Kai Zhong, Yongming Xiong and Wangwang Fang
Buildings 2025, 15(12), 2119; https://doi.org/10.3390/buildings15122119 - 18 Jun 2025
Viewed by 333
Abstract
Under cyclic moving load action, tensile-dominant structures are prone to crack initiation due to cumulative damage effects. The presence of cracks leads to structural stiffness degradation and nonlinear redistribution of dynamic characteristics, thereby compromising str18uctural integrity and service performance. The current research on [...] Read more.
Under cyclic moving load action, tensile-dominant structures are prone to crack initiation due to cumulative damage effects. The presence of cracks leads to structural stiffness degradation and nonlinear redistribution of dynamic characteristics, thereby compromising str18uctural integrity and service performance. The current research on the dynamic behavior of cracked structures predominantly focuses on transient analysis through high-fidelity finite element models. However, the existing methodologies encounter two critical limitations: computational inefficiency and a trade-off between model fidelity and practicality. Thus, this study presents an innovative analytical framework to investigate the dynamic response of cracked simply supported beams subjected to moving loads. The proposed methodology conceptualizes the cracked beam as a system composed of multiple interconnected sub-beams, each governed by the Euler–Bernoulli beam theory. At crack locations, massless rotational springs are employed to accurately capture the local flexibility induced by these defects. The transfer matrix method is utilized to derive explicit eigenfunctions for the cracked beam system, thereby facilitating the formulation of coupled vehicle–bridge vibration equations through modal superposition. Subsequently, dynamic response analysis is conducted using the Runge–Kutta numerical integration scheme. Extensive numerical simulations reveal the influence of critical parameters—particularly crack depth and location—on the coupled dynamic behavior of the structure subjected to moving loads. The results indicate that at a constant speed, neither crack depth nor position alters the shape of the beam’s vibration curve. The maximum deflection of beams with a 30% crack in the middle span increases by 14.96% compared to those without cracks. Furthermore, crack migration toward the mid-span results in increased mid-span displacement without changing vibration curve topology. For a constant crack depth ratio (γi = 0.3), the progressive migration of the crack position from 0.05 L to 0.5 L leads to a 26.4% increase in the mid-span displacement (from 5.3 mm to 6.7 mm). These findings highlight the efficacy of the proposed method in capturing the complex interactions between moving loads and cracked concrete structures, offering valuable insights for structural health monitoring and assessment. Full article
(This article belongs to the Section Building Structures)
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17 pages, 68021 KiB  
Article
A Low-Power Differential Temperature Sensor with Chopped Cascode Transistors and Switched-Capacitor Integration
by Junyi Yang, Thomas Gourousis, Mengting Yan, Ruyi Ding, Ankit Mittal, Milin Zhang, Francesco Restuccia, Aatmesh Shrivastava, Yunsi Fei and Marvin Onabajo
Electronics 2025, 14(12), 2381; https://doi.org/10.3390/electronics14122381 - 11 Jun 2025
Viewed by 630
Abstract
Embedded differential temperature sensors can be utilized to monitor the power consumption of circuits, taking advantage of the inherent on-chip electrothermal coupling. Potential applications range from hardware security to linearity, gain/bandwidth calibration, defect-oriented testing, and compensation for circuit aging effects. This paper introduces [...] Read more.
Embedded differential temperature sensors can be utilized to monitor the power consumption of circuits, taking advantage of the inherent on-chip electrothermal coupling. Potential applications range from hardware security to linearity, gain/bandwidth calibration, defect-oriented testing, and compensation for circuit aging effects. This paper introduces the use of on-chip differential temperature sensors as part of a wireless Internet of Things system. A new low-power differential temperature sensor circuit with chopped cascode transistors and switched-capacitor integration is described. This design approach leverages chopper stabilization in combination with a switched-capacitor integrator that acts as a low-pass filter such that the circuit provides offset and low-frequency noise mitigation. Simulation results of the proposed differential temperature sensor in a 65 nm complementary metal-oxide-semiconductor (CMOS) process show a sensitivity of 33.18V/°C within a linear range of ±36.5m°C and an integrated output noise of 0.862mVrms (from 1 to 441.7 Hz) with an overall power consumption of 0.187mW. Considering a figure of merit that involves sensitivity, linear range, noise, and power, the new temperature sensor topology demonstrates a significant improvement compared to state-of-the-art differential temperature sensors for on-chip monitoring of power dissipation. Full article
(This article belongs to the Special Issue Advances in RF, Analog, and Mixed Signal Circuits)
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9 pages, 9851 KiB  
Article
Manipulation of Topological Edge States and Realization of Zero-Dimensional Higher-Order Topological Point States
by Jiahui Ren, Wenjing Ding, Sihan Wang and Shiwei Tang
Micromachines 2025, 16(6), 686; https://doi.org/10.3390/mi16060686 - 7 Jun 2025
Viewed by 512
Abstract
Topological photonics has provided revolutionary ideas for the design of next-generation photonic devices due to its unique light transmission properties. This paper proposes a honeycomb photonic crystal structure based on a mirror-symmetric interface and numerically simulates the precise manipulation of topological edge states [...] Read more.
Topological photonics has provided revolutionary ideas for the design of next-generation photonic devices due to its unique light transmission properties. This paper proposes a honeycomb photonic crystal structure based on a mirror-symmetric interface and numerically simulates the precise manipulation of topological edge states and the robust excitation of high-order topological corner states in this structure. Specifically, two honeycomb photonic crystals with non-trivial topological properties form an interface through mirror-symmetric stitching. Continuous adjustment of the spacing between their coupling pillars can induce the closure and reopening of topological edge state energy bands, accompanied by significant band inversion, revealing the dynamic process of topological phase transitions. Furthermore, zero-dimensional high-order topological corner states are observed at the junction of boundaries with different topological properties. Their localized field strengths are strictly confined and exhibit strong robustness against structural defects. This study not only provides a new mechanism for the local symmetry manipulation of topological edge states but also lays a foundation for the design of high-order topological photonic crystals and the practical application of topological photonic devices. Full article
(This article belongs to the Special Issue Novel Electromagnetic and Acoustic Devices)
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11 pages, 2884 KiB  
Article
The Design of a Circulator Based on Topological Photonic Crystals
by Yulin Zhao, Feng Liang, Jianfei Han, Jingsen Li, Haihua Hu, Weihao Zhang and Xiangjun Tan
Photonics 2025, 12(6), 581; https://doi.org/10.3390/photonics12060581 - 7 Jun 2025
Viewed by 463
Abstract
Topological photonic crystals have garnered significant attention due to their fascinating topological edge states. These states are robust against sharp bends and defects and exhibit the novel property of unidirectional transmission. In this study, we analyze the topological edge states of gyromagnetic topological [...] Read more.
Topological photonic crystals have garnered significant attention due to their fascinating topological edge states. These states are robust against sharp bends and defects and exhibit the novel property of unidirectional transmission. In this study, we analyze the topological edge states of gyromagnetic topological photonic crystals in analogy with the quantum Hall effect. Through expanding and shrinking six dielectric cylinders, the optical quantum spin Hall effect is achieved. And helical edge states with pseudo-spin are demonstrated. Owing to the novel topological properties of these edge states, robust waveguides are proposed. Furthermore, integrating these two distinct types of topological states, a novel circulator with topological characteristics is designed. These topologically protected photonic devices will be beneficial for developing integrated circuits. Full article
(This article belongs to the Section Optoelectronics and Optical Materials)
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14 pages, 4691 KiB  
Article
Conjugated Polymer Nanoparticles and Thin Films of Defect-Free Cyclic P3HT: Effects of Polymer Topology on the Nanostructure
by Tomohisa Watanabe, Masatoshi Maeki, Manabu Tokeshi, Tianle Gao, Feng Li, Takuya Isono, Kenji Tajima, Toshifumi Satoh, Shin-ichiro Sato and Takuya Yamamoto
Molecules 2025, 30(12), 2490; https://doi.org/10.3390/molecules30122490 - 6 Jun 2025
Viewed by 533
Abstract
Conjugated polymer nanoparticles (CP NPs) attract attention as nanoscale materials used for a variety of applications. In relation to this, the internal structure of CP NPs is an important factor for their properties, and numerous investigations have been carried out to control their [...] Read more.
Conjugated polymer nanoparticles (CP NPs) attract attention as nanoscale materials used for a variety of applications. In relation to this, the internal structure of CP NPs is an important factor for their properties, and numerous investigations have been carried out to control their nanomorphology. Here, we report the formation of CP NPs from defect-free cyclic poly(3-hexylthiophene) (c-P3HT) using a microfluidic device, and the effect of polymer topology on their structural and solvatochromic properties was investigated. CP NPs from c-P3HT exhibited reduced particle sizes and hypsochromic shifts in the absorption spectrum when compared to CP NPs obtained from corresponding linear P3HT (l-P3HT). Furthermore, steady responses in the solvatochromism of CP NPs from c-P3HT were observed, while those from l-P3HT displayed molecular weight dependency. These topology effects were caused by the change in the conjugation length, solubility, and crystallinity upon cyclization. Grazing incidence X-ray scattering (GIXS) studies of spin-coated P3HT films further showed a reduced interchain order and a larger proportion of face-on molecular orientation on a substrate for c-P3HTs. The various distinct structures observed for c-P3HT indicate the use of polymer topology as a means of nanostructure regulation. Full article
(This article belongs to the Section Macromolecular Chemistry)
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26 pages, 1989 KiB  
Review
The Role of the AGPAT2 Gene in Adipose Tissue Biology and Congenital Generalized Lipodystrophy Pathophysiology
by Maria Eduarda Cardoso de Melo, Letícia Marques Gomes da Silva, Ana Carolina Costa Cavalcante, Josivan Gomes Lima and Julliane Tamara Araújo de Melo Campos
Int. J. Mol. Sci. 2025, 26(11), 5416; https://doi.org/10.3390/ijms26115416 - 5 Jun 2025
Viewed by 721
Abstract
1-Acylglycerol-3-phosphate O-acyltransferase (1-AGPAT) is an enzyme family composed of 11 isoforms. Notably, 1-AGPAT 2, the most studied isoform since its discovery, is a critical enzyme in the triglyceride synthesis pathway, converting lysophosphatidic acid to phosphatidic acid. In addition, AGPAT2 gene expression is shown [...] Read more.
1-Acylglycerol-3-phosphate O-acyltransferase (1-AGPAT) is an enzyme family composed of 11 isoforms. Notably, 1-AGPAT 2, the most studied isoform since its discovery, is a critical enzyme in the triglyceride synthesis pathway, converting lysophosphatidic acid to phosphatidic acid. In addition, AGPAT2 gene expression is shown to be essential for adipocyte development and maturation. Defects in AGPAT2 are responsible for significant pathophysiological alterations related to adipose tissue (AT). Pathogenic variants in this gene are the molecular etiology of Congenital Generalized Lipodystrophy type 1 (CGL1), in which fatty tissue is absent from birth. Metabolically, these individuals have several metabolic complications, including hypoleptinemia, hypoadiponectinemia, hyperglycemia, and hypertriglyceridemia. Furthermore, numerous AGPAT2 pathogenic variants that enormously affect the amino acid sequence, the tertiary structure of 1-AGPAT 2, and their transmembrane and functional domains were found in CGL1 patients. However, studies investigating the genotype–phenotype relationship in this disease are scarce. Here, we used bioinformatics tools to verify the effect of the main pathogenic variants reported in the AGPAT2 gene: c.366-588del, c.589-2A>G, c.646A>T, c.570C>A, c.369-372delGCTC, c.202C>T, c.514G>A, and c.144C>A in the 1-AGPAT 2 membrane topology. We also correlated the phenotype of CGL1 subjects harboring these variants to understand the genotype–phenotype relationship. We provided an integrative view of clinical, genetic, and metabolic features from CGL1 individuals, helping to understand the role of 1-AGPAT 2 in the pathogenesis of this rare disease. Data reviewed here highlight the importance of new molecular studies to improve our knowledge concerning clinical and genetic heterogeneity in CGL1. Full article
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