Search Results (1,051)

Bornaviruses are neurotropic, negative-sense RNA viruses with zoonotic potential, notably Borna disease virus 1 (BoDV-1) and variegated squirrel bornavirus 1 (VSBV-1). BoDV-1 is endemic in certain regions of Central Europe and maintained in bicolored white-toothed shrews, but its presence in Croatia has not been investigated. Given Croatia’s diverse biogeography and the prevalence of rodent-borne diseases, this study aimed to investigate the presence of orthobornaviruses in wild canids and mustelids. Brain samples from red foxes (Vulpes vulpes), golden jackals (Canis aureus moreoticus), wolves (Canis lupus), martens (Martes martes) and badgers (Meles meles) were analysed using pan-bornavirus RT-PCR. Despite successful RNA extraction and internal control amplification, bornavirus RNA was not detected in any of the 860 animal samples tested. Although no orthobornavirus RNA was detected, the results still provide valuable information: bornavirus infections appear to be absent or extremely rare in Croatian wild canids and mustelids. By excluding these species as current potential reservoir hosts, this study helps to refine the geographical extent of bornavirus endemicity and emphasises the importance of continuous One Health surveillance in regions with favourable ecological conditions for zoonotic spillover. Full article

Vitamin D plays an important role in bone metabolism and may influence postoperative healing processes. This study evaluated the association between preoperative serum vitamin D levels and recovery after mandibular third molar extraction. This secondary exploratory analysis included 122 healthy patients undergoing surgical extraction of an impacted mandibular third molar, of whom 98 had complete datasets for clinical and radiographic evaluation. Postoperative outcomes included pain intensity, facial swelling, trismus, early soft tissue healing assessed with the Wachtel Early Healing Index, and bone regeneration evaluated four months after surgery using CBCT-based fractal dimension analysis. Serum vitamin D levels were not significantly associated with postoperative pain, trismus, or early soft tissue healing. A weak correlation was observed between lower vitamin D levels and greater swelling along the tragus–pogonion line on postoperative day 1 (ρ = −0.21, p = 0.035), with no significant associations at later time points. Fractal dimension analysis did not demonstrate significant differences between groups. Within the limitations of this secondary exploratory analysis, vitamin D levels showed limited and inconsistent associations with postoperative outcomes, and their clinical relevance remains uncertain. Full article

To address the prominent fatigue failure risk of planetary gears in power-split hybrid buses and the lack of quantitative damage analysis across various operating modes in existing studies, this paper focuses on the front planetary gear set of a power-split hybrid bus. Based on a full-vehicle co-simulation model, loads under full operating conditions are decomposed into 11 operating modes, mode-switching loads are analyzed and extracted, and mode-decomposed and mode-switching fatigue loading spectra are compiled. Fatigue simulation is then conducted using Miner’s linear damage accumulation rule. Results show that the sun gear directly coupled to motor is the system’s most fatigue-susceptible component, exhibiting significant asymmetric unilateral tooth flank damage. The hybrid electric vehicle (HEV) mode contributes approximately 88% of total damage to the sun gear’s right flank, dominating system fatigue damage. Transient mode-switching conditions account for approximately 60% of total damage to the sun gear’s left flank, serving as the core damage source. Compared with the traditional full-condition merging method, the proposed mode-decomposed method improves the conservatism of life prediction. This work provides methodological support for refined strength design and targeted optimization of power-split hybrid transmission systems. Full article

Extracting periodic fault pulses caused by gear surface fatigue in reducers is often hindered by transmission path interference and strong background noise. Moreover, the traditional Variational Mode Decomposition (VMD) and Maximum Correlation Kurtosis Decomposition (MCKD) method rely on manual parameter selection, which limits its practicality. To address these issues, this paper proposes a parameter-adaptive VMD-MCKD method based on vibration signals for extracting gear surface fatigue fault features. Using the reciprocal of the peak indicator squared of decomposed signals as fitness functions, the method employs the global search capability of the Sparrow Search Algorithm to adaptively select optimal VMD-MCKD configurations. The optimized VMD-MCKD method is applied to decompose gear surface fatigue fault signals, effectively filtering out noise while highlighting periodic fault pulses caused by gear fatigue. Envelope demodulation is then performed to extract characteristic frequency components of gear surface fatigue faults. Experimental results demonstrate that the proposed method can adaptively extract periodic fault pulse components from strong noise environments, achieving a 2-fold improvement in signal kurtosis and enhanced robustness. Full article

The electro-hydraulic pump (EHP), as the primary power component of the electro-hydrostatic actuator, typically operates in a wet environment filled with hydraulic oil, thereby experiencing vibration response alterations due to the added mass of the fluid. Accurate identification of the wet modal characteristics is essential for improving the fidelity of electromagnetic vibration prediction in EHPs. In this work, an integrated EHP is investigated. A finite-element model is established to perform dry and wet modal analyses, from which the first nine natural frequencies and associated mode shapes are extracted. Dry and wet experimental modal tests are then conducted using an impact-hammer setup to validate the numerical model. The results indicate a systematic reduction in natural frequencies under oil-filled conditions, with more pronounced shifts in the lower-order modes; a maximum decrease of 10.92% is observed. On this basis, the stator tooth electromagnetic forces are obtained from two-dimensional electromagnetic finite-element simulations, and vibration responses are predicted via modal superposition using either dry or wet modal parameters. Finally, vibration measurements are performed under oil-filled operating conditions. The measured spectra exhibit pronounced tonal components at the electrical fundamental frequency and its even harmonics, and wet modal-based electromagnetic vibration prediction improves the accuracy by 78.90% relative to the dry modal-based prediction. These findings provide both theoretical support and practical guidance for low-vibration and low-noise design of EHPs. Full article

Background: Feline chronic gingivostomatitis (FCGS) is refractory stomatitis in cats. The cure rate of tooth extraction selected as a primary surgical treatment is insufficient. Methods: 52 FCGS-suspected cats, including 22 tooth-extracted and 30 unextracted cats, were studied. Commercially available antiviral and antibacterial agents were orally administered as initial treatment, followed by the antiviral agent solely as maintenance therapy. We examined the influence of prior tooth extraction on the therapeutic efficacy of these two drugs by analyzing changes in some physical signs and clinical laboratory biomarkers. Results: Mass spectrometric analysis revealed the active ingredients of antibacterial and antiviral were Moxifloxacin and Molnupiravir, respectively. All physical signs (weight, appetite, activity level, grooming behavior, ptyalism, erythema) showed statistically significant improvements with combined administration of these drugs. Numbers of white blood cells, neutrophils and monocytes, as well as circulating levels of total protein, albumin, globulin, and serum amyloid-A all statistically significantly decreased with their administration (p < 0.0001). Conclusions: No statistically significant differences were detected between two FCGS groups in the changes in any of the above physical signs or clinical biomarker levels, indicating combination therapy with antibacterial and antiviral agents leads to effective treatment of FCGS, regardless of whether prior tooth extraction was performed or not. Full article

Background/Objectives: Vision-language models (VLMs) such as GPT (Generative Pre-Trained Transformer) have shown potential for medical image interpretation; however, challenges remain in generating reliable radiological findings in clinical practice, as exemplified by dental pathologies. This study proposes a Self-correction Loop with Structured Output (SLSO) framework as an integrated processing methodology to enhance the accuracy and reliability of AI-generated findings for jaw cysts in dental panoramic radiographs. Methods: Dental panoramic radiographs with jaw cysts were used to implement a 10-step integrated processing framework incorporating image analysis, structured data generation, tooth number extraction, consistency checking, and iterative regeneration. The framework functioned as an external validation mechanism for GPT outputs. Performance was compared against the conventional Chain-of-Thought (CoT) method across seven evaluation items: transparency, internal structure, borders, root resorption, tooth displacement, relationships with other structures, and tooth number. Results: The SLSO framework improved output accuracy for multiple items compared to the CoT method, with the most notable improvements observed in tooth number identification, tooth displacement detection, and root resorption assessment. In successful cases, consistently structured outputs were achieved after up to five regenerations. The framework enforced explicit negative finding descriptions and suppressed hallucinations, although accurate identification of extensive lesions spanning multiple teeth remained limited. Conclusions: This investigation established the feasibility of the proposed integrated processing methodology and provided a foundation for future validation studies with larger, more diverse datasets. Full article

Background/Objectives: Medication-related osteonecrosis of the jaw (MRONJ) is a rare but severe complication of antiresorptive therapy for osteoporosis. This study investigated bacterial adhesion and microbial composition on two suture materials and their potential impact on early wound healing following tooth extraction in patients receiving antiresorptive therapy. Methods: In this prospective exploratory clinical study with partially randomized allocation, female patients undergoing antiresorptive therapy were evaluated for clinical parameters, including the Mombelli Plaque Index (MPI), Mombelli Bleeding Index (MBI), oral smear analysis, and Early Wound Healing Score (EHS). Suture samples (Vicryl and Monocryl, Ethicon, Germany) were removed after 10 days, measured, and weighed. Bacterial DNA was isolated and quantified by qPCR targeting the albumin and 16S rRNA genes. In addition, 16S rRNA gene amplicon sequencing was performed to assess the microbial community composition. Statistical and bioinformatic analyses were conducted to compare materials and evaluate the clustering patterns. Results: Fifty-two suture samples were analyzed. Vicryl exhibited significantly higher 16S rRNA gene copy numbers than Monocryl, indicating increased bacterial colonization, whereas albumin gene copy numbers were significantly higher in Monocryl. The suture weight correlated primarily with albumin gene copy numbers. Amplicon sequencing revealed no material-dependent differences in the microbial composition; instead, samples clustered predominantly by patient, particularly in split-mouth cases. The wound healing outcomes based on the EHS were comparable between materials. Conclusions: Although Vicryl and Monocryl differ in bacterial load and host material deposition, the microbial community composition is primarily patient-specific and the clinical healing outcomes are similar. Surgical management and patient-related factors appear more critical than suture material selection. Full article

Adequate alveolar bone volume is a prerequisite for predictable and long-term success in dental implant therapy. Physiological post-extraction remodeling frequently results in horizontal and vertical ridge deficiencies, which may compromise optimal implant placement. Guided bone regeneration (GBR) has become a cornerstone procedure in implant dentistry, with clinical outcomes largely influenced by the biological and mechanical characteristics of grafting materials. Different bone grafts and their combinations are currently clinically applicable, each exhibiting distinct osteogenic, osteoinductive, and osteoconductive properties, as well as varying resorption profiles and volumetric stability. This narrative review aims to analyze the biological principles of alveolar ridge augmentation, compare the properties of commonly used graft materials, evaluate clinical outcomes, and discuss emerging regenerative strategies. Literature published between 2000 and 2025 was assessed to synthesize current evidence regarding graft integration, bone formation, desorption dynamics, and clinical indications. Autogenous bone remains the gold standard due to its combined osteogenic, osteoinductive, and osteoconductive potential; however, its limitations have driven the development of alternative materials, including allografts, xenografts, alloplastic substitutes, demineralized tooth matrices, platelet concentrates, and customized scaffolds. While no single material is universally ideal, appropriate selection based on defect characteristics and clinical objectives is essential for predictable outcomes. Future research should prioritize long-term comparative trials, biomaterial standardization, and biologically enhanced regenerative approaches. Full article

Alveolar osteitis (AO) and postoperative pain are common complications after dental extractions. Excessive fibrinolysis leading to premature clot loss contributes to AO. Tranexamic acid (TXA), an antifibrinolytic agent, may stabilize post-extraction blood clots and reduce AO, although evidence from randomized controlled trials (RCTs) remains inconsistent. This systematic review and meta-analysis evaluated the effectiveness of topical TXA in preventing AO and reducing postoperative pain following dental extractions. PubMed, Embase, Scopus, and CENTRAL were searched from inception to June 2025 using terms related to “dental extraction” and “tranexamic acid”. Only English-language human studies were included. Eligible studies were RCTs assessing topical TXA versus placebo, saline, or plain gauze, reporting AO and/or pain outcomes. Non-RCTs, in vitro or animal studies, and trials lacking relevant outcomes or controls were excluded. Two reviewers independently screened and selected studies. Following PRISMA guidelines, two reviewers extracted data and assessed risk of bias with the Cochrane RoB-2 tool. Pooled analyses used random-effects models, with risk ratios (RRs) for AO and standardized mean differences (SMDs) for pain. AO was defined as exposed bone, foul odor, or persistent pain after day 3. Pain was measured on the Visual Analogue Scale (VAS) on days 3 and 7. Five RCTs (378 patients) were included. TXA significantly reduced AO incidence compared with controls (RR = 0.49; 95% CI: 0.32–0.76; p = 0.001; I² = 0%), indicating a ~50% risk reduction. Pain outcomes showed no significant differences on day 3 (SMD = −0.36; 95% CI: −0.95 to 0.24; p = 0.24; I² = 84%) or day 7 (SMD = −0.43; 95% CI: −1.34 to 0.48; p = 0.36; I² = 93%). Topical TXA significantly reduces the risk of AO after dental extraction, while its effect on postoperative pain remains inconsistent. Its safety, accessibility, and low cost support its use as a preventive adjunct in dental extractions. Further standardized, high-quality RCTs are needed to clarify its role in pain management. Full article

Background: Closing extraction spaces with clear aligners remains a significant biomechanical challenge, frequently involving difficulties in sagittal control, torque expression, and intra-arch anchorage. Although various sequential or phased retraction strategies exist, the Caterpillar Motion protocol has not yet been formally defined. This clinical report describes the Caterpillar Motion staging protocol and illustrates its application through representative extraction cases, rather than providing a systematic review or experimental comparison. Case Presentation: Two adult patients with extraction-based malocclusions were treated using the Caterpillar Motion staging protocol. Case 1 involved bimaxillary first-premolar extractions with maximum anchorage requirements and periodontal limitations in the mandibular incisors. Case 2 presented as a full Class II malocclusion requiring maxillary first-premolar extractions with moderate anchorage for sagittal camouflage. In both cases, tooth movement was organized into alternating functional groups, with waves limited to 2 mm of sagittal closure. Discussion: The Caterpillar Motion protocol reduces the risk of aligner bowing effect, increases effective crown engagement, and redistributes anchorage demands by preventing simultaneous shortening of both arch extremities. Both cases demonstrated controlled anterior retraction, stable posterior anchorage, and favorable root parallelism. Conclusions: Caterpillar Motion offers a biomechanically coherent and clinically reproducible staging strategy for clear aligner extraction therapy. Further controlled studies are needed to validate its advantages over traditional linear and en-masse protocols. Full article

Objectives: This study aimed to investigate preventive management strategies and optimal intervention timing for dental ankylosis of primary teeth complicated by suspected pre-eruptive intracoronal resorption (PEIR), providing an evidence-based framework for clinical diagnosis and management. Methods: This case retrospectively reports a 7-year-old patient with an ankylosed mandibular left second primary molar (tooth 75), exhibiting radiographic features suggestive of pre-eruptive intracoronal resorption. The patient was in the mixed dentition stage with dental crowding. Preventive and interceptive orthodontic management was implemented to address space deficiency and guide occlusal development. The timing of extraction and space maintenance of tooth 75 was guided by space regaining, PEIR lesion progression, and crown development of tooth 35. Results: The permanent successor of tooth 75 (tooth 35) erupted successfully, dental crowding was alleviated, and a favorable occlusion was established. Conclusions: Early diagnosis and timely, individualized intervention for ankylosed primary teeth play an important role in preventing malocclusion and promoting normal eruption of the permanent successor tooth. Full article

Objectives: The objective of this study is to evaluate the effect of 635 nm photobiomodulation on the rate and magnitude of maxillary canine distalization following extraction of the maxillary first premolars in adult patients. Materials and Methods: This randomized, controlled, split-mouth clinical trial included 18 adult patients undergoing extraction-based orthodontic treatment for Class II malocclusion. Maxillary first premolars were extracted, and canine distalization was performed using nickel–titanium closed-coil springs delivering a constant force of 150 g, supported by orthodontic mini-implants providing absolute anchorage. Photobiomodulation was applied on one randomized side using a 635 nm diode laser operating at 100 mW in continuous-wave mode, with an 8 mm handpiece diameter. Laser irradiation was delivered in contact mode to two application sites per session corresponding to the buccal and palatal aspects of the maxillary canine root, with an exposure time of 60 s per site. Irradiation was performed according to a predefined schedule over a 45-day observation period, while the contralateral side served as a sham-treated control. Tooth movement was assessed by repeated measurements of inter-bracket distance. A linear mixed-effects model was used to analyze the effects of treatment, time, and their interaction on tooth movement dynamics. Results: The linear mixed-effects model revealed a significant interaction between treatment and time (p < 0.001), indicating a greater rate of canine distalization on the photobiomodulation-treated side compared with the control side. Treatment and time also demonstrated significant main effects. After 45 days, the mean cumulative canine displacement was approximately 1.6 mm greater on the photobiomodulation side than on the control side. Age and sex did not significantly influence tooth movement. Conclusions: Photobiomodulation at a wavelength of 635 nm significantly increased the rate of maxillary canine distalization in adult extraction cases over a 45-day observation period. Full article

Background/Objectives: Sex analysis in dental radiographs plays a central role in forensic identification, especially when biological material is compromised or incomplete. While most AI-based studies rely on complete dentition or craniofacial structures, this study investigates whether sex-based information can be extracted solely through segmentation of third molars in panoramic radiographs. Methods: A retrospective dataset containing 2818 third molar annotations from 757 panoramic images with balanced class distribution across training, validation, and testing subsets was constructed. Three sample segmentation-based deep learning models—YOLOv12n, YOLO26n, and RT-DETR v2—were evaluated under the same training conditions using detection-focused metrics including sensitivity, recall, and mAP. Results: YOLOv12n demonstrated the most balanced performance, achieving the highest mAP@0.50 score of 0.810 and mAP@0.50–0.95 score of 0.574; RT-DETR v2 showed higher sensitivity but lower localization accuracy and significantly longer training time. YOLO26n yielded the highest recall rate but showed an increase in false positives. Class-based analyses indicated sex-specific morphological variability in third molar anatomy, showing consistently higher detection performance in female samples. Conclusions: These results demonstrate that isolated third molars encode distinctive sex-related signals and that segmentation-focused frameworks offer an interpretable and clinically relevant alternative to whole-image classification in forensic dentistry. Future studies should incorporate larger multi-population datasets, multi-tooth integration, and explainable AI techniques to further improve robustness and applicability. Full article

Background/Obectives: Alveolar bone resorption after tooth extraction compromises esthetics and implant placement. Conventional alveolar ridge preservation (ARP) relies on grafting. This randomized controlled study evaluated a graft-free, lamina-based approach aimed at preserving ridge morphology by protecting the buccal cortical plate. Methods: Forty alveoli were randomly assigned to Guided Alveolar Ridge Preservation (G-ARP) with a subperiosteally positioned cortical lamina (test) or unassisted healing (control; CTRL). Cone-beam computed tomography (CBCT) was performed before extraction and after five months. Vertical and horizontal dimensional changes were statistically compared. Results: Healing was uneventful. At five months, the G-ARP group showed a vertical gain of 0.5 mm and a horizontal reduction of 0.2 mm, whereas the CTRL group exhibited a vertical loss of 1.7 mm (p < 0.01) and a horizontal loss of 2.7 mm (p < 0.001). Effect sizes were large for vertical change and very large for horizontal change (Hedges’ g = 0.95 and 2.19, respectively). Regeneration occurred through native bone formation without grafts. Conclusions: Subperiosteal placement of a cortical lamina effectively preserved ridge dimensions after extraction. This graft-free approach may offer technical and biological advantages while supporting new bone regeneration. Full article