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Veterinary Sciences
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Biomarkers in Veterinary Medicine
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Biomarkers in Veterinary Medicine

A special issue of Veterinary Sciences (ISSN 2306-7381). This special issue belongs to the section "Veterinary Microbiology, Parasitology and Immunology".

Deadline for manuscript submissions: 25 May 2026 | Viewed by 3524

Special Issue Editor

Prof. Takashi Kuribayashi

E-Mail Website
Guest Editor
Department of Veterinary Nursing and Health Science, School of Veterinary Medicine, Azabu University, Kanagawa 252-5201, Japan
Interests: biochemical parameter; clinical significance; acute phase protein; cytokine; veterinary disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biomarkers are important indicators for evaluating pharmacology, toxicity, etc., in veterinary diagnosis, treatment, and basic research using experimental animals. In veterinary medicine, the use of appropriate biomarkers as indicators can lead to appropriate and timely diagnosis. They can also help elucidate disease mechanisms and properly evaluate the pharmacological effects and toxicity of new compounds. In this Special Issue, we invite contributions on the utility of novel or existing biomarkers.

We invite you to submit original research papers, reviews, and communications to our Special Issue.

Prof. Takashi Kuribayashi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Veterinary Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomarkers
  • veterinary medicine
  • diagnosis
  • treatment
  • inflammation

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Published Papers (3 papers)

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Research

18 pages, 296 KB  
Article
Response to Two Standardized Exercise Tests in Dogs with Different Cephalic Biotypes
by Brenda Reyes-Sotelo, Julio Martínez-Burnes, Ismael Hernández-Avalos, Patricia Mora-Medina, Adriana Domínguez-Oliva, Fabiola Torres-Bernal, Cynthia González-López and Daniel Mota-Rojas
Vet. Sci. 2025, 12(11), 1058; https://doi.org/10.3390/vetsci12111058 - 3 Nov 2025
Viewed by 269
Abstract
Dogs are classified according to their total cephalic index into three biotypes: dolichocephalic, mesocephalic, and brachycephalic. The latter has emerged due to the deliberate selection of extreme phenotypic traits during breeding, which has intensified the expression of associated conformational defects and led to [...] Read more.
Dogs are classified according to their total cephalic index into three biotypes: dolichocephalic, mesocephalic, and brachycephalic. The latter has emerged due to the deliberate selection of extreme phenotypic traits during breeding, which has intensified the expression of associated conformational defects and led to several medical disorders. The Brachycephalic Obstructive Airway Syndrome (BOAS) is a respiratory condition directly linked to these conformational traits. Dogs affected by BOAS present a wide range of clinical signs, including respiratory noise, exercise intolerance, syncope episodes, or even sudden death. This study aimed to evaluate craniofacial anatomical differences and similarities among dogs of different cephalic biotypes (dolichocephalic, mesocephalic, and brachycephalic) and to determine how two exercise tolerance tests—a 6 min walk and a 1000 m walk—influence physiological parameters. Eighty dogs from different breeds were included and classified according to their biotype. Morphometric data from the head, body, and limbs were obtained. Additionally, physiological parameters, including heart rate, respiratory rate, blood pressure, oxygen saturation, and rectal temperature, were evaluated before and after the tolerance tests. The results indicated that dogs tolerated both exercise tests. Dolichocephalic and mesocephalic dogs showed a greater tolerance to or greater respiratory adaptation during walking. Despite the brachycephalic biotype, a wide dispersion at a distance of 1000 m, indicating that those with a higher BOAS grade did not require emergency medical assistance during the tests. However, evidence of rostral shortening (<38 mm), together with facial foreshortening and measurements ≥ 20 mm for necks, chest circumference, and nasal fold, suggested a higher risk of airway obstruction in brachycephalic dogs diagnosed with BOAS grades 2 and 3 compared to dolichocephalic and mesocephalic dogs. This anatomical conformation was associated with significant alterations in physiological parameters including heart rate, respiratory rate, oxygen saturation below 90%, and temperature, which did not return to baseline values 10 min post-exercise. This showed significant differences between the biotypes in the distance in the 1000 m test (H = 11.74; p = 0.0028) and between the subdivisions (p = 0.0389), where G3 covered less distance than G2 (699.1 m vs. 932.77 m. These findings suggest that extreme brachycephalic conformation impairs the respiratory function and leads to thermoregulatory inefficiency, potentially compromising the animals’ survival under physical stress. Moreover, the application of safe walking tests and non-invasive morphometric measurements is suggested to facilitate prompt diagnosis of BOAS. Full article
(This article belongs to the Special Issue Biomarkers in Veterinary Medicine)
12 pages, 260 KB  
Article
Reference Intervals for Biochemical Analytes in Clinically Healthy Adult Lusitano Horses
by Maria João Pires, Mário Cotovio, Felisbina Queiroga, Carlos André Pires and Ana C. Silvestre-Ferreira
Vet. Sci. 2025, 12(7), 656; https://doi.org/10.3390/vetsci12070656 - 11 Jul 2025
Viewed by 943
Abstract
To date, serum biochemical analytes reference intervals (RIs) in Lusitano horses have not been studied. This study aimed to establish the RIs for biochemical analytes following the American Society of Veterinary Clinical Pathology guidelines and to compare them with the general equine population’s [...] Read more.
To date, serum biochemical analytes reference intervals (RIs) in Lusitano horses have not been studied. This study aimed to establish the RIs for biochemical analytes following the American Society of Veterinary Clinical Pathology guidelines and to compare them with the general equine population’s RIs. Blood samples were collected from 76 clinically healthy adult Lusitano horses, and RIs of 22 biochemical variables were determined using Reference Value Advisor software. Lusitano horse-specific RIs are proposed for the following variables: total protein (3.9–7.0 g/dL), albumin (2.5–3.8 g/dL), globulin (1.1–3.7 g/dL), total bilirubin (1.0–5.6 mg/dL), direct bilirubin (0.09–0.68 mg/dL), indirect bilirubin (0.7–5.2 mg/dL), urea (21.0–38.9 mg/dL), creatinine (0.9–2.0 mg/dL), aspartate aminotransferase (150.7–345.1 IU/L), alkaline phosphatase (60.7–227.4 IU/L), lactate dehydrogenase (247.6–959.0 IU/L), glucose (75.5–131.5 mg/dL), cholesterol (58.6–125.2 mg/dL), sodium (129.0–154.9 mmol/L), phosphorus (1.8–4.5 mmol/L), chloride (90.3–107.0 mmol/L), and calcium (8.9–12.6 mg/dL). Different RIs were identified for healthy adult Lusitano horses for 17/22 serum biochemical analytes tested, emphasizing the need for breed-specific RIs to prevent misinterpretation of laboratory results. Full article
(This article belongs to the Special Issue Biomarkers in Veterinary Medicine)
21 pages, 3797 KB  
Article
Infrared Thermography and Physiological Variables as Methods for Recognizing Fear in Domestic Cats (Felis catus) Using Three Pharmacological Models: Cannabidiol, Gabapentin, and Synthetic Facial Pheromones
by Fabiola Torres-Bernal, Julio Martínez-Burnes, Ismael Hernández-Avalos, Adriana Olmos-Hernández, Adriana Domínguez-OIiva, Brenda Reyes-Sotelo, Cynthia González-López, Diana Villanueva-Pereyra and Daniel Mota-Rojas
Vet. Sci. 2025, 12(6), 523; https://doi.org/10.3390/vetsci12060523 - 27 May 2025
Cited by 1 | Viewed by 1675
Abstract
This study aimed to assess changes in the surface temperature and physiological parameters of cats exposed to a fear model involving negative dog–cat interactions, receiving three pharmacological options: a single dose of cannabidiol, gabapentin, or synthetic facial pheromones. The surface temperature of the [...] Read more.
This study aimed to assess changes in the surface temperature and physiological parameters of cats exposed to a fear model involving negative dog–cat interactions, receiving three pharmacological options: a single dose of cannabidiol, gabapentin, or synthetic facial pheromones. The surface temperature of the upper and lower limbs, facial, dorsal, and appendicular thermal windows was assessed through infrared thermography. Additionally, heart rate, respiratory rate, and rectal temperature were recorded. Eighty male and female domestic cats were included in the study and randomly divided into four groups: CONTROL (placebo, 2 mL/cat orally), CBD (cannabidiol, 2 mg/kg orally), GABA (gabapentin, 100 mg/cat orally), and SFP (synthetic facial pheromone, two sprays/carrier). All cats underwent six experimental phases: Tbasal−, T1stfear, T1strecovery, Tbasal+, T2ndfear, and T2ndrecovery. Drug administration was carried out at the end of T1strecovery; the time between drug administration and Tbasal+ differed according to each drug’s nature. Statistical differences were obtained between experimental groups and times in the average surface temperature of thermal windows and cardiorespiratory parameters. In particular, the CBD, GABA, and SFP groups exhibited differences during T2ndfear, in contrast to the control and T1stfear groups. In conclusion, the results suggest a pharmacological effect of CBD, GABA, and SFP on cats’ physiological alterations in response to fear. Full article
(This article belongs to the Special Issue Biomarkers in Veterinary Medicine)
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