Search Results (6,464)

Accurate perception of dynamic carbon intensity is a prerequisite for low-carbon demand-side response. However, traditional grid-average carbon factors lack the spatio-temporal granularity required for real-time regulation. To address this, this paper proposes a “Prediction-Optimization” closed-loop framework for electric vehicle (EV) fleets. First, a hybrid forecasting model (VMD-BSLO-CTL) is constructed. By integrating Variational Mode Decomposition (VMD) with a CNN-Transformer-LSTM network optimized by the Blood-Sucking Leech Optimizer (BSLO), the model effectively captures multi-scale features. Validation on the UK National Grid dataset demonstrates its superior robustness against prediction horizon extension compared to state-of-the-art baselines. Second, a multi-objective Model Predictive Control (MPC) strategy is developed to guide EV charging. Applied to a real-world station-level scenario, the strategy navigates the trade-offs between user economy and grid stability. Simulation results show that the proposed framework simultaneously reduces economic costs by 4.17% and carbon emissions by 8.82%, while lowering the peak-valley difference by 6.46% and load variance by 11.34%. Finally, a cloud-edge collaborative deployment scheme indicates the engineering potential of the proposed approach for next-generation low-carbon energy management. Full article

Shiga toxin-producing Escherichia coli (STEC) is a zoonotic pathogen of public health concern, requiring a One Health approach to clarify its transmission and distribution. However, its prevalence and genomic characteristics in livestock and companion animals remain underexplored in low-income countries. We investigated prevalence and genomic features of STEC in animals in western Ghana, representing the first genomic report of STEC in Ghana. Fecal samples (97) were collected from goats (n = 33), sheep (n = 33), dogs (n = 30), and a cat (n = 1), with STEC detected in 12.1% of goats and sheep samples. Whole-genome sequencing identified serotypes O38:H26, O43:H2, and O157:H7. stx1c and stx2b genes were detected in O38:H26 and O43:H2, whereas stx2c and key virulence genes (chuA, eae, esp, nle, tir, and toxB) were exclusively found in O157:H7. Phylogenetic analysis revealed that O38:H26 isolates form a cluster closely related to clinical strains from the UK. O43:H2 isolates exhibited diverse stx profiles, linking animal, environmental, and clinical strains from North America and the UK. O157:H7 isolates were genetically similar to European clinical and food-derived strains, suggesting that goats and sheep are important STEC reservoirs in Ghana, offering data for public health risk assessment and effective One Health-based control strategies. Full article

Weeds pose a significant threat to crop yields, both in quantitative and qualitative terms. Modern agriculture relies heavily on herbicides; however, their excessive use can lead to negative environmental impacts. As a result, recent research has increasingly focused on Integrated Weed Management (IWM), which employs multiple complementary strategies to control weeds in a holistic manner. Nevertheless, large-scale adoption of this approach requires a solid understanding of the underlying tactics. This systematic review analyses recent studies (2013–2022) on herbicide alternatives for weed control across major cropping systems in the EU-27 and the UK, providing an overview of current knowledge, the extent to which IWM tactics have been investigated, and the main gaps that help define future research priorities. The review relied on the IWMPRAISE framework, which classifies weed control tactics into five pillars (direct control, field and soil management, cultivar choice and crop establishment, diverse cropping systems, and monitoring and evaluation) and used Scopus as a scientific database. The search yielded a total of 666 entries, and the most represented pillars were Direct Control (193), Diverse Cropping System (183), and Field and Soil Management (172). The type of crop most frequently studied was arable crops (450), and the macro-area where the studies were mostly conducted was Southern Europe (268). The tactics with the highest number of entries were Tillage Type and Cultivation Depth (110), Cover Crops (82), and Biological Control (72), while those with the lowest numbers were Seed Vigor (2) and Sowing Depth (2). Overall, this review identifies research gaps and sets priorities to boost IWM adoption, leading policy and funding to expand sustainable weed management across Europe. Full article

Housing stock is observed to be associated with high carbon emissions, high fuel poverty and low comfort levels in the UK. Retrofitting the housing stock is one of the best solutions to address these problems. This paper directly corresponds with human and planetary health in terms of climate change, human health and mental health by addressing the challenges of housing retrofit at scale. Retrofitting houses can also contribute to social equity, reduced use of planetary resources and better financial and physical comfort. Despite the availability of the right technology, government grants and the potential to acquire supply chain and skilled labour, the progress of retrofit is extremely poor. Importantly, the UK is off track to achieve net zero by 2050, and the housing stock contributes 18.72% of the total emissions. The problem is further exacerbated by the 30.4 million units of housing stock. Robust strategies are required to retrofit the housing stock at scale. The study uses a qualitative modelling method under the diffusion of innovations theory to formulate a retrofit-at-scale strategy for the UK. Findings recommend focusing on skill development, show homes, research and innovation, supply chain development, business models, government grants and regulatory tools in a trajectory from 2025 to 2050. The proposed strategy is aligned with the segments of the diffusion of innovation theory. Although the analysis was performed with reference to the UK, the findings are transferable, considering the broader and urgent concerns related to human and planetary health. Full article

The capacity of the United Kingdom (UK) to prosecute technology-enabled financial and economic crime (FEC) is increasingly shaped by the Collingridge dilemma. Even though the dilemma was broadly conceptualized in technology governance, its application to prosecutorial and enforcement practice, evidentiary standards, and criminal liability attribution represents uncharted scholarly territory. Through socio-legal mixed methods combining doctrinal analysis, case studies, and comparative analysis, the paper shows how the dilemma’s two horns or pillars (i.e., early epistemic uncertainty and late institutional inertia) manifest in criminal law and regulatory contexts. The paper finds that just like the European Union and United States, the UK criminal enforcement ecosystem exhibits both horns across cryptocurrency, algorithmic trading, artificial intelligence (AI), and fintech domains. By integrating supplementary theories such as responsive regulation, precautionary principles and technological momentum, the study advances a socio-legal framework that explains enforcement inertia and doctrinal gaps in liability attribution for emerging technologies. The paper demonstrates how epistemic uncertainty and institutional entrenchment shape enforcement outcomes and proposes adaptive strategies for anticipatory governance including technology-literate capacity building, anticipatory legal reform, and data-driven public-private coordination. These recommendations balance ex-ante legal clarity (reducing uncertainty) with ex-post enforcement agility (overcoming entrenchment) to provide a normative framework for navigating the Collingridge dilemma in FEC prosecution. Full article

Flooding is an increasing climate risk in the UK, yet schools remain marginal in resilience planning. Flood events disrupt education, heighten pupil anxiety, increase staff workload and unsettle communities, but these experiences are rarely documented in ways that inform policy. This study examines how schools in the East and West Midlands regions of the UK have experienced and adapted to flooding. Eight qualitative case studies were undertaken in flood-affected schools using semi-structured interviews with key staff, site visits and documentary evidence. Interview transcripts were thematically analysed using NVivo to explore past flood events, levels of preparedness, and readiness for measures such as Property Flood Resilience, Sustainable Drainage Systems and Climate Action Plans. Findings show wide variation in awareness, emergency procedures and engagement with local authorities. Most schools had faced flooding or near misses but lacked formal guidance or flood-specific plans, leading to improvised responses led internally by staff. Despite limited funding, inconsistent communication and exclusion from wider planning, schools demonstrated adaptive potential and willingness to support community preparedness. The study offers evidence to guide headteachers, policymakers and local authorities in strengthening school-based flood resilience and supporting the development of a resilience innovation blueprint for flood-prone schools in the UK. Full article

Background/Objectives: This qualitative study examines strengths and strains faced by professionals working with young carers throughout the United Kingdom (UK) in the context of society’s youngest carers; young carers in early childhood (YCEC) (0–8 years). Methods: The Power Threat Meaning Framework (PTMF) was utilised to map key findings of three focus groups. This conceptual lens offers a narrative-based understanding of ways in which power operates in society. Increasingly applied to explore experiences of individuals, communities, and groups, the PTMF proposes that concepts of distress are founded in broader contexts of injustice and social inequalities. Twenty-four participants were recruited from throughout the UK via the Carers Trust Young Carers Alliance. Results: Findings highlight the strength of legal, ideological, and economic power shaping societal beliefs and policy concerning YCEC. This informs constructs of perceived social norms regarding who young carers are most likely to be, and where they may be found. This power threatens the health and well-being of YCEC, impacting the ability of professionals to provide optimal support. Inappropriate policy formed from these assumptions disempowers those providing services to young carers at the frontline of service delivery. Professionals and adults with living experience of caring in their early childhoods reflect upon silent tensions that exist within society, suggesting that YCEC remain the ‘elephant in the room’. Conclusions: We make recommendations to review the efficacy of statutory mandates concerning the needs assessment of young carers in England, and to align policy concerning early childhood and young carers to embed young carers’ rights consistently, starting in early childhood. Full article

While drill music is often talked about in relation to crime, it is often overlooked as an art form and cultural practice. Consequently, its artists are rarely heard from. To address this societal and academic gap, we have conducted in-depth interviews with ten UK artists from this genre and subculture. This article presents the shared meanings these UK drill artists attach to the motivation to make their own music, the music subgenre and its culture, and its ongoing criminalisation. We do so by conceptualising these meanings as counter-narratives. The article departs from the observation that these counter-narratives present themselves in drill, as a form of expression, on two dimensions: drill as the outcome of intra-group expression of emotions and social relations, and as the platform to engage with social injustice on the inter-group level. An interdisciplinary theoretical framework, combining psychological insights on needs, philosophical cues on (mis)recognition, and the lens intersectionality, allows us to study and bridge these two dimensions. We identify twelve counter-narratives that were validated by a majority of respondents. The study, besides analysing these in-depth counter-narratives, also foregrounds UK drill artists’ agency generally absent from both societal and academic discourse. Full article

Background: Leakage is a major concern for individuals living with a stoma and may negatively impact quality of life (QoL). A digital leakage notification system (DLNS) recently launched in the UK provides timely notifications to users via their smartphone when faeces is detected underneath the baseplate. This provides predictability and enables users to take proactive measures to help avoid leakages outside the baseplate. Methods: A single-arm, observational, longitudinal study of the DLNS, including its associated support service, has been initiated to follow 300 users for a year in the UK to evaluate long-term health benefits of the DLNS and its implications for healthcare resource utilisation in a real-world setting. The DLNS is prescribed by healthcare professionals (HCPs), and all users were invited to participate in the study. Study participants complete questionnaires capturing data on QoL (using the Ostomy Leak Impact tool), number of leakages outside the baseplate, utilisation of ostomy products, interactions with HCPs, and work productivity (using the Work Productivity and Activity Impairment questionnaire) at baseline and then every third month for one year. Data from the planned interim analysis of the first 100 participants who had been in the study for 6 months is presented. Results: Use of the DLNS for 6 months together with the associated support service was associated with a 51% reduction in leakage episodes outside the baseplate (p < 0.001) and great improvements in QoL (p < 0.001). Use of the DLNS reduced the number of unplanned baseplate changes due to worry about leakage by 47% (p < 0.001) and overall was associated with a reduction in the number of baseplates used by 14% (p = 0.002). Total time spent with HCPs related to stoma care was reduced by 65% after 6 months compared with baseline (p < 0.001). Work absenteeism and presenteeism improved significantly with the use of the DLNS. Conclusions: The interim results of this prospective, longitudinal study provided first insights into the long-term benefits of the DLNS in a real-world setting. ClinicalTrials.gov ID: NCT06554015. Full article

Background: Adult females with Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Disorder (ADHD) are frequently underdiagnosed due to gender bias, overlapping symptoms, and limited awareness among healthcare professionals. The scarcity of research on this subject—particularly in the UK context—underscores the need for further investigation. Accordingly, the aim of this study was to explore the lived experiences of adult females receiving a late diagnosis of ASD and/or ADHD and to identify key barriers within the UK diagnostic pathway. This study addresses a critical knowledge gap by examining the factors contributing to delayed diagnosis within the United Kingdom. Study Design and Method: The study employed a qualitative approach, utilising an anonymous online questionnaire survey comprising nine open-ended questions. Responses were obtained from 52 UK-based females aged 35–65 years who had either received or were awaiting a diagnosis of ASD and/or ADHD. Data were analysed thematically within a constructivist framework. Findings: The analysis revealed three overarching themes: (i) limited understanding and lack of empathy among healthcare professionals, (ii) insufficient post-diagnostic support, with most participants reporting no follow-up care, and (iii) a complex, protracted diagnostic process, often involving waiting periods exceeding three years. Gender bias and frequent misdiagnosis were recurrent issues, contributing to significant psychological distress. These findings underscore the need for systemic reforms and align closely with gaps identified in the existing literature. Conclusions: The findings emphasise the urgent need for gender-sensitive diagnostic frameworks, enhanced professional training, and a person-centred approach to care. Key recommendations include shortening diagnostic waiting times, strengthening healthcare professionals’ knowledge base, and ensuring equitable and consistent post-diagnostic support. Full article

Spinal muscular atrophy (SMA) is a genetic condition that causes the degeneration of motor neurons in the spinal cord. Newborn blood spot (NBS) screening can potentially enable diagnosis before symptoms, and presymptomatic treatment is considered to be more effective than symptomatic treatment. In this paper, we present an overview of a cost-effectiveness model of NBS screening for SMA in the UK, informed by key clinical trials and the relevant published literature. Our analyses suggest that implementing screening could result in better outcomes and lower costs compared to the current approach of no screening plus treatment. However, several uncertainties and limitations of the model remain. These include uncertainty in the reimbursement status of nusinersen and risdiplam in the future; the ‘actual’ costs of treatments, as they are under confidential commercial agreements; uncertainty in the long-term effectiveness of presymptomatic and symptomatic treatment; and uncertainty around the incidence of SMA and the costs and the accuracy of NBS screening. An SMA in-service evaluation (ISE) that could capture data specific to the UK is under consideration, and an appropriately designed ISE with ongoing data collection could support periodic updates of clinical and cost-effectiveness estimates of NBS screening for SMA in the UK. Full article

The electrification of transport is rapidly reshaping power distribution networks, introducing new technical, regulatory, and operational challenges for Distribution System Operators (DSOs). This article presents an international review of electromobility integration strategies, analyzing experiences from Europe, Canada, Australia, and Greece. It examines how DSOs address grid impacts through smart charging, vehicle-to-grid (V2G) services, and demand flexibility mechanisms, alongside evolving regulatory and market frameworks. European initiatives—such as Germany’s Energiewende and the UK’s Demand Flexibility Service—demonstrate how coordinated planning and interoperability standards can transform electric vehicles (EVs) into valuable distributed energy resources. Case studies from Canada and Greece highlight region-specific challenges, such as limited access in remote communities or island grid constraints, while Australia’s high PV penetration offers unique opportunities for PV–EV synergies. The findings emphasize that DSOs must evolve into active system operators supported by digitalization, flexible market design, and user engagement. The study concludes by outlining implementation barriers, policy implications, and a roadmap for DSOs. Full article

Lean implementations often deploy tools in isolation, leaving gaps in how abnormalities are exposed, resolved at the root cause, escalated when needed, and converted into organisational learning. This study proposes a five-stage closed-loop routine for daily factory management that integrates problem visibility, standardised shop-floor cadence, disciplined problem-solving, and tiered escalation within a single operating logic. The novelty lies not in the individual Lean tools, but in the specification of cadence, triggers, accountable roles, and verification steps that connect them into a replicable end-to-end routine. The model was evaluated through a 19-month longitudinal, single-site field intervention (quasi-experimental before–and–after) on the bottleneck production line of a pharmaceutical plant in Hengoed, Wales (UK). Line OEE increased by over 50% in relative terms. At factory level, total output increased by 20% year-on-year in 2024 (context indicator), alongside qualitative field observations of shorter time-to-resolution and improved cross-functional coordination. As a single-site study, external validity is context-dependent; nevertheless, the paper provides a specified closed-loop routine and field evidence on the operational effects of embedding an integrated Lean cycle into daily management. Practically, the study provides a specified routine that practitioners can replicate and adapt; academically, it contributes to Lean implementation research by showing how tool bundles can be operationalised as an end-to-end daily management routine with observable performance effects. Full article

Migration is as old as human history. Over the centuries, there was never a time when migration stopped. The nineteenth century was characterised by the migration of Europeans to Africa. These movements were attributed to colonisation, commerce, and Christianisation. Christianity was used as a conduit of colonisation and the deculturation of the recipients of the missionary gospel. At the turn of the twenty-first century, there was a significant influx of Africans migrating to Europe. Among these migrants were worshippers from the Wesleyan Methodist Church in Zimbabwe (WMCZ). Using a missiological framework, this paper employs a qualitative research methodology to argue that the establishment of the WMCZ Fellowship, grounded in the mission and ecclesiology of the home church in the United Kingdom, is both a reverse and distant mission. To achieve this aim, this paper unpacks the methodology and the theoretical framework. It will also trace the development of the WMCZ in the United Kingdom (UK), discuss the hybridisation of Christianity, and justify the notion that the Fellowship is both a reverse and distant mission. The study makes recommendations that support the growth of the Fellowship. It concludes by arguing that the development of migrant churches in the UK can turn the MCB into a church with a white history, a black/multiracial face, and a white head that will eventually use a multiracial mind to survive in a white historical ecclesiology. Full article

Background/Objectives: A key disadvantage of DNA vaccines is ineffective uptake of plasmid DNA, resulting in low immunogenicity. A way to overcome it is forced DNA delivery, which requires specialized equipment and/or reagents. Effective delivery of plasmids without specialized devices or using commonly available ones would significantly increase DNA vaccine applicability. Here, we delivered DNA by intradermal injections, facilitating them by optimized sonoporation (SP) or electroporation (EP), and we compared these methods by their capacity to support the production of foreign proteins in mice. Methods: DNA delivery was optimized using the plasmid encoding firefly luciferase (Luc) (pVaxLuc). Luc production was assessed by bioluminescence imaging (BLI) (IVIS, PerkinElmer, Shelton, CT, USA; LumoTrace Fluo, Abisense, Dolgoprudny, Russia). Female BALB/c mice were injected intradermally (id) with pVaxLuc in phosphate buffers of varying ionic strengths. Injection sites were subjected to SP (Intelect Mobile, Chattanooga, UK) or EP (CUY21EDITII, BEX Co., Tokyo, Japan) or left untreated. Optimal delivery protocols were selected based on the highest in vivo levels of photon flux according to BLI. Optimal protocols for id injections with/without EP were applied to DNA-immunized mice with HIV-1 clade A reverse transcriptase. Antibody response induced by DNA immunization was assessed by ELISA. Results: The optimal phosphate buffers for id delivery had ionic strengths from 81 to 163 mmol/L. The optimal SP regimen included an acoustic pressure of 2.4 W/cm² applied in a duty cycle of 2%. The optimal EP regimen included bipolar driving pulses of 100 V, a pulse duration of 10 ms, and an interval between the pulses of 20 ms. Optimized DNA delivery by id/SP injection was inferior to both id/EP and id alone. DNA immunization with HIV-1 RT by id injections induced anti-RT antibodies in a titer of 10⁴ and by id/EP in a titer of 10⁵. Conclusions: Electroporation of the sites of id DNA injection provided the highest levels of production of luciferase reporters and induced a strong antibody response against HIV-1 RT. Full article