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30 pages, 2794 KiB  
Article
Plant Diversity of Concessions Held by Catholic Religious Groups in Three Cities of the Democratic Republic of the Congo
by Léa Mukubu Pika, Serge Mugisho Mukotanyi, David Pyame Onyo, Aloïse Bitagirwa Ndele, Joël Mobunda Tiko, Julien Bwazani Balandi, Kouagou Raoul Sambieni, Jean Pierre Meniko To Hulu, Jean-François Bastin, Jeroen Meersmans, Yannick Useni Sikuzani and Jan Bogaert
Sustainability 2025, 17(15), 6732; https://doi.org/10.3390/su17156732 - 24 Jul 2025
Viewed by 724
Abstract
Urbanization’s environmental challenges have increased interest in urban biodiversity, traditionally focused on public green spaces, which are shrinking as urban growth escapes government control. This study examines the understudied role of private actors—specifically Concessions held by Catholic Religious Groups (CRGs)—in biodiversity conservation across [...] Read more.
Urbanization’s environmental challenges have increased interest in urban biodiversity, traditionally focused on public green spaces, which are shrinking as urban growth escapes government control. This study examines the understudied role of private actors—specifically Concessions held by Catholic Religious Groups (CRGs)—in biodiversity conservation across three DRC cities (Bukavu, Kisangani, Lubumbashi). CRGs were selected due to Catholicism’s dominance and socio-economic influence in the DRC. A systematic flora inventory of 70 randomly sampled CRGs identified 220 species from 76 families and 185 genera. Although the CRG area was smaller in Lubumbashi (1.1 ha) than Bukavu (3.7 ha) and Kisangani (5.2 ha), the area did not correlate with species richness. Plant composition varied significantly within and between cities, dominated by phanerophytes and exotic species. These findings underscore the importance of including private stakeholders in urban biodiversity conservation. Full article
(This article belongs to the Section Sustainability, Biodiversity and Conservation)
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16 pages, 2350 KiB  
Article
The Impact of the Spread of Risks in the Upstream Trade Network of the International Cobalt Industry Chain
by Xiaoxue Wang, Han Sun, Linjie Gu, Zhenghao Meng, Liyi Yang and Jinhua Cheng
Sustainability 2025, 17(15), 6711; https://doi.org/10.3390/su17156711 - 23 Jul 2025
Viewed by 222
Abstract
The intensifying global competition for cobalt resources and the increasing likelihood of trade decoupling and disruption are profoundly impacting the global energy transition. In a globalized trade environment, a decline in cobalt supply from exporting countries can spread through the trade network, negatively [...] Read more.
The intensifying global competition for cobalt resources and the increasing likelihood of trade decoupling and disruption are profoundly impacting the global energy transition. In a globalized trade environment, a decline in cobalt supply from exporting countries can spread through the trade network, negatively affecting demand countries. Quantitative analysis of the negative impacts of export supply declines in various countries can help identify early risks in the global supply chain, providing a scientific basis for energy security, industrial development, and policy responses. This study constructs a trade network using trade data on metal cobalt, cobalt powder, cobalt concentrate, and ore sand from the upstream (mining, selection, and smelting) stages of the cobalt industry chain across 155 countries and regions from 2000 to 2023. Based on this, an impact diffusion model is established, incorporating the trade volumes and production levels of cobalt resources in each country to measure their resilience to shocks and determine their direct or indirect dependencies. The study then simulates the impact on countries (regions) when each country’s supply is completely interrupted or reduced by 50%. The results show that: (1) The global cobalt trade network exhibits a ‘one superpower, multiple strong players’ characteristic. Congo (DRC) has a far greater destructive power than other countries, while South Africa, Zambia, Australia, Russia, and other countries have higher destructive power due to their strong storage and production capabilities, strong smelting capabilities, or as important trade transit countries. (2) The global cobalt trade network primarily consists of three major risk areas. The African continent, the Philippines and Indonesia in Southeast Asia, Australia in Oceania, and Russia, the United States, China, and the United Kingdom in Eurasia and North America form the primary risk zones for global cobalt trade. (3) When there is a complete disruption or a 50% reduction in export supply, China will suffer the greatest average demand loss, far exceeding the second-tier countries such as the United States, South Africa, and Zambia. In contrast, European countries and other regions worldwide will experience the smallest average demand loss. Full article
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21 pages, 2049 KiB  
Article
Tracking Lava Flow Cooling from Space: Implications for Erupted Volume Estimation and Cooling Mechanisms
by Simone Aveni, Gaetana Ganci, Andrew J. L. Harris and Diego Coppola
Remote Sens. 2025, 17(15), 2543; https://doi.org/10.3390/rs17152543 - 22 Jul 2025
Viewed by 1016
Abstract
Accurate estimation of erupted lava volumes is essential for understanding volcanic processes, interpreting eruptive cycles, and assessing volcanic hazards. Traditional methods based on Mid-Infrared (MIR) satellite imagery require clear-sky conditions during eruptions and are prone to sensor saturation, limiting data availability. Here, we [...] Read more.
Accurate estimation of erupted lava volumes is essential for understanding volcanic processes, interpreting eruptive cycles, and assessing volcanic hazards. Traditional methods based on Mid-Infrared (MIR) satellite imagery require clear-sky conditions during eruptions and are prone to sensor saturation, limiting data availability. Here, we present an alternative approach based on the post-eruptive Thermal InfraRed (TIR) signal, using the recently proposed VRPTIR method to quantify radiative energy loss during lava flow cooling. We identify thermally anomalous pixels in VIIRS I5 scenes (11.45 µm, 375 m resolution) using the TIRVolcH algorithm, this allowing the detection of subtle thermal anomalies throughout the cooling phase, and retrieve lava flow area by fitting theoretical cooling curves to observed VRPTIR time series. Collating a dataset of 191 mafic eruptions that occurred between 2010 and 2025 at (i) Etna and Stromboli (Italy); (ii) Piton de la Fournaise (France); (iii) Bárðarbunga, Fagradalsfjall, and Sundhnúkagígar (Iceland); (iv) Kīlauea and Mauna Loa (United States); (v) Wolf, Fernandina, and Sierra Negra (Ecuador); (vi) Nyamuragira and Nyiragongo (DRC); (vii) Fogo (Cape Verde); and (viii) La Palma (Spain), we derive a new power-law equation describing mafic lava flow thickening as a function of time across five orders of magnitude (from 0.02 Mm3 to 5.5 km3). Finally, from knowledge of areas and episode durations, we estimate erupted volumes. The method is validated against 68 eruptions with known volumes, yielding high agreement (R2 = 0.947; ρ = 0.96; MAPE = 28.60%), a negligible bias (MPE = −0.85%), and uncertainties within ±50%. Application to the February-March 2025 Etna eruption further corroborates the robustness of our workflow, from which we estimate a bulk erupted volume of 4.23 ± 2.12 × 106 m3, in close agreement with preliminary estimates from independent data. Beyond volume estimation, we show that VRPTIR cooling curves follow a consistent decay pattern that aligns with established theoretical thermal models, indicating a stable conductive regime during the cooling stage. This scale-invariant pattern suggests that crustal insulation and heat transfer across a solidifying boundary govern the thermal evolution of cooling basaltic flows. Full article
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24 pages, 3066 KiB  
Article
Urban Flood Susceptibility Mapping Using GIS and Analytical Hierarchy Process: Case of City of Uvira, Democratic Republic of Congo
by Isaac Bishikwabo, Hwaba Mambo, John Kowa Kamanda, Chérifa Abdelbaki, Modester Alfred Nanyunga and Navneet Kumar
GeoHazards 2025, 6(3), 38; https://doi.org/10.3390/geohazards6030038 - 21 Jul 2025
Viewed by 350
Abstract
The city of Uvira, located in the eastern Democratic Republic of Congo (DRC), is increasingly experiencing flood events with devastating impacts on human life, infrastructure, and livelihoods. This study evaluates flood susceptibility in Uvira using Geographic Information Systems (GISs), and an Analytical Hierarchy [...] Read more.
The city of Uvira, located in the eastern Democratic Republic of Congo (DRC), is increasingly experiencing flood events with devastating impacts on human life, infrastructure, and livelihoods. This study evaluates flood susceptibility in Uvira using Geographic Information Systems (GISs), and an Analytical Hierarchy Process (AHP)-based Multi-Criteria Decision Making approach. It integrates eight factors contributing to flood occurrence: distance from water bodies, elevation, slope, rainfall intensity, drainage density, soil type, topographic wetness index, and land use/land cover. The results indicate that proximity to water bodies, drainage density and slope are the most influential factors driving flood susceptibility in Uvira. Approximately 87.3% of the city’s land area is classified as having high to very high flood susceptibility, with the most affected zones concentrated along major rivers and the shoreline of Lake Tanganyika. The reliability of the AHP-derived weights is validated by a consistency ratio of 0.008, which falls below the acceptable threshold of 0.1. This research provides valuable insights to support urban planning and inform flood management strategies. Full article
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36 pages, 3151 KiB  
Article
Floristic Diversity and Stand Structure of Tree Species in Historical Rubber Plantations (Hevea brasiliensis Wild ex A. Juss) in Sankuru, DR Congo: Implications for Biodiversity Conservation
by Joël Mobunda Tiko, Serge Shakanye Ndjadi, Jean Pierre Azenge, Yannick Useni Sikuzani, Lebon Aganze Badesire, Prince Baraka Lucungu, Maurice Kesonga Nsele, Julien Bwazani Balandi, Jémima Lydie Obandza-Ayessa, Josué Muganda Matabaro, Jean Pierre Mate Mweru, Olivia Lovanirina Rakotondrasoa and Jean Pierre Meniko To Hulu
Conservation 2025, 5(3), 37; https://doi.org/10.3390/conservation5030037 - 21 Jul 2025
Viewed by 512
Abstract
The rubber plantations in Sankuru province, located in the Democratic Republic of Congo (DRC), have historically been pivotal to the regional economy. However, the absence of suitable silvicultural practices has promoted self-regeneration, resulting in the proliferation of diverse species. This study aims to [...] Read more.
The rubber plantations in Sankuru province, located in the Democratic Republic of Congo (DRC), have historically been pivotal to the regional economy. However, the absence of suitable silvicultural practices has promoted self-regeneration, resulting in the proliferation of diverse species. This study aims to characterize species richness and plant structure of these plantations. To this end, 80 subplots measuring 0.25 hectares were meticulously established, with a proportionate division between state-owned and farmer plantations. The results obtained from this study indicate that these plantations are home to approximately 105 species, classified into 33 distinct botanical families, with dominant families such as Fabaceae, Meliaceae, Euphorbiaceae, Olacaceae, Clusiaceae, and Moraceae. Despite the similarity between the two types of plantations (Cs = 58%), significant disparities were observed in terms of individuals, 635 ± 84.06 and 828 ± 144.62 (p < 10−3); species, 41 ± 7.49 and 28 ± 4.59 (p < 10−3); families, 19 ± 3.06 and 16 ± 1.62 (p < 10−2); and basal area, 29.88 ± 5.8 and 41.37 ± 7.57 (p < 10−2) for state and peasant plantations, respectively. State plantations exhibited greater diversity (H′ = 1.87) and enhanced equity (J’ = 0.43) than peasant plantations. The diametric structure exhibited an inverted J-shaped distribution, indicating constant and regular regeneration of these plantations. The upper canopy dominates the vertical structure in both types of plantations, with a significantly higher proportion in peasant plantations (83.60%) than in state plantations (73.8%), ANOVA (F (2.24 = 21.78), df = 24; p = 4.03 × 10−6). The findings indicate that the sustainable management of these plantations could incorporate agroecological principles to promote the coexistence of rubber production and biodiversity conservation while contributing to the restoration of degraded ecosystems and the well-being of local communities. Full article
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14 pages, 4342 KiB  
Review
Spatiotemporal Distribution and Risk Factors of African Swine Fever Outbreak Cases in Uganda for the Period 2010–2023
by Eddie M. Wampande, Robert Opio, Simon P. Angeki, Corrie Brown, Bonto Faburay, Rose O. Ademun, Kenneth Ssekatawa, David D. South, Charles Waiswa and Peter Waiswa
Viruses 2025, 17(7), 998; https://doi.org/10.3390/v17070998 - 16 Jul 2025
Viewed by 296
Abstract
This paper describes the spatiotemporal distribution and risk factors of African Swine Fever (ASF) in Uganda for the period of 2010 through 2023. The study utilized a comprehensive dataset from monthly reports (2010–2023) from District Veterinary Officers (DVOs), the Ministry of Agriculture, Animal [...] Read more.
This paper describes the spatiotemporal distribution and risk factors of African Swine Fever (ASF) in Uganda for the period of 2010 through 2023. The study utilized a comprehensive dataset from monthly reports (2010–2023) from District Veterinary Officers (DVOs), the Ministry of Agriculture, Animal Industry and Fisheries (MAAIF), and the Food and Agriculture Organization, Uganda. Using GPS coordinates, ASF cases were mapped using QGIS to show ASF distribution and spread in Uganda. Moran’s I analysis was used to delineate clusters of ASF. A total of 1521 ASF cases were recorded. The data show that cases of ASF were disseminated throughout the country, with more cases of ASF documented in the central region and border districts (hotspots for ASF), and few cases were reported in Acholi, Karamoja, and Lango, Ankole, West Nile, and Kigezi sub-regions. The time series analysis revealed incidences of ASF disease occurring year-round; notable peak cases were observed in some districts, and districts with ≥30,000 pigs reported higher cases of ASF. The Moran’s I (≥1) analysis showed that ASF is either aggregated (p = 0.01), especially in central districts bordering Tanzania and lake shores, or sporadic in occurrence. The disease was present in 66% of the districts, with ASF occurring throughout the year. More cases were aggregated in central and border districts and districts with large pig populations (≥30,000). Sporadic cases were reported in districts bordering the DRC, Sudan, Kenya, the lake shores, Karamoja, Acholi, and Lango sub-regions. Full article
(This article belongs to the Section Animal Viruses)
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25 pages, 24048 KiB  
Article
SD-LSTM: A Dynamic Time Series Model for Predicting the Coupling Coordination of Smart Agro-Rural Development in China
by Chunlin Xiong, Yilin Zhang and Weijie Wang
Agriculture 2025, 15(14), 1491; https://doi.org/10.3390/agriculture15141491 - 11 Jul 2025
Viewed by 368
Abstract
The rapid advancement of digital information technology in rural China has positioned smart agro-rural development as a key driver of agricultural modernization. This study focuses on the theme of digital rural construction (DRC) and high-quality agricultural development (HAD), combining the two into smart [...] Read more.
The rapid advancement of digital information technology in rural China has positioned smart agro-rural development as a key driver of agricultural modernization. This study focuses on the theme of digital rural construction (DRC) and high-quality agricultural development (HAD), combining the two into smart agriculture and rural development. Utilizing panel data from 31 Chinese provinces from 2011 to 2022, a comprehensive evaluation index system is constructed to assess development levels. The entropy weight method and kernel density estimation are employed to evaluate indicator performance and capture dynamic distribution patterns. A coupling coordination model is used to analyze the spatio-temporal evolution of the interaction between the two systems, while a hybrid SD-LSTM (System Dynamics–Long Short-Term Memory) model forecasts coordination trends over the next six years. Results reveal a steady upward trend in both systems, with coordination levels improving from “moderate imbalance” to “moderate coordination.” A distinct spatial pattern emerges, characterized by “high in the east, low in the west” and a mismatch between high coupling and low coordination. Forecasts suggest a continued progression toward “good coordination.” The findings offer policy implications for enhancing digital village initiatives, accelerating rural technological diffusion, and strengthening regional collaboration—providing valuable insights into advancing China’s smart rural transformation and agricultural modernization. Full article
(This article belongs to the Section Agricultural Economics, Policies and Rural Management)
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27 pages, 7655 KiB  
Article
Subsidy Policy Interactions in Agricultural Supply Chains: An Interdepartmental Coordination Perspective
by Aibo Yao, Lin Jiang, Bingxue Guo and Wei Li
Agriculture 2025, 15(14), 1464; https://doi.org/10.3390/agriculture15141464 - 8 Jul 2025
Viewed by 236
Abstract
The efficacy of government subsidy programs in agriculture is frequently compromised by internal policy conflicts that arise between competing government departments. This challenge is addressed herein, with a focus on the policy environment in China, through the development of a game-theoretic model of [...] Read more.
The efficacy of government subsidy programs in agriculture is frequently compromised by internal policy conflicts that arise between competing government departments. This challenge is addressed herein, with a focus on the policy environment in China, through the development of a game-theoretic model of an agricultural supply chain. This model explicitly incorporates two competing government bodies—the Agriculture and Rural Affairs Department (ARAD) and the Development and Reform Commission (DRC)—each with distinct objectives and performance indicators. Within this framework, the strategic interactions of four subsidy types are analyzed: production and cold-chain subsidies (ARAD), and platform operation and blockchain subsidies (DRC). The findings reveal that department-specific performance indicators can significantly distort the overall effectiveness of subsidies. While individual subsidies may achieve their intended departmental goals, their combined impact is shown to be complex and frequently suboptimal in the absence of higher-level coordination. Notably, a subsidy portfolio combining production and platform operation subsidies is found to consistently yield superior performance in maximizing social welfare. Ultimately, this research contributes a new framework for understanding subsidy policies and provides actionable insights for optimizing interdepartmental coordination to enhance supply chain performance. Full article
(This article belongs to the Section Agricultural Economics, Policies and Rural Management)
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27 pages, 1836 KiB  
Article
Benchmarking Virtual Physics Labs: A Multi-Method MCDA Evaluation of Curriculum Compliance and Pedagogical Efficacy
by Rama M. Bazangika, Ruffin-Benoît M. Ngoie, Jean-Roger M. Bansimba, God’El K. Kinyoka and Billy Nzau Matondo
Information 2025, 16(7), 587; https://doi.org/10.3390/info16070587 - 8 Jul 2025
Viewed by 355
Abstract
In this paper, we propose the use of virtual labs (VLs) as a solution to bridge the gap between theory and practice in physics education. Through an experiment conducted in two towns in the Democratic Republic of the Congo (DRC), we demonstrate that [...] Read more.
In this paper, we propose the use of virtual labs (VLs) as a solution to bridge the gap between theory and practice in physics education. Through an experiment conducted in two towns in the Democratic Republic of the Congo (DRC), we demonstrate that our proposed lab (BRVL) is more effective than global alternatives in correcting misconceptions and ensuring compliance with the current curriculum in the DRC. We combine Conjoint Analysis (from SPSS) to weigh selected criteria—curriculum compliance, knowledge construction, misconception correction, and usability—alongside eight MCDA methods: AHP, CAHP, TOPSIS, ELECTRE I, ELECTRE II, ELECTRE TRI, PROMETHEE I, and PROMETHEE II. Our findings show that, among six VLs, BRVL consistently outperforms global alternatives like Algodoo and Physion in terms of pedagogical alignment, curriculum compliance, and correction of misconceptions for Congolese schools. Methodologically, the respondents are consistent and in agreement, despite individual differences. The sensitivity analysis of the ELECTRE and PROMETHEE methods has shown that changes in parameter values do not alter the conclusion that BRVL is the best among the compared VLs. Full article
(This article belongs to the Special Issue New Applications in Multiple Criteria Decision Analysis, 3rd Edition)
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14 pages, 1911 KiB  
Article
Chaining Differential Reinforcement of Compliance and Functional Communication Training to Treat Challenging Behavior Maintained by Negative Reinforcement
by Emily L. Ferris, Alexandra R. Howard, Eleni Baker, Andrew R. Craig, Henry S. Roane and William E. Sullivan
Behav. Sci. 2025, 15(7), 891; https://doi.org/10.3390/bs15070891 - 30 Jun 2025
Viewed by 506
Abstract
Differential reinforcement of compliance (DRC) and functional communication training (FCT) are two effective treatments for escape-maintained behavior. They each, however, have unique limitations. This study aimed to replicate and extend past work by isolating the effects of each treatment and assessing for treatment [...] Read more.
Differential reinforcement of compliance (DRC) and functional communication training (FCT) are two effective treatments for escape-maintained behavior. They each, however, have unique limitations. This study aimed to replicate and extend past work by isolating the effects of each treatment and assessing for treatment preference. FCT produced larger reductions in challenging behavior and lower levels of compliance relative to DRC, which produced elevated levels of both compliance and challenging behavior. Additionally, all participants preferred FCT to DRC. Overall, challenging behavior was low and compliance was high when both treatments were embedded within a chained schedule, and these reductions were maintained throughout fading. Full article
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19 pages, 1289 KiB  
Article
Upholding the Right to Health in Contexts of Displacement: A Whole-of-Route Policy Analysis in South Africa, Kenya, Somalia, and the Democratic Republic of Congo
by Rebecca Walker, Jo Vearey, Ahmed Said Bile and Genèse Lobukulu Lolimo
Int. J. Environ. Res. Public Health 2025, 22(7), 1042; https://doi.org/10.3390/ijerph22071042 - 30 Jun 2025
Viewed by 488
Abstract
The Sustainable Development Goals commit states to Universal Health Coverage (UHC) for all; yet displaced populations—including asylum seekers, refugees, internally displaced persons (IDPs), and undocumented migrants—remain systematically excluded from national health systems across southern and eastern Africa. This paper applies a whole-of-route, rights-based [...] Read more.
The Sustainable Development Goals commit states to Universal Health Coverage (UHC) for all; yet displaced populations—including asylum seekers, refugees, internally displaced persons (IDPs), and undocumented migrants—remain systematically excluded from national health systems across southern and eastern Africa. This paper applies a whole-of-route, rights-based framework to examine how legal status, policy implementation, and structural governance shape healthcare access for displaced populations across South Africa, Kenya, Somalia, and the Democratic Republic of Congo (DRC). Drawing on 70 key informant interviews and policy analysis conducted between 2020 and 2025, the study finds that despite formal commitments to health equity, access remains constrained by restrictive legal regimes, administrative discretion, and fragmented service delivery models. Critical gaps persist in migration-sensitive planning, gender-responsive care, and mental health integration. The findings highlight the limitations of rights-based rhetoric in the absence of legal coherence, intersectoral coordination, and political will. To realise UHC in displacement contexts, health systems must move beyond citizen-centric models and embed migration-aware, inclusive, and sustainable approaches across all stages of displacement. Without such structural reforms, displaced populations will remain at the margins of national health agendas—and the promise of health for all will remain unmet. Full article
(This article belongs to the Special Issue SDG 3 in Sub-Saharan Africa: Emerging Public Health Issues)
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14 pages, 1822 KiB  
Article
Phylogenetic Analysis of the Mpox Virus in Sub-Saharan Africa (2022–2024)
by Millicent Ochieng, Daniel Kiboi, Carolyne Nasimiyu, Eric Osoro, Dorcus C. A. Omoga and Josiah O. Kuja
Biology 2025, 14(7), 773; https://doi.org/10.3390/biology14070773 - 26 Jun 2025
Viewed by 1189
Abstract
Mpox, caused by the Mpox virus (MPXV), is a re-emerging zoonotic disease in the Poxviridae family. Since 2022, sub-Saharan Africa has experienced recurrent outbreaks, with the Democratic Republic of the Congo (DRC) accounting for 96% of the 567 confirmed cases reported in the [...] Read more.
Mpox, caused by the Mpox virus (MPXV), is a re-emerging zoonotic disease in the Poxviridae family. Since 2022, sub-Saharan Africa has experienced recurrent outbreaks, with the Democratic Republic of the Congo (DRC) accounting for 96% of the 567 confirmed cases reported in the African region by the World Health Organization as of June 2024. Despite MPXV’s endemic presence, its genomic diversity and evolutionary dynamics remain poorly characterized. We analyzed 270 MPXV genomes from 13 sub-Saharan African countries (2022–2024), representing the most geographically comprehensive regional dataset from the outbreak period. Phylogenetic analysis identified two geographically distinct clades: Clade I (East/Central Africa) and Clade II (West/Southern Africa). A marked disparity in APOBEC3-associated mutations was observed, with Clade IIb exhibiting significantly higher enrichment than Clade I, suggesting clade-specific host adaptation pressures. These mutations predominantly target genes involved in immune evasion and replication. Preliminary functional predictions indicated that selected missense mutations may impact on protein stability, underscoring the need for further experimental validation. Our findings provide the first pan–sub-Saharan analysis of MPXV clade divergence and reinforce the importance of sustained, regionally informed genomic surveillance to monitor viral evolution and guide outbreak response strategies across Africa. Full article
(This article belongs to the Section Biochemistry and Molecular Biology)
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18 pages, 2609 KiB  
Article
Assessment of Oral Poliovirus Vaccine Viability and Titer at Delivery Points in Kinshasa, the Democratic Republic of the Congo: Implications for Cold Chain Management
by Gracia Kashitu-Mujinga, Anguy Makaka-Mutondo, Meris Matondo-Kuamfumu, Fabrice Mambu-Mbika, Junior Bulabula-Penge, Trésor Kabeya-Mampuela, Frida Nkawa, Grace Wanet-Tayele, Bibiche Nsunda-Makanzu, Pierre Nsele-Muntatu, Lusamba Kabamba, Antoine Nkuba-Ndaye, Aimé Mwana wa bene Cikomola, Elisabeth Mukamba-Musenga and Steve Ahuka-Mundeke
Vaccines 2025, 13(7), 680; https://doi.org/10.3390/vaccines13070680 - 25 Jun 2025
Viewed by 439
Abstract
Background: Poliomyelitis is a vaccine-preventable disease, with oral poliomyelitis vaccines (OPVs) and injectable poliomyelitis vaccines. In the Democratic Republic of the Congo (DRC), circulating vaccine-derived polioviruses (VDPVs) persist due to intrinsic and extrinsic factors, including the quality of the cold chain, which may [...] Read more.
Background: Poliomyelitis is a vaccine-preventable disease, with oral poliomyelitis vaccines (OPVs) and injectable poliomyelitis vaccines. In the Democratic Republic of the Congo (DRC), circulating vaccine-derived polioviruses (VDPVs) persist due to intrinsic and extrinsic factors, including the quality of the cold chain, which may make the vaccines less effective. This study’s objective was to evaluate the cold chain’s quality of OPVs and its effect on the vaccine’s viability and potency at different levels in health systems in Kinshasa. Methods: A cross-sectional study was conducted in Kinshasa, collecting OPVs at different levels of the health pyramid. Vaccine viability was assessed by cell culture using a modified World Health Organization (WHO) protocol, and the viral titer was determined using the Karber formula. The vaccine titer was classified as “very good”, “good”, or “poor” according to the WHO standard’s viral titer. Results: A total of 53 vaccines were collected and analyzed, compressing 38 bivalent oral poliomyelitis (bOPV) vaccines and 15 novel oral poliomyelitis vaccines, type 2 (nOPV2). The viral titer ranged from log105.8 to log 107.3 and from log105.4 to log108.9 for the nOPV2 and the bOPV, respectively. Of these 53 vaccine samples, 10% of the bOPVs showed viral titers below the recommended WHO threshold (>106 CCID50/dose), 100% of the nOPV2 had viral titers within the WHO standards (>105 CCID50/dose), and a significant decline in the viral titer was observed for both types of vaccines (nOPV2 and bOPV) as the distribution progressed along the level of the health pyramid. Conclusions: This study demonstrated that the viral titer of OPV declined from central to peripheral areas in routine and campaign strategies in Kinshasa. Full article
(This article belongs to the Section Vaccines and Public Health)
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8 pages, 206 KiB  
Commentary
Clinical and Occupational Predictors of Mortality in Ebola Virus Disease: A Commentary from the Democratic Republic of Congo (2018–2020)
by Jean Paul Muambangu Milambo and Charles Bitamazire Businge
Infect. Dis. Rep. 2025, 17(3), 71; https://doi.org/10.3390/idr17030071 - 18 Jun 2025
Viewed by 337
Abstract
Background: This commentary analyzes demographic, clinical, and occupational characteristics associated with Ebola virus disease (EVD) outcomes during the 2018–2020 outbreak in the Democratic Republic of Congo (DRC). Methods: A total of 3477 EVD cases were included. Descriptive statistics and univariate and multivariate Cox [...] Read more.
Background: This commentary analyzes demographic, clinical, and occupational characteristics associated with Ebola virus disease (EVD) outcomes during the 2018–2020 outbreak in the Democratic Republic of Congo (DRC). Methods: A total of 3477 EVD cases were included. Descriptive statistics and univariate and multivariate Cox regression analyses were performed to evaluate associations between clinical outcomes and patient characteristics. Comorbidity estimates and healthcare worker (HCW) occupational exposure data were incorporated based on the literature. Results: The median age was 26.5 years (SD = 16.1), with the majority (59.7%) aged 20–59. Males represented 51.3% of the cohort. Most patients (81.8%) worked in occupations that were not disease-exposing. Overall, 450 patients (12.9%) died. Although comorbidities initially appeared predictive of mortality (unadjusted HR: 3.05; 95% CI: 2.41–3.87), their effect was not statistically significant after adjustment (adjusted HR: 1.17; 95% CI: 0.87–1.59; p = 0.301). The strongest predictor of death was clinical status at admission: patients classified as “very sick” had an alarmingly high adjusted hazard ratio (HR) of 236.26 (95% CI: 33.18–1682.21; p < 0.001). Non-disease-exposing occupations were also associated with increased mortality (adjusted HR: 1.75; 95% CI: 1.33–2.31; p < 0.001). Conclusions: Despite improvements in outbreak response, mortality remains disproportionately high among patients presenting in critical condition and those outside the health sector. These findings underscore the importance of early detection strategies and enhanced protection for all occupational groups during EVD outbreaks. Full article
16 pages, 2091 KiB  
Article
Effectiveness of Pyrethroid-Piperonyl Butoxide Nets Versus Standard Pyrethroid-Only Nets in Preventing Malaria in Children Under 10 Years Living in Kisantu Health Zone, Democratic Republic of the Congo
by Gillon Ilombe, Joris Losimba Likwela, Philippe Lukanu, Aimée Lulebo, Nicole Muela, Joachim Mariën, Kennedy Makola Mbanzulu, Baby Mabanzila, Junior Rika Matangila, Fiacre Agossa, Eric Mukomena, Sylvie Linsuke, Albert Kalonji, Pascal Lutumba, Jean-Pierre Van Geertruyden and Seth R. Irish
Trop. Med. Infect. Dis. 2025, 10(6), 172; https://doi.org/10.3390/tropicalmed10060172 - 18 Jun 2025
Viewed by 533
Abstract
Democratic Republic of the Congo (DRC) is among the countries that have a high malaria incidence. In an effort to combat this public health challenge, innovative tools and strategies are being developed and evaluated. Among the new generation of nets with improved effectiveness [...] Read more.
Democratic Republic of the Congo (DRC) is among the countries that have a high malaria incidence. In an effort to combat this public health challenge, innovative tools and strategies are being developed and evaluated. Among the new generation of nets with improved effectiveness of insecticides, those treated with a combination of piperonyl butoxide (PBO) and pyrethroids appear to be a promising malaria control tool. This study evaluated the effectiveness of this combination under community conditions of use in the DRC. A quasi-experimental study was carried out from January to December 2018, in Kisantu Health Zone. Thirty villages were randomly allocated as clusters (1:1) to receive one of two types of long-lasting insecticidal nets (LLIN) treated with deltamethrin alone, or PBO with deltamethrin. After the intervention, the assessments were conducted monthly, quarterly, and every six months for malaria infection, mosquito density, and LLIN durability, respectively. Comparison of changes in different indices between the two groups was made using generalized linear models to correct for non-linear effects. A total of 1790 children were included. There was a significant non-linear effect of time (months) on the malaria infection incidence. The malaria infection incidence was higher in January–March, May–June, and November. It remained higher in the control group compared to the intervention group over time. Similarly, there was a significant non-linear effect of time on the density of both Anopheles funestus s.l. and Anopheles gambiae s.l. These densities decreased after the first month following the intervention and increased after 6 months. Twelve months later, a cohort follow-up showed that the bio-efficacy of LLINs was better in the intervention group. The nets treated with the combination of PBO and deltamethrin appear to be more effective for malaria control under community conditions in the DRC, but a loss of chemical durability is noted after the first year of use. Full article
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