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Keywords = terahertz time domain spectroscopy (THz-TDS)

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15 pages, 4734 KiB  
Article
Research on the Terahertz Modulation Performance of VO2 Thin Films with Surface Plasmon Polaritons Structure
by Tao Chen, Qi Zhang, Jin Wang, Jiran Liang and Weibin Zhou
Coatings 2025, 15(7), 838; https://doi.org/10.3390/coatings15070838 - 17 Jul 2025
Viewed by 307
Abstract
This paper focuses on the switching and modulation techniques of terahertz waves, develops VO2 thin-film materials with an SPP structure, and uses terahertz time-domain spectroscopy (THz-TDS) to study the semiconductor–metal phase transition characteristics of VO2 thin films, especially the photoinduced semiconductor–metal [...] Read more.
This paper focuses on the switching and modulation techniques of terahertz waves, develops VO2 thin-film materials with an SPP structure, and uses terahertz time-domain spectroscopy (THz-TDS) to study the semiconductor–metal phase transition characteristics of VO2 thin films, especially the photoinduced semiconductor–metal phase transition characteristics of silicon-based VO2 thin films. The optical modulation characteristics of silicon-based VO2 thin films to terahertz waves under different light excitation modes, such as continuous light irradiation at different wavelengths and femtosecond pulsed laser irradiation, were analyzed. Combining the optical modulation characteristics of silicon-based VO2 thin films with the filtering characteristics of SPP structures, composite structures of VO2 thin films with metal hole arrays, composite structures of VO2 thin films with metal block arrays, and silicon-based VO2 microstructure arrays were designed. The characteristics of this dual-function device were tested experimentally. The experiment proves that the VO2 film material with an SPP structure has a transmission rate dropping sharply from 32% to 1% under light excitation; the resistivity changes by more than six orders of magnitude, and the modulation effect is remarkable. By applying the SPP structure to the VO2 material, the material can simultaneously possess modulation and filtering functions, enhancing its optical performance in the terahertz band. Full article
(This article belongs to the Section Thin Films)
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10 pages, 1976 KiB  
Article
kHz Noise-Suppressed Asymmetric Dual-Cavity Bidirectional Femtosecond Fiber Laser
by Yongli Liu, Zhaohui Zhang, Pingan Liu and Liguo Zhu
Photonics 2025, 12(7), 671; https://doi.org/10.3390/photonics12070671 - 2 Jul 2025
Viewed by 259
Abstract
We demonstrate a novel bidirectional mode-locked ultrafast fiber laser based on an asymmetric dual-cavity architecture that enables freely tunable repetition rate differentials at the kilohertz level, while maintaining inherent common-mode noise suppression through precision thermomechanical stabilization. Through cascaded amplification and nonlinear temporal compression, [...] Read more.
We demonstrate a novel bidirectional mode-locked ultrafast fiber laser based on an asymmetric dual-cavity architecture that enables freely tunable repetition rate differentials at the kilohertz level, while maintaining inherent common-mode noise suppression through precision thermomechanical stabilization. Through cascaded amplification and nonlinear temporal compression, we obtained bidirectional pulse durations of 33.2 fs (clockwise) and 61.6 fs (counterclockwise), respectively. The developed source demonstrates exceptional capability for asynchronous optical sampling applications, particularly in enabling the compact implementation of real-time measurement systems such as terahertz time-domain spectroscopy (THz-TDS) systems. Full article
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15 pages, 4137 KiB  
Article
Non-Destructive Thickness Measurement of Energy Storage Electrodes via Terahertz Technology
by Zhengxian Gao, Xiaoqing Jia, Jin Wang, Zhijun Zhou, Jianyong Wang, Dongshan Wei, Xuecou Tu, Lin Kang, Jian Chen, Dengzhi Chen and Peiheng Wu
Sensors 2025, 25(13), 3917; https://doi.org/10.3390/s25133917 - 23 Jun 2025
Viewed by 440
Abstract
Precision thickness control in new energy electrode coatings is a critical determinant of battery performance characteristics. This study presents a non-destructive inspection methodology employing terahertz time-domain spectroscopy (THz-TDS) to achieve high-precision coating thickness measurement in lithium iron phosphate (LFP) battery manufacturing. Industrial THz-TDS [...] Read more.
Precision thickness control in new energy electrode coatings is a critical determinant of battery performance characteristics. This study presents a non-destructive inspection methodology employing terahertz time-domain spectroscopy (THz-TDS) to achieve high-precision coating thickness measurement in lithium iron phosphate (LFP) battery manufacturing. Industrial THz-TDS systems mostly adopt fixed threshold filtering or Fourier filtering, making it disssssfficult to balance noise suppression and signal fidelity. The developed approach integrates three key technological advancements. Firstly, the refractive index of the material is determined through multi-peak amplitude analysis, achieving an error rate control within 1%. Secondly, a hybrid signal processing algorithm is applied, combining an optimized Savitzky–Golay filter for high-frequency noise suppression with an enhanced sinc function wavelet threshold technique for signal fidelity improvement. Thirdly, the time-of-flight method enables real-time online measurement of coating thickness under atmospheric conditions. Experimental validation demonstrates effective thickness measurement across a 35–425 μm range, achieving a 17.62% range extension and a 2.13% improvement in accuracy compared to conventional non-filtered methods. The integrated system offers a robust quality control solution for next-generation battery production lines. Full article
(This article belongs to the Section Physical Sensors)
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15 pages, 2061 KiB  
Article
Defect Recognition in Composite Materials Using Terahertz Spectral Imaging with ResNet18-SVM Approach
by Zhongmin Wang, Jiaojie Chen, Yilong Xin, Yongbin Guo, Yizhang Li, Huanyu Sun and Xiuwei Yang
Materials 2025, 18(11), 2444; https://doi.org/10.3390/ma18112444 - 23 May 2025
Viewed by 491
Abstract
Multilayer composite materials often develop internal defects at varying depths due to manufacturing and environmental factors. Traditional planar scanning methods lack the ability to pinpoint defect locations in depth. This study proposes a terahertz time-domain spectroscopy (THz-TDS)-based defect detection method using continuous wavelet [...] Read more.
Multilayer composite materials often develop internal defects at varying depths due to manufacturing and environmental factors. Traditional planar scanning methods lack the ability to pinpoint defect locations in depth. This study proposes a terahertz time-domain spectroscopy (THz-TDS)-based defect detection method using continuous wavelet transform (CWT) to convert spectral signals into time-frequency images. These are analyzed by the ResNet18 model combined with a support vector machine (SVM) classifier. Comparative experiments with four classical deep learning models and three classifiers show that the Residual Network with 18 layers (ResNet18-SVM) approach achieves the highest accuracy of 98.56%, effectively identifying three types of defects. The results demonstrate the method’s strong feature extraction, depth resolution, and its potential for nondestructive evaluation of multilayer structures. Full article
(This article belongs to the Section Manufacturing Processes and Systems)
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19 pages, 5369 KiB  
Article
Interactions of Terahertz Photons with Phonons of Two-Dimensional van der Waals MoS2/WSe2/MoS2 Heterostructures and Thermal Responses
by Jingwen Huang, Ningsheng Xu, Yumao Wu, Xue Ran, Yue Fang, Hongjia Zhu, Weiliang Wang, Huanjun Chen and Shaozhi Deng
Materials 2025, 18(7), 1665; https://doi.org/10.3390/ma18071665 - 4 Apr 2025
Viewed by 863
Abstract
The interaction between terahertz (THz) photons and phonons of materials is crucial for the development of THz photonics. In this work, typical two-dimensional (2D) van der Waals (vdW) transition metal chalcogenide (TMD) layers and heterostructures are used in THz time-domain spectroscopy (TDS) measurements, [...] Read more.
The interaction between terahertz (THz) photons and phonons of materials is crucial for the development of THz photonics. In this work, typical two-dimensional (2D) van der Waals (vdW) transition metal chalcogenide (TMD) layers and heterostructures are used in THz time-domain spectroscopy (TDS) measurements, low-wavenumber Raman spectroscopy measurements, calculation of 2D materials’ phonon spectra, and theoretical analysis of thermal responses. The TDS results reveal strong absorption of THz photons in the frequency range of 2.5–10 THz. The low-wavenumber Raman spectra show the phonon vibration characteristics and are used to establish phonon energy bands. We also set up a computational simulation model for thermal responses. The temperature increases and distributions in the individual layers and their heterostructures are calculated, showing that THz photon absorption results in significant increases in temperature and differences in the heterostructures. These give rise to interesting photothermal effects, including the Seebeck effect, resulting in voltages across the heterostructures. These findings provide valuable guidance for the potential optoelectronic application of the 2D vdW heterostructures. Full article
(This article belongs to the Special Issue Terahertz Vibrational Spectroscopy in Advanced Materials)
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13 pages, 5633 KiB  
Article
Mechanistic Study of L-Rhamnose Monohydrate Dehydration Using Terahertz Spectroscopy and Density Functional Theory
by Bingxin Yan, Zeyu Hou, Yuhan Zhao, Bo Su, Cunlin Zhang and Kai Li
Molecules 2025, 30(5), 1189; https://doi.org/10.3390/molecules30051189 - 6 Mar 2025
Viewed by 783
Abstract
L-rhamnose has recently gained attention for its potential to enhance vaccine antigenicity. To optimize its use as a vaccine adjuvant, it is important to understand the dehydration behavior of L-rhamnose monohydrate, which plays a critical role in modifying its physicochemical properties. This study [...] Read more.
L-rhamnose has recently gained attention for its potential to enhance vaccine antigenicity. To optimize its use as a vaccine adjuvant, it is important to understand the dehydration behavior of L-rhamnose monohydrate, which plays a critical role in modifying its physicochemical properties. This study investigated the spectroscopic characteristics of L-rhamnose and its monohydrate using terahertz time-domain spectroscopy (THz-TDS), Raman spectroscopy, and powder X-ray diffraction (PXRD). The results indicate that THz-TDS can more effectively distinguish the spectral features of these two compounds and can be used to reflect the structural changes in L-rhamnose monohydrate before and after dehydration. THz spectral data show that dehydration of L-rhamnose occurs at 100 °C, and continuous heating at 100 °C can complete the dehydration process within 6 min. Density functional theory (DFT) calculations revealed that water molecule vibrations significantly affect the THz absorption peaks. These findings indicate that removing water during dehydration causes substantial changes in molecular structure and dynamics. Overall, this study highlights the value of combining THz-TDS with DFT calculations to investigate the structures of carbohydrates and their hydrates, providing an accurate method for understanding the dehydration process and molecular interactions in hydrated systems. This approach holds significant importance for the development of effective vaccine adjuvants. Full article
(This article belongs to the Special Issue Exclusive Feature Papers in Analytical Chemistry)
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10 pages, 2881 KiB  
Article
Observation of Boson Peak of Fragile Baltic Amber Glass by Terahertz Time-Domain Spectroscopy
by Toru Sasaki, Soo Han Oh, Tatsuya Mori and Seiji Kojima
Materials 2024, 17(23), 5956; https://doi.org/10.3390/ma17235956 - 5 Dec 2024
Viewed by 1115
Abstract
Amber is a fragile (in Angell’s classification) natural glass that has performed maturation processes over geological time. The terahertz dynamics of Baltic amber that was about 40 million years old were studied by terahertz time-domain spectroscopy (THz-TDS) in the frequency range of 0.2 [...] Read more.
Amber is a fragile (in Angell’s classification) natural glass that has performed maturation processes over geological time. The terahertz dynamics of Baltic amber that was about 40 million years old were studied by terahertz time-domain spectroscopy (THz-TDS) in the frequency range of 0.2 and 6.0 THz. In general, the intensity of a boson peak is weak for fragile glass. In the terahertz transmission spectra of Baltic amber in the previous study, no boson peak was observed upon slow cooling. However, in the present study, upon rapid cooling down to 15 K, the boson peak was observed clearly at 0.36 THz by the suppression of ice nucleation of confined water. The dynamic correlation length determined by the boson peak frequency was compared with the static structure correlation length and the scale of the medium-range order as determined by the first sharp diffraction peak of X-ray diffraction (XRD) in the recent literature. It was found that the dynamic correlation length determined by THz-TDS was closely related to the static correlation length determined by the XRD analysis. Full article
(This article belongs to the Special Issue Terahertz Vibrational Spectroscopy in Advanced Materials)
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13 pages, 2482 KiB  
Article
Optical and Geometrical Properties from Terahertz Time-Domain Spectroscopy Data
by George Youssef, Nha Uyen T. Huynh and Somer Nacy
Materials 2024, 17(23), 5854; https://doi.org/10.3390/ma17235854 - 29 Nov 2024
Viewed by 1172
Abstract
Terahertz waves are nondestructive and non-ionizing to synthetic and natural materials, including polymeric and biological materials. As a result, terahertz-based spectroscopy has emerged as a suitable technique to uncover fundamental molecular mechanisms and material properties in this electromagnetic spectrum regime. In terahertz time-domain [...] Read more.
Terahertz waves are nondestructive and non-ionizing to synthetic and natural materials, including polymeric and biological materials. As a result, terahertz-based spectroscopy has emerged as a suitable technique to uncover fundamental molecular mechanisms and material properties in this electromagnetic spectrum regime. In terahertz time-domain spectroscopy (THz-TDS), the material’s optical properties are resolved using the raw time-domain signals collected from the sample and air reference data depending on accurate prior knowledge of the sample geometry. Alternatively, different spectral analysis algorithms can extract the complex index of refraction of optically thick or optically thin samples without specific thickness knowledge. A THz-TDS signal without apparent Fabry–Pérot oscillations is commonly associated with optically thin samples, whereas the terahertz signal of optically thick samples exhibits distinct Fabry–Pérot oscillations. While several extraction algorithms have been reported a priori, the steps from reducing the time-domain signal to calculating the complex index of refraction and resolving the correct thickness can be daunting and intimidating while obscuring important steps. Therefore, the objective is to decipher, demystify, and demonstrate the extraction algorithms for Fabry–Pérot-absent and -present terahertz signals for various polymers with different molecular structure classifications and nonlinear optical crystal zinc telluride. The experimental results were in good agreement with previously published values while elucidating the contributions of the molecular structure to the stability of the algorithms. Finally, the necessary condition for manifesting Fabry–Pérot oscillations was delineated. Full article
(This article belongs to the Special Issue Terahertz Materials and Technologies in Materials Science)
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13 pages, 7300 KiB  
Article
The Use of Terahertz Computed Tomography and Time Domain Spectroscopy to Evaluate Symmetry in 3D Printed Parts
by Dolores Termini, John Federici, Ian Gatley and Louis Rizzo
Polymers 2024, 16(23), 3296; https://doi.org/10.3390/polym16233296 - 26 Nov 2024
Viewed by 994
Abstract
3D printing has become essential to many fields for its low-cost production and rapid prototyping abilities. As 3D printing becomes an alternative manufacturing tool, developing methods to non-destructively evaluate defects for quality control is essential. This study integrates the non-destructive terahertz (THz) analysis [...] Read more.
3D printing has become essential to many fields for its low-cost production and rapid prototyping abilities. As 3D printing becomes an alternative manufacturing tool, developing methods to non-destructively evaluate defects for quality control is essential. This study integrates the non-destructive terahertz (THz) analysis methods of terahertz time-domain spectroscopy (THz-TDS) and terahertz computed tomography (THz CT) to image and assess 3D printed resin structures for defects. The terahertz images were reconstructed using MATLAB, and the rotational symmetry of various structures before and after the introduction of defects was evaluated by calculating the mean squared deviation (MSD), which served as a symmetry parameter to indicate the presence of defects. Structures A and B had MSD values that were at least three standard deviations larger after introducing defects to their structures, showing a significant change in symmetry and indicating the existence of defects. Similarly, in structure C, blockages in parts made with different post-cures were identified based on the increase in MSD values for those slices. For structure D, the presence of a defect increased the MSD value by 14%. The results of this study verify that the MSD calculated for the rotational symmetry of the structures was greater when defects were present, accurately reflecting the anticipated breaks in symmetry. This paper demonstrates that terahertz imaging, combined with MSD analysis, is a viable procedure to identify and quantify defects in rotationally symmetric 3D printed structures. Full article
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16 pages, 3710 KiB  
Article
Experimental Analysis of Terahertz Wave Scattering Characteristics of Simulated Lunar Regolith Surface
by Suyun Wang and Kazuma Hiramatsu
Remote Sens. 2024, 16(20), 3819; https://doi.org/10.3390/rs16203819 - 14 Oct 2024
Cited by 2 | Viewed by 1338
Abstract
This study investigates terahertz (THz) wave scattering from a simulated lunar regolith surface, with a focus on the Brewster feature, backscattering, and bistatic scattering within the 325 to 500 GHz range. We employed a generalized power-law spectrum to characterize surface roughness and fabricated [...] Read more.
This study investigates terahertz (THz) wave scattering from a simulated lunar regolith surface, with a focus on the Brewster feature, backscattering, and bistatic scattering within the 325 to 500 GHz range. We employed a generalized power-law spectrum to characterize surface roughness and fabricated Gaussian correlated surfaces from Durable Resin V2 using 3D printing technology. The complex dielectric permittivity of these materials was determined through THz time-domain spectroscopy (THz-TDS). Our experimental setup comprised a vector network analyzer (VNA) equipped with dual waveguide frequency extenders for the WR-2.2 band, transmitter and receiver modules, polarizing components, and a scattering chamber. We systematically analyzed the effects of root-mean-square (RMS) height, correlation length, dielectric constant, frequency, polarization, and observation angle on THz scattering. The findings highlight the significant impact of surface roughness on the Brewster angle shift, backscattering, and bistatic scattering. These insights are crucial for refining theoretical models and developing algorithms to retrieve physical parameters for lunar and other celestial explorations. Full article
(This article belongs to the Special Issue Future of Lunar Exploration)
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14 pages, 3670 KiB  
Article
Novel THz Metasurface Biosensor for High-Sensitivity Detection of Vitamin C and Vitamin B9
by Ningyi Wang, Bingwei Liu, Xu Wu and Yan Peng
Photonics 2024, 11(9), 820; https://doi.org/10.3390/photonics11090820 - 30 Aug 2024
Cited by 1 | Viewed by 1868
Abstract
Vitamin C (VC) and Vitamin B9 (VB9) are essential micronutrients integral to numerous biological functions and critical for maintaining human health. The rapid detection of these vitamins is important for verifying nutritional supplements and aiding in clinical diagnoses. This study combined terahertz time-domain [...] Read more.
Vitamin C (VC) and Vitamin B9 (VB9) are essential micronutrients integral to numerous biological functions and critical for maintaining human health. The rapid detection of these vitamins is important for verifying nutritional supplements and aiding in clinical diagnoses. This study combined terahertz time-domain spectroscopy (THz-TDS) with metasurface technology to develop a fast, sensitive, and non-destructive detection method for VC and VB9. Firstly, we determined the characteristic absorption peaks and molecular vibration modes of VC and VB9 within the 0.5–4.0 THz range through quantum chemical calculation and THz-TDS measurement. Then, we designed and fabricated a metasurface biosensor to match its resonance peak with the communal peak of VC and VB9, enhancing the interaction between THz waves and these vitamins. Using this biosensor, we analyzed solutions with different concentrations of VC and VB9. An increase in vitamin concentrations resulted in frequency shifts in the THz resonance peak. Quantifiable relationships between frequency shifts and the vitamin concentrations were established. The detection limits achieved were 158.82 ng/µL for VC and 353.57 ng/µL for VB9, respectively. This method not only demonstrates high sensitivity but also simplifies the operational process, offering an innovative tool for applications in food safety monitoring and clinical diagnostics. Full article
(This article belongs to the Section Optical Interaction Science)
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14 pages, 5008 KiB  
Article
Terahertz Spectra of Mannitol and Erythritol: A Joint Experimental and Computational Study
by Zeyu Hou, Bingxin Yan, Yuhan Zhao, Bo Peng, Shengbo Zhang, Bo Su, Kai Li and Cunlin Zhang
Molecules 2024, 29(13), 3154; https://doi.org/10.3390/molecules29133154 - 2 Jul 2024
Cited by 1 | Viewed by 1288
Abstract
Sugar substitutes, which generally refer to a class of food additives, mostly have vibration frequencies within the terahertz (THz) band. Therefore, THz technology can be used to analyze their molecular properties. To understand the characteristics of sugar substitutes, this study selected mannitol and [...] Read more.
Sugar substitutes, which generally refer to a class of food additives, mostly have vibration frequencies within the terahertz (THz) band. Therefore, THz technology can be used to analyze their molecular properties. To understand the characteristics of sugar substitutes, this study selected mannitol and erythritol as representatives. Firstly, PXRD and Raman techniques were used to determine the crystal structure and purity of mannitol and erythritol. Then, the THz time-domain spectroscopy (THz-TDS) system was employed to measure the spectral properties of the two sugar substitutes. Additionally, density functional theory (DFT) was utilized to simulate the crystal configurations of mannitol and erythritol. The experimental results showed good agreement with the simulation results. Finally, microfluidic chip technology was used to measure the THz spectroscopic properties of the two sugar substitutes in solution. A comparison was made between their solid state and aqueous solution state, revealing a strong correlation between the THz spectra of the two sugar substitutes in both states. Additionally, it was found that the THz spectrum of a substance in solution is related to its concentration. This study provides a reference for the analysis of sugar substitutes. Full article
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13 pages, 4802 KiB  
Article
Terahertz Sensing of L-Valine and L-Phenylalanine Solutions
by Jingyi Shu, Xinli Zhou, Jixuan Hao, Haochen Zhao, Mingming An, Yichen Zhang and Guozhong Zhao
Sensors 2024, 24(12), 3798; https://doi.org/10.3390/s24123798 - 12 Jun 2024
Cited by 4 | Viewed by 1268
Abstract
To detect and differentiate two essential amino acids (L-Valine and L-Phenylalanine) in the human body, a novel asymmetrically folded dual-aperture metal ring terahertz metasurface sensor was designed. A solvent mixture of water and glycerol with a volume ratio of 2:8 was proposed to [...] Read more.
To detect and differentiate two essential amino acids (L-Valine and L-Phenylalanine) in the human body, a novel asymmetrically folded dual-aperture metal ring terahertz metasurface sensor was designed. A solvent mixture of water and glycerol with a volume ratio of 2:8 was proposed to reduce the absorption of terahertz waves by reducing the water content. A sample chamber with a controlled liquid thickness of 15 μm was fabricated. And a terahertz time-domain spectroscopy (THz-TDS) system, which is capable of horizontally positioning the samples, was assembled. The results of the sensing test revealed that as the concentration of valine solution varied from 0 to 20 mmol/L, the sensing resonance peak shifted from 1.39 THz to 1.58 THz with a concentration sensitivity of 9.98 GHz/mmol∗L−1. The resonance peak shift phenomenon in phenylalanine solution was less apparent. It is assumed that the coupling enhancement between the absorption peak position of solutes in the solution and the sensing peak position amplified the terahertz localized electric field resonance, which resulted in the increase in frequency shift. Therefore, it could be shown that the sensor has capabilities in performing the marker sensing detection of L-Valine. Full article
(This article belongs to the Special Issue Terahertz Sensors)
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13 pages, 6163 KiB  
Article
Qualitative and Quantitative Detection of Typical Reproductive Hormones in Dairy Cows Based on Terahertz Spectroscopy and Metamaterial Technology
by Shuang Liang, Jingbo Zhao, Wenwen Zhao, Nan Jia, Zhiyong Zhang and Bin Li
Molecules 2024, 29(10), 2366; https://doi.org/10.3390/molecules29102366 - 17 May 2024
Cited by 1 | Viewed by 2035
Abstract
Progesterone (PROG) and estrone (E1) are typical reproductive hormones in dairy cows. Assessing the levels of these hormones in vivo can aid in estrus identification. In the present work, the feasibility of the qualitative and quantitative detection of PROG and E [...] Read more.
Progesterone (PROG) and estrone (E1) are typical reproductive hormones in dairy cows. Assessing the levels of these hormones in vivo can aid in estrus identification. In the present work, the feasibility of the qualitative and quantitative detection of PROG and E1 using terahertz time-domain spectroscopy (THz-TDS) and metamaterial technology was preliminarily investigated. First, the time domain spectra, frequency domain spectra, and absorption coefficients of PROG and E1 samples were collected and analyzed. A vibration analysis was conducted using density functional theory (DFT). Subsequently, a double-ring (DR) metamaterial structure was designed and simulated using the frequency domain solution algorithm in CST Studio Suite (CST) software. This aimed to ensure that the double resonance peaks of DR were similar to the absorption peaks of PROG and E1. Finally, the response of DR to different concentrations of PROG/E1 was analyzed and quantitatively modeled. The results show that a qualitative analysis can be conducted by comparing the corresponding DR resonance peak changes in PROG and E1 samples at various concentrations. The best R2 for the PROG quantitative model was 0.9872, while for E1, it was 0.9828. This indicates that terahertz spectral–metamaterial technology for the qualitative and quantitative detection of the typical reproductive hormones PROG and E1 in dairy cows is feasible and worthy of in-depth exploration. This study provides a reference for the identification of dairy cow estrus. Full article
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13 pages, 3573 KiB  
Article
High-Density Polyethylene Custom Focusing Lenses for High-Resolution Transient Terahertz Biomedical Imaging Sensors
by Debamitra Chakraborty, Robert Boni, Bradley N. Mills, Jing Cheng, Ivan Komissarov, Scott A. Gerber and Roman Sobolewski
Sensors 2024, 24(7), 2066; https://doi.org/10.3390/s24072066 - 24 Mar 2024
Cited by 6 | Viewed by 2114
Abstract
Transient terahertz time-domain spectroscopy (THz-TDS) imaging has emerged as a novel non-ionizing and noninvasive biomedical imaging modality, designed for the detection and characterization of a variety of tissue malignancies due to their high signal-to-noise ratio and submillimeter resolution. We report our design of [...] Read more.
Transient terahertz time-domain spectroscopy (THz-TDS) imaging has emerged as a novel non-ionizing and noninvasive biomedical imaging modality, designed for the detection and characterization of a variety of tissue malignancies due to their high signal-to-noise ratio and submillimeter resolution. We report our design of a pair of aspheric focusing lenses using a commercially available lens-design software that resulted in about 200 × 200-μm2 focal spot size corresponding to the 1-THz frequency. The lenses are made of high-density polyethylene (HDPE) obtained using a lathe fabrication and are integrated into a THz-TDS system that includes low-temperature GaAs photoconductive antennae as both a THz emitter and detector. The system is used to generate high-resolution, two-dimensional (2D) images of formalin-fixed, paraffin-embedded murine pancreas tissue blocks. The performance of these focusing lenses is compared to the older system based on a pair of short-focal-length, hemispherical polytetrafluoroethylene (TeflonTM) lenses and is characterized using THz-domain measurements, resulting in 2D maps of the tissue refractive index and absorption coefficient as imaging markers. For a quantitative evaluation of the lens effect on the image resolution, we formulated a lateral resolution parameter, R2080, defined as the distance required for a 20–80% transition of the imaging marker from the bare paraffin region to the tissue region in the same image frame. The R2080 parameter clearly demonstrates the advantage of the HDPE lenses over TeflonTM lenses. The lens-design approach presented here can be successfully implemented in other THz-TDS setups with known THz emitter and detector specifications. Full article
(This article belongs to the Special Issue Research Development in Terahertz and Infrared Sensing Technology)
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