Search Results (9,982)

The rapid advancement of flexible and stretchable electronics has raised new demands for conductive materials with high conductivity and excellent mechanical properties. Compared to traditional conductive materials, gallium-based liquid metals exhibit a compelling set of attributes—including intrinsic deformability, high conductivity, good thermal conductivity, and a liquid state at or near room temperature—that address the critical requirements for conductors in flexible and stretchable electronics. However, the broader application of gallium-based liquid metals is limited by intrinsic challenges, such as oxidation tendency and high surface tension, while their multifunctional potential remains to be fully explored and developed. This paper provides a comprehensive review of gallium-based liquid metals, spanning from their fundamental concepts including intrinsic properties and processing characteristics (oxidative layer/droplet engineering) and functionalization techniques to their diverse applications in flexible electronics. It concisely summarizes key factors, existing issues, and challenges encountered during the design, research, and application of gallium-based liquid metals, aiming to provide guidance and assistance for subsequent research and applications. Full article

Background: Adiponectin is an adipokine with insulin-sensitizing, anti-inflammatory, and cytoprotective properties that also plays a key role in metabolic adaptation to exercise. Although its regulation after resistance exercise has been extensively documented, less is known about its short-term modulation and its correlation with muscle damage markers following resistance training. Methods: Nine resistance-trained young men completed two sessions of total-body resistance exercise: (1) high time under tension (TUT) (5-1-2-1 cadence, to failure; ETS1) and (2) moderate TUT (2-1-2-1 cadence, two repetitions in reserve; ETS2). Plasma and saliva samples were collected before exercise and at 15 min, 24 h, and 48 h after exercise to assess total adiponectin by ELISA. Plasma creatine kinase (CK) and a Visual Analog Scale (VAS) were also measured for muscle soreness. Results: Plasma adiponectin significantly decreased from baseline to 48 h post-exercise in both sessions (p < 0.001), with no differences between the TUT conditions. Salivary adiponectin remained unchanged. Although a significant increase in CK and a decrease in adiponectin were observed at the group level, correlation analysis revealed no significant linear relationship between the magnitude of CK elevation and adiponectin reduction. Conclusions: Overall, these findings support the role of adiponectin as a marker of acute metabolic adaptation to resistance exercise. Acute resistance exercise elicited a time-dependent decrease in circulating adiponectin, irrespective of TUT. The temporal pattern of adiponectin decrease coincided with the rise in muscle damage markers, yet the lack of direct correlation suggests distinct regulatory mechanisms, while the lack of salivary changes underscores the complexity of adipokine regulation in vivo and suggests that saliva is not a reliable indicator of changes in circulating adiponectin. Full article

Background and Objectives: Mechanical alignment (MA) has long been the gold standard in total knee arthroplasty (TKA), aiming for neutral hip–knee–ankle alignment with proven long-term survivorship. However, up to 20% of patients remain dissatisfied, often due to neglect of individual constitutional limb variation and subsequent soft tissue imbalance. This has driven the development of alternative alignment philosophies. This current concepts review aims to determine the various evolving alignment strategies, elucidate their underlying principles, and demonstrate the available clinical outcomes data. Materials and Methods: This review examines MA and the paradigm shift towards personalized alignment techniques, including Kinematic Alignment (KA), restricted Kinematic Alignment (rKA), inverse Kinematic Alignment (iKA), adjusted mechanical alignment (aMA), and the most recent evolution, Functional Alignment (FA). Results: Kinematic alignment and its derivatives (rKA, iKA) seek to better replicate native joint morphology and tension, often reducing the need for soft tissue releases and improving functional outcomes compared to MA. rKA and iKA introduce protective boundaries to avoid extreme phenotypes and possible instability. FA leverages robotic platforms and integrates these principles with real-time gap balancing, demonstrating promise for consistent, personalized outcomes. Some reports, however, advise caution with adjusted Mechanical Alignment (aMA), particularly those that result in phenotypes such as Coronal Plane Alignment of the Knee (CPAK) VII or VIII, which may increase the risk of revision. Conclusions: The philosophy of TKA has evolved from a uniform mechanical target (MA) to a more nuanced, patient-specific strategy. While promising mid- to long-term outcomes and comparable survival data support the viability of KA and its derivatives, critical needs remain, including standardizing nomenclature (especially for FA) and conducting high-quality comparative trials. Future directions involve leveraging high-volume intraoperative data and Artificial Intelligence (AI) to refine decision-making and further personalize alignment strategies, without compromising long-term implant survivorship. Full article

Cryptocurrencies play a central role in modern financial markets; however, geopolitical tensions and environmental concerns raise critical questions about their stability and informational efficiency. This study distinguishes between green cryptocurrencies (GCs), based on low-energy validation mechanisms, and dirty cryptocurrencies (DCs), which rely on energy-intensive protocols, to examine their behaviour under geopolitical stress. The objective of this paper is to assess how information dynamics, market resilience, and efficiency differ between GCs and DCs during periods of heightened geopolitical uncertainty, with particular focus on the Russia–Ukraine war. Using daily data from 28 April 2019 to 5 October 2023, we employ advanced information-theoretic measures, including mutual information, the rolling local nearest-neighbour entropy estimator (RLNNEE), and approximate entropy. The results show that DCs exhibit stronger information dominance than GCs, with this gap widening during the conflict. In contrast, GCs display lower but more stable mutual information, indicating greater informational resilience. Approximate entropy further reveals a decline in market complexity during the war period. Overall, the findings highlight the relevance of entropy-based tools for evaluating stability and risk in cryptocurrency markets facing geopolitical shocks. Full article

Cable-driven wrench applicators (CDWAs) are parallel robotic systems that apply controlled wrenches to the robot end-effector through cable actuation. The presented study introduces a framework for the performance evaluation of CDWAs based on dedicated metrics. It focuses on the geometric analysis of n-cable CDWAs controlling $n-2$ wrench components and on the experimental comparison of a 4-cable architecture with an 8-cable CDWA. The geometric analysis reveals intrinsic properties of the 4-cable system’s tension distribution and inherent limits in achieving specific control objectives. Both simulations and experimental validation demonstrate that the 4-cable CDWA attains comparable performance in wrench control while requiring higher tensions, yet offers greater ease of use and mechanical simplicity. Full article

Taboos differentially reinforce socially constructed gender and sexual hierarchies that affect the experiences of all people—women, men, queer, heterosexual, and transgender people. In Delhi, India, institutions of heteropatriarchy, buttressed by colonial history, reproduce and naturalize limits to the agency and economic autonomy of women and queer people. These intimate economics influence and are influenced by people making decisions regarding relationships and have broad repercussions in society. How do individuals and groups simultaneously question, remake, and enlarge gendered categories and experiences? Interviews with middle-class people are discussed in the context of scholarship that considers the social, political, and historical contexts of the region. Interview responses are triangulated with ethnographic participation in Delhi-based events that examine and confront aspects of heteropatriarchal regulation of people regarding categories of gender and sexual expression. Themes emerge regarding how people create and access knowledge, economic autonomy, relationships, and family formation. The conclusion discusses ways in which the erosion of taboos reveals changing roles and identities and how these changes affect the hierarchal gender binary, producing social tensions and paradoxes. Full article

Unconventional low-permeability reservoirs present significant production challenges due to the poor imbibition and displacement efficiency of conventional polymer fracturing fluids. The injection of nanoparticle (NP) compounds into polymer fracturing fluid base systems, such as linear gels or slickwater, has garnered significant research interest due to their superior performance. However, previous studies have primarily focused on evaluating the fluid’s properties, while its imbibition and oil displacement mechanisms within reservoirs remain unclear. Herein, the imbibition mechanism of nanoparticle composite polymer fracturing fluid was systematically investigated from macro and micro perspectives using low-field nuclear magnetic resonance (LF-NMR), atomic force microscopy (AFM), interfacial rheology, and other technical means. The results showed that the imbibition recovery using polymer fracturing fluid was 10.91% higher than that achieved with conventional slickwater. Small and medium pores were identified as the primary contributors to oil drainage. Nanoparticles can be adsorbed on the rock wall in the deep reservoir to realize wettability reversal from oil-wet to water-wet, reducing crude oil adhesion. Furthermore, a strong interaction between the adsorbed NPs and cleanup agents at the oil–water interface was observed, which reduces interfacial tension to 0.95 mN·m⁻¹, mitigates the Jamin effect, and enhances interfacial film deformability. NPs increase the interfacial dilatational modulus from 6.0 to 14.4 mN·m⁻¹, accelerating fluid exchange and oil stripping. This work provides a consolidated mechanistic framework linking NP-induced interfacial modifications to enhanced pore-scale drainage, offering a scientific basis for designing next-generation fracturing fluids. We conclude that NP-compound systems hold strong potential for low-permeability reservoir development, and future efforts must focus on optimizing NP parameters for specific reservoir conditions and overcoming scalability challenges for field deployment. Full article

Since a significant part of the Italian territory was not seismically classified until 2003, most existing bridges have been designed—for decades—disregarding earthquake-induced excitations. In fact, this means that load-bearing devices and shear keys of presently in-service infrastructures may not be up to current codes, both in terms of resistance and displacement capacity. Robust investigations are hence required for verifications and possible retrofit. In this study, the seismic behaviour of a case study post-tensioned concrete bridge built in the 1980s is numerically analysed. The examined structure is 440 m long and composed of nine spans, built with precast segments using the balance cantilever construction method. The deck is divided into two parts connected by a hinged joint in the middle of the central span, obtained with three shear keys and originally designed to allow for thermal expansion only. Most importantly, the mid-span hinge, the end joints and the bearing devices were originally designed without considering the effects of seismic action. In order to preliminarily investigate the performance of devices and joints, the case study bridge is analysed by means of non-linear dynamic time history simulations, formulating different hypotheses about the non-linear behaviour of the load bearings. Forces and displacements over time are obtained for a set of seven accelerograms, and maximum values are compared to the capacity of the bridge devices. Results are then critically discussed. Full article

The objective of this study was to develop multifunctional chitosan (CT) derivatives by conjugating oleic acid (OLA) and caffeic acid (CAF) to improve water solubility at neutral pH, enhance interfacial activity, and provide antioxidant protection in oil-in-water emulsions. Two CAF-incorporation strategies—1-(3-dimethylaminopropyl)-3-ethylcarbodiimide·HCl/N-hydroxysuccinimide (EDC/NHS)-mediated amide coupling and ascorbic acid/H₂O₂-initiated free radical grafting—were employed to functionalize the CT–OLA backbone. The CT–OLA–CAF conjugates generated via the free radical pathway exhibited markedly lower viscosity and interfacial tension than those produced through EDC/NHS coupling, thereby highlighting the respective advantages and limitations associated with these two synthesis approaches. Chemically, CAF incorporation substantially enhanced the antioxidant capacity of the conjugates—surpassing that of both CT and CT—OLA and conferred excellent protection to photo-oxidatively labile β-carotene in o/w emulsions. Full article

Background/Objectives: Noncontact knee ligament injuries, including anterior cruciate ligament (ACL) ruptures and medial collateral ligament (MCL) sprains, are prevalent in sports that involve frequent cutting and pivoting. Conventional rigid knee braces can offer stability but often compromise comfort and performance, whereas soft sleeve-type supports provide minimal mechanical protection. The purpose of this study was to evaluate the acute biomechanical effects of a tensioned cable knee bracing system on peak knee valgus angle and external knee abduction moment during a controlled lateral shuffle task. Methods: Ten physically active adults (mean age 21.7 ± 3.8 years) performed submaximal lateral shuffle movements under three conditions: unbraced, sleeve-only (zero-tension), and a novel tensioned cable brace. Three-dimensional knee kinematics and ground reaction forces were collected, and peak knee valgus angle and external abduction moment were calculated during the eccentric phase of each movement. Results: Wearing the knee brace under tension significantly reduced knee valgus angle (4.5° vs. 7.9°) and peak external knee abduction moment (1.6 vs. 2.0–2.1 Nm/kg) compared to the unbraced condition. Conclusions: These findings indicate that the tensioned cable brace effectively reduced frontal plane knee loading during a lateral shuffle task, indicating its potential as an effective bracing approach. Full article

Emerging mid-sized cities in the Global South face growing challenges in aligning transport infrastructure with equity and safety objectives under conditions of rapid urban expansion. While accessibility metrics are widely used in transport planning, their ability to capture functional inequalities and safety-related dynamics remains limited, particularly in corridor-level assessments. This study examines structural and functional accessibility patterns along two planned BRT corridors in Querétaro, Mexico, an emerging mid-sized Latin American city. The analysis integrates spatial accessibility indicators, selected urban process proxies related to inequality and road safety, and AI-based modeling to explore non-linear spatial associations across fine-grained corridor segments. Structural accessibility is evaluated using network-based indicators, while functional accessibility reflects observed service dynamics and operational conditions. Spatial correlations and artificial neural networks are employed as exploratory tools to identify co-occurring patterns rather than causal relationships. Results reveal pronounced spatial mismatches between structural and functional accessibility, socio-spatial marginalization, and crash concentration, highlighting corridor segments where future BRT implementation may either reinforce or mitigate existing inequalities. By framing BRT corridors as test cases, the study contributes a transferable diagnostic framework for assessing accessibility–equity–safety tensions in emerging mid-sized cities. Full article

This article analyses the official Catholic Religious Education (CRES) programmes in Chile, Brazil, Costa Rica and Colombia from the perspective of complexity sciences, using the concept of self-organisation as a central analytical axis. Given Latin American contexts marked by religious pluralism, cultural transformation, institutional crisis and youth subjectivities, it is proposed that the adequacy of CRES does not depend solely on content or methodologies, but also on the systemic architecture that articulates students, classrooms and institutions in relation to their environment. Methodologically, the study develops a framework of three thresholds of educational self-organisation—reactive, reflective, and ecological—and applies it comparatively to the four national programmes, examining how they distribute agency, learning capacity, and openness to context at the student, classroom, and school-environment levels. The analysis reveals that, although all programmes activate relevant forms of reactive and reflective self-organisation, only some partially enable thresholds of ecological self-organisation capable of sustainably integrating contemporary sociocultural and religious complexity. The results allow us to identify structural tensions between current curriculum designs and the demands of increasingly complex environments. Full article

This study examines the mechanical response of medium-manganese TRIP steels under different stress states, focusing on deformation-induced austenite-to-martensite transformation and ageing phenomena. Two steels with distinctly different ferrite–austenite morphologies and retained austenite (RA) fractions were analysed: a globular microstructure with 18% RA and a lamellar microstructure with 14% RA, produced by single (SA) and double annealing (DA), respectively. Continuous and interrupted tests were performed under in-plane shear, uniaxial tension, and plane strain stress states. Strain fields were analysed using high-resolution digital image correlation, while RA fractions were quantified as a function of strain by ex situ X-ray diffraction. The results demonstrate a pronounced stress-state dependence. SA samples exhibit discontinuous yielding, with uniaxial tests showing clear Lüders band formation. Both steels exhibit dynamic strain ageing manifested by Portevin–Le Chatelier (PLC) serrations and associated strain bands, which are most pronounced under uniaxial tension, weaker in plane strain, and barely detectable in in-plane shear. Static strain ageing is also evidenced by a strengthened yield response upon unloading–reloading in all samples. The SA globular microstructure exhibits higher PLC band inclination angles than the lamellar DA microstructure, consistent with its more pronounced anisotropy. The propagation velocity in uniaxial tensile samples decreases with increasing strain following the work-hardening response. For both steels, the austenite-to-martensite transformation rate is highest in uniaxial tension, slightly reduced in plane strain, and strongly suppressed under in-plane shear. A Beese–Mohr/Johnson–Mehl–Avrami–Kolmogorov formulation incorporating stress triaxiality and Lode angle captures these trends for both steels. For the stress states considered, the DA condition exhibits a consistently higher transformation rate than the SA condition, accompanied by a higher work-hardening rate. These findings highlight the coupled role of stress state and microstructural morphology in governing localisation behaviour and strain-induced transformation in medium-manganese steels. Full article

Microbial biosurfactants have emerged as natural and sustainable alternatives to synthetic surfactants used in the food industry, due to the growing demand for biodegradable and safe ingredients. Produced by bacteria, fungi, and yeasts, these compounds exhibit important physicochemical properties, such as emulsifying capacity, surface tension reduction, foam stabilization, and favorable interaction with different food matrices. In addition to their technological function, they exhibit relevant biological activities, including antioxidant and antimicrobial action, which contribute to the control of lipid oxidation and microbiological deterioration. These characteristics make biosurfactants attractive for applications in emulsions, fermented beverages, aerated products, probiotic systems, and bioactive packaging. The objective of this work is to provide a narrative literature review that integrates recent advances in the production, functionality, safety, sustainability, and application perspectives of biosurfactants in the food sector. In the field of production, biotechnological advances have made it possible to overcome historical limitations such as high cost and low yield. Strategies such as the use of agro-industrial waste, metabolic engineering, microbial co-cultures, continuous fermentations, and in situ removal techniques have increased efficiency and reduced environmental impacts. Despite the advances, significant challenges remain. Future prospects and advances tend to facilitate industrial adoption and consolidate biosurfactants as strategic ingredients for the development of more sustainable, functional, and technologically advanced foods. Full article

Ongoing global disruptions, including pandemics, geopolitical tensions, and climate-driven events, have exposed vulnerabilities in healthcare supply chains (HSCs). This study examines how artificial intelligence (AI) is reshaping HSCs to improve agility, resilience, and sustainable performance. Using a systematic literature review with PRISMA-style screening across Scopus and Web of Science, the study is complemented by bibliometric analysis and latent Dirichlet allocation topic modeling to analyze peer-reviewed articles. The results indicate an exponential increase in AI-enabled HSC research, concentrated in a small number of journals and spanning a globally diverse author community. Three dominant thematic clusters emerged: (1) sustainability-oriented supply chain design, (2) disruption and resilience management, and (3) healthcare-focused digital transformation. Across these themes, AI, digital twins, Internet of Things, and simulation are evolving from efficiency tools to strategic enablers of decision intelligence, supporting real-time sensing, scenario analysis, and proactive risk mitigation. The study highlights a convergence of “triple transformation” in which digitalization, resilience, and sustainability are increasingly co-dependent capabilities in HSCs. However, persistent barriers exist, including data quality issues, legacy systems, workforce skill gaps, limited model interpretability, and incomplete governance frameworks, which constrain large-scale adoption. The findings indicate a need for longitudinal and multi-method studies on human–AI collaboration, trust calibration, and leadership in AI-enabled HSCs. This study provides practical guidance for healthcare organizations looking to leverage AI in developing agile, resilient, and sustainable supply chain ecosystems. Full article