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26 pages, 8518 KB  
Article
CVA-Net: Multi-View 3D Reconstruction for Fringe Projection Profilometry via Cross-View Attention and Sim2Real Learning
by Zuqiong Chen, Xiaopin Zhong and Yibin Tian
Photonics 2026, 13(6), 601; https://doi.org/10.3390/photonics13060601 (registering DOI) - 21 Jun 2026
Abstract
Fringe projection profilometry (FPP) is widely used for 3D reconstruction, but conventional single-view FPP systems suffer from inherent occlusions and shadow regions, leading to incomplete surface recovery. In this study, we propose CVA-Net, an end-to-end deep learning framework with cross-view attention (CVA) that [...] Read more.
Fringe projection profilometry (FPP) is widely used for 3D reconstruction, but conventional single-view FPP systems suffer from inherent occlusions and shadow regions, leading to incomplete surface recovery. In this study, we propose CVA-Net, an end-to-end deep learning framework with cross-view attention (CVA) that directly reconstructs dense depth maps from multi-view fringe patterns. CVA-Net simultaneously processes four fringe images acquired from orthogonal projection directions and leverages a CVA module to explicitly model inter-view dependencies, enabling adaptive fusion of complementary information. A 3D U-Net backbone with attention gates, atrous spatial pyramid pooling (ASPP), and an auxiliary parameter estimation branch further enhances reconstruction accuracy and structural consistency via multitask learning. To support Sim2Real network training, we build a Blender-based digital twin of a multi-view FPP system and generate a large-scale synthetic dataset with perfect ground truth. Extensive experiments on both synthetic and real-world objects demonstrate that CVA-Net significantly outperforms state-of-the-art single-view methods. With a symmetric four-view configuration and fringe period of 8, CVA-Net achieves an MAE of 0.0359 mm, an MSE of 0.0379 mm2 and an RMSE of 0.1947 mm, reducing the MAE, MSE, and RMSE by 32.8%, 54.1%, and 32.2%, respectively, compared to the best single-view competitor. Ablation studies validate the contribution of each architectural component, while real-system experiments demonstrate the feasibility of transferring a network trained purely on synthetic data to practical FPP measurements without domain adaptation. Although further improvements are required to enhance reconstruction accuracy under real imaging conditions, the proposed framework provides an effective initial step toward bridging the gap between digital-twin-based training and real-world multi-view FPP applications. CVA-Net provides a robust, occlusion-aware solution for multi-view FPP reconstruction. Full article
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23 pages, 5222 KB  
Article
Fracture Interferences in Combined Vertical–Horizontal Well Patterns and Their Field Application
by Shuai Li, Guangqing Zhang and Hu Cao
Processes 2026, 14(12), 2010; https://doi.org/10.3390/pr14122010 (registering DOI) - 20 Jun 2026
Abstract
Combined Vertical–Horizontal Well Patterns (CVHWPs) have been increasingly applied in mature and complex reservoirs, such as the C5 Block. Their application is attractive because they provide extensive reservoir coverage and high development efficiency. However, close well spacing and the three-dimensional configuration of vertical [...] Read more.
Combined Vertical–Horizontal Well Patterns (CVHWPs) have been increasingly applied in mature and complex reservoirs, such as the C5 Block. Their application is attractive because they provide extensive reservoir coverage and high development efficiency. However, close well spacing and the three-dimensional configuration of vertical and horizontal wells can induce strong stress-shadow interference. This interference makes fracture propagation difficult to control and may reduce stimulation effectiveness. To address this problem, a multi-well, multi-fracture induced-stress model for CVHWP stimulation was developed in this study. The model was validated using laboratory three-stage fracturing experiments, including two horizontal-well stages and one vertical-well stage, together with field observations. Across three stages, the calculated stress intensity factors at breakdown are closely matched, validating the induced-stress model. When the vertical well was fractured first, the horizontal principal-stress difference at the adjacent horizontal stage increased by 2.01 MPa, which was unfavorable for branched fracture development. In contrast, when the horizontal stage was fractured first, the stress difference decreased by 3.25 MPa at the subsequent horizontal stage and by 3.89 MPa at the vertical-well stage. This sequence is preferable because fractures generated from the vertical well impose a stronger stress perturbation on adjacent horizontal-well fractures than fractures generated from the horizontal well impose on the subsequent vertical-well fracture. Under the tested CVHWP conditions, the horizontal-well fractures tended to form nearly symmetric bi-wing planar fractures, whereas branched fractures were more likely to develop in the vertical well. Therefore, for CVHWP reservoirs with close vertical–horizontal well spacing and significant stress interference, fracturing the horizontal well before the vertical well is recommended to control fracture propagation and promote multiple-fracture formation. Field application of this sequence showed notable production improvement, indicating that the proposed method can provide practical guidance for unconventional well-pattern fracturing design. Full article
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19 pages, 3879 KB  
Article
Biomechanical Evaluation of Sacral Load Redistribution Following Unilateral and Bilateral Sacroiliac Joint Disruption: A Three-Dimensional Finite Element Comparison of Three Fixation Strategies
by Bünyamin Arı, Melih Canlıdinç and Nafiz Yaşar
Symmetry 2026, 18(6), 1061; https://doi.org/10.3390/sym18061061 (registering DOI) - 20 Jun 2026
Abstract
Sacroiliac joint (SIJ) disruption alters posterior pelvic ring stability and can produce abnormal sacral stress redistribution; the symmetry of sacral load transfer following different fixation strategies remains controversial. This study compared sacral stress patterns under unilateral and bilateral SIJ instability for three fixation [...] Read more.
Sacroiliac joint (SIJ) disruption alters posterior pelvic ring stability and can produce abnormal sacral stress redistribution; the symmetry of sacral load transfer following different fixation strategies remains controversial. This study compared sacral stress patterns under unilateral and bilateral SIJ instability for three fixation constructs using a three-dimensional finite element (FE) model. A lumbosacral–pelvic FE model was reconstructed from computed tomography data of a healthy adult and validated against previously published pelvic biomechanical data. SIJ instability was simulated by reducing the friction coefficient to represent ligamentous failure. Three fixation constructs were analyzed: anterior plate combined with posterior screw fixation (Model 1), spinopelvic fixation (Model 2), and hybrid fixation (Model 3). A 750 N axial compressive load was applied to simulate static standing. Peak sacral von Mises stress, stress amplification factors (SAFs), and left–right asymmetry ratios were computed and compared with the intact reference. Model 1 produced the highest sacral stress amplification (SAF = 3.46 under unilateral instability; peak stress 265.40 MPa). Model 2 reduced peak sacral stress (125.66 MPa under bilateral instability; SAF = 1.64), but values remained above the intact-model baseline. Model 3 yielded sacral stress closest to the intact condition under bilateral instability (81.64 MPa; SAF = 1.06), with near-symmetric load distribution in the bilateral injury configuration. Fixation topology strongly influenced sacral load transfer: hybrid fixation (Model 3) produced sacral stress magnitudes closest to the intact model, particularly under bilateral instability, whereas spinopelvic fixation (Model 2) showed more consistent left–right symmetry under unilateral injury. No single construct was superior across all symmetry-related outcomes. Hybrid stabilization may provide a biomechanically balanced approach to highly unstable posterior pelvic ring injuries under the simulated static axial-loading conditions. Full article
(This article belongs to the Section Life Sciences)
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22 pages, 658 KB  
Article
Bayesian Estimation of Autoregressive Models with Exogenous Variables Under Scale-Mixtures of Normal Errors
by Ayman A. Amin and Shuhrah A. Alghamdi
Mathematics 2026, 14(12), 2188; https://doi.org/10.3390/math14122188 - 18 Jun 2026
Viewed by 78
Abstract
Autoregressive models with exogenous variables (ARX) constitute a fundamental class of dynamic regression models used extensively for time series analysis across a wide range of applications. A pervasive limitation of the existing Bayesian analyses of ARX models is their near-exclusive reliance on the [...] Read more.
Autoregressive models with exogenous variables (ARX) constitute a fundamental class of dynamic regression models used extensively for time series analysis across a wide range of applications. A pervasive limitation of the existing Bayesian analyses of ARX models is their near-exclusive reliance on the Gaussian error assumption, which is routinely violated in empirical applications exhibiting heavy-tailed innovations, distributional outliers, or excess kurtosis. To address this deficiency, we develop a rigorous Bayesian estimation framework for these models whose errors are drawn from the scale-mixtures of normal (SMN) family, which is a rich, symmetric, heavy-tailed class of distributions. Exploiting the hierarchical stochastic representation of the SMN family through observation-specific latent scale-mixing variables, the ARX model is embedded in an augmented data structure that restores Gaussian conditional structure. Under three distinct prior formulations—namely, normal-gamma, Zellner’s g-prior, and Jeffreys’ prior—we derive closed-form full conditional posterior distributions for the ARX coefficient vector and the error scale parameter, which follow multivariate normal and inverse-gamma distributions, respectively. In addition, for the SMN-specific shape parameters, we derive the full conditional posteriors for each distribution in the family, and some of them are non-standard distributions handled by embedding Metropolis-Hastings steps within the Gibbs sampler. The resulting hybrid MCMC algorithm is validated through a comprehensive simulation study spanning three ARX model configurations and all three SMN special cases. A real macroeconomic application to US consumer price inflation demonstrates the practical utility of the framework, confirming heavy-tailed residuals and yielding precise, well-calibrated posterior estimates. Full article
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29 pages, 1871 KB  
Article
Point -in-Time Backtesting of Momentum-Trend Equity Strategies: A Formal Bias Taxonomy, ATR Trailing Stop Analysis, and Investor-Experience Metrics
by Xavier Fonseca
Mathematics 2026, 14(12), 2182; https://doi.org/10.3390/math14122182 - 17 Jun 2026
Viewed by 139
Abstract
Systematic trend-following strategies applied to equity markets are widely studied, yet most reported performance statistics are non-reproducible in live trading. This paper makes three contributions. First, we introduce a formal taxonomy of look-ahead bias organised around point-in-time correctness: a strategy is point-in-time correct [...] Read more.
Systematic trend-following strategies applied to equity markets are widely studied, yet most reported performance statistics are non-reproducible in live trading. This paper makes three contributions. First, we introduce a formal taxonomy of look-ahead bias organised around point-in-time correctness: a strategy is point-in-time correct if, for every decision time t, its information set lies in the natural filtration Ft. Three bias classes—universe-membership contamination, price-data forward leakage, and stop-exit sequencing violations—are characterised as filtration breaches. Second, we formalise the average true range (ATR) trailing stop as a stochastic recurrence and codify its monotonic non-decreasing ratcheting property (Lemma 1), providing a structural per-trade loss bound. Third, we exhibit a closed-form construction (Theorem 1) of two return sequences with identical Sharpe ratios but arbitrarily divergent maximum consecutive negative-year runs, establishing investor-experience metrics as independent optimisation objectives. We complement these contributions with an 18-year empirical study (2008–2025) on the NASDAQ-100 with reconstructed point-in-time index constituency (Class I compliant) and measured residual Class II exposure, applying combinatorially symmetric cross-validation (CSCV) to a 14-configuration ATR-multiplier grid. The grid exhibits a stop-multiplier-insensitive, CAGR-flat region across k[3.5,7.0] (CAGR 10.28–10.39%, net of Dutch progressive tax) and a uniform maximum consecutive negative-year run of 1 across all 14 configurations. The correlation-matrix eigenvalue spectrum of the grid is dominated by a single mode (λ1=13.91 of 14), yielding an effective independent-test count of Meff=1.09. This near-degeneracy persists in a parallel grid with the regime classifier disabled, establishing the ATR multiplier as a structurally near-redundant parameter for this strategy class. The associated PBO value of =0.9351 co-occurs with this near-degeneracy under the CSCV maximum-selection rule. The plateau-level performance survives Bonferroni correction for both M=14 and Meff. The combined evidence supports a region-based interpretation of robust strategy parameters rather than single-point optimisation. Full article
(This article belongs to the Special Issue New Advances in Mathematical Economics and Financial Modelling)
33 pages, 3890 KB  
Article
Robust Spatial Georeferencing for UAV-UGV Mobile Mapping Platforms in Urban Canyons via Asymmetric GNSS/UWB Fusion
by Jiajia Chen, Xing’ao Wang, Zhibo Fang, Ming Gao, Ying Xu and Zhiyou Zhang
Remote Sens. 2026, 18(12), 1967; https://doi.org/10.3390/rs18121967 - 13 Jun 2026
Viewed by 144
Abstract
Reliable spatial georeferencing of mobile mapping platforms is a fundamental prerequisite for high-fidelity urban remote sensing products such as 3D point clouds and digital twins. However, in deep urban canyons, severe signal occlusion and multipath effects reduce visible GNSS satellites, causing ambiguity resolution [...] Read more.
Reliable spatial georeferencing of mobile mapping platforms is a fundamental prerequisite for high-fidelity urban remote sensing products such as 3D point clouds and digital twins. However, in deep urban canyons, severe signal occlusion and multipath effects reduce visible GNSS satellites, causing ambiguity resolution (AR) failure and degraded observation geometry for UGV-borne systems. Conventional Vehicle-to-Vehicle (V2V) cooperation offers limited improvement due to symmetric ground-level occlusion. To overcome this, we propose an asymmetric GNSS/UWB fusion method that introduces Unmanned Aerial Vehicles (UAVs) as high-altitude dynamic spatial anchors to reconstruct the 3D observation geometry. Two contributions are presented: (i) an asymmetric heterogeneous stochastic model coupling carrier-to-noise ratio (C/N0) and elevation angle to handle the quality disparity between air and ground sensor links, preventing multipath contamination of high-fidelity UAV observations; and (ii) a dynamic baseline constrained least-squares algorithm integrating Ultra-Wideband (UWB) ranging to stabilize GNSS positioning under high-dynamic relative motion. Validated through high-fidelity simulations and field experiments, the method achieves a 98.2% AR success rate and sub-decimeter 3D accuracy under extreme occlusion (≤3 visible satellites), while urban-canyon tests demonstrate 100% positioning availability across all evaluated epochs and reduce the 95th-percentile 3D error from 7.25 m to 0.19 m under the tested single-UAV/single-UGV configuration. The framework supports smart city modeling, 3D reconstruction, and infrastructure monitoring. Full article
28 pages, 2770 KB  
Article
Schwarzschild–Letelier Spacetime Surrounded by a King Dark Matter Halo: Geodesic, Shadow, and Thermodynamics
by Faizuddin Ahmed and Edilberto O. Silva
Universe 2026, 12(6), 174; https://doi.org/10.3390/universe12060174 - 11 Jun 2026
Viewed by 144
Abstract
We investigate a static and spherically symmetric Schwarzschild–Letelier Black Hole immersed in a King Dark Matter Halo and analyze how the combined effects of the cloud of strings and the dark-matter environment modify the spacetime geometry, particle dynamics, and thermodynamic behavior of the [...] Read more.
We investigate a static and spherically symmetric Schwarzschild–Letelier Black Hole immersed in a King Dark Matter Halo and analyze how the combined effects of the cloud of strings and the dark-matter environment modify the spacetime geometry, particle dynamics, and thermodynamic behavior of the black hole. Particular attention is devoted to the motion of both massless photons and massive test particles in this black hole background. In the geodesic analysis, we derive the effective potential and study the properties of circular photon orbits, the associated black-hole shadow radius, and the innermost stable circular orbit (ISCO), highlighting the role played by the cloud of strings parameter and the King dark-matter halo parameters in shifting the orbital structure relative to the standard Schwarzschild case. To further characterize the spacetime from a topological perspective, we investigate the unstable circular null orbit using a normalized vector field constructed within the framework of Duan’s ϕ-Mapping Topological Current Theory. Through this method, we identify the corresponding topological charge and examine the relation between the photon sphere and the underlying topological structure of the black-hole configuration. In addition, we explore the thermodynamic properties of the system by computing the Hawking temperature, entropy, Helmholtz free energy, and heat capacity, thereby analyzing the black hole’s local and global thermodynamic stability. The influence of the surrounding dark-matter halo and cloud of strings on the phase structure and thermal behavior is discussed in detail. We further study the thermodynamic topology of the system via the off-shell free-energy formalism, which provides insight into possible thermodynamic phase transitions and the topological classification of black-hole states. Our analysis demonstrates that the combined effects of the cloud of strings and the King dark-matter halo significantly modify the horizon structure, geodesic dynamics, shadow characteristics, and thermodynamic properties of the black hole when compared with the standard Schwarzschild solution. Full article
(This article belongs to the Special Issue 10th Anniversary of Universe: Galaxies and Their Black Holes)
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18 pages, 4679 KB  
Article
Characteristics of Heterogeneous Photovoltaic Power Generation Systems for Small Long-Endurance Unmanned Surface Vehicles
by Siyan Qin, Weiwei Yang, Xiao Wu, Yi Cai and Bingzhen Wang
Energies 2026, 19(12), 2804; https://doi.org/10.3390/en19122804 - 11 Jun 2026
Viewed by 189
Abstract
Taking a small long-endurance unmanned surface vehicle (USV) with a trapezoidal cross-section deck structure as the research object, this study investigates the power generation characteristics of a heterogeneous photovoltaic (PV) system consisting of two symmetrically arranged PV arrays with different orientations, under various [...] Read more.
Taking a small long-endurance unmanned surface vehicle (USV) with a trapezoidal cross-section deck structure as the research object, this study investigates the power generation characteristics of a heterogeneous photovoltaic (PV) system consisting of two symmetrically arranged PV arrays with different orientations, under various electrical connection schemes, tilt angles, and heading angles. A PV power prediction model that accounts for dynamic USV attitude changes was established, and the simulation model was validated based on a trapezoidal deck test setup with a tilt angle of 26.6°. Using this model, the daily cumulative energy yields of the independent and parallel configurations were simulated and analyzed under different tilt and heading angles, focusing on the power generation efficiency of the heterogeneous PV system under seakeeping hull constraints. The results show that at a tilt angle of 24°, the daily cumulative energy yield of the heterogeneous system is approximately 95% of that of the horizontal layout, indicating that the trapezoidal frame structure maintains high power generation efficiency while improving wave resistance. The heading angle has only a minor effect on the daily cumulative energy yield, suggesting that variations in course during marine navigation have little impact on power generation. Nevertheless, a significant coupling effect exists between heading angle and tilt angle. Taking a tilt angle of 60° as an example, when the heading increases from 0° to 90°, the energy yield deficit increases from 26.5% to 30.5%. The parallel configuration exhibits slightly lower energy loss at non-south headings and offers a simplified system structure, although its absolute energy yield is marginally lower at large tilt angles. These findings provide practical design guidance for heterogeneous PV systems in sustained ocean observation, climate research, and other long-duration marine missions. Future work will focus on sea trials, hybrid energy integration, and durability studies to further validate and extend these findings. Full article
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33 pages, 1190 KB  
Article
The Minimal Geometric Deformation Method to Construct Anisotropic Solutions for Polytropic Configurations
by Tayyab Naseer, Muhammad Sharif, Aleena Tehreem, Komal Hassan and Ahmed Emara
Math. Comput. Appl. 2026, 31(3), 99; https://doi.org/10.3390/mca31030099 - 7 Jun 2026
Viewed by 149
Abstract
The minimal geometric deformation method is applied on Einstein–Maxwell field equations in this study to obtain two novel exact anisotropic solutions for polytropic configurations. A static spherically symmetric seed structure penetrated by the anisotropic fluid distribution is taken into consideration in order to [...] Read more.
The minimal geometric deformation method is applied on Einstein–Maxwell field equations in this study to obtain two novel exact anisotropic solutions for polytropic configurations. A static spherically symmetric seed structure penetrated by the anisotropic fluid distribution is taken into consideration in order to accomplish this goal. The gravitational interaction of the new Lagrangian density is then coupled with the initial fluid configuration, representing an additional matter source. We obtain the field equations that correspond to the associated charged fluid sources. Two separate decoupled systems are developed when the field equations are subjected to a radial transformation. By applying the distinct constraints, each system’s solution is determined individually. The entire fluid configuration is then generated by combining these solutions via a certain linear combination. The constraints needed to determine the integration constants in the internal solutions are provided by junction conditions at the interface between the interior and exterior geometry. The suggested models are then verified by comparing them graphically under the observational data from the CenX3 candidate star. In conclusion, for certain values of the decoupling parameter, our derived relativistic solutions satisfy established physical acceptability requirements. Full article
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22 pages, 6176 KB  
Article
Efficient Buckling Analysis of Thin-Walled Composite Beams with Symmetric and Unsymmetric Layups Using a GBT–Ritz Approach
by Navid Kharghani and Christian Mittelstedt
J. Compos. Sci. 2026, 10(6), 307; https://doi.org/10.3390/jcs10060307 - 4 Jun 2026
Viewed by 489
Abstract
Thin-walled composite beams with unsymmetric laminates are attracting increasing attention in lightweight aerospace and mechanical structures because they enable enhanced stiffness tailoring and weight reduction beyond the limitations of conventional symmetric stacking sequences. However, despite their practical relevance, unsymmetric thin-walled laminates have received [...] Read more.
Thin-walled composite beams with unsymmetric laminates are attracting increasing attention in lightweight aerospace and mechanical structures because they enable enhanced stiffness tailoring and weight reduction beyond the limitations of conventional symmetric stacking sequences. However, despite their practical relevance, unsymmetric thin-walled laminates have received comparatively limited attention in the available buckling literature due to the additional complexity introduced by membrane–bending coupling effects. This study presents an efficient and physically transparent formulation for the buckling analysis of thin-walled composite beams with both symmetric and unsymmetric layups by combining Generalized Beam Theory (GBT) with the Ritz method. The proposed GBT-Ritz framework captures global, local, distortional, torsional, and shear-related deformation modes while consistently incorporating laminate coupling effects associated with unsymmetric configurations. The formulation is applicable to open, closed, branched, and unbranched cross-sections commonly encountered in aerospace structures. Validation against ABAQUS V2017 shell finite element models demonstrates excellent agreement (with discrepancies generally below 6%) in predicting critical buckling loads and mode shapes for various geometries and boundary conditions. The results show that unsymmetric laminates can significantly influence buckling behavior, particularly in open sections and intermediate beam lengths where coupling effects become dominant. Compared with conventional finite element approaches, the proposed method achieves substantially lower computational cost (providing speed-up factors of 1.5 to 2.5) while preserving clear physical insight into interacting instability mechanisms. Overall, the developed framework provides an efficient and practically relevant tool for the analysis and design of advanced thin-walled composite structures with tailored unsymmetric laminates. Full article
(This article belongs to the Special Issue Composite Thin-Walled Structures: Stability and Damage)
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13 pages, 1388 KB  
Article
Axial Force Transmission Through Orthosis Straps in a Neonatal Hip Flexion–Abduction Orthosis: An Exploratory In Vivo Study in Infants with Developmental Dysplasia of the Hip
by Paul Schwanitz von Keitz, Kira Henriette Liebau, Wolfram Mittelmeier and Susanne Froehlich
Children 2026, 13(6), 777; https://doi.org/10.3390/children13060777 - 2 Jun 2026
Viewed by 165
Abstract
Background: Developmental dysplasia of the hip (DDH) is the most common congenital musculoskeletal disorder in newborns. Flexion–abduction orthoses are widely used in early treatment; however, in vivo data on their biomechanical load characteristics remain limited. This study aimed to evaluate axial force transmission [...] Read more.
Background: Developmental dysplasia of the hip (DDH) is the most common congenital musculoskeletal disorder in newborns. Flexion–abduction orthoses are widely used in early treatment; however, in vivo data on their biomechanical load characteristics remain limited. This study aimed to evaluate axial force transmission in a hip flexion–abduction orthosis and to compare load patterns between healthy newborns and infants with DDH. Methods: In this exploratory observational study, 36 newborns (19 healthy, 17 with unilateral DDH) were examined within the first week of life. Axial forces transmitted through a Mittelmeier–Graf hip flexion–abduction orthosis (MGO) were measured using integrated force sensors under symmetrical and asymmetrical adjustment configurations. Intergroup comparisons were performed using non-parametric statistical tests. Results: Mean axial forces were significantly higher in healthy infants than in those with DDH under both symmetrical (4.02 N vs. 2.51 N; p = 0.019) and asymmetrical (3.67 N vs. 1.83 N; p = 0.001) conditions. Relative load corresponded to approximately 11–12% of body weight in healthy infants and 5–7% in the DDH group. No significant intra-individual differences were observed between dysplastic and contralateral hips. Orthosis configuration (symmetrical vs. asymmetrical) did not significantly affect load distribution. Conclusions: This exploratory in vivo study demonstrates that axial load transmission in a hip flexion–abduction orthosis is low and influenced by underlying hip pathology. Infants with DDH generate lower forces than healthy newborns, potentially reflecting altered biomechanics. As no significant differences were observed between orthosis configurations, symmetrical adjustment may be favored in clinical practice due to better usability and compliance. Further studies with larger cohorts are needed to confirm these findings. Full article
(This article belongs to the Section Pediatric Orthopedics & Sports Medicine)
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31 pages, 8870 KB  
Article
Adenosine and 1,N6-Ethenoadenosine-Derived Nucleolipids: Synthesis, Lipophilicity (logP), and Cytotoxic Activity Compared to Conventional Cytostatics in Glioma and Glioblastoma Cell Lines
by Mona Lünswilken, Eugenia Bender-Arnst, Fatima Barakat, Eugen Leinweber, Uwe Beginn, Gabriel A. Bonaterra and Ralf Kinscherf
Int. J. Mol. Sci. 2026, 27(11), 4922; https://doi.org/10.3390/ijms27114922 - 29 May 2026
Viewed by 207
Abstract
A series of nucleolipid derivatives based on adenosine and 1,N6-ethenoadenosine was synthesized, and their cytotoxicity was evaluated in glioma and glioblastoma cell models. Twenty O-2′,3′-ketalized nucleolipid derivatives were prepared as symmetric and asymmetric adenosine analogs. The lipophilicity was determined using the [...] Read more.
A series of nucleolipid derivatives based on adenosine and 1,N6-ethenoadenosine was synthesized, and their cytotoxicity was evaluated in glioma and glioblastoma cell models. Twenty O-2′,3′-ketalized nucleolipid derivatives were prepared as symmetric and asymmetric adenosine analogs. The lipophilicity was determined using the octanol/water partition method, yielding logPOW values from −0.04 to 4.08. First, cytotoxicity was screened in rat/human glioma cell lines (BT4Ca/GOS-3) using a PrestoBlue™ viability assay, with 5-fluorouridine (5-FUrd) as the reference compound. Selected derivatives with the highest cytotoxicity were evaluated in human glioblastoma cell lines U87 and U251, and their efficacy was compared with the chemotherapeutic agent temozolomide (TMZ). PMA-differentiated human THP-1 macrophages were used to assess cytotoxic side effects in human immune-related cells. Several derivatives induced 90–100% cytotoxicity at 50 µM after 48 h, with cytotoxicity increasing with alkyl chain length and reaching a maximum for derivatives bearing medium-length chains (C15–C17). In contrast, shorter or longer chains caused reduced activity. Cytotoxicity was independent of symmetric or asymmetric ketal configuration, while 1,N6-ethenoadenosine ketal derivatives displayed higher activity than the corresponding adenosine ketals. These novel derivatives indicate that lipophilicity and alkyl chain length are responsible for the cytotoxic effect in glioma and glioblastoma, and that they are more effective than 5-FUrd and TMZ. Full article
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22 pages, 3625 KB  
Article
Topics and Insights on 1-D Tension Stiffening of an RC Member
by David Z. Yankelevsky, Yuri S. Karinski, Dina Tsemakh and Vladimir R. Feldgun
Materials 2026, 19(11), 2303; https://doi.org/10.3390/ma19112303 - 29 May 2026
Viewed by 273
Abstract
One-dimensional (1-D) tension stiffening is a fundamental behavior of structural concrete. It refers to the composite uniaxial behavior of a slender, symmetric concrete member of constant cross-section, bonded to a single reinforcing bar (rebar) along its axis. The rebar is subjected to tension [...] Read more.
One-dimensional (1-D) tension stiffening is a fundamental behavior of structural concrete. It refers to the composite uniaxial behavior of a slender, symmetric concrete member of constant cross-section, bonded to a single reinforcing bar (rebar) along its axis. The rebar is subjected to tension by a pair of axial tensile forces applied at its ends. Despite the apparent simplicity of this configuration, the problem represents a cornerstone in RC mechanics. During the loading process, cracks are formed at different cross-sections along the structural member at stages where the tensile stress in the concrete at these cross-sections reaches the concrete tensile strength level. Each crack formation reduces the overall axial stiffness of the RC member, while inducing stress and strain redistributions in both the concrete and the rebar. The interaction between the concrete and the rebar is governed by the bond–slip relationship along their interface, which plays a critical role in controlling the transfer of stresses, the development of strains and the evolution of cracking. Most existing analytical and numerical models addressing this problem are based on simplifying assumptions assuming constant (deterministic) material properties and are denoted herein as “deterministic models”. Comparisons between analysis results of such models and experimental observations reveal substantial discrepancies in terms of the number of cracks, their spatial distribution, crack spacing, and the order of crack formation. Considering these inconsistencies, the present study postulates that the inherent variability of concrete properties, particularly its tensile strength, has a decisive influence on the structural response. To address this issue, the tensile strength of concrete is treated as a random variable characterized by the prescribed mean tensile strength and the coefficient of variation (CoV). The “stochastic analyses” with the variable tensile strength are conducted using an exact one-dimensional finite element formulation that explicitly accounts for discrete crack formation within the structural domain. These analyses yield results that differ markedly from those predicted by the deterministic approaches and exhibit characteristics that are in closer agreement with experimental evidence. These analyses indicate a more complex behavior of real structural members. It demonstrates that the CoV significantly influences the magnitude of cracking loads, crack locations, crack spacing, and the order of crack formation. The findings highlight the critical role of even slight material variability in tension stiffening behavior and justify the incorporation of concrete strength variability in tension stiffening modeling. Full article
(This article belongs to the Section Construction and Building Materials)
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25 pages, 358 KB  
Article
Kleisli Semantics and Hypergraph Composition for Greimasian Narrative Programs
by Michael Fowler
Mathematics 2026, 14(11), 1860; https://doi.org/10.3390/math14111860 - 27 May 2026
Viewed by 182
Abstract
This article proposes a category-theoretic formalization of Greimasian narrative programs (NPs) that makes their compositional structure mathematically precise. Building on a reconstruction of the actantial model as a categorical schema, we introduce a refined typological schema of actants and derive Set-valued instances [...] Read more.
This article proposes a category-theoretic formalization of Greimasian narrative programs (NPs) that makes their compositional structure mathematically precise. Building on a reconstruction of the actantial model as a categorical schema, we introduce a refined typological schema of actants and derive Set-valued instances corresponding to role-indexed elements of a narrative. NPs are represented within a categorical schema whose selected morphisms are interpreted using monadic semantics on Set. In particular, the List monad provides Kleisli semantics for modeling non-atomic, list-valued actantial configurations, while the Maybe monad encodes optional dependencies between programs. This yields a compact, structured representation of narrative programs as structured data with an intrinsic compositional interpretation. To account for the compositional dynamics of narrative formation, we lift these constructions into a diagrammatic setting by freely generating a symmetric monoidal category from the set of actants, adjoining narrative program generators, and subsequently equipping the resulting structure with Frobenius operations to obtain a hypergraph category. In this framework, narrative programs act as generators of morphisms, and their composition is realized through wiring diagrams. A narrative trajectory is thereby realized categorically as a single composite morphism. This approach provides a unified mathematical framework for structural semiotics, connecting data-level representations of narrative elements with their compositional realization in discourse. Full article
(This article belongs to the Special Issue Mathematical Logic and Category Theory with Applications)
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17 pages, 9186 KB  
Article
Adaptive Zincophilic Synergistic Double-Network Hydrogel Electrolyte for Low-Temperature Long-Life Zinc Batteries
by Xiyao Huang, Wenwu Wang, Yibo Xiong, Zeyu Ma, Zilu Hu, Huimin Liang, Xiaoqiao Liao, Hongbin Su, Liang He and Xiaoyu Liu
Micromachines 2026, 17(6), 662; https://doi.org/10.3390/mi17060662 - 27 May 2026
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Abstract
Aqueous zinc-ion batteries are promising for large-scale energy storage due to their intrinsic safety, low cost, and environmental friendliness. However, their practical application is severely impeded by water-induced parasitic reactions and uncontrollable dendrite growth at the anode interface. Furthermore, the freezing of aqueous [...] Read more.
Aqueous zinc-ion batteries are promising for large-scale energy storage due to their intrinsic safety, low cost, and environmental friendliness. However, their practical application is severely impeded by water-induced parasitic reactions and uncontrollable dendrite growth at the anode interface. Furthermore, the freezing of aqueous electrolytes at subzero temperature restricts their all-weather viability. Herein, we report a hydrogel electrolyte with interfacial regulation capabilities. By optimizing interfacial ion transport, the hydrogel electrolyte guides uniform Zn2+ deposition, effectively mitigating parasitic reactions and dendrite growth while enabling exceptional low-temperature tolerance. Consequently, the symmetric Zn//Zn cell using the hydrogel electrolyte delivers ultra-high cycling stability for 4000 h at 0.5 mA cm−2 under −30 °C. When assembled into full cells, the Zn//NH4V4O10 configuration operates stably for 4000 cycles at 5 A g−1, exhibiting outstanding capacity retention. Furthermore, the assembled flexible pouch cell maintains 86% of initial capacity after 900 cycles at 3 A g−1. Notably, the pouch cells demonstrate reliable operation and structural integrity under severe conditions, such as ice baths, bending, and piercing. This work provides an effective strategy for durable, wide-temperature, and intrinsically safe flexible aqueous energy storage systems. Full article
(This article belongs to the Special Issue Advancing Energy Storage Techniques: Chemistry, Materials and Devices)
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