Search Results (532)

Strawberry (Fragaria × ananassa (Weston) Rozier) is a high-value crop whose market success depends on fruit quality traits such as sweetness, firmness, and pigmentation. In sustainable agriculture, wood distillates are gaining interest as natural biostimulants. This study evaluated the effects of foliar application of two commercial wood distillates (WD1 and WD2) and one produced in a pilot plant at the Institute for Bioeconomy of the National Research Council of Italy (IBE-CNR) on strawberry physiology, fruit yield, and fruit quality under greenhouse conditions. Non-destructive ecophysiological measurements were integrated using optical sensors for proximal phenotyping, enabling continuous monitoring of plant physiology and fruit ripening. Leaf gas exchange and chlorophyll fluorescence were measured with a portable photosynthesis system, while vegetation indices and pigment-related parameters were obtained using spectroradiometric sensors and fluorescence devices. To assess the functional relevance of vegetation indices, a linear regression analysis was performed between net photosynthetic rate (A) and the Photochemical Reflectance Index (PRI), confirming a significant positive correlation and supporting PRI as a proxy for photosynthetic efficiency. All treatments improved photosynthetic efficiency during fruiting, with significant increases in net photosynthetic rate, quantum yield of photosystem II, and electron transport rate compared to control plants. IBE-CNR and WD2 enhanced fruit yield, while all treatments increased fruit soluble solids content. Non-invasive monitoring enabled real-time assessment of physiological responses and pigment accumulation, confirming the potential of wood distillates as biostimulants and the value of advanced sensing technologies for sustainable, data-driven crop management. Full article

The packaging sector is undergoing a significant transformation driven by increasing environmental challenges and new European regulatory frameworks. The Packaging and Packaging Waste Regulation (PPWR), following the European Green Deal and Circular Economy Action Plan, introduces five strategic priorities: waste prevention, recyclability, recycled content, compostable materials, and reusable systems. This framework aims to systematically review the current state of academic research in relation to these five intervention areas, assessing the extent to which the scientific literature supports the regulation’s circular economy objectives. The PPWR sets guidelines for key aspects such as packaging treatment, recycling targets, Extended Producer Responsibility (EPR) and material optimization. These aspects are strongly linked to market dynamics, driving innovation and new developments in packaging design. This study aims to provide a comprehensive overview of the industry’s evolution, with a focus on the crucial role of the circular economy in addressing the persistent issue of packaging waste. By conducting a systematic literature review using the PRISMA method, the research explores the relationship between the regulation’s structural design and the European Commission’s priority areas. The results reveal that waste prevention and reusability are the most researched areas, particularly concerning environmental assessments and regulatory tools like EPR. Additionally, while recyclability has been studied from technical and environmental perspectives, there is still a lack of research on how it connects with supply chain and material market trends. Strengthening these connections could significantly enhance recycling efficiency and improve the sustainability of packaging systems. Furthermore, financial incentives and policy strategies could play a key role in facilitating the transition to a circular economy. Addressing these gaps will foster a more integrated understanding of sustainable packaging solutions. Full article

The matter of aligning universities’ curricula with the actual demands of a constantly changing labor market has become an important issue nowadays, due to the prevailing mismatches between acquired skills and competences during education years and the necessities of current jobs. Disequilibria and inequalities in the labor market often generate general disappointment with education degrees. With the pressure of technological advancements and AI integration in many areas of work, future employees’ career paths are challenged even more, and the adaptability of higher education institutions to the real needs of the labor market is questioned. Artificial intelligence (AI) is the technology that allows computer systems and machines to simulate human learning, problem-solving, and decision-making. This paper aims to explore if universities in Romania foster sustainable human capital development through enhancing their educational programs to fit the changes produced by artificial intelligence and how the reskilling of graduates will play a hugely significant role in staying resilient during such disruptions. A quantitative survey was conducted among recent Romanian university graduates to outline their perceptions of curriculum relevance and their level of preparedness for the AI-driven job market. The results highlight gaps between formal education and labor market demands in terms of limited exposure to AI-related skills and a growing need for reskilling to secure suitable jobs for graduates in the long term, while also emphasizing the importance of aligning educational policies with sustainable labor market integration. Full article

Belimumab, a human monoclonal antibody that works against B-cell activating factor (BAFF), has significantly advanced the management of systemic lupus erythematosus (SLE). Beyond the initial Phase III randomised controlled trials (RCTs) that demonstrated efficacy for belimumab as an add-on to non-biological standard therapy (ST) along with a favourable safety profile, more than 50 post hoc analyses of RCT data have provided additional insights into its clinical utility. These analyses have shown uniformly that belimumab increases the likelihood of achieving meaningful reductions in disease activity, sustained low disease activity, and improved health-related quality of life (HRQoL) outcomes, with more pronounced benefits in serologically active SLE. Studies focusing on organ-specific manifestations revealed that belimumab confers benefits across multiple SLE facets, with prominent effects on musculoskeletal and mucocutaneous symptoms. Along the same lines, post hoc analyses of the BLISS-LN trial demonstrated benefit from belimumab regarding multiple renal outcomes, including reduced renal flare rates, improved glomerular filtration rate, and improved histological findings in repeat kidney biopsies. Long-term extension studies and real-world evidence confirm its durable efficacy and safety, with continued reductions in overall disease activity, glucocorticoid use, and healthcare resource utilisation over several years. By exploring different efficacy endpoints, person-centred outcomes, disease trajectories, and characteristics across organ manifestations, this body of post-marketing evidence has not only enhanced our understanding of belimumab use in SLE but also constitutes a comprehensive framework for future clinical trial design and development of novel therapeutic strategies. The present review summarises key findings of post hoc analyses of RCTs and observational studies of belimumab. Full article

The research is centered on how India’s top-tier IT companies—the “Big Six” of TCS, Infosys, HCLTech, Wipro, Cognizant, and Tech Mahindra—are integrating sustainability in their digitally driven operations, platforms, and business models. The study employs a mixed methodology, combining critical case study analysis with Fuzzy Delphi validation to assess triangular fuzzy numbers, centroid-based defuzzification, and consensus thresholds. The study explores how AI, big data, analytics, and digital marketing influence environmentally sustainable consumption behaviors within global ecosystems. Results show that, despite limited consumer control, these companies shape sustainability-related behavior indirectly through backend systems, digital platforms, and algorithmic logic—known as “invisible architecture”. This study confirms six main sustainability factors through expert consensus. Noteworthy among those are Digital Infrastructure for Sustainability, Platform Logic for Behavioral Change, and AI-Enabled Analytics and Recommendations. Thematic cross-case results reveal both the promise and ethical challenges of digital sustainability, including the prevalence of greenwashing and risks of overconsumption. Full article

Organic vanilla production in Mexico holds significant promise but faces substantial challenges that impact its sustainability and market competitiveness. As the native region of Vanilla planifolia, Mexico is endowed with rich biodiversity and a deep cultural heritage surrounding vanilla cultivation. Organic production systems in the country predominantly rely on traditional agroforestry practices, manual pollination, and artisanal curing methods, all of which enhance the quality and distinctiveness of Mexican vanilla. However, production is hindered by critical factors, including low genetic diversity and susceptibility to phytopathogenic diseases, particularly stem and root rot caused by Fusarium oxysporum. In recent years, the application of in vitro micropropagation techniques has shown great potential for obtaining pathogen-free plants and conserving germplasm, offering a sustainable alternative to strengthen organic systems and reduce pressure on wild populations. The labor-intensive processes, yield variability, and the complexity of adhering to organic certification standards are additional challenges to overcome. Shifts in consumer preferences toward natural and sustainably produced goods have increased demand for organic vanilla, offering Mexican producers an opportunity to gain a more prominent position in the global market. Advancing research into disease management, fostering genetic conservation, and integrating scientific advances with traditional know-how are vital strategies for overcoming current limitations. In this context, organic vanilla production represents not only an economic opportunity but also a means to conserve biodiversity, support rural communities, and maintain the legacy of one of Mexico’s most emblematic agricultural products. This review was conducted using a qualitative, narrative analysis of recent scientific literature, technical reports, and case studies related to organic vanilla production in Mexico. Full article

Background: Tyrosine kinase inhibitors (TKIs) are crucial to treating endocrine-related malignancies, including advanced thyroid cancers and neuroendocrine tumors, but their benefit is tempered by cutaneous adverse events (CAEs) that impair adherence and quality of life. Objective: To summarize the dermatologic toxicities of TKIs used in endocrine oncology and provide practical, multidisciplinary guidance for prevention and management. Methods: Narrative synthesis of clinical trial reports, post-marketing studies, and specialty guidelines pertinent to lenvatinib, vandetanib, cabozantinib, and other commonly used TKIs, integrating dermatologic and endocrine perspectives on mechanisms and care pathways. Results: VEGFR-targeted TKIs frequently cause hand–foot skin reaction, xerosis, fissuring, paronychia, and impaired wound healing; multikinase inhibition also produces alopecia, pigmentary changes, and mucositis. Epidermal growth factor receptor (EGFR) and rearranged during transfection (RET) inhibition with vandetanib is associated with acneiform eruption, photosensitivity, and nail fragility. Pathogenesis reflects on-target inhibition of VEGF/EGFR signaling leading to keratinocyte dysfunction, vascular fragility, and altered eccrine mechanics. Early risk stratification, patient education, and bundle-based prophylaxis (emollients, keratolytics, urea-based creams, sun protection) reduce incidence and severity. Grade-based algorithms combining topical corticosteroids/antibiotics, dose interruptions or reductions, and short systemic courses (e.g., doxycycline, antihistamines) enable symptom control while maintaining anticancer intensity. Close coordination around procedures minimizes wound-healing complications. Conclusions: Dermatologic toxicities are predictable, mechanism-linked, and manageable with proactive, multidisciplinary care. Standardized prevention and treatment pathways tailored to specific TKIs—particularly lenvatinib, vandetanib, and cabozantinib—can preserve dose intensity, optimize quality of life, and sustain antineoplastic efficacy. Full article

Agriculture is a sector that is subject to regulation and far-reaching public intervention, especially in developed countries. In Poland, a country that passed through a system transformation, inclusion in the European Union’s (EU) Common Agricultural Policy (CAP) mechanisms and the internal market has resulted in positive and multi-dimensional effects for farmers and rural development. This fact is reflected in the evolution of farmers’ attitudes toward the EU, changing from opposition and distrust to acceptance and support. The purpose of the paper is to trace shifts in the political dynamics surrounding the CAP and EU membership among farmers, and to explore their causes. The findings suggest that, following the most recent policy reform—which involved increased environmental and climate commitments alongside market uncertainty—farmers have begun to lean towards a Eurosceptic orientation once more, whilst simultaneously demonstrating ambivalent attitudes towards the CAP. In light of the fragmented representation, the recent protests highlighted a mobilization of grassroots efforts in the pursuit of farmers’ interests. Hence, a question arises regarding the stability of this critical perspective, particularly in the context of future reforms to CAP as well as the economic and climate-related challenges for sustainable agricultural development. This study is based on a literature review alongside economic and social data derived from surveys and public statistics. Full article

This study examines the association between Saudi banks’ internal adoption of AI-enabled FinTech-related digital tools and their financial performance, sustainability performance, and financial stability over the period 2015–2024. Using a panel dataset of 10 banks, the analysis investigates how the adoption of AI-driven technologies—such as machine-learning credit assessment, robo-advisory systems, and automated compliance tools—is related to market performance (Tobin’s Q), accounting performance (ROA and ROE), financial stability (Z-Score), and sustainability outcomes measured by both Bloomberg ESG Disclosure Score and the LSEG ESG performance-oriented score. To ensure robust inference and reduce simultaneity concerns, the empirical strategy employs Pooled OLS and Fixed Effects Models with Driscoll–Kraay standard errors, as well as a dynamic Fixed Effects Models incorporating lagged dependent variables, lagged independent variables, and shock-interaction terms. Bank-specific characteristics—including size, age, leverage, liquidity, loan-to-deposit ratio, non-performing loans, net interest margin, market capitalization, and board size—are included as controls. The findings indicate a positive and statistically significant relationship between banks’ internal adoption of AI-enabled digital/FinTech-related technologies and their financial performance, sustainability performance, and financial stability. These relationships remain robust across estimation approaches, providing insights for policymakers, regulators, and bank managers seeking to advance digital transformation while safeguarding financial soundness and supporting sustainable development in the Saudi banking sector. Full article

This article develops a model of inclusive innovation aimed at strengthening the sustainability of the Opuntia ficus-indica (prickly pear) value chain in Sonsón (Antioquia, Colombia), situating the problem within the broader Latin American context of local agri-food systems under market and climate pressures. The study employs a mixed-methods approach, combining fieldwork in rural veredas (villages), producer surveys, focus groups, and interviews with key stakeholders, along with social cartography, production process mapping, farm georeferencing, and document analysis. Relational diagrams (based on Atlas.ti conventions) and agent-based modeling are incorporated to represent interactions, knowledge flows, and governance rules. A unique ecosystem unprecedented in the literature is proposed, structured around three pillars: (i) preservation and appropriation of the fruit and traditional knowledge, (ii) social context, and (iii) use. These pillars position key capabilities for fostering either inclusive or traditional innovations. The smallholder farmer and the inclusive intermediary emerge as transversal relational actors, a critical condition for overcoming failed attempts at producer association and entrenched oligopsonistic dependencies. The article concludes that combining these three pillars with local capacities and a bottom-up inclusive intermediation approach reduces power asymmetries, strengthens associativity and commercialization, redistributes value toward the origin, and preserves traditional knowledge. As a result, it contributes to endogenous development and offers adaptable pathways for other agri-food value chains. Full article

Tertiary buildings, characterized by temporary uses and frequent renovations of internal spaces, present some criticalities in terms of the consumption of materials that quickly become waste, despite their high residual value, not exploited for further use. The goal of rethinking the life cycle of building products, and related construction systems, enabling multiple cycles of use and extending the life span of the products, presupposes new Organizational Models and changes throughout the whole building process. This paper presents two Pilot Projects (developed within Re-NetTA research), which experiment with innovative Organizational Models and disassembly construction solutions in the tertiary building sector with the goal of extending the life cycle of materials and products through reusing and remanufacturing. The Pilot Projects involve two key operators: a manufacturer and a Third Sector organization. The paper highlights the fundamental key role of digital technologies by analyzing the following: (i) the development of virtual models to understand the technical feasibility for disassembly and to foresee reuse and remanufacturing scenarios; and (ii) the use of digital twin, augmented reality, and web-based platforms as a support tools, to put the products on a virtual market to reach customers before the activities of remanufacturing. Finally, the enabling conditions for improving circularity are discussed in terms of design process, environmental and economic sustainability assessment, and operator networking. Full article

Adaptive facades represent the result of a complex combination of innovative technologies, components, and materials, as well as mechanical, electronic, or digital technologies from sectors outside the construction world (technology transfer), which require a constant multidisciplinary systemic approach. Unlike traditional envelopes, adaptive facades integrate aesthetics, functionality, and energy performance within a single system. This field of research has long been the subject of study by important institutions and research groups that have identified the macro-categories of adaptive envelopes that cover the largest share of the market and have defined the first ISO standards related to dynamic shading, chromogenic envelopes, and active ventilated facades. From the state-of-the-art analysis, adaptive facade systems exhibit short response times, measurable in seconds or minutes, while medium- to long-term adaptability remains underexplored. The objective of this study is to address this gap by considering durability and circularity. Analysis of a database of 329 building envelopes reveals a predominance of short-term strategies within the environmental domain, while long-term strategies focus on material durability and resilience through system regeneration and reuse. These strategies allow for maintaining energy performance by reducing degradation. Ongoing research integrates these strategies with reusability and circularity, extending the perspective beyond the building’s service life to support sustainable lifecycle approaches. Full article

The United Nations Sustainable Development Goal (SDG) 12.3 and the Malabo Declaration both address the critical issue of food loss and waste (FLW), but they differ in scope, timelines and regional focus. While SDG 12.3 provides a global framework and target of 2030, the Malabo Declaration reflects Africa’s pressing need to reduce FLW by 2025. Despite these targets and focus on FLW reduction by the global community, high FLW of fruits and vegetables continues to persist in many parts of Africa due to systemic constraints related to limitations in governance, financing and knowledge. It is estimated that up to 50% of nutritious fruits and vegetables are lost and yet supply hardly meets demand. The objective of this review was to identify the causes of FLW as well as possible solutions to reduce FLW in three fruit and vegetable values chains in East Africa. These three fruit and vegetable value chains were categorized as (i) “exotic, produced all year round, highly perishable and very inexpensive”, (ii) “exotic and indigenous, seasonal production, somewhat perishable and somewhat expensive” and (iii) “indigenous, produced all year round, extremely perishable and inexpensive”, represented by tomatoes, mangoes and indigenous leafy green vegetables, respectively. The upstream (farmer to market place) and downstream (market place to fork) causes of FLW are discussed and their respective solutions are suggested. The solutions provided herein are not only economically viable but also practical and can be adopted for the reduction of FLW in fruit and vegetable value chains in East Africa. This approach could result in the simultaneous increase of the access and affordability of fruits and vegetables for low-income consumers in East Africa. Full article

Background/Objectives: Local production is a global priority for increasing access to routine, outbreak, and pandemic vaccines and leads to a variety of direct and indirect benefits for countries. This study aimed to characterize the enabling environment for the sustainable production of influenza vaccines, including for epidemic and pandemic preparedness. Methods: National/local vaccine manufacturers were surveyed to capture data on influenza vaccine market contributions, government support for local production, and involvement in national pandemic preparedness activities. Using a conceptual framework for sustainable local production of influenza vaccines for epidemic and pandemic preparedness, manufacturers described 41 global/regional, national, and institutional sustainability factors across policy, health system, research and development (R&D), and regulatory thematic domains. In addition to the survey, key findings from country-level sustainability assessments of vaccine production in Bangladesh, Brazil, Indonesia, Serbia, and Viet Nam were analyzed to complement survey results. Results: This study included 12 participants representing 11 manufacturers from 10 countries. Of the 11 manufacturers, six reported that their countries have policies that support local production, but most manufacturers reported benefiting from some level of direct or indirect support by the government. Manufacturers considered 40/41 factors as important for sustainable production of influenza vaccines, and among the four domains, influenza prevention and control policies, influenza burden data, quality management, and regulatory filing capacity ranked highly. Additionally, manufacturers ranked factors related to cohesive policies for local production promotion and business/strategic planning at the manufacturer level as the top sustainability factors. Conclusions: Manufacturers broadly agreed on the importance of cohesive policies, evidence-based public health priorities, robust R&D and manufacturing investments, and regulatory readiness, though perceptions varied across contexts and company characteristics. Sustainable local production of influenza vaccines should be driven by the alignment of policies, investments, and demand. Full article

Street greening is widely recognized as influencing resident well-being and housing prices, and street-view imagery provides a fine-grained data source for quantifying urban microenvironments. However, existing research predominantly relies on single indicators such as the Green View Index (GVI) and overall green coverage/volume lacking a systematic analysis of how the hierarchical structure of trees, shrubs, and grass relates to housing prices. This study examines the high-density block context of Tianjin’s six urban districts. Using the Street Greening Space Structure (SGSS) dataset to construct greening structure configurations, we integrate housing-price data, neighborhood attributes, and 13,280 street-view images from the study area. We quantify how “visibility and hierarchical ratios” are capitalized on in the housing market and identify auditable threshold ranges and contextual gating. We propose an urban–forest structural system centered on visibility and hierarchical ratios that links street-level observability to ecosystem services. Employing an integrated framework combining Geographical-XGBoost (G-XGBoost) and SHapley Additive exPlanations (SHAP), we move beyond average effects to reveal structural detail and contextual heterogeneity in capitalization. Our findings indicate that tree visibility G_TVI is the most robust and readily capitalized price signal: when G_TVI increases from approximately 0.06 to 0.12–0.16, housing prices rise by about 8%–10%. Hierarchical structure is crucial: balanced tree–shrub ratios and moderate shrub–grass ratios translate “visible green” into functional green. Capitalization effects are environmentally conditioned—more pronounced along corridors with high centrality and accessibility—and are likewise common in dense East Asian metropolises (e.g., Beijing, Shanghai, Seoul, and Tokyo) and rapidly motorizing cities (e.g., Bangkok and Jakarta). These patterns suggest parametric prescriptions that prioritize canopy-corridor continuity and keep ratios within actionable threshold bands. We translate these findings into urban greening strategies that prioritize canopy continuity, under-canopy permeability, and maintainability, providing sustainability-oriented, parameterized guidance for converting urban greening structure into ecological capital for sustainable cities. Full article