Search Results (36,175)

Cardiomyopathies represent a heterogeneous group of myocardial disorders, traditionally classified by phenotype into hypertrophic, dilated, and arrhythmogenic. Historically, these conditions have been attributed to high-penetrance rare variants in key structural genes, consistent with a classical Mendelian pattern of inheritance. However, emerging evidence suggests that this model does not fully capture the full spectrum and complexity of disease expression. Many patients do not harbor identifiable pathogenic variants, while others carrying well-known disease-causing variants remain unaffected. This highlights the role of incomplete penetrance, likely modulated by additional genetic modifiers. Recent advances in genomics have revealed a broader view of the genetic basis of cardiomyopathies, introducing new players such as common genetic variants identified as risk alleles, as well as intermediate-effect variants. This continuum of genetic risk, reflecting an overall genetic influence, interacts further with environmental and lifestyle factors, likely contributing together to the observed variability in clinical presentation. This model offers a more realistic framework for understanding genetic inheritance and helps provide a clearer picture of disease expression and penetrance. This review explores the evolving genetic architecture of cardiomyopathies, spanning from a monogenic foundation to intermediate-risk variants and complex polygenic contribution. Recognizing this continuum is essential for enhancing diagnostic accuracy, guiding family screening strategies, and enabling personalized patient management. Full article

Background/Objectives: Grief in cancer patients represents a multidimensional psychological response encompassing anticipatory, existential, and identity-related distress. While the recent literature has examined grief in caregivers, family members, and even healthcare professionals, the psychological grief experienced by patients themselves following a cancer diagnosis remains comparatively understudied and insufficiently characterized in empirical research. This systematic review aims to evaluate observational studies that used validated psychometric instruments to measure grief in adult cancer patients and to synthesize findings on the significance of grief in this population. Methods: Following PRISMA 2020 guidelines, a systematic search of PubMed, CINAHL, and PsycINFO was conducted to identify observational studies that employed validated tools to assess grief among adult cancer patients. The inclusion criteria required the use of psychometrically validated grief instruments and the collection of quantitative data. Fifteen studies met eligibility criteria and were included in the final analysis. Results: Grief symptoms were consistently present at moderate to high levels across diverse cancer types, care settings, and geographic regions. Preparatory Grief in Advanced Cancer (PGAC) scores often exceeded thresholds associated with clinical concern, with correlations observed between grief and psychological variables such as anxiety (r = 0.63), depression (r = 0.637), hopelessness (r = 0.63), and dignity (r = 0.654). Demographic factors (e.g., younger age, female gender) and illness perceptions (e.g., identity centrality, stigma) further intensified grief. Grief was a predominant psychological concern even when general distress measures failed to capture its presence. Conclusions: Future research is essential to identify an effective public health strategy for addressing grief through structured screening conducted in primary care and outpatient medical settings, coupled with accessible referral pathways to community-based support groups and coordinated follow-up services to facilitate grief management. Full article

Background and Objectives: Orthodontic treatment, whether fixed or removable, offers several benefits, including improved aesthetics, enhanced oral function, and increased self-confidence. However, it may also cause discomfort and pain, particularly following adjustment visits. This study aimed to assess pain characteristics (latency and continuity), food impairment, weight loss, and analgesic use in relation to treatment duration and appliance type. Methods: This observational study included 160 orthodontic patients who completed a structured questionnaire comprising 13 single-choice items. The questionnaire assessed age, gender, residential environment, educational status, type and duration of orthodontic treatment, pain characteristics (duration, latency, continuity), food impairment, and analgesic use. Inclusion criteria specified patients with moderate anterior crowding undergoing fixed orthodontic treatment or treatment with clear aligners on both arches, for at least one month. All fixed appliance cases involved 0.022-inch-slot Roth prescription brackets. Results: Patients undergoing fixed orthodontic treatment reported a higher frequency of pain (91.4%), greater need for analgesics (95.2%), and more food impairment compared to those with clear aligners. Patients treated for less than 6 months more frequently reported pain lasting 1 week (57.1%), while those treated for 1–2 years more commonly reported pain lasting several days (43.8%). Conclusions: Fixed orthodontic appliances are associated with greater discomfort, longer pain latency, more frequent analgesic use, and higher dietary impact compared to clear aligners. These findings emphasize the importance of personalized patient counseling and proactive pain management to improve compliance, enhance quality of life, and support informed decision-making in orthodontic care. Full article

Objectives: Recently, increased attention has been given to pumpkin due to its proved nutritional components, which include antioxidant, antifatigue, and anti-inflammatory effects. The aim of the present work was to assess the impact of Cucurbita pepo L. (CP) on chronic unpredictable mild stress (CUMS)-induced changes in lymphoid organs through evaluating its effect on the histological structure of spleen, thymus gland, and lymph nodes compared to the antidepressant fluoxetine (FLU). Materials and Methods: Fifty male albino rats equally distributed into five groups that included control, control + CP, CUMS-exposed, FLU-treated, and CP-treated groups were used in this study. Rats were exposed to CUMS for 4 weeks, and treatment (either with FLU or CP) was started after 14 days of exposure. Behavior of the rats, serum corticosterone, oxidants/antioxidants profile, proinflammatory cytokines, and gene expression of glucocorticoid receptor (GR) and β-adrenergic receptor (β2-AR) were assessed after 28 days. Spleen, thymus gland, and lymph nodes were histopathologically assessed. Results: CP administration significantly reduced the CUMS-induced behavioural changes evident by the significant reduction in immobility time (p = 0.02) and corticosterone level (p < 0.001). Biochemically, CP reduced TNF-α and IL-6 (p < 0.001) and markedly alleviated the changes in oxidants/antioxidants in the serum and lymphoid organs compared to fluoxetine. CP significantly (p < 0.001) reduced CUMS-induced changes in GR and (β2-AR). Histopathologically, CP alleviated changes observed in the spleen, lymph nodes, and thymus gland. It significantly reduced the number of CD4, CD8, CD68, CD20, and caspase-3 immunopositive cells in the studied organs. Conclusions: This study proved the potential efficacy of CP in alleviating depression-associated immunodysregulation either alone or in combination with antidepressant therapy. Full article

We investigate the affine term structure models (ATSMs) with unspanned stochastic volatility (USV). Our aim is to test their ability to generate accurate cross-sectional behavior and time-series dynamics of bond yields. Comparing the restricted models and those with USV, we test whether they produce both reasonable estimates for the short rate variance and cross-sectional fit. Essentially, a joint approach from both time series and options data for estimating risk-neutral dynamics in ATSMs should be followed. Due to the scarcity of derivative data in emerging markets, we estimate the model using only time-series of bond yields. A Bayesian estimation approach combining Markov Chain Monte Carlo (MCMC) and the Kalman filter is employed to recover the model parameters and filter out latent state variables. We further incorporate macro-economic indicators and GARCH-based volatility as external validation of the filtered latent volatility process. The $A_1\left(4\right)$USV performs better both in and out of sample, even though the issue of a tension between time series and cross-section remains unresolved. Our findings suggest that even without derivative instruments, it is possible to identify and interpret risk-neutral dynamics and volatility risk using observable time-series data. Full article

Groundwater contamination by nitrates (NO₃⁻) and nitrites (NO₂⁻) is an urgent problem in rural areas of Eastern Europe, with profound public health and sustainability implications. This paper presents an integrated assessment of groundwater vulnerability and water quality in rural wells in the Ceanu Mare commune, Cluj County, Romania—a representative area of the Northern Transylvania Basin, characterized by diverse geological structures, intensive agricultural activities, and incomplete public water infrastructure. This study combines detailed hydrochemical analyses, household-level studies, and geological context to identify and quantify key factors influencing nitrate and microbial contamination in rural wells, providing a comprehensive perspective on water quality challenges in the central part of Romania. This study adopts a multidisciplinary approach, integrating detailed geotechnical investigations conducted through four strategically located boreholes. These are complemented by extensive hydrogeological and lithological characterization, as well as rigorous chemical and microbiological analyses of nearby wells. The results reveal persistently elevated concentrations of NO₃⁻ and NO₂⁻, commonly associated with inadequate livestock waste management and the proximity of manure storage areas. Microbiological contamination was also frequent. In this study, the NO₃⁻ levels in well water ranged from 39.7 to 48 mg/L, reaching up to 96% of the EU/WHO threshold (50 mg/L), while the NO₂⁻ concentrations varied from 0.50 to 0.69 mg/L, exceeding the legal limit (0.5 mg/L) in 87% of the sampled wells. Ammonium (NH₄⁺) was detected (0.25–0.34 mg/L) in all the wells, below the maximum allowed limit (0.5 mg/L) but indicative of ongoing organic pollution. All the well water samples were non-compliant for microbiological parameters, with E. coli detected in 100% of cases (5–13 CFU/100 mL). The regional clay–marl substrate offers only limited natural protection against pollutant infiltration, primarily due to lithological heterogeneity and discontinuities observed within the clay–marl layers in the study area. This research delivers a replicable model for rural groundwater assessment and addresses a critical gap in regional and European water safety studies. It also provides actionable recommendations for sustainable groundwater management, infrastructure development, and community risk reduction in line with EU water directives. Full article

Energy generation from renewable sources has increased exponentially worldwide, particularly wind energy, which is converted into electricity through wind turbines. The growing demand for renewable energy has driven the development of horizontal-axis wind turbines with larger dimensions, as the energy captured is proportional to the area swept by the rotor blades. In this context, the dynamic loads typically observed in wind turbine towers include vibrations caused by rotating blades at the top of the tower, wind pressure, and earthquakes (less common). In offshore wind farms, wind turbine towers are also subjected to dynamic loads from waves and ocean currents. Vortex-induced vibration can be an undesirable phenomenon, as it may lead to significant adverse effects on wind turbine structures. This study presents a two-dimensional transient model for a rigid body anchored by a torsional spring subjected to a constant velocity flow. We applied a coupling of the Fourier pseudospectral method (FPM) and immersed boundary method (IBM), referred to in this study as IMERSPEC, for a two-dimensional, incompressible, and isothermal flow with constant properties—the FPM to solve the Navier–Stokes equations, and IBM to represent the geometries. Computational simulations, solved at an aspect ratio of $\varphi =4.0$, were analyzed, considering Reynolds numbers ranging from $Re=150$ to Re = 1000 when the cylinder is stationary, and $Re=250$ when the cylinder is in motion. In addition to evaluating vortex shedding and Strouhal number, the study focuses on the characterization of space–time symmetry during the galloping response. The results show a spatial symmetry breaking in the flow patterns, while the oscillatory motion of the rigid body preserves temporal symmetry. The numerical accuracy suggested that the IMERSPEC methodology can effectively solve complex problems. Moreover, the proposed IMERSPEC approach demonstrates notable advantages over conventional techniques, particularly in terms of spectral accuracy, low numerical diffusion, and ease of implementation for moving boundaries. These features make the model especially efficient and suitable for capturing intricate fluid–structure interactions, offering a promising tool for analyzing wind turbine dynamics and other similar systems. Full article

Objective: This study aimed to explore the burden attributable to different groups of risk factors (environmental/occupational, behavioral, and metabolic) in Saudi Arabia that were stratified by gender and year and measured by summary exposure values (SEVs) and disability-adjusted life years (DALYs) per 100,000. Design: This study was structured as a systematic analysis. Methods: Using the GBD 2021 data, we extracted information on different risk factors attributed to the disease burden in Saudi Arabia to quantify the differences in exposure value (SEV) and disability-adjusted life year (DALY) rates (per 100,000) between females and males across different years. Results: Over the years, sustained progress in reducing the number of DALYs attributable to specific environmental and occupational risks has been observed, as well as a slight decrease in some behavioral risks. The highest disease burden was attributed to metabolic and behavioral risk factors, with body mass index being the leading risk factor for both genders. Between 1990 and 2021, the age-standardized DALY rate in those with high body mass indices increased by 168.4% and reached 3436.23 (95% UI 1878.7–5031.5) in males and increased by 125.2% to reach 2952.6 (95% UI 1456.9–4.407) in females. The age-standardized SEVs were the highest in females with a high body mass index, reaching an SEV of 57.98 (95% UI: 64.1–49.2), and in males, an SEV of 50.75 (95% UI: 57.1–42.3) was achieved. Regarding their attributable deaths in 2021, metabolic risk factors were identified as the primary contributors to NCD mortality in 2021. Conclusions: These results reveal persistent health disparities between males and females, underscoring the urgent need for gender-specific research, policies, and interventions. Strategies aimed at promoting health and reducing disease burden should acknowledge the unique health challenges encountered by males and females. Full article

Petroleum-contaminated soil is an increasingly severe environmental issue. The integration of phytoremediation and microbial remediation can effectively mitigate their individual limitations and enhance remediation efficiency. In this study, four newly isolated bacterial strains (including Cytobacillus and Rhodococcus) that exhibited preferential degradation of distinct petroleum components were combined with the rhamnolipid-producing strain Pseudomonas aeruginosa SL-1. The immobilization of this petroleum-degrading microbial consortium was performed by biochar adsorption and sodium alginate embedding, subsequently optimized using response surface methodology (0.75 g·L⁻¹ of biochar, 40 g·L⁻¹ of sodium alginate, and 40 g·L⁻¹ of calcium chloride). The results showed that the highest petroleum degradation rate (97.1%) of immobilized bacterial consortium was achieved at 72 h at a petroleum concentration of 5.0 g·L⁻¹. When combined with Sudan grass for soil bioremediation, the degradation rate reached 72.8% after 120 d for soil containing 5.0 g·kg⁻¹ of petroleum, higher than the results for the treatments with only immobilized bacterial consortium (53.0%) or Sudan grass (49.2%). Furthermore, significant improvements were observed for soil pH; nitrogen, phosphorus, and potassium contents; and urease, dehydrogenase, and catalase activities. Composite treatment also significantly increased the diversity and richness of the soil bacterial community and regulated its structure, function, and network composition. This study offers theoretical insights and potential practical applications for the enhanced bioremediation of petroleum-contaminated soils. Full article

The Bignoniaceae family encompasses numerous species of ecological, medicinal, and cultural significance, yet its ethnobotanical value remains underexplored in many regions of Thailand. This study investigates the diversity, phenology, cultural relevance, and traditional uses of Bignoniaceae species in Maha Sarakham Province, Northeastern Thailand. Through semi-structured interviews with 260 local informants across 13 districts—alongside field observations and herbarium voucher collections—we documented 27 species across 21 genera. These integrated methods enabled the identification of key culturally significant species and provided insights into their traditional uses. Phenological data revealed clear seasonal patterns in flowering and fruiting, aligned with the regional climatic cycle. Quantitative ethnobotanical indices—including Species Use Value (SUV), Genera Use Value (GUV), Relative Frequency of Citation (RFC), Cultural Importance Index (CI), and Cultural Food Significance Index (CFSI)—were employed to evaluate species significance. Results indicate that species such as Dolichandrone serrulata, D. spathacea, and Oroxylum indicum hold high cultural and practical value, particularly in traditional medicine, spiritual practices, and local landscaping. These findings underscore the critical role of Bignoniaceae in sustaining biocultural diversity and emphasize the urgency of preserving traditional botanical knowledge amid environmental and socio-economic change. Moreover, the insights contribute to broader efforts in cultural heritage preservation and biodiversity conservation across tropical and subtropical regions. Full article

This paper explores the role of one-part alkali-activated cement, utilizing metakaolin as a precursor, in the long-term stabilization of mining tailings. Investigating three key factors (Si/Al and Na/Si ratios and curing period), this study reveals insights into the mechanical performance and microstructure of alkali-activated cemented iron ore tailings. Unconfined compressive strength test, statistical analysis, and Scanning Electron Microscopy analysis with Energy Dispersive Spectroscopy were performed. Findings indicate that the Si/Al ratio significantly influences strength, with an optimal ratio of 3.5. The Na/Si ratio introduces complexity, affecting alkali availability and reactivity, leading to nuanced strength variations. Extended curing periods consistently enhance the strength of alkali-activated cement, highlighting its dynamic nature. Notably, the 7-day specimens exhibit a less homogeneous distribution, weaker bonding, and decreased structural integrity compared to their 60-day counterparts. This research underscores the intricate nature of alkali-activated cement hydration, emphasizing the interdependence of Si/Al and Na/Si ratios. The observed strengthening effect with prolonged curing suggests the potential for tailoring these materials to specific applications. Addressing a research gap, especially in applying alkali-activation to mining tailings stabilization, this study highlights metakaolin’s role as a suitable precursor. Full article

This study investigates the effect of accelerated aging on the microstructure and surface properties of synthetic sports surfaces, with the goal of developing a more representative laboratory simulation method. Three common types of polyurethane-based sports surfaces were examined: (1) a dual-layer SBR base with a thin EPDM spray topcoat; (2) a single-layer EPDM surface with a smooth finish; and (3) a dual-layer “sandwich” structure with a rough EPDM upper layer. Samples were tested for slip resistance (PTV), abrasion resistance, and surface morphology using SEM, as well as surface roughness and tensile properties before and after aging. Method combining UV radiation and water spray was introduced and evaluated. Microstructural analysis with roughness measurements revealed surface degradation in all materials, with more extensive damage observed in the UV + spray cycle. Slip resistance results showed reduced performance in dry conditions and improved values in wet conditions post-aging. The single-layer EPDM surface demonstrated the highest initial dry PTV, while the dual-layer with spray had the lowest. After aging, all surfaces exhibited smaller differences between dry and wet performance but no longer met dry condition standards. These results may guide future revisions of performance testing standards and contribute to the development of safer, longer-lasting synthetic sports surfaces. Full article

Increased concern for human health and the environment has pushed various industries to adopt new approaches towards satisfying modern regulations. Strategies to achieve these approaches include utilizing lightweight materials, repurposing waste materials, and substituting synthetic polymers with bio-based counterparts. This study investigates the effects of treated fly ash (C) and bio-based polyamide 10.10 (PA10) on the thermal, morphological, and mechanical properties of glass fiber (GF)-reinforced polyamide 6 (PA6). Our main objective was to develop a composite that would allow for the partial replacement of glass fiber in reinforced polyamide 6 composites (PA6-30G) while maintaining a favorable balance of mechanical properties. Composites processed via melt processing demonstrated enhanced mechanical properties compared to PA6-30G. Notably, significant improvements were observed in impact strength and tensile strain at break. The addition of PA10 resulted in increases of 18% in impact strength and 35% in tensile strain relative to PA6-30G. Complementary, structural and morphological analyses confirmed strong interfacial interactions within the composite matrix. These findings indicate that a PA6/PA10 hybrid composite may represent a viable alternative material for potential automotive applications. Full article

Structural health monitoring in resource-constrained environments demands crack segmentation models that match the accuracy of heavyweight convolutional networks while conforming to the power, memory, and latency limits of watt-level edge devices. This study presents a lightweight dual-attention network, which is a four-stage U-Net compressed to one-quarter of the channel depth and augmented—exclusively at the deepest layer—with a compact dual-attention block that couples channel excitation with spatial self-attention. The added mechanism increases computation by only 19%, limits the weight budget to 7.4 MB, and remains fully compatible with post-training INT8 quantization. On a pixel-labelled concrete crack benchmark, the proposed network achieves an intersection over union of 0.827 and an F1 score of 0.905, thus outperforming CrackTree, Hybrid 2020, MobileNetV3, and ESPNetv2. While refined weight initialization and Dice-augmented loss provide slight improvements, ablation experiments show that the dual-attention module is the main factor influencing accuracy. With 110 frames per second on a 10 W Jetson Nano and 220 frames per second on a 5 W Coral TPU achieved without observable accuracy loss, hardware-in-the-loop tests validate real-time viability. Thus, the proposed network offers cutting-edge crack segmentation at the kiloflop scale, thus facilitating ongoing, on-device civil infrastructure inspection. Full article

Gastric cancer remains a major global health challenge, largely due to its biological heterogeneity and limited treatment options for advanced stages. Among the numerous molecular players involved in its pathogenesis, galectins—β-galactoside-binding lectins—have emerged as key modulators of tumor behavior. These multifunctional proteins influence diverse processes including cell proliferation, invasion, immune evasion, stromal remodeling, and therapy resistance. Recent advances in experimental and clinical research have shed light on the complex roles of galectin family members—particularly Galectin-1, -3, and -9—in shaping the tumor microenvironment and driving disease progression. This review highlights the current understanding of galectin biology in gastric cancer, with emphasis on their structural characteristics, cellular localization, functional diversity, and translational relevance. By synthesizing insights from molecular studies and clinicopathological observations, we explore the potential of galectins as biomarkers and therapeutic targets in the evolving landscape of gastric cancer research. Full article