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Article

15 Citations

3,935 Views

10 Pages

Pyrrole-Containing Alkaloids from a Marine-Derived Actinobacterium Streptomyces zhaozhouensis and Their Antimicrobial and Cytotoxic Activities

Chang-Su Heo,
Jong Soon Kang,
Joo-Hee Kwon,
Cao Van Anh and
Hee Jae Shin

Mar. Drugs2023, 21(3), 167;https://doi.org/10.3390/md21030167

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6 March 2023

Two new alkaloids, streptopyrroles B and C (1 and 2), were discovered through a chemical investigation of the ethyl acetate (EtOAc) extract from a marine-derived actinomycete, Streptomyces zhaozhouensis, along with four known analogs (3–6). The...

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Article

3 Citations

2,772 Views

15 Pages

Metabolic Blockade-Based Genome Mining of Sea Anemone-Associated Streptomyces sp. S1502 Identifies Atypical Angucyclines WS-5995 A–E: Isolation, Identification, Biosynthetic Investigation, and Bioactivities

Yuyang Wang,
Le Zhou,
Xiaoting Pan,
Zhangjun Liao,
Nanshan Qi,
Mingfei Sun,
Hua Zhang,
Jianhua Ju and
Junying Ma

Mar. Drugs2024, 22(5), 195;https://doi.org/10.3390/md22050195

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25 April 2024

Marine symbiotic and epiphyte microorganisms are sources of bioactive or structurally novel natural products. Metabolic blockade-based genome mining has been proven to be an effective strategy to accelerate the discovery of natural products from both...

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