Search Results (83)

The objective of this paper is to ascertain the manner in which the Qurʾān teaching activities are conducted in Jaʿfarī communities that are part of the multicultural structure of Türkiye. The methodological approach of this study is a case study design. This study’s sample consists of nine instructors who voluntarily work in Qurʾān teaching centres for Jaʿfarī communities. Criterion sampling and maximum diversity were employed in the selection of the participants. The data were collected using a semi-structured interview form. The collected data were subjected to a descriptive analysis. This study’s findings are as follows: firstly, the importance of early childhood education in the transmission of the Qurʾān among the Jaʿfarīs is evident. Secondly, the basis of this teaching is the Alif-Baa Juz education. Thirdly, mosques, association centres and neighbourhood houses play an important role in this teaching activity. Finally, according to Qurʾān instructors, traditionally the mosques were the primary centres for Qurʾān education; however, this has been lost especially after the pandemic. In addition to having the knowledge and competency of the recitation of the Qurʾān, the instructors who are supposed to work in these places are required to behave in accordance with Islamic morality. Over the recent times, families have started to prioritise their children’s academic success over religious education. Lastly, Jaʿfarīs do not have any safety concerns pertaining to the state while carrying out religious education activities. The findings, in general, reveal that Jaʿfarīs have similarities with the traditional teaching of Qurʾān in terms of method, content, materials and to some extent instructor competence, etc. The results of this paper are significant in terms of providing a concrete indicator of the pluralistic understanding that Türkiye advocates in religious education policies and in understanding the religious education practices of Jaʿfarī communities. Full article

Wetlands provide the world with important ecosystem services (ES) including carbon (C) storage. The Ramsar Convention (RC) is the only global treaty on wetlands outside of the United Nations (UN) with 172 contracting parties across the world as of 2025. The goals of the convention are to promote the wise use and conservation of wetlands, designation of suitable wetlands as wetlands of international importance, and international cooperation. The problem is that there is no consensus for standard global analysis, which is needed to ensure wetlands conservation. The novelty of this study is the use of methodology that combines satellite-based land cover change analysis with high-resolution spatial databases to help understand the change in wetlands area over time and identify potential hotspots for C loss. Greenhouse gas (GHG) emissions from wetland conversions represent “transboundary” damages. Therefore, C loss from wetlands conversions can be expressed through the “realized” social cost of C (SC-CO₂) which is a conservative estimate of the damages caused by carbon dioxide (CO₂) release. A case study of the contiguous United States of America (USA) using raster analysis within ArcGIS Pro showed key findings that almost 53% of the wetlands area was lost between 1780 and 1980, starting with 894,880.7 km² in 1780 and falling to 422,388.2 km² in 1980. This net loss generated damages including midpoint total soil C loss (6.7 × 10¹³ kg of C) with associated midpoint “realized” social costs of C (SC-CO₂) value of $11.4T (where T = trillion = 10¹², $ = United States dollars, USD). Recent analysis of the contiguous USA (2001–2021) revealed wetlands area losses and damages in all states. The newly demonstrated method for rapid monitoring of wetlands changes over time can be integrated into systems for worldwide monitoring to support the RC wise use concept. Full article

On October 16th 1843, the prominent Irish mathematician Sir William Rowan Hamilton, in an inspired act of vandalism, carved his famous $i^2=j^2=k^2=ijk=-1$ on the Brougham Bridge in Dublin, thus starting a major clash of ideas with the potential to change the course of history. Quaternions, as he called his invention, were quite useful in describing Newtonian mechanics, and as it turned out later—also quantum and relativistic phenomena, which were yet to be discovered in the next century. However, the scientific community did not embrace this new approach with enthusiasm: there was a battle to be fought and Hamilton failed to make a compelling case probably because he was standing alone at the time. Although Quaternions were soon to find useful applications in geometry and physics (with the works of Clifford, Cayley, Maxwell, Einstein, Pauli, and Dirac), the battle seemed lost a few decades after Hamilton’s death. But, a century later computer algorithms turned the tides, and nowadays we are witnessing a revived interest in the subject, prompted by technology. Full article

Background: Hypophosphatasia (HPP) is an inherited disease caused by low activity of tissue-nonspecific alkaline phosphatase. Dental characteristics include premature loss of primary teeth, enlarged pulp chambers, and enamel hypoplasia. Although enzyme replacement therapy with asfotase alfa was approved in 2015, there are few reports about the dental outcomes of this treatment. Case presentation: A 1-year-old girl referred to our hospital had already lost two primary teeth at the time of her initial visit. She started enzyme replacement therapy 6 days after birth, and genetic analysis later confirmed the diagnosis of HPP. At the age of 4 years and 7 months, 11 primary teeth had been lost, and some of the exfoliated teeth showed inflammatory root resorption or root fracture. There was also a history of abscess formation in a non-carious primary molar. Conclusions: This report suggests that early enzyme replacement therapy may prevent traditional tooth loss in patients with HPP. It also highlights the new challenges posed for dental professionals in providing infection control in large pulp cavities and receding periodontal tissue. Full article

This study aimed to evaluate the antimicrobial effectiveness of different disinfection protocols for dentures by combining methods, varying intervention sequences, sodium hypochlorite (NaOCl) concentrations (0.1% and 0.25%), and post-exposure to intraoral temperature. The heat-polymerized poly(methylmethacrylate) (PMMA) was divided into groups (n = 15): control (C, distilled water immersion), B (brushing), I0.1% and I0.25% (isolated NaOCl immersion), B + I0.1% and B + I0.25% (brushing followed by immersion), I + B0.1% and I + B0.25% (immersion followed by brushing), and B + I0.1% + T and B + I0.25% + T (brushing, NaOCl immersion, and overnight exposure to 35 °C ± 2 °C). The post-disinfection exposure to intraoral temperature simulated the denture use during sleeping time. Quantitative evaluation was performed by colony-forming unit (CFU/mL) counting of C. albicans and qualitative analysis by scanning electron microscopy (SEM) images. Data were processed by one-way ANOVA with Tukey’s post-hoc test to compare different protocols at the same concentration and among groups (α ≤ 0.05). Applying 0.25% NaOCl in associated protocols, the intervention sequence was no different (B + I and I + B) and caused the lowest C. albicans counts. The 0.1% NaOCl lost part of its action when the immersion method started the protocols. B + I0.25%, I0.25% + B, and B + I0.1% had similar antimicrobial efficacy, but the intraoral temperature (B + I + T) reduced the efficacy of these protocols, regardless of NaOCl concentration. Residual biofilm recolonization was also detected in SEM images. In conclusion, all the combinations between mechanical and chemical methods using 0.25% NaOCl were the most effective against C. albicans. The antimicrobial efficacy of NaOCl at 0.1% changes depending on the intervention sequence. The intraoral temperature influenced the C. albicans recolonization after the disinfection protocols. Full article

In this time series study, the temporal sequences of postmortem changes in brains kept at different temperatures were investigated in different areas of mouse brains. Fixation of tissues kept at different storage temperatures (4 °C, 22 °C, 37 °C) was delayed for four time points (24, 120, 168, 336 h). Histological and immunohistochemical investigations were carried out to determine how postmortem autolysis may affect the cellular morphology and the expression of neural cell epitopes. Results showed that the autolytic changes started earlier in brains at 22 °C and 37 °C and in the grey matter compared to the white matter, with the cerebellum and hippocampus showing the earliest postmortem changes. The cellular antigens were differently affected by the autolytic process overtime: NeuN and Olig2 immunoreactivity was gradually lost at the nuclear site and diffused into the cytoplasm; increased background staining was observed with SMI-32; GFAP showed an increase in immunolabeling, whereas 2F11 immunoreactivity decreased. This study suggests that the morphological analysis and immunohistochemical investigation of the brain tissue could be satisfactorily applied to forensic cases, providing useful data for the estimation of the postmortem interval. Full article

Arcangelo Scacchi (1810–1893) one of the greatest Italian geoscientists known worldwide, especially for his contributions in the fields of mineralogy and volcanology, dedicated his early years to malacological and zoological works. This paper aims to pay homage to a lesser-known side of the scientist, focusing on a malacological work related to fossils from his hometown, Gravina, in Puglia (southern Italy), located within the boundaries of the MurGEopark, which is aspiring to become a UNESCO Global Geopark (aUGGp), and at the border of Parco Nazionale dell’Alta Murgia (Alta Murgia National Park). Among others, Arcangelo Scacchi described 16 new species of molluscs but his precious collection, hosted in Naples, in the Real Museo Mineralogico (Royal Mineralogical Museum), now Museo di Paleontologia dell’Università di Napoli Federico II (Museum of Palaeontology of the University of Naples Federico II), was partly lost. In recent years, research has allowed the resampling of some species he described for the first time in 1835. Starting from this material, the figure of Scacchi was highlighted to the public through the temporal exhibitions and the use of 3D digital models of these resampled fossils. This activity represents: (i) a tribute to the first modern geoscientist who worked in the area of the MurGEopark, (ii) an instrument to preserve palaeontological remains of international importance, and (iii) a public opportunity to know this kind of geocultural heritage enriching the potential examples of (geo)dissemination in the MurGEopark. Full article

The global food security crisis is emphasized by the alarming amount of food waste, where about one-third of the world’s food production, roughly 1.3 billion metric tons, is lost annually. Pathogens, such as Botrytis cinerea, contribute significantly to this loss by attacking stored agricultural produce. These attacks typically start when pathogens infiltrate small fruit wounds, remain dormant, and then switch to an aggressive necrotrophic stage upon ripening, causing significant postharvest food losses. In response to this challenge, this study presents an innovative application of Reverse Transcriptase Loop-Mediated Isothermal Amplification (RT-LAMP). This method is increasingly recognized for its simplicity and effectiveness, distinguishing itself from more complex molecular diagnostic techniques. This study focuses on developing a heat-dry RT-LAMP desiccation method designed to be simple, robust, rapid, sensitive, and specific in detecting Botrytis cinerea. This method lies in its utilization of a desiccation process, where heat is utilized to preserve crucial components such as primers and enzymes in the presence of trehalose. A 5% trehalose with an amplification time of 1 h and 40 min was optimal for the assay detection of latent Botrytis cinerea. This method exhibited a sensitivity of 10 femtograms and was tailored specifically to the Botrytis cinerea PLF marker. Validation was performed using RNA extracted from an infected tomato, establishing a detection threshold of 1 ng/µL, approximately 500 pg of synthesized DNA target marker. This discovery holds significant implications, suggesting the potential for developing dry RT-LAMP kits that are adaptable for both laboratory and field usage. Furthermore, this method shows promise as a diagnostic tool for other neglected pathogenic diseases, representing a substantial advancement in agricultural pathology and supporting endeavors to enhance food security. Full article

Background and Objectives: Hereditary angioedema (HAE) is characterized by unpredictable skin and mucosal angioedema attacks. We aimed to find the frequency of sexual-activity-triggered attacks (STAs) and understand how the sexual life of HAE with C1-inhibitor deficiency (HAE-C1INH) patients is affected. Materials and Methods: Adult HAE-C1INH patients were included in this cross-sectional study, which started in March 2020. Demographic information, marriage properties, gender-specific sexual life characteristics, and the HAE-specific histories of the patients were collected. The Hospital Anxiety and Depression Scale (HADS) and the Turkish version of the New Sexual Satisfaction Scale (NSSS) were applied to all participants. Results: Among 42 symptomatic HAE patients, 33 (78.57%) had genital attacks and 17 (42.5%) had STAs. Ten (58.8%) had genital pain, tenderness, or swelling, and five (29.4%) had isolated abdominal and groin pain. Eight (47.1%) patients with STAs experienced a HAE attack during their first time engaging in sexual intercourse. Anxiety/depression scales, NSSS scores, and distribution of other HAE attack localizations were similar in patients with and without STAs, and no gender differences were observed. Compared to the patients without STAs, the ratio of patients who stated that their sexual lives were negatively affected and that they lost their sexual desire was higher in patients with STAs. Conclusions: Genital or abdominal attacks triggered by sexual activity may be more common than thought. Sexual activity should also be questioned for evaluating attack triggers. There is a possibility of triggering an attack with the first and ongoing sexual intercourse, and patients should be informed to keep their attack treatment medications ready in advance. Full article

The structural deformation monitoring of civil infrastructures can be performed using different geomatic techniques: topographic measurements with total stations and levels, TLS (terrestrial laser scanning) acquisitions, and drone-based SfM (structure from motion) photogrammetric surveys, among others, can be applied. In this work, these techniques are used for the floodgate gaps and the rubber joints deformation monitoring of the MOSE system (Modulo Sperimentale Elettromeccanico), the civil infrastructure that protects Venice and its lagoon (Italy) from high waters. Since the floodgates are submerged most of the time and cannot be directly measured and monitored using high-precision data, topographic surveys were performed in accessible underwater tunnels. In this way, after the calculation of the coordinates of some reference points, the coordinates of the floodgate corners were estimated knowing the geometric characteristics of the system. A specific activity required the acquisition of the TLS scans of the stairwells in the shoulder structures of the Treporti barrier because many of the reference points fixed on the structures were lost during the placement of elements on the seabed. They were replaced with new points whose coordinates in the project/as-built reference system were calculated by applying the Procrustean algorithm by means of homologous points. The procedure allowed the estimation of the transformation parameters with maximum residuals of less than 2.5 cm, a value in agreement with the approximation of the real concrete structures built. Using the obtained parameters, the coordinates of the new reference points were calculated in the project reference system. Once the 3D orientation of all caissons in the barrier was reconstructed, the widths of the floodgate gaps were estimated and compared with the designed values and over time. The obtained values were validated in the Treporti barrier using a drone-based SfM photogrammetric survey of the eight raised floodgates, starting from the east shoulder caisson. The comparison between floodgate gaps estimated from topographic and TLS surveys, and those obtained from measurements on the 3D photogrammetric model, provided a maximum difference of 1.6 cm. Full article

Background/Objectives: Psychological distress is a significant concern among cancer patients, negatively affecting their quality of life and adherence to treatment. The Cancer Patient Empowerment Program (CancerPEP) was developed as a comprehensive, home-based intervention aimed at reducing psychological distress by incorporating physical activity, dietary guidance, and social support. This study aimed to evaluate the feasibility, accrual and attrition rates, safety, and effectiveness of the CancerPEP intervention, with and without the biofeedback device, on psychological distress from baseline to 6 months, specifically focusing on the effects of group randomization and the difference between pre- and post-intervention results. Methods: This single-site, crossover randomized clinical trial included 104 cancer patients who were randomized to receive the CancerPEP intervention, with or without a Heart Rate Variability (HRV) biofeedback monitor. At 6 months, participants who did not receive the device were allowed to use one until the end of the year, while those who did receive the device were followed up to 12 months. Randomization was stratified by the presence or absence of clinically significant psychological distress and metastatic status. Psychological distress was assessed using the Kessler Psychological Distress Scale (K10) at baseline, 6 months, and 12 months. The primary endpoint was the presence of nonspecific psychological distress, as measured by the K10 scale at 6 months from the trial start, based on group randomization. A secondary exploratory analysis assessed psychological distress at baseline, 6 months, and 12 months for both groups, while controlling for group randomization and prognostic covariates. Prognostic covariates included age; comorbidities; time between diagnosis and randomization; treatment modality; relationship status; and use of prescribed medications for anxiety, depression, or both. An exploratory sub-analysis was conducted for the breast cancer subgroup, based on the sample size available after recruitment. The trial is registered at ClinicalTrials.gov (NCT05508412). Results: The provision of the HRV biofeedback monitor in conjunction with the CancerPEP intervention did not significantly affect the primary outcome in either the full sample or the breast cancer subgroup, indicating that the HRV biofeedback provision was not beneficial in this trial. No self-reported or otherwise discovered adverse events at the 6-month mark were observed. About 10% of participants were lost to follow-up in both the early and late HRV monitor provision groups. Participation in the CancerPEP program led to a significant reduction in psychological distress over time. The odds of psychological distress were significantly higher at the start of the trial than at the end of the intervention (aOR = 2.64, 95% CI: 1.53–4.56) or 6 months after the intervention (aOR = 2.94, 95% CI: 1.62–5.30). Similarly, in the breast cancer subgroup, distress was higher at the trial’s start than at 6 months, i.e., after the intervention (aOR = 2.25, 95% CI: 1.24–4.08), or at the end of the trial at 12 months (aOR = 2.73, 95% CI: 1.35–5.52). Conclusions: CancerPEP significantly reduces psychological distress in cancer patients, with consistent improvements noted across various cancer types and stages, including benefits specifically for breast cancer patients. These findings build upon the success of the Prostate Cancer Patient Empowerment Program (PC-PEP), indicating that a similar comprehensive intervention can be advantageous for all cancer patients and may be further tailored to address specific needs. With its holistic approach—encompassing physical, dietary, and psychosocial support—CancerPEP shows promise as a vital component of survivorship care. Ongoing 24-month evaluations will yield critical data on its long-term benefits. Additionally, a randomized trial with a control group (usual care without intervention) for breast cancer patients is currently under way and could potentially guide the integration of CancerPEP into standard oncology care to enhance patient outcomes and quality of life. Full article

Soil degradation in Europe is mostly represented by soil erosion that, as a sediment production mechanism, is the main environmental threat to many watersheds, including the Bovilla watershed (Tirana), useful for the supply of drinking water to the city, and therefore, the care of water quality is of particular interest. The soil erosion of the Bovilla watershed was monitored in a work set up in June 2017. Following this work, this research updates the previous data on soil loss at the Bovilla watershed in t/ha/year to September 2019 and focuses on the identification and monetary evaluation of the ecosystem services (ESs) linked to soil erosion (loss of carbon, loss of mineral elements, habitat quality, crop productivity, and sustainable tourism suitability). Then, we applied the replacement cost analysis to test the economic convenience and suggest the adoption of sustainable land management practices (e.g., reforestation) able to improve the quality water in this watershed. The study carried out demonstrates that the values of soil lost due to erosion vary depending on the type of land use (ranging from average values of 120.32 t/ha for bare land to values of 8.16 t/ha for wooded areas). Furthermore, from the application of monetary methods for the evaluation of some ecosystem services linked to erosion (loss of carbonaceous and mineral elements, habitat quality, productivity, suitability for sustainable tourism), it clearly emerges that the value of the productivity of agricultural crops varies from EUR 0 to 35,320.50/ha and that the service represents a more incisive service than the previous ones, so much so as to make the conversion of some agricultural land with high productivity values into wooded areas economically disadvantageous. The data from this study may help to develop Bovilla watershed management strategies for erosion and pollution control and sediment remediation mainly in agricultural lands. A program of measures can be effective for controlling soil erosion, but it must be implemented over long time frames, and it requires relevant investments from the public and private sectors, also with a view to increase the allocation of economic values of monetary compensation aimed at those who decide to start forestation projects on highly productive soils. Full article

This study investigates the enhancement of vehicle warm-up performance using phase-change materials (PCMs) and various thermal storage methods. The primary objective is to utilize the thermal energy lost during engine cooling to improve the cold-start performance, thereby reducing fuel consumption and emissions. Thermal storage devices incorporating PCMs were developed and tested by measuring temperature changes and energy transfer over soaking periods of 4, 8, 16, and 24 h. The results show energy transfers of 591, 489, 446, and 315 kJ at 4, 8, 16, and 24 h, respectively. In terms of the warm-up time, the use of thermal storage devices reduced the time required to reach 70 °C by up to 24.45%, with significant reductions observed across all soaking periods. This reduction in the warm-up time directly contributes to faster engine stabilization, leading to proportional improvements in fuel efficiency and a corresponding decrease in exhaust emissions, including CO₂. The findings highlight the effectiveness of PCMs in improving the engine warm-up performance and emphasize the importance of optimizing thermal storage systems to balance energy efficiency and practical application considerations. Additionally, the experimental data provide useful benchmark information for computational simulation validation, enabling the further optimization of automotive thermal management systems. Integrating a PCM-based thermal storage device can significantly enhance a vehicle’s warm-up performance, leading to reduced fuel consumption and lower emissions. Full article

Methane is a powerful greenhouse gas with a 25 times higher 100-year warming potential than carbon dioxide and is a target for mitigation to achieve climate goals. To control and curb methane emissions, estimates are required from the sources and sectors which are typically generated using bottom-up methods. However, recent studies have shown that national and international bottom-up approaches can significantly underestimate emissions. In this study, we present three bottom-up approaches used to estimate methane emissions from all emission sectors in the Denver-Julesburg basin, CO, USA. Our data show emissions generated from all three methods are lower than historic measurements. A Tier 1/2 approach using IPCC emission factors estimated 2022 methane emissions of 358 Gg (0.8% of produced methane lost by the energy sector), while a Tier 3 EPA-based approach estimated emissions of 269 Gg (0.2%). Using emission factors informed by contemporary and region-specific measurement studies, emissions of 212 Gg (0.2%) were calculated. The largest difference in emissions estimates were a result of using the Mechanistic Air Emissions Simulator (MAES) for the production and transport of oil and gas in the DJ basin. The MAES accounts for changes to regulatory practice in the DJ basin, which include comprehensive requirements for compressors, pneumatics, equipment leaks, and fugitive emissions, which were implemented to reduce emissions starting in 2014. The measurement revealed that normalized gas loss is predicted to have been reduced by a factor of 20 when compared to 10-year-old normalization loss measurements and a factor of 10 less than a nearby oil and production area (Delaware basin, TX); however, we suggest that more measurements should be made to ensure that the long-tail emission distribution has been captured by the modeling. This study suggests that regulations implemented by the Colorado Department of Public Health and Environment could have reduced emissions by a factor of 20, but contemporary regional measurements should be made to ensure these bottom-up calculations are realistic. Full article

Follicle-stimulating hormone (FSH) administration is applied in the management of subjects affected by hypogonadotropic hypogonadism. Whilst this application is widely recognized and established alone or in combination with human chorionic gonadotropin (hCG), a similar strategy is empirically advocated in idiopathic male factor infertility (MFI). In this setting, FSH therapy has been used to increase sperm quantity, quality, and pregnancy rate when FSH plasma concentrations are below 8 IU/L and when the seminal tract is not obstructed. In the literature, several studies suggested that giving FSH to patients with idiopathic MFI increases sperm count and motility, raising the overall pregnancy rate. However, this efficacy seems to be limited, and about 10–18 men should be treated to achieve one pregnancy. Thus, several papers suggest the need to move from a replacement approach to an overstimulating approach in the management of FSH therapy in idiopathic MFI. To this aim, it is imperative to determine some pharmacologic markers of FSH efficacy. Furthermore, it should be useful in clinical practice to distinguish, before starting the treatment, among patients who might respond or not to FSH treatment. Indeed, previous studies suggest that infertile men who have normal levels of gonadotropins in plasma might not respond to FSH treatment and about 50% of patients might be defined as “non-responders”. For these reasons, identifying predictive markers of FSH action in spermatogenesis and clinical markers of response to FSH treatment is a fascinating area of study that might lead to new developments with the aim of achieving personalization of the treatment of male infertility. From this perspective, seminal parameters (i.e., spermatid count), testicular cytology, genetic assessment, and miRNA or protein markers in the future might be used to create a tailored FSH therapy plan. The personalization of FSH treatment is mandatory to minimize side effects, to avoid lost time with ineffective treatments, and to improve the efficacy, predicting the most efficient dose and the duration of the treatment. This narrative review’s objective is to discuss the role of the different putative factors which have been proposed to predict the response to FSH treatment in idiopathic infertile men. Full article