Search Results (750)

The choice of treatment for skin cancer depends on several factors: histology, location, size and depth of the cancer, available technologies, cost-effectiveness, general health, and patient preferences. Both superficial and electron beam radiotherapy have proven effective for certain types of skin cancer, with a cure rate greater than 90%, with the final option for a given patient being individualized. Providing superior esthetics in certain anatomical locations places superficial radiotherapy as the primary option for treating superficial tumors, as cure rates are similar to most surgical options. The current existence of brachytherapy equipment with specialized small-size applicators, extremely stable, easy to use, with outpatient application, and reduced treatment time, offers additional benefits compared to surgery. Full article

This study aimed to evaluate whether the Synerjet system can maximize the transdermal delivery and skin rejuvenation of nano-NMN. In a 4-week split-face trial (n = 21), this combination demonstrated marked clinical superiority over topical nano-NMN alone (p < 0.001), yielding enhanced improvements in wrinkles (with 170.56% relative improvement in periorbital and 154.45% in nasolabial region compared to the control group), pore volume (176.62%), and deep hydration (188.02%). Regarding dermal integrity, the test group showed a 111.56% superior increment in skin elasticity and a 149.75% more effective optimization of melanin intensity relative to the control. Notably, deep-tissue hydration at a 2.5 mm depth demonstrated a 188.02% higher gain, suggesting that the modality significantly fortifies the skin’s physiological moisture reservoir. The test group exhibited a marked improvement over the control across all cutaneous parameters (p < 0.001). Our findings demonstrate that a new combinatorial approach using EP-assisted microjet of a Synerjet system after cold plasma pretreatment and a nano-NMN 10% ampoule resulted in significantly greater improvements in wrinkles, pores, elasticity, pigmentation, and deep skin hydration compared to topical application alone. Consequently, these results demonstrated that the Synerjet system effectively overcame the inherent limitations of nano-delivery technologies, offering a promising modality for advanced cutaneous rejuvenation and a robust framework for future professional dermatological treatments. Full article

As the pace of modern life continues to accelerate, the pressure participants face is growing, and mental health issues are becoming increasingly prominent. Against this backdrop, meditation, as a proven method for stress relief and relaxation, has garnered widespread attention. However, many people face challenges during meditation, such as difficulty entering a meditative state quickly or achieving sub-optimal outcomes. This is particularly true for beginners, who often struggle to accurately gauge the rhythm of meditation and thus fail to fully harness its regulatory effects on both body and mind. To address these issues, this study proposes a handheld meditation device. By making contact with the body via sensors, the device can measure multiple physiological metrics in real time, including skin conductance, electromyography, and heart rate. Based on these measurements, the device can monitor the user’s emotional fluctuations in real time. When emotional changes are detected, it uses the data to play music, release specific scents, or adjust lighting ambiance, thereby dynamically regulating the user’s psychological state. This helps users better immerse themselves in a meditative state and effectively enhances the benefits of meditation. This paper provides an in-depth analysis of the device’s design principles, detailing its hardware components—including various sensors and emotional regulation modules—and explaining the operational logic of its software algorithms. The effectiveness and reliability of the device were verified through rigorous experiments. The study also thoroughly examines the application prospects and potential value of this handheld meditation device, exploring new approaches and methods for the development of meditation technology and related equipment. Full article

Staphylococcus aureus (Staph) infections are a pressing health concern in the White Mountain Apache (WMA) Tribal community, where invasive Staph infection rates far exceed those in the general U.S. population. This study explored community perspectives to guide culturally tailored education and prevention strategies. We conducted 42 in-depth interviews and focus group discussions with healthcare providers, traditional practitioners, and community members. Thematic analysis showed that participants had familiarity with the term “MRSA” (methicillin-resistant Staph), although many did not recognize it as a form of Staph, per se. Barriers to timely care-seeking included lack of transportation, stigma, and misconceptions about infection causes. With regard to biomedical approaches to prevention, participants preferred products like antiseptic nasal sprays and antimicrobial skin cleansers due to ease of use. Community members emphasized the need for simple, bilingual educational materials grounded in Apache culture and delivered by trusted figures. The findings underscore the importance of culturally grounded education and prevention approaches. Implementation and scaling of these strategies may enhance health literacy, reduce infection rates, and promote holistic wellness in Indigenous communities. Full article

Efficient detection of aircraft surface defects (ASD) is a cornerstone of aviation safety. However, ASD detection is challenged by microscopic defect scales, extremely low contrast, and severe background interference. This paper proposes the Multi-Scale Discriminative Edge Enhancement Network (DEE-Net) based on an improved YOLO11. First, to mitigate feature dissipation of tiny defects, a lossless reassembly mechanism using space-to-depth convolution (SPD-Conv) is introduced, safeguarding sub-pixel topological information through space-to-depth conversion. Second, an adaptive selective edge-enhancement (ASE) module, integrating a dual-domain selection mechanism (DSM), is designed to suppress non-target redundant information on the fuselage skin. Finally, a Wise-CIoU loss function with a non-monotonic focusing mechanism is introduced to enhance localization stability under stringent IoU thresholds. Experimental results demonstrate that DEE-Net outperforms the baseline, improving mAP50 by 7.15% and mAP50-95 by 2.43%. To provide a more reliable evaluation, a 5-fold cross-validation experiment is further conducted on the original non-augmented images, and the results are reported as mean ± standard deviation. The cross-validation results provide a more conservative estimate and indicate that the proposed method achieves competitive performance across different data partitions. Full article

Introduction: Fish skin is the first line of defense against the aquatic environment, acting as a physical, chemical, and immunological barrier. In addition to preventing pathogen entry, the skin and its mucus contribute to osmoregulation, innate immunity, and redox balance. Skin lesions—caused by mechanical damage, parasites, environmental stress, or handling—disrupt this barrier, increasing susceptibility to infections, inflammation, and production losses. Thus, efficient skin regeneration is essential for fish welfare and performance. Nutrition plays a key role in this process by providing substrates for epithelial repair, immune function, and antioxidant defense. Among dietary factors, zinc (Zn) is particularly important due to its involvement in cell proliferation, enzymatic activity, and maintenance of skin integrity. Objective: Our objective is to assess the effectiveness of image-based analysis in quantifying the skin healing process in Atlantic salmon fed diets supplemented with zinc. Methodology: The trial comprised three dietary treatments: a control diet with 42 mg Zn per kg (D1), and two diets supplemented up to 120 mg/kg of zinc, derived from inorganic (D2) or organic (D3) forms. Pit-tagged fish with an initial body weight (78 ± 0.1 g) were fed the diets for 75 days. After 15 days of experimental feeding, a standardized wound lesion (2.5 mm diameter × 0.5 mm depth) was inflicted in deeply anesthetized fish, with a disposable biopsy punch, in the dorsal area. After wound infliction, the fish resumed their normal feeding regime for the rest of the trial days. The progression of skin wound healing was assessed using standardized digital image analysis. High-resolution photographs of individual wounds were collected 8, 16, 24 and 32 days post-wounding. All images were acquired under standardized conditions with the inclusion of ArUco identifiers to enable a subsequent computer-assisted comparison. Morphometric parameters (wound width, diameter, perimeter and area) were used to assess wound contraction and closure over time. In parallel, a semi-quantitative visual scoring system was applied to each wound image to capture qualitative aspects of healing that are not fully described by morphometric data alone. Results: Full data analysis is currently underway, but the first results show beneficial effects of dietary zinc supplementation on the skin regenerative process. Conclusions: The combined use of objective digital measurements and standardized visual scoring enabled a comprehensive evaluation of wound healing progress, bridging quantitative tissue remodeling with biologically relevant phenotypic outcomes. This image-based framework provides a sensitive and reproducible approach for assessing dietary interventions targeting skin regeneration and barrier restoration in Atlantic salmon. Full article

Optical coherence tomography (OCT) is an optical imaging modality that provides high-resolution cross-sectional imaging of biological tissues noninvasively. In Fourier-domain OCT, axial resolution is governed by both the center wavelength and the spectral bandwidth of the light source; therefore, limited or discontinuous bandwidth degrades depth resolution and introduces sidelobes and artifacts in OCT images. To address these issues in OCT image reconstruction from gapped spectra, a sparse parameter estimation approach based on Sparse Iterative Covariance-based Estimation (SPICE) is proposed in this study. By utilizing a sparse parameter estimation framework to directly resolve depth-dependent components from discontinuous interferograms, SPICE enhances axial resolution while suppressing sidelobe artifacts inherent in standard interpolation. Experiments on multi-layered tape, oral epithelium, and finger skin show that SPICE visually suppresses gap-induced sidelobe artifacts and improves structural interpretability under representative gap conditions. Quantitative evaluations on multi-layer tape and biological tissues show that SPICE reduces axial FWHM by 30–45%, increases SSIM by 0.15–0.25, and achieves significantly lower computational cost than GAPES (p < 0.01). Full article

Deep wounds often lead to severe complications such as persistent infection, biofilm formation, and high patient morbidity. While skin injuries can usually be managed with functional dressings, wounds in deep layers without sufficient treatment may serve as primary entry points for bacterial infection, thereby posing a significant life-threatening risk to patients. With the rising prevalence of chronic diseases and an aging population, effective strategies for enhanced wound healing are still in high demand. In this study, an injectable and thermoresponsive hexamethylene diisocyanate–Pluronic F127 copolymer–hyaluronic acid composite hydrogel loaded with polyhexamethylene biguanide (PHMB) and epidermal growth factor (EGF), named PEHHPG, was developed for joint therapy of deep wounds. PEHHPG self-gels at 37 °C and stabilizes both agents in the gel matrix. Based on the results of microbial colony assay and analysis of fibroblast growth kinetics, PEHHPG with ≥200 ppm of PHMB and ≥0.15 μg/mL of EGF can eradicate bacteria and enhance cell proliferation in vitro, illustrating the functionalities of PEHHPG. Given the aforementioned effects, together with the recognized advantages of injectable hydrogels such as wound shape/depth adaptation, low adhesiveness, exudate absorptiveness, and moisture maintenance, the developed PEHHPG is anticipated to be a feasible dressing material for deep wound treatment after further in vivo examinations. Full article

The objective of this research was to evaluate different commercial eubiotics. The eubiotics were evaluated individually and in combination on growth performance, carcass traits, and gut structure in broilers fed sorghum–soybean meal diets. A total of 1000 Ross 308 male broilers were randomly allocated to one of five dietary treatments with eight replicates of 25 broilers each. The experimental treatments were: 1. CON (basal diet), 2. ENR (basal diet + Enradin^® 100 g/ton), 3. PF (basal diet + Probion-forte© 300 g/ton), 4. PF+ EB (basal diet + Probion-forte© and EndoBan FT^® 250 and 250 g/ton, respectively), 5. CPP (basal diet + CRINA^® Poultry Plus 300 g/ton). Broilers fed with eubiotic-supplemented diets showed significantly ameliorated growth performance compared with the control group (CON p < 0.05). Carcass weight was also significantly higher in broilers fed with eubiotics than those fed CON (the basal diet, p < 0.05). Gut structure analysis showed an increased villus height and mucosal thickness in the duodenum of eubiotic-treated groups (p < 0.05). The mixed supplementation of Probion-forte© and EndoBan^®(PF-EB) induced greater villus height and mucosal thickness in the jejunum and ileum (p < 0.05). Additionally, supplementation with PPR (CRINA^® Poultry Plus) increased crypt depth in the duodenum and jejunum (p < 0.05), whereas PF (Probion-forte©) improved the villus height-to-crypt depth ratio in the duodenum and ileum (p < 0.05). Consequently, dietary supplementation with these commercial eubiotics, individually and in combination, could ameliorate productive performance, carcass yield, skin pigmentation, and gut structure in broilers. Full article

Aircraft skin defect recognition is a safety-critical visual inspection task in which lightweight models must maintain high diagnostic accuracy while suppressing false alarms caused by complex surface textures, illumination variations, and weak defect patterns. This study proposes HQCA-Net, a simulation-based hybrid quantum-classical channel attention network for reliable aircraft skin defect recognition. The core component, termed Residual Quantum Channel Attention (RQCA), embeds a 10-qubit variational quantum circuit into a classical ResNet-18 backbone to perform compact and structured nonlinear feature recalibration, introducing only 30 trainable quantum-gate parameters. The quantum circuit is evaluated using state-vector simulation, and this study focuses on model-level feature recalibration, reliability, and robustness within the evaluated dataset rather than implementation on physical quantum hardware. Experiments on a six-class aircraft skin defect dataset show that HQCA-Net achieves 97.93% classification accuracy and a global false positive rate of 0.49%, outperforming ResNet-18 and classical lightweight attention mechanisms including SE, ECA, and SimAM. Additional analyses using confidence calibration, Grad-CAM visualization, Gaussian noise perturbation, few-shot training, and circuit-depth ablation further indicate that the proposed RQCA module improves feature discrimination and false-alarm suppression under compact parameter constraints. These results suggest that the hybrid quantum-classical attention module can serve as a parameter-efficient nonlinear feature recalibration strategy for reliable visual defect inspection under the tested experimental conditions. Full article

Large civil infrastructures, including high-rise buildings, bridges, offshore platforms, transmission towers, tall chimneys, basements below the water table, etc., are often supported on pile foundations. Apart from the usual dead loads and live loads imposed by superstructures, these piles are often subjected to significant uplift forces due to overturning moments or hydrostatic pressure resulting from the effects of wind and wave loading, traffic movement, buoyancy, etc. Piles that withstand tensile loads are termed tension piles. Since the soil is unable to resist tensile stress, the pullout loads imposed on tension piles are prevented primarily by downward skin friction at the pile–soil interface, as well as by the self-weight of the piles. In this paper, a numerical model was developed using boundary element analysis, wherein piles were assumed to be made of an elastic–perfectly plastic material, and the soil was modeled using a parabolic model. The developed model was validated with available experimental results, and acceptable agreement was found. An in-depth study by detailed parametric analysis revealed that the parabolic soil model yielded satisfactory results. Extensive full-scale case studies were also performed to study the influence of various factors on tension pile performance. A set of important conclusions was drawn from the entire work. Full article

With the transition to deep coal mining, the transparent detection of hidden geological hazards in the floor strata is fundamental for production safety. In mine seismic exploration, gliding waves—inhomogeneous plane waves propagating along the coal–rock interface—offer a unique advantage for penetrating high-velocity floors via the skin effect, overcoming the total reflection limitations of conventional in-seam waves. This study investigates the propagation laws and anomaly response characteristics of floor gliding waves using super-critical incidence theory and high-order staggered-grid finite difference simulations. The results demonstrate that the apparent velocities of gliding P and S-waves are bounded by those of the coal and host rock, exhibiting minimal dispersion. Quantitative analysis using a penetration depth model reveals that while penetration depth is frequency-dependent—with lower frequencies providing deeper reach—high-frequency components remain essential for high-resolution imaging. Crucially, the proposed method was validated through a field Case Study at the 11123 working face. By utilizing a specialized deep-hole excitation strategy to ensure super-critical incidence, the inversion successfully identified a hidden fault extending up to 60 m below the floor, which was subsequently confirmed by rock roadway excavation. These findings establish a robust physical basis for designing underground floor-detection systems and provide a significant theoretical reference for addressing detection blind spots in deep mining environments. Full article

A structurally simple three-layer optical absorber is proposed and systematically investigated, consisting of a continuous Ti ground plane, a SiO₂ dielectric spacer, and a Ti tetrahedral nanostructure. The absorber is constructed on a periodic square unit cell, where the lateral dimension directly determines the base width and sidewall inclination angle of the tetrahedral structure, thereby enabling effective modulation of the optical response. Full-wave electromagnetic simulations performed using COMSOL Multiphysics (version 6.0) are employed to evaluate the influence of geometric parameters on broadband absorption behavior. The optimized structure achieves a near-unity absorptivity of 0.9999 at 200 nm and maintains an effective absorption bandwidth (absorptivity > 0.9) spanning 200–3000 nm, covering the ultraviolet, visible, and near-infrared spectral regions. Parametric analysis reveals that the tetrahedral height primarily governs long-wavelength extension through enhanced optical path length, graded-index transition, and improved electromagnetic field confinement, while the unit cell width strongly influences impedance matching and localized field localization. In contrast, the Ti ground layer thickness exhibits minimal influence once it exceeds the optical skin depth, confirming its primary role as a transmission-blocking reflective substrate. Impedance retrieval analysis shows that the real part of the normalized impedance remains close to unity and the imaginary part approaches zero over most of the operating range, demonstrating that the ultrabroadband absorption behavior is dominated by effective impedance matching rather than isolated narrowband resonances. Furthermore, electric and magnetic field distribution analyses reveal that electromagnetic energy dissipation is concentrated near the tetrahedral apex and metal–dielectric interfaces, indicating the coexistence of localized plasmonic modes, cavity-assisted absorption, and multi-scale optical confinement. Full article

Introduction: Standard abdominoplasty inevitably causes scarring in the umbilical region. Given the aesthetic significance of the navel, as the central anatomical landmark of the anterior abdominal wall, techniques that preserve the natural anatomy are warranted. The criteria for patient selection for such operations remain poorly defined, limiting their clinical application. Objective: The aim of this study was to define the indications and contraindications for scarless abdominoplasty in the umbilical region through a comparative analysis of clinical and subjective outcomes. Materials and Methods: A comparative study was conducted involving 115 patients operated on between 2021 and 2026. The experimental group consisted of 32 patients who underwent abdominoplasty without scarring in the umbilical region, while the control group comprised 83 patients who underwent standard abdominoplasty with umbilical transposition. The technique of scarless abdominoplasty in the umbilical region entailed limited mobilization of the cutaneous–subcutaneous flap, energy-based ultrasound-assisted liposuction in the supraumbilical region, suturing of rectus abdominis diastasis when clinically indicated, and fixation of the umbilicus in its physiological position without a skin incision around it. Energy-based ultrasound-assisted liposuction permits skin contraction in the supraumbilical area through a controlled internal thermal effect. The incidence of complications and BODY-Q questionnaire outcomes were evaluated at 3 months, 6 months, and one year. No significant differences in baseline clinical characteristics were observed between the groups. Results: The overall rate of postoperative complications in the experimental group was 18.8% (n = 6), compared to 24.1% (n = 20) in the control group; the difference was not statistically significant (p > 0.05). According to the BODY-Q questionnaire, patients in the experimental group reported significantly higher satisfaction with scar appearance (91.0 ± 3.5 vs. 83.0 ± 5.7; p < 0.001) and the umbilical region. The umbilicus retained its anatomically natural shape and depth. The use of energy-based ultrasound-assisted liposuction in the supraumbilical area contributed to the contraction of the upper cutaneous–subcutaneous flap, which made it possible to prevent extensive mobilization and the formation of a significant scar around the umbilicus in these patients. Conclusions: Scarless abdominoplasty in the umbilical region is a safe and effective technique in appropriately selected patients. Energy-based ultrasound-assisted liposuction produces an internal thermal effect that enhances the contraction of the cutaneous flap. Indications for this method comprise a moderate amount of excess skin tissue in the supraumbilical region, preserved skin elasticity, a normal or high umbilical position, and rectus abdominis diastasis grade I–II. Contraindications include pronounced excess skin tissue in the supraumbilical region, a low umbilical position, and general somatic contraindications to surgery. Full article

Background: Retinol has consistently demonstrated efficacy in improving signs of skin aging. However, recent European Union regulations have limited its cosmetic concentration to 0.3%, creating the need for new formulations to be capable of maintaining high efficacy, safety, and tolerance. Material and Methods: This clinical study aimed to evaluate and compare the rejuvenating effects and tolerance of a 0.5% retinol serum with a new equivalent technology, Retinduo^®, which previously showed promising preclinical results. A single-center, prospective, randomized, controlled, double-blind, two-arm parallel study was conducted in 40 Caucasian women aged 38–60 years with moderate photoaging (Glogau II). A total of 20 participants applied Retinduo^® serum and 20 applied retinol 0.5%, following a progressive application protocol. Clinical and instrumental assessments measured hydration, firmness, elasticity, tone homogeneity, melanin levels, skin roughness, wrinkle parameters, and stratum corneum thickness. Results and Discussion: Both formulations significantly improved hydration, firmness, and elasticity from day 28 onward. Retinduo^® showed a significant increase in viscoelasticity (R8) from day 56, while retinol 0.5% did not demonstrate significant changes in this parameter. Melanin reduction was observed with Retinduo^® at days 28 and 56 and with retinol 0.5% just at day 28. Although a reduction in melanin was observed with both ingredients, the reduction was more significant with Retinduo^® at 56 days. Both treatments reduced the thickness of the stratum corneum; however, with Retinduo^®, a significant and more pronounced reduction was achieved after 3 months of treatment (30% (p = 0.0001) vs. 12% (p = 0.033). Retinduo^® demonstrated significant wrinkle depth reduction at day 28 and in wrinkle amplitude (width and length of wrinkles) at the end of treatment, while 0.5% retinol showed a positive trend in this parameter. Both products exhibited excellent tolerance. Conclusions: Overall, Retinduo^® achieved comparable or slightly superior anti-aging effects while aligning with current European regulatory limits. Full article