Search Results (1,721)

Federated learning enables collaborative data mining without centralizing raw data, but communication budgets remain a practical bottleneck in distributed deployment. Existing federated optimization methods mainly address statistical heterogeneity or aggregation stability, while client participation is often treated as full participation or random sampling. This paper proposes FedBudget, a budget-aware client selection method for communication-constrained federated data mining. In each round, FedBudget constructs a scheduling score from historical utility, stability, freshness, communication cost, and a coverage-aware penalty, and then greedily selects clients under a given communication budget. The aggregation stage follows the standard sample-size-weighted selected-client FedAvg rule, which makes the scheduling contribution directly attributable. Experiments on AI4I, Mammography, Shuttle, SMD, and SWaT compare FedBudget with representative federated optimization and scheduling baselines. Statistical analysis shows that FedBudget significantly reduces communication cost and improves communication-normalized performance relative to budgeted optimization baselines, while maintaining competitive AUC and PR-AUC. Larger-scale experiments with 20 and 50 simulated clients show mean performance-per-MB improvements of 4.019 and 1.945, respectively, together with lower mean communication cost. Sensitivity and convergence analyses confirm the robustness of the proposed scheduling mechanism and its stable communication–performance trade-off. These results indicate that explicit budget-aware participation modeling improves communication efficiency in federated data mining while preserving a simple and compatible training pipeline. Full article

Background: Recovery between repeated high-intensity efforts is essential to limit fatigue and performance decline in soccer. This study examined the effects of cold water immersion (CWI), foam rolling (FR), and passive recovery during a 15 min interval between two 5 m shuttle run tests (5mSRTs) on physical performance, perceptual responses, and biochemical markers of muscle damage and inflammation. Methods: Fifteen soccer players (age: 22.6 ± 2.03 years) completed passive recovery, FR, and lower-body CWI at 15 °C in a randomized crossover design. Creatine kinase (CK), lactate dehydrogenase (LDH), C-reactive protein (CRP), aspartate transaminase (AST), delayed onset muscle soreness (DOMS), and belief questionnaire scores were assessed before the first 5mSRT and immediately after, and then 24 h, 48 h, and 72 h after the second 5mSRT. Results: Between the first and the second 5mSRT, TD remained unchanged following CWI (p = 0.21), whereas significant decreases were observed following passive recovery (p = 0.025) and FR (p = 0.028). Also, BD decreased after passive recovery (p = 0.03). At 48 h, CWI elicited lower CK (p = 0.01) and LDH (p = 0.003) than passive recovery, whereas FR resulted in lower AST concentrations (p = 0.01). Participants reported higher belief scores following CWI and FR than passive recovery throughout the recovery period (p < 0.05). No between-condition differences were observed for FI, PD, RPE, DOMS, or CRP (all p > 0.05). Conclusions: CWI may help preserve repeated-running performance and attenuate selected markers of muscle damage following repeated high-intensity intermittent exercise in soccer players, whereas FR demonstrated only limited physiological effects. Full article

Lung cancer ranks first in both incidence and mortality among all malignancies, and tumor microenvironment (TME)-induced CD8⁺ T cell exhaustion is a critical factor driving immune evasion and compromising the efficacy of immunotherapy. MicroRNAs (miRNAs), as key post-transcriptional regulators, shuttle between lung cancer cells and CD8⁺ T cells via extracellular vesicles (EVs), serving as critical communication hubs that reshape the TME. This review systematically synthesizes recent literature to summarize the regulatory patterns of miRNAs on functions of lung cancer cells and CD8⁺ T cells, and dissect the molecular mechanisms underlying miRNA-mediated bidirectional crosstalk between these two cell types. This review focuses on the dual-pronged immune evasion strategy employed by lung cancer cells to counteract CD8⁺ T cells. On the one hand, lung cancer cells aberrantly express endogenous miRNAs, such as miR-20a, miR-149-5p, and miR-326, to remodel their surface ligands and establish immune camouflage. On the other hand, they actively secrete EVs enriched in specific miRNAs, including miR-7108-3p, miR-651-5p, and miR-24-3p, which directly suppress CD8⁺ T cell function. Furthermore, lung cancer cells secrete additional miRNAs, notably miR-6794-5p, miR-708-5p, and miR-1234-3p, to reprogram other TME components, namely tumor-associated macrophages (TAMs), natural killer (NK) cells, and myeloid-derived suppressor cells (MDSCs). These reprogrammed cells, in turn, indirectly attenuate CD8⁺ T cells through a relay-like mechanism via immunosuppressive cytokines or surface checkpoint molecules produced by these cells. In addition, competing endogenous RNA (ceRNA) networks formed by long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) in lung cancer cells regulate miRNA activity at multiple levels, further impairing the immune effector functions of CD8⁺ T cells. Conversely, activated CD8⁺ T cells also secrete miRNA-containing EVs, which deliver these miRNAs to tumor cells, thereby inhibiting tumor progression. Elucidation of this miRNA-based bidirectional communication network will not only advance our understanding of immune evasion mechanisms in lung cancer but also provide novel insights into cell-free immunotherapeutic approaches based on CD8⁺ T cell-derived vesicles. Full article

Geometric accuracy assessment is a fundamental prerequisite for the application of high-resolution optical satellite imagery, yet it remains particularly challenging in the absence of ground control points. This study proposes a consistency-driven accuracy assessment framework for ZY-3 satellite imagery that systematically bridges the conventional separation between block adjustment and accuracy evaluation. The framework is built upon a unified geometric error model that accommodates both inter-image consistency assessment and absolute accuracy evaluation within a common mathematical formulation. Recognizing the inherent uncertainties of publicly available reference data, a hierarchical validation chain is established: the Google Earth (GE) and Shuttle Radar Topography Mission (SRTM) datasets are first validated against WorldView imagery to bound their intrinsic errors, and subsequently employed as references for ZY-3 accuracy assessment. This design enables the simultaneous evaluation of planimetric accuracy, vertical accuracy, and inter-image consistency without reliance on ground control points. Experimental validation conducted on 1368 ZY-3 scenes covering a study area of 1.9 million km² yields a planimetric RMSE of 3.33 m and a vertical RMSE of 4.27 m. The results demonstrate that higher inter-image consistency empirically correlates with improved absolute positioning accuracy, and that the proposed framework not only reliably evaluates geometric quality but also provides diagnostic insights that can inform proactive adjustment strategies. The proposed method thus offers a practical and transparent solution for the geometric accuracy detection and enhancement of large-area ZY-3 satellite imagery. Full article

Safety perceptions are central to destination choice and visitor satisfaction at tourist venues, yet research on crime and public safety in theme park settings remains sparse. This study examines visitor perceptions of public safety at the two most-attended theme park destinations in the United States—Walt Disney World (Orlando, FL, USA) and the Disneyland Resort (Anaheim, CA, USA)—across three domains: within the parks, in parking lots, and on shuttle buses. Using data from a Qualtrics survey, this brief report compared safety perceptions by gender across both destinations. Findings indicate that visitors overwhelmingly perceive themselves as safe within the parks; however, safety perceptions are somewhat lower in parking lots and on shuttle buses. Importantly, while males and females report comparable perceptions of safety within the parks, females report significantly lower safety perceptions in parking lots and on shuttle buses, especially at Disney World. Implications for future research and practice are noted. Full article

Background: Rugby sevens demands distinct physical profiles across positions. This study investigated anthropometric and physical fitness characteristics of Chinese national team male rugby sevens players. Methods: Twenty-one players (forwards: n = 10, backs: n = 11) completed anthropometric measurements, linear sprints (10 m, 40 m, 50 m, and 60 m), agility tests (T-test, Illinois, 20 shuttle run), Wingate anaerobic test, Yo-Yo intermittent recovery test level 2, goalpost shuttle run, vital capacity, and VO₂peak. Players were split into fast/slow groups by median 40 m time. Results: Forwards were significantly taller (adjusted p = 0.0022, d = 2.78), heavier (adjusted p = 0.0073, d = 1.76), and had greater muscle mass (adjusted p = 0.027, d = 1.47) with large effect sizes compared with backs. Backs showed significantly better agility with large effect sizes (Illinois: adjusted p = 0.018, d = 2.00). When players were classified into fast and slow sprint groups by median 40 m time, the fast group exhibited significantly better 10 m (adjusted p = 0.04, d = −2.00), 50 m (adjusted p = 0.017, d = −1.98), and 60 m (adjusted p = 0.017, d = −1.71) performance. Conclusion: Playing positions in Chinese rugby sevens present significantly different body size and agility profiles. When grouped by sprint speed, faster players possess superior multi-distance sprinting capacities. Both positional and sprint capabilities should guide training and selection. Full article

Objectives: This study aimed to examine the effects of three different warm-up protocols on performance, physiological, and perceptual responses in high-level water polo players. Methods: Ten international-level athletes (Tier 4; mean ± SD: age 22.4 ± 3.53 years; height 1.78 ± 0.06 m; body mass 75.83 ± 6.44 kg) completed three experimental conditions in a randomized, counterbalanced design: dryland, in-water, and combined warm-up. Following each warm-up condition, participants performed the Water Polo Intermittent Shuttle Test (WIST), while performance (distance covered and average speed), blood lactate concentration ([La⁻]), heart rate (HR), tympanic temperature, and rating of perceived exertion (RPE) were assessed. Statistical significance was set at p ≤ 0.05. Results: Players covered greater distances following the in-water (331.5 ± 151.24 m) and combined (358.5 ± 134.06 m) warm-ups compared to dryland (226.5 ± 129.51 m; p < 0.01; ES = 2.00 and 1.53, respectively), with no significant differences between in-water and combined conditions (p = 0.381; ES = 0.29). Physiological responses following the WIST were largely similar between conditions, although [La⁻] was higher in the dryland condition (12.46 ± 4.46 mmol·L⁻¹) compared to the combined condition at 10 min post-exercise (8.66 ± 2.47 mmol·L⁻¹; p = 0.03; ES = 0.80). No differences were found for HR, tympanic temperature, or RPE. Conclusions: These findings suggest that warm-up protocols including an in-water component are more effective than dryland-only routines for optimizing intermittent performance in water polo players. However, combining dryland and in-water exercises does not appear to provide additional benefits compared to in-water warm-up alone. Full article

The heart is a highly energy-demanding organ that depends on metabolic flexibility to adjust substrate utilization in response to changes in nutrient availability, endocrine signals, and energetic demands. Accumulating evidence demonstrates that dietary patterns are key determinants of myocardial metabolic homeostasis, affecting substrate selection, mitochondrial function, nutrient-sensing pathways, and long-term transcriptional and epigenetic regulation. This review analyzes the molecular mechanisms through which diet regulates cardiac metabolism and explores how chronic nutritional exposures influence the myocardial energetic phenotype. The physiological regulation of cardiac substrate utilization is described, with emphasis on fatty acids, glucose, ketone bodies, and branched-chain amino acids, underscoring the importance of metabolic flexibility in sustaining cardiac efficiency. The regulation of substrate transport and oxidation is examined, including the roles of the carnitine shuttle, insulin signaling, AMPK, mTOR, PPARα–PGC-1α, SIRT3, and other nutrient-sensing networks that coordinate mitochondrial ATP production. The effects of dietary composition and meal timing, such as caloric restriction and intermittent fasting, are discussed as modulators of myocardial metabolism. The adverse effects of chronic nutrient excess are reviewed, including lipotoxicity, glucotoxicity, insulin resistance, mitochondrial dysfunction, oxidative stress, pseudo-hypoxia, fetal metabolic reprogramming, and maladaptive cardiac remodeling. Recent findings on the gut–heart axis, microbiota-derived metabolites, circadian regulation, and metabolic–epigenetic interactions are also considered. Overall, current evidence supports the view that diet is an important and potentially modifiable regulator of the cardiac metabolic phenotype. Advancing the understanding of diet–metabolism interactions may enable the development of targeted nutritional strategies to maintain metabolic flexibility, enhance cardiac bioenergetics, and prevent the progression of heart failure and other cardiometabolic diseases. Full article

Iron, with the unique stability of its nucleus, occupies an unusual position among the elements: its abundance on Earth is not simply a geological accident but a direct consequence of nuclear reactions that happened inside stars billions of years ago. Formed at the final stages of fusion in stars, iron spread through space by supernova explosions and became part of the material that formed Earth, eventually becoming the dominant component of the planet’s core. At the surface, iron’s redox chemistry shaped the early atmosphere and oceans, and its availability as a soluble ferrous ion in the anaerobic Archean ocean made it a natural cofactor for the first enzymatic reactions. That same redox flexibility and the ability of iron to shuttle between Fe²⁺ and Fe³⁺ across a wide range of electrochemical potentials explain why virtually every major metabolic pathway in biology depends on iron in one form or another. Yet iron is also dangerous: free and chelated iron can catalyze the production of toxic hydroxyl radicals through Fenton chemistry, the reactivity of which depends strongly on the nature of the chelating ligand, and every living system must balance its need for iron against the oxidative damage that uncontrolled iron causes. This tension between catalytic necessity and chemical toxicity has driven much of the regulatory complexity we observe in modern iron metabolism. In this review, we first outline iron’s journey from its formation in stars to its role in shaping Earth’s structure and the emergence of early iron-dependent biology. We then discuss in detail how fundamental physical and chemical factors continue to influence living systems. Full article

This study aimed to identify the variables that best explain the performance of young male kayakers over 200 and 500 m across two categories, U14 and U16, and to determine whether stroke rate (SR), as described for senior athletes, is also a determining factor in performance in these categories. Twenty-four young Iberian kayakers (Portuguese and Spanish), 13.63 ± 1.50 years, distributed in two competitive categories, U14 (12.67 ± 0.47 years) and U16 (15.57 ± 0.73 years), were evaluated in terms of training, maturity, anthropometry, limb volumes, body composition, equipment, physical fitness, balance, and performance. Water/shoulder distance correlated significantly at both race distances in both age categories. The observed differences between U14 and U16 may reflect the influence of kayaking experience and maturity-related factors, which are likely to affect several performance-related variables. These results suggest the need to produce a specific evaluation battery for U14 that includes the water/shoulder distance, the 20 m shuttle run test, and the BESS test. Another one for U16 consists of the water/shoulder distance test, the pull-up test, and the sit-up test. This study also highlights the importance of designing training programs that enable young kayakers to perform the paddle technique with maximum efficiency at a high SR. Full article

Biochar has attracted increasing attention for aquatic pollution control, particularly due to its capacity to accelerate the rate-limiting steps of denitrification in wastewater treatment. While early research primarily focused on the adsorption capacity of biochar, recent studies have increasingly investigated its role as a redox-active mediator that facilitates electron transfer. This review critically synthesizes the multifaceted mechanisms of biochar-enhanced denitrification, establishing a link between synthesis parameters (feedstock, pyrolysis kinetics) and physicochemical functionalities (pore architecture, redox-active functional groups). Specifically, we elucidate how precise regulation of pyrolysis temperature dictates the dominant electron transfer pathway: low-temperature biochar (<500 °C) facilitates electron shuttling via oxygen-containing functional groups (e.g., quinone moieties), whereas high-temperature biochar (>700 °C) promotes direct interspecies electron transfer (DIET) through graphitic conduction. We systematically decouple biochar-mediated electron transfer into three pathways: functional group-driven shuttling, solid-state conductive matrix transfer via conjugated π-electrons, and material-assisted DIET. Crucially, we emphasize that validating true DIET requires direct biological evidence of electroactive machinery. Furthermore, the review details how biochar modulates the biological microenvironment, upregulating key denitrification genes (narG, nirS/K, nosZ) and enriching functional microbial consortia. By integrating advances in surface modification—such as heteroatom doping and metal loading—we propose strategies to engineer biochar for optimized nitrate-to-nitrogen conversion. Future perspectives underscore the need for balancing electron-donating capacity with structural stability, developing low-energy functionalization techniques, and conducting life-cycle assessments to facilitate the scale-up of sustainable, high-efficiency nitrogen removal systems. Full article

Exosomes, nanoscale extracellular vesicles released by virtually all cell types, have emerged as pivotal mediators of intercellular communication and play a crucial role in the pathophysiology of numerous acute and chronic diseases, including a wide spectrum of urological disorders. By acting as sophisticated biological shuttles, exosomes transport a rich and highly specific molecular cargo—comprising proteins, lipids, messenger RNAs, microRNAs, and other nucleic acids—that reflects the physiological or pathological state of their cell of origin. Owing to these unique properties, exosomes are increasingly recognized as promising biomarkers for the diagnosis, prognosis, and monitoring of a broad range of inflammatory, degenerative, and neoplastic diseases. Beyond their diagnostic value, exosomes have attracted considerable attention as therapeutic tools, given their ability to promote tissue regeneration, modulate immune responses, and serve as potential targeted drug-delivery systems for small molecules, biologics, vaccines, and gene-based therapies. Notably, exosomes recapitulate many of the beneficial biological effects traditionally attributed to stem cells, while potentially offering a more practical alternative. As cell-free entities, they may reduce—though not entirely eliminate—several risks associated with cell transplantation, such as uncontrolled proliferation and immune rejection, and they raise fewer ethical concerns, making them attractive candidates for regenerative and precision medicine. In urology, the diagnostic, prognostic, and therapeutic applications of exosomes are rapidly expanding, with particularly promising advances observed in bladder, prostate, and kidney diseases. Growing evidence also supports their relevance in a variety of benign urological conditions, including erectile dysfunction, male infertility, neurogenic bladder, urethral stricture disease, stress urinary incontinence, and bladder pain syndrome. This review synthesizes contemporary knowledge on the biological significance and clinical potential of exosomes in urology, highlighting their emerging role as biomarkers and therapeutics, with a special focus on benign urological disorders. We emphasize that the current evidence base in benign urology is largely preclinical, and that clinical translation, although promising, remains at an early stage. Full article

The black soil region of Northeast China is a key grain-production area where cropland water erosion threatens soil fertility and sustainability. We diagnosed cropland soil loss across six diagnostic years/time slices (2001, 2005, 2010, 2015, 2020, and 2024) using a Revised Universal Soil Loss Equation (RUSLE)-based remote-sensing workflow implemented in Google Earth Engine (GEE). Rainfall erosivity was derived from Climate Hazards Group InfraRed Precipitation with Station data (CHIRPS) daily precipitation, soil erodibility from SoilGrids, topography from the Shuttle Radar Topography Mission digital elevation model (SRTM DEM), vegetation cover from the Landsat normalized difference vegetation index (NDVI), and cropland extent from ESA WorldCover; alternative rainfall sources, cropland masks, and P-factor settings were used for sensitivity analyses. Under the slope-graded P-factor scenario, mean annual soil loss ranged from 1.60 to 3.07 t ha⁻¹ yr⁻¹, and the proportion of cropland exceeding T = 2 t ha⁻¹ yr⁻¹ ranged from 25.2% to 52.9%. Soil loss fluctuated among years because rainfall erosivity and cover-management effects partly counteracted each other. Risk was concentrated in sloping piedmont and hilly cropland, whereas broad plains were dominated by very slight and slight erosion. P-factor parameterization represented the largest structural uncertainty. The workflow provides regional screening evidence for field verification and conservation-practice assessment, rather than direct site-specific engineering prescriptions. Full article

Pyruvate kinase (PK) is the terminal rate-limiting enzyme of glycolysis and occupies a central position in plant energy metabolism and carbon skeleton allocation. Plant PK isoenzymes comprise the cytosolic pyruvate kinase (PKc) and the plastidic pyruvate kinase (PKp), which differ markedly in gene origin, protein structure, subcellular localization, and physiological function, exhibiting independent evolutionary histories and functional diversification. Recent studies have revealed that PKc possesses dynamic subcellular distribution, allowing it to shuttle among the cytosol, mitochondria, and nucleus, where it participates in stress responses and epigenetic regulation through protein–protein interactions. PKp is localized to plastids and connects carbon metabolism with lipid biosynthesis and the methylerythritol phosphate (MEP) pathway by supplying pyruvate, thereby playing critical roles in seed development and oil accumulation. This review comprehensively summarizes recent advances in plant PKc and PKp concerning protein structure and subunit composition, tissue-specific expression, subcellular localization, protein interaction networks, activity regulation, and their effects on plant growth, development, and stress responses. In addition, phylogenetic tree, motif, and domain analyses of pyruvate kinase genes from Oryza sativa (rice), Glycine max (soybean), Gossypium hirsutum (cotton), Solanum tuberosum (potato), Arachis hypogaea (peanut), and Arabidopsis thaliana, as well as promoter cis-element analyses, are performed. This review aims to provide theoretical references for crop quality improvement and stress-resilient breeding. Full article

Background/Objectives: Self-reported physical activity is widely used in non-communicable disease (NCD) surveillance, yet its individual-level agreement with field-based markers of cardiorespiratory fitness remains poorly characterised in Gulf Cooperation Council (GCC) populations. This study examined the association, agreement, and directional discordance between self-reported physical activity (IPAQ Short Form, IPAQ-SF) and field-assessed functional capacity (Incremental Shuttle Walk Test, ISWT) among university students in Kuwait. Methods: In 389 students (76.3% female; mean age 20.2 ± 2.3 years) in Kuwait, IPAQ-SF activity was classified as low, moderate, or high and ISWT distance into sample-derived tertiles. Spearman correlations, Kruskal–Wallis tests with Dunn pairwise comparisons, cross-tabulation, and unweighted, linear-weighted, and quadratic-weighted Cohen’s kappa were used. Results: IPAQ activity showed a weak but significant correlation with ISWT distance (ρ = 0.209, p < 0.001). ISWT performance did not differ between the low- and moderate-IPAQ categories (Bonferroni-adjusted Dunn p = 0.162). Agreement was slight across all kappa estimates (unweighted κ = 0.083; linear-weighted κ = 0.137; quadratic-weighted κ = 0.192), with matching category assignment in only 38.8% of participants; lower-than-tertile IPAQ classification occurred in 42.9% and higher-than-tertile in 18.3%. Directional discordance differed significantly by sex (p < 0.001). A rank-based partial correlation adjusting for BMI, age, and sex was attenuated but remained significant (r = 0.144, p = 0.004). Conclusions: IPAQ-SF categories showed poor individual-level agreement with sample-derived ISWT functional-capacity tertiles among university students in Kuwait. Self-reported physical activity and field-based functional capacity should therefore be interpreted as complementary rather than interchangeable measures. Larger multi-university studies across the GCC are needed to confirm these findings. Full article