Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Journals

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Article Types

Countries / Regions

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Search Results (21,807)

Search Parameters:
Keywords = shaping effect

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
29 pages, 1778 KiB  
Article
The Impact of Rural Digital Economy Development on Agricultural Carbon Emission Efficiency: A Study of the N-Shaped Relationship
by Yong Feng, Shuokai Wang and Fangping Cao
Agriculture 2025, 15(15), 1583; https://doi.org/10.3390/agriculture15151583 - 23 Jul 2025
Abstract
This study investigates the impact of rural digital economy development on agricultural carbon emission efficiency, aiming to elucidate the intrinsic mechanisms and pathways through which digital technology enables low-carbon transformation in agriculture, thereby contributing to the achievement of agricultural carbon neutrality goals. Based [...] Read more.
This study investigates the impact of rural digital economy development on agricultural carbon emission efficiency, aiming to elucidate the intrinsic mechanisms and pathways through which digital technology enables low-carbon transformation in agriculture, thereby contributing to the achievement of agricultural carbon neutrality goals. Based on provincial-level panel data from China spanning 2011 to 2022, this study examines the relationship between the rural digital economy and agricultural carbon emission efficiency, along with its underlying mechanisms, using bidirectional fixed effects models, mediation effect analysis, and Spatial Durbin Models. The results indicate the following: (1) A significant N-shaped-curve relationship exists between rural digital economy development and agricultural carbon emission efficiency. Specifically, agricultural carbon emission efficiency exhibits a three-phase trajectory of “increase, decrease, and renewed increase” as the rural digital economy advances, ultimately driving a sustained improvement in efficiency. (2) Industrial integration acts as a critical mediating mechanism. Rural digital economy development accelerates the formation of the N-shaped curve by promoting the integration between agriculture and other sectors. (3) Spatial spillover effects significantly influence agricultural carbon emission efficiency. Due to geographical proximity, regional diffusion, learning, and demonstration effects, local agricultural carbon emission efficiency fluctuates with changes in neighboring regions’ digital economy development levels. (4) The relationship between rural digital economy development and agricultural carbon emission efficiency exhibits a significant inverted N-shaped pattern in regions with higher marketization levels, planting-dominated areas of southeast China, and digital economy demonstration zones. Further analysis reveals that within rural digital economy development, production digitalization and circulation digitalization demonstrate a more pronounced inverted N-shaped relationship with agricultural carbon emission efficiency. This study proposes strategic recommendations to maximize the positive impact of the rural digital economy on agricultural carbon emission efficiency, unlock its spatially differentiated contribution potential, identify and leverage inflection points of the N-shaped relationship between digital economy development and emission efficiency, and implement tailored policy portfolios—ultimately facilitating agriculture’s green and low-carbon transition. Full article
(This article belongs to the Section Agricultural Economics, Policies and Rural Management)
22 pages, 1783 KiB  
Article
Active Touch Sensing for Robust Hole Detection in Assembly Tasks
by Bojan Nemec, Mihael Simonič and Aleš Ude
Sensors 2025, 25(15), 4567; https://doi.org/10.3390/s25154567 - 23 Jul 2025
Abstract
In this paper, we propose an active touch sensing algorithm designed for robust hole localization in 3D objects, specifically aimed at assembly tasks such as peg-in-hole operations. Unlike general object detection algorithms, our solution is tailored for precise localization of features like hole [...] Read more.
In this paper, we propose an active touch sensing algorithm designed for robust hole localization in 3D objects, specifically aimed at assembly tasks such as peg-in-hole operations. Unlike general object detection algorithms, our solution is tailored for precise localization of features like hole openings using sparse tactile feedback. The method builds on a prior 3D map of the object and employs a series of iterative search algorithms to refine localization by aligning tactile sensing data with the object’s shape. It is specifically designed for objects composed of multiple parallel surfaces located at distinct heights; a common characteristic in many assembly tasks. In addition to the deterministic approach, we introduce a probabilistic version of the algorithm, which effectively compensates for sensor noise and inaccuracies in the 3D map. This probabilistic framework significantly improves the algorithm’s resilience in real-world environments, ensuring reliable performance even under imperfect conditions. We validate the method’s effectiveness for several assembly tasks, such as inserting a plug into a socket, demonstrating its speed and accuracy. The proposed algorithm outperforms traditional search strategies, offering a robust solution for assembly operations in industrial and domestic applications with limited sensory input. Full article
(This article belongs to the Collection Tactile Sensors, Sensing and Systems)
17 pages, 2001 KiB  
Article
A Methodological Route for Teaching Vocabulary in Spanish as a Foreign Language Using Oral Tradition Stories: The Witches of La Jagua and Colombia’s Linguistic and Cultural Diversity
by Daniel Guarín
Educ. Sci. 2025, 15(8), 949; https://doi.org/10.3390/educsci15080949 - 23 Jul 2025
Abstract
Oral tradition stories hold a vital place in language education, offering rich repositories of linguistic, cultural, and historical knowledge. In the Spanish as a Foreign Language (SFL) context, their inclusion provides dynamic opportunities to explore diversity, foster critical and creative thinking, and challenge [...] Read more.
Oral tradition stories hold a vital place in language education, offering rich repositories of linguistic, cultural, and historical knowledge. In the Spanish as a Foreign Language (SFL) context, their inclusion provides dynamic opportunities to explore diversity, foster critical and creative thinking, and challenge dominant epistemologies. Despite their pedagogical potential, these narratives remain largely absent from formal curricula, with most SFL textbooks still privileging canonical works, particularly those from the Latin American Boom or European literary texts. This article aims to provide practical guidance for SFL instructors on designing effective, culturally responsive materials for the teaching of vocabulary. Drawing on a methodological framework for material design and a cognitive approach to vocabulary learning, I present original pedagogical material based on a Colombian oral tradition story about the witches of La Jagua (Huila, Colombia) to inspire educators to integrate oral tradition stories into their classrooms. As argued throughout, oral narratives not only support vocabulary acquisition and intercultural competence but also offer students meaningful engagement with the values, worldviews, and linguistic diversity that shape Colombian culture. This approach redefines language teaching through a more descriptive, contextualized, and culturally grounded lens, equipping learners with pragmatic, communicative, and intercultural skills essential for the 21st century. My goal with this article is to advocate for teacher agency in material creation, emphasizing that educators are uniquely positioned to design pedagogical resources that reflect their own cultural realities and local knowledge and to adapt them meaningfully to their students’ needs. Full article
Show Figures

Figure 1

25 pages, 1693 KiB  
Article
Study on Heat Transfer of Fluid in a Porous Media by VOF Method with Fractal Reconstruction
by Shuai Liu, Qingyong Zhu and Wenjun Xu
Energies 2025, 18(15), 3935; https://doi.org/10.3390/en18153935 - 23 Jul 2025
Abstract
This paper addresses the critical gap in the existing literature regarding the combined buoyancy–Marangoni convection of power-law fluids in three-dimensional porous media with complex evaporation surfaces. Previous studies have rarely investigated the convective heat transfer mechanisms in such systems, and there is a [...] Read more.
This paper addresses the critical gap in the existing literature regarding the combined buoyancy–Marangoni convection of power-law fluids in three-dimensional porous media with complex evaporation surfaces. Previous studies have rarely investigated the convective heat transfer mechanisms in such systems, and there is a lack of effective methods to accurately track fractal evaporation surfaces, which are ubiquitous in natural and engineering porous media (e.g., geological formations, industrial heat exchangers). This research is significant because understanding heat transfer in these complex porous media is essential for optimizing energy systems, enhancing thermal management in industrial processes, and improving the efficiency of phase-change-based technologies. For this scientific issue, a general model is designed. There is a significant temperature difference on the left and right sides of the model, which drives the internal fluid movement through the temperature difference. The upper end of the model is designed as a complex evaporation surface, and there is flowing steam above it, thus forming a coupled flow field. The VOF fractal reconstruction method is adopted to approximate the shape of the complex evaporation surface, which is a major highlight of this study. Different from previous research, this method can more accurately reflect the flow and phase change on the upper surface of the porous medium. Through numerical simulation, the influence of the evaporation coefficient on the flow and heat transfer rate can be determined. Key findings from numerical simulations reveal the following: (1) Heat transfer rates decrease with increasing fractal dimension (surface complexity) and evaporation coefficient; (2) As the thermal Rayleigh number increases, the influence of the Marangoni number on heat transfer diminishes; (3) The coupling of buoyancy and Marangoni effects in porous media with complex evaporation surfaces significantly alters flow and heat transfer patterns compared to smooth-surfaced porous media. This study provides a robust numerical framework for analyzing non-Newtonian fluid convection in complex porous media, offering insights into optimizing thermal systems involving phase changes and irregular surfaces. The findings contribute to advancing heat transfer theory and have practical implications for industries such as energy storage, chemical engineering, and environmental remediation. Full article
(This article belongs to the Section J: Thermal Management)
12 pages, 549 KiB  
Systematic Review
Emerging Technologies in the Treatment of Orbital Floor Fractures: A Systematic Review
by Lorena Helgers, Ilze Prikule, Girts Salms and Ieva Bagante
Medicina 2025, 61(8), 1330; https://doi.org/10.3390/medicina61081330 - 23 Jul 2025
Abstract
Background and Objectives: Orbital floor fractures are challenging to treat, due to the complex orbital anatomy and limited surgical access. Emerging technologies—such as virtual surgical planning (VSP), 3D printing, patient-specific implants (PSIs), and intraoperative navigation—offer promising advancements to improve the surgical precision [...] Read more.
Background and Objectives: Orbital floor fractures are challenging to treat, due to the complex orbital anatomy and limited surgical access. Emerging technologies—such as virtual surgical planning (VSP), 3D printing, patient-specific implants (PSIs), and intraoperative navigation—offer promising advancements to improve the surgical precision and clinical outcomes. This review systematically evaluates and synthesizes current technological modalities with respect to their accuracy, operative duration, cost-effectiveness, and postoperative functional outcomes. Materials and Methods: A systematic review was conducted according to the PRISMA 2020 guidelines. The PubMed, Scopus, and PRIMO databases were searched for clinical studies published between 2019 and September 2024. Out of 229 articles identified, 9 met the inclusion criteria and were analyzed using the PICO framework. Results: VSP and 3D printing enhanced diagnostics and presurgical planning, offering improved accuracy and reduced planning time. Pre-bent PSIs shaped on 3D models showed superior accuracy, lower operative times, and better cost efficiency compared to intraoperative mesh shaping. Custom-designed PSIs offered high precision and clinical benefit but required a longer production time. Intraoperative navigation improved implant positioning and reduced the complication rates, though a detailed cost analysis remains limited. Conclusions: VSP, 3D printing, and intraoperative navigation significantly improve surgical planning and outcomes in orbital floor reconstruction. Pre-bent PSIs provide a time- and cost-effective solution with strong clinical performance. While customized PSIs offer accuracy, they are less practical in time-sensitive settings. Navigation systems are promising tools that enhance outcomes and may serve as an alternative to custom implants when time or resources are limited. Full article
(This article belongs to the Special Issue Craniomaxillofacial Surgery: Latest Innovations and Challenges)
Show Figures

Figure 1

18 pages, 4335 KiB  
Article
DEM Study on the Impact of Liner Lifter Bars on SAG Mill Collision Energy
by Yong Wang, Qingfei Xiao, Saizhen Jin, Mengtao Wang, Ruitao Liu and Guobin Wang
Lubricants 2025, 13(8), 321; https://doi.org/10.3390/lubricants13080321 - 23 Jul 2025
Abstract
The semi-autogenous grinding (SAG) mill, renowned for its high efficiency, high production capacity, and low cost, is widely used for crushing and grinding equipment. However, the current understanding of the overall particle behavior influencing its efficiency remains relatively limited, particularly the impact of [...] Read more.
The semi-autogenous grinding (SAG) mill, renowned for its high efficiency, high production capacity, and low cost, is widely used for crushing and grinding equipment. However, the current understanding of the overall particle behavior influencing its efficiency remains relatively limited, particularly the impact of the shape of SAG mill liners on material behavior. This study employs discrete element method (DEM) simulation technology to investigate the effects of different liner structures on particle trajectories and collision energy, systematically investigating the impact of lifter bars angle, height, and the number of lifter bars on grinding efficiency. The results of single-factor simulations indicate that when the lifter bars height (230 mm) and the number of lifter bars (36) are fixed, the total collision energy dissipation between steel balls and ore, as well as among ore particles, reaches a maximum of 526,069.53 J when the lifter bars angle is 25°. When the lifter bar angle is fixed at 25° and the number of lifter bars is set to 36, the maximum collision energy dissipation of 627,606.06 J occurs at a lifter bars height of 210 mm. When the angle (25°) and height (210 mm) are fixed, the highest energy dissipation of 443,915.37 J is observed with 12 lifter bars. Results from the three-factor, three-level orthogonal experiment reveal that the number of lifter bars exerts the most significant influence on grinding efficiency, followed by the angle and height. The optimal combination is determined to be a 20° angle, 12 lifter bars, and a 210 mm height, resulting in the highest total collision energy dissipation of 700,334 J. This represents an increase of 379,466 J compared to the original SAG mill liner configuration (320,868 J). This research aims to accurately simulate the motion of discrete particles within the mill through DEM simulations, providing a basis for optimizing the operational parameters and structural design of SAG mills. Full article
(This article belongs to the Special Issue Tribology in Ball Milling: Theory and Applications)
Show Figures

Figure 1

14 pages, 553 KiB  
Article
Overconfidence and Investment Loss Tolerance: A Large-Scale Survey Analysis of Japanese Investors
by Honoka Nabeshima, Mostafa Saidur Rahim Khan and Yoshihiko Kadoya
Risks 2025, 13(8), 142; https://doi.org/10.3390/risks13080142 - 23 Jul 2025
Abstract
Accepting a certain degree of investment loss risk is essential for long-term portfolio management. However, overconfidence bias within financial literacy can prompt excessively risky behavior and amplify susceptibility to other cognitive biases. These tendencies can undermine investment loss tolerance beyond the baseline level [...] Read more.
Accepting a certain degree of investment loss risk is essential for long-term portfolio management. However, overconfidence bias within financial literacy can prompt excessively risky behavior and amplify susceptibility to other cognitive biases. These tendencies can undermine investment loss tolerance beyond the baseline level shaped by sociodemographic, economic, psychological, and cultural factors. This study empirically examines the association between overconfidence and investment loss tolerance, which is measured by the point at which respondents indicate they would sell their investments in a hypothetical loss scenario. Using a large-scale dataset of 161,765 active investors from one of Japan’s largest online securities firms, we conduct ordered probit and ordered logit regression analyses, controlling for a range of sociodemographic, economic, and psychological variables. Our findings reveal that overconfidence is statistically significantly and negatively associated with investment loss tolerance, indicating that overconfident investors are more prone to prematurely liquidating assets during market downturns. This behavior reflects an impulse to avoid even modest losses. The findings suggest several possible practical strategies to mitigate the detrimental effects of overconfidence on long-term investment behavior. Full article
35 pages, 7193 KiB  
Article
Macrozoobenthos Response to Sediment Contamination near the S/s Stuttgart Wreck: A Biological and Chemical Assessment in the Gulf of Gdańsk, Southern Baltic Sea
by Anna Tarała, Diana Dziaduch, Katarzyna Galer-Tatarowicz, Aleksandra Bojke, Maria Kubacka and Marcin Kalarus
Water 2025, 17(15), 2199; https://doi.org/10.3390/w17152199 - 23 Jul 2025
Abstract
This study provides an up-to-date assessment of the environmental status in the area of the S/s Stuttgart wreck in the southern Baltic Sea, focusing on macrozoobenthos, sediment chemistry, and contamination in Mytilus trossulus soft tissues. Comparative analyses from 2016 and 2023 revealed increased [...] Read more.
This study provides an up-to-date assessment of the environmental status in the area of the S/s Stuttgart wreck in the southern Baltic Sea, focusing on macrozoobenthos, sediment chemistry, and contamination in Mytilus trossulus soft tissues. Comparative analyses from 2016 and 2023 revealed increased species richness and distinct benthic assemblages, shaped primarily by depth and distance from the wreck. Among macrozoobenthos, there dominated opportunistic species, characterized by a high degree of resistance to the unfavorable state of the environment, suggesting adaptation to local conditions. Elevated concentrations of heavy metals were detected in sediments, with maximum values of Cd—0.85 mg·kg−1, Cu—34 mg·kg−1, Zn—119 mg·kg−1, and Ni—32.3 mg·kg−1. However, no significant correlations between sediment contamination and macrozoobenthos composition were found. In Mytilus trossulus, contaminant levels were mostly within regulatory limits; however, mercury concentrations reached 0.069 mg·kg−1 wet weight near the wreck and 0.493 mg·kg−1 at the reference station, both exceeding the threshold defined in national legislation (0.02 mg·kg−1) (Journal of Laws of 2021, item 568). Condition indices for Macoma balthica were lower in the wreck area, suggesting sublethal stress. Ecotoxicological tests showed no acute toxicity in most sediment samples, emphasizing the complexity of pollutant effects. The data presented here not only enrich the existing literature on marine pollution but also contribute to the development of more effective environmental protection strategies for marine ecosystems under international protection. Full article
20 pages, 821 KiB  
Review
Global Perspectives on Rabies Control and Elimination: A Scoping Review of Dog Owners’ Knowledge, Attitudes, and Practices
by Moumita Das, Valeriia Yustyniuk, Andres M. Perez and Maria Sol Perez Aguirreburualde
Pathogens 2025, 14(8), 728; https://doi.org/10.3390/pathogens14080728 - 23 Jul 2025
Abstract
Rabies is a fatal but entirely vaccine-preventable disease, with the highest risk in areas where free-roaming domestic dogs are prevalent. Understanding dog owners’ knowledge, attitudes, and practices (KAP) is crucial for shaping effective rabies control strategies. This scoping review aimed to synthesize global [...] Read more.
Rabies is a fatal but entirely vaccine-preventable disease, with the highest risk in areas where free-roaming domestic dogs are prevalent. Understanding dog owners’ knowledge, attitudes, and practices (KAP) is crucial for shaping effective rabies control strategies. This scoping review aimed to synthesize global evidence from studies evaluating dog owners’ KAP to identify behavioral factors relevant to rabies prevention and control. A systematic literature search was conducted using PubMed, Web of Science, and Scopus, covering the period from 2012 to 2025. Seventy full-text articles were included based on predefined criteria. The findings reveal substantial gaps in dog owners’ knowledge, beliefs, and behaviors regarding rabies prevention. While general awareness of rabies is high among dog owners, their knowledge about transmission, clinical signs, and the fatal nature of the disease is inconsistent, with significant variability across studies. The vaccination uptake also varied widely across studies, ranging from less than 1% to over 90%, with no study reporting full coverage. Furthermore, a strong positive correlation was found between vaccination practice and the awareness of vaccine benefits (r = 0.69, p = 0.004). Common barriers to vaccination include lack of information, vaccine accessibility, distance to clinics, and personal constraints. These insights underscore the importance of early and targeted communication about vaccination campaigns. Future research should focus on periodically evaluating KAP before and after interventions to better inform rabies control efforts. Full article
(This article belongs to the Special Issue Current Challenges in Veterinary Virology)
20 pages, 18430 KiB  
Article
Automated Strain-Based Processing Route Generation for Curved Plate Forming in Shipbuilding
by Lichun Chang, Yao Zhao, Zhenshuai Wei and Hua Yuan
J. Mar. Sci. Eng. 2025, 13(8), 1399; https://doi.org/10.3390/jmse13081399 - 23 Jul 2025
Abstract
Curved plate forming is essential in shipbuilding but traditionally relies on manual methods with low efficiency. Achieving automation in curved plate forming requires robust methods to generate processing solutions. This paper introduces a novel method for deriving the processing routes and strain distributions [...] Read more.
Curved plate forming is essential in shipbuilding but traditionally relies on manual methods with low efficiency. Achieving automation in curved plate forming requires robust methods to generate processing solutions. This paper introduces a novel method for deriving the processing routes and strain distributions necessary to form complex curve plate using integrated heating and mechanical rolling forming equipment. The key aspects of this method include analyzing the target surface and solving for the required processing strains based on finite element analysis, discretizing the strain paths and refining them into engineering-feasible processing routes, deriving processing schemes from the calculated strains, and predicting and validating the processing schemes using the inherent strain method. The method is validated by applying it to typical surface of ship hull plates. Key outcomes demonstrate the method’s effectiveness and applicability: (1) The proposed method effectively establishes a quantitative relationship between the target surface geometry, processing routes, and the required processing strains. (2) By analyzing various target surface cases, the method demonstrates wide applicability. Standardized procedures can be applied to different surface shapes to derive the necessary processing routes and strains, thereby laying a solid foundation for the automation of curved hull plate forming. (3) Experimental forming tests on typical curved surfaces confirm that the processing schemes based on the proposed strain generation method can reliably achieve the desired geometries, showcasing the method’s capability to guide practical forming processes. The comparison between the formed and target shapes shows that the processing deviation of the schemes generated by this method remains within 5 mm, demonstrating high accuracy. Full article
(This article belongs to the Section Ocean Engineering)
20 pages, 12036 KiB  
Article
Spatiotemporal Mapping of Grazing Livestock Behaviours Using Machine Learning Algorithms
by Guo Ye and Rui Yu
Sensors 2025, 25(15), 4561; https://doi.org/10.3390/s25154561 - 23 Jul 2025
Abstract
Grassland ecosystems are fundamentally shaped by the complex behaviours of livestock. While most previous studies have monitored grassland health using vegetation indices, such as NDVI and LAI, fewer have investigated livestock behaviours as direct drivers of grassland degradation. In particular, the spatial clustering [...] Read more.
Grassland ecosystems are fundamentally shaped by the complex behaviours of livestock. While most previous studies have monitored grassland health using vegetation indices, such as NDVI and LAI, fewer have investigated livestock behaviours as direct drivers of grassland degradation. In particular, the spatial clustering and temporal concentration patterns of livestock behaviours are critical yet underexplored factors that significantly influence grassland ecosystems. This study investigated the spatiotemporal patterns of livestock behaviours under different grazing management systems and grazing-intensity gradients (GIGs) in Wenchang, China, using high-resolution GPS tracking data and machine learning classification. the K-Nearest Neighbours (KNN) model combined with SMOTE-ENN resampling achieved the highest accuracy, with F1-scores of 0.960 and 0.956 for continuous and rotational grazing datasets. The results showed that the continuous grazing system failed to mitigate grazing pressure when grazing intensity was reduced, as the spatial clustering of livestock behaviours did not decrease accordingly, and the frequency of temporal peaks in grazing behaviour even showed an increasing trend. Conversely, the rotational grazing system responded more effectively, as reduced GIGs led to more evenly distributed temporal activity patterns and lower spatial clustering. These findings highlight the importance of incorporating livestock behavioural patterns into grassland monitoring and offer data-driven insights for sustainable grazing management. Full article
(This article belongs to the Section Smart Agriculture)
Show Figures

Figure 1

21 pages, 1548 KiB  
Review
Nanotechnology-Based Delivery of CRISPR/Cas9 for Cancer Treatment: A Comprehensive Review
by Mohd Ahmar Rauf, Afifa Rao, Siva Sankari Sivasoorian and Arun K. Iyer
Cells 2025, 14(15), 1136; https://doi.org/10.3390/cells14151136 - 23 Jul 2025
Abstract
CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats-associated protein 9)-mediated genome editing has emerged as a transformative tool in medicine, offering significant potential for cancer therapy because of its capacity to precisely target and alter the genetic modifications associated with the disease. However, a [...] Read more.
CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats-associated protein 9)-mediated genome editing has emerged as a transformative tool in medicine, offering significant potential for cancer therapy because of its capacity to precisely target and alter the genetic modifications associated with the disease. However, a major challenge for its clinical translation is the safe and efficient in vivo delivery of CRISPR/Cas9 components to target cells. Nanotechnology is a promising solution to this problem. Nanocarriers, owing to their tunable physicochemical properties, can encapsulate and protect CRISPR/Cas9 components, enabling targeted delivery and enhanced cellular uptake. This review provides a comprehensive examination of the synergistic potential of CRISPR/Cas9 and nanotechnology in cancer therapy and explores their integrated therapeutic applications in gene editing and immunotherapy. A critical aspect of in vivo CRISPR/Cas9 application is to achieve effective localization at the tumor site while minimizing off-target effects. Nanocarriers can be engineered to overcome biological barriers, thereby augmenting tumor-specific delivery and facilitating intracellular uptake. Furthermore, their design allows for controlled release of the therapeutic payload, ensuring sustained efficacy and reduced systemic toxicity. The optimization of nanocarrier attributes, including size, shape, surface charge, and composition, is crucial for improving the cellular internalization, endosomal escape, and nuclear localization of CRISPR/Cas9. Moreover, surface functionalization with targeting ligands can enhance the specificity of cancer cells, leading to improved gene-editing accuracy. This review thoroughly discusses the challenges associated with in vivo CRISPR/Cas9 delivery and the innovative nanotechnological strategies employed to overcome them, highlighting their combined potential for advancing cancer treatment for clinical application. Full article
Show Figures

Figure 1

21 pages, 1201 KiB  
Article
Seasonal and Dietary Effects on the Hematobiochemical Parameters of Creole Goats in the Peruvian Andes
by Aníbal Rodríguez-Vargas, Emmanuel Alexander Sessarego, Katherine Castañeda-Palomino, Huziel Ormachea, Fritz Trillo, Víctor Temoche-Socola, José Antonio Ruiz-Chamorro and Juancarlos Alejandro Cruz
Vet. Sci. 2025, 12(8), 687; https://doi.org/10.3390/vetsci12080687 - 23 Jul 2025
Abstract
Creole goats have adapted to the harsh Andean environment, yet the physiological impacts of high-altitude production systems remain underexplored. This study assessed seasonal and dietary influences on the hematological and biochemical profiles of 45 Creole goats in the Peruvian Andes. The animals were [...] Read more.
Creole goats have adapted to the harsh Andean environment, yet the physiological impacts of high-altitude production systems remain underexplored. This study assessed seasonal and dietary influences on the hematological and biochemical profiles of 45 Creole goats in the Peruvian Andes. The animals were assigned to three diets: D1 (grazing), D2 (grazing + 2000 g hay), and D3 (grazing + 400 g concentrate), across rainy and dry seasons. Biweekly blood sampling measured urea, cholesterol, total protein, albumin, ALP, ALT, WBCL, NeuP, LymP, HGB, and MCV. Season exerted the strongest influence (p < 0.001), with modest dietary effects and a consistent effect of sampling time. Urea, total protein, and albumin increased during the rainy season, though only urea responded significantly to diet. Leukocytosis rose in the dry season and with higher-protein diets, suggesting heightened immune activation under environmental stress. Hemoglobin peaked in the rainy season and early sampling, indicating better oxygenation. MCV and body weight were higher in the dry season, with weight unaffected by diet. These results underscore the complex interplay of environmental and nutritional factors in shaping goat physiology at high altitudes, emphasizing the importance of dynamic modeling in sustainable Andean livestock systems. Full article
Show Figures

Figure 1

16 pages, 2582 KiB  
Article
Optimization of Scanning Distance for Three Intraoral Scanners from Different Manufacturers: An In Vitro Accuracy Analysis
by Perla Hokayem, Rim Bourgi, Carlos Enrique Cuevas-Suárez, Miguel Ángel Fernández-Barrera, Juan Eliezer Zamarripa-Calderón, Hani Tohme, Adam Saleh, Nicolas Nassar, Monika Lukomska-Szymanska and Louis Hardan
Prosthesis 2025, 7(4), 88; https://doi.org/10.3390/prosthesis7040088 - 23 Jul 2025
Abstract
Background: Accuracy of optical impressions—defined by the intraoral scanner (IOS)’s trueness and precision per International Organization for Standardization (ISO) standards—is influenced by both operator- and patient-related factors. Thus, this in vitro study aimed to (1) evaluate how scanning distance affects the accuracy of [...] Read more.
Background: Accuracy of optical impressions—defined by the intraoral scanner (IOS)’s trueness and precision per International Organization for Standardization (ISO) standards—is influenced by both operator- and patient-related factors. Thus, this in vitro study aimed to (1) evaluate how scanning distance affects the accuracy of three different intraoral scanners (IOSs), and (2) identify the optimal scanning distance for each scanner. Methods: A maxillary arch model was obtained using polyvinyl siloxane impression material and poured with Type IV stone (Octa-rock royal®, Kulzer, Germany). Using three different types of IOSs—the trios 3 shape (TRIOS ® cart, 3Shape, Copenhagen, Denmark); the Helios 500 (Eighteeth ®, Changzhou, China); and the Heron (3Disc ®, Herndon, VA 20170, USA)—ten scans were performed with each of the IOSs with five predetermined distances: 0 mm, 2.5 mm, 5 mm, 7.5 mm, and 10 mm. Spacers of varying heights were designed using Meshmixer version 3.5 (Autodesk, Inc., Mill Valley, CA, USA) and three-dimensional printed with the Form 2 printer (Formlabs, Somerville, MA, USA). The scanned data was processed using Geomagic Control X (Version 16.0.2.16496, 3D Systems, Wilsonville, OR, USA). Statistical analyses were performed using R Statistical Software (version 4.2.2), with significance set at α = 0.05. Results: Scanning distance significantly influenced scan accuracy for all three scanners. The 3Disc scanner demonstrated the highest accuracy at a 7.5 mm distance, while both the Helios and Trios scanners achieved their best accuracy at a 5 mm distance, as indicated by the lowest root mean square (RMS) values (p < 0.05). Conclusions: To conclude, each IOS has an optimal scanning distance for best accuracy. TRIOS 3 outperformed the others in both trueness and precision. Future studies should examine these effects under full-arch and clinical conditions. Full article
Show Figures

Figure 1

16 pages, 4298 KiB  
Article
Investigation of Flame Structure and PAHs’ Evolution in a Swirl-Stabilized Spray Flame at Elevated Pressure
by Wenyu Wang, Runfan Zhu, Siyu Liu, Yong He, Wubin Weng, Shixing Wang, William L. Roberts and Zhihua Wang
Energies 2025, 18(15), 3923; https://doi.org/10.3390/en18153923 - 23 Jul 2025
Abstract
Swirl spray combustion has attracted significant attention due to its common usage in gas turbines. However, the high pressure in many practical applications remains a major obstacle to the deep understanding of flame stability and pollutant formation. To address this concern, this study [...] Read more.
Swirl spray combustion has attracted significant attention due to its common usage in gas turbines. However, the high pressure in many practical applications remains a major obstacle to the deep understanding of flame stability and pollutant formation. To address this concern, this study investigated a swirl spray flame fueled with n-decane at elevated pressure. Planar laser-induced fluorescence (PLIF) of OH and polycyclic aromatic hydrocarbons (PAHs) were used simultaneously, enabling the distinction of the locations of OH, PAHs, and mixtures of them, providing detailed information on flame structure and evolution of PAHs. The effects of swirl number and ambient pressure on reaction zone characteristics and PAHs’ formation were studied, with the swirl number ranging from 0.30 to 1.18 and the pressure ranging from 1 to 3 bar. The data suggest that the swirl number changes the flame structure from V-shaped to crown-shaped, as observed at both atmospheric and elevated pressures. Additionally, varying swirl numbers lead to the initiation of flame divergence at distinct pressure levels. Moreover, PAHs of different molecular sizes exhibit significant overlap, with larger PAHs able to further extend downstream. The relative concentration of PAH increased with pressure, and the promoting effect of pressure on producing larger PAHs was significant. Full article
(This article belongs to the Special Issue Challenges and Opportunities in the Global Clean Energy Transition)
Show Figures

Figure 1

Back to TopTop