Search Results (591)

Background/Objectives: The practices that parents use to feed their infants have important implications for life course health and well-being. However, little is known about the infant feeding experiences and decisions of parents with developmental disabilities. This study used a mixed methods design to gain an in-depth understanding of the infant feeding experiences and decisions of parents with developmental disabilities in the United States. Methods: Between July 2024 and June 2025, 18 parents with developmental disabilities completed a one-time quantitative survey, seven of whom also completed three individual qualitative interviews. Analytical procedures included descriptive statistics of quantitative survey data and thematic analysis of qualitative interviews, followed by integration of the two forms of data. All interview participants completed member checking of preliminary themes. Results: Parents with developmental disabilities described varied experiences with breastfeeding, formula feeding, and introducing solid foods to their infants at around six months. Four disability-related factors influenced parents’ decisions across different infant feeding practices: (1) sensitivity to sensory stimuli; (2) demands on executive function; (3) “rigid thinking” about breastfeeding; and (4) medication use. Conclusions: Findings suggest parents with developmental disabilities may benefit from direct and customized support with infant feeding. Changes to improve access to disability-affirming care are warranted. Full article

Background/Objectives: The Chinese porcupine (Hystrix hodgsoni) is a distinctive rodent species characterized by specialized ecological adaptations and sensory traits; however, genomic resources for this species have remained limited. This study aims to provide a reliable reference for comparative and evolutionary analyses by constructing a high-quality genome. Methods: We generated a chromosome-level genome assembly of the Chinese porcupine using long-read sequencing combined with chromatin conformation-based scaffolding, followed by comprehensive structural and functional annotation. Comparative genomic analyses across representative mammals and functional enrichment analyses were conducted to investigate lineage-specific gene family dynamics. Results: The assembled genome shows high contiguity and completeness. Comparative analyses revealed a substantial number of gene families significantly expanded along the porcupine lineage. Functional enrichment demonstrated strong overrepresentation of olfactory-related processes, including olfactory receptor activity, odorant binding, and detection of chemical stimuli. Additionally, several expanded families were associated with epidermal differentiation, keratinization, and skin development. Conclusions: Gene family expansions in the Chinese porcupine are biased toward sensory perception and epidermal functions, suggesting potential genetic bases for its enhanced environmental sensing and integumentary specialization. This assembly provides an important genomic resource for porcupine research and new insights into the molecular mechanisms underlying sensory and skin-related adaptations in rodents. Full article

Dental pain due to dentine hypersensitivity or pulpitis is characterized by short or lasting episodes of pain triggered by normally innocuous stimuli originating from exposed dentine. Both represent the most frequent pain of the orofacial region. Transient receptor potential (TRP) superfamily of ion channels participates in the detection of different modalities of sensibility in the mammalian sensory teeth system, i.e., trigeminal neurons and odontoblasts. In particular, some members of the melastatin family (TRPM) serve as molecular thermal sensors, and temperature is one of the most potent stimuli in triggering dentine hypersensitivity. Here we review and update the information about the distribution of TRPM channels in the trigeminal ganglion and dental pulp cells, especially odontoblasts, in humans and animal models. In addition to the well-known sensory roles of TRPM, other functions such as the development and mineralization of teeth are considered. Full article

Traditional taste evaluation relies heavily on manual sensory analysis, which is highly subjective and inefficient with poor cross-individual generalization, limiting its application in industrial flavor detection. To achieve accurate cross-subject taste recognition, this paper proposes an electroencephalogram (EEG) classification method based on a meta-learning wavelet graph convolutional neural network (ML-WGCNet) under sweet- and bitter-taste stimuli. Sucrose (sweetness) and quinine (bitterness) were used as stimulation sources, each prepared at six concentration gradients, including a water control. EEG signals were detected from 20 subjects. First, the Morlet wavelet transform was applied to decompose the EEG signals in the time–frequency domain, extracting the maximum and average energy values from five frequency bands as core features. A graph structure was then constructed using electrodes as nodes and Pearson correlation coefficients between electrodes as edge weights. A lightweight graph convolutional neural network (GCN) is employed to model spatial correlations among brain regions. Finally, by integrating a meta-learning framework and adopting leave-one-subject-out cross-validation, the model can rapidly adapt to new subjects. The experimental results show that the proposed method achieves average accuracies of 76.03% and 77.01% in cross-subject classification of sweet and bitter tastes, respectively. The corresponding precision values are 79.94% and 79.53%, the recall values are 75.77% and 78.51%, and the F1-scores are 78.24% and 78.08%, respectively, demonstrating that the proposed model significantly outperforms existing mainstream EEG classification methods. Full article

Background/Objectives: Auditory processing disorders (APDs), defined as impaired neural processing of acoustic stimuli despite normal peripheral hearing, often co-occur with neurodevelopmental disorders (NDDs) and may contribute to language, attentional, and learning difficulties. Emerging evidence suggests that shared neurotransmitter systems may represent a common neurobiological substrate underlying these conditions. The aim of this study is to integrate current evidence on glutamatergic, GABAergic, and monoaminergic systems in neurodevelopmental and auditory processing disorders in children and adolescents, and to evaluate the hypothesis that shared neurotransmitter dysregulation may underlie their clinical overlap. Methods: A narrative review of the literature was conducted through electronic searches in PubMed and Embase up to 31 December 2025, using keywords related to neurotransmitters, NDDs and APDs. Results: Available evidence indicates that an imbalance between excitatory glutamatergic and inhibitory GABAergic neurotransmission has been proposed as a central mechanism in NDDs and may also contribute to auditory processing difficulties through altered neural synchrony, sensory gating and temporal auditory coding. Findings collectively suggest the hypothesis of shared neurotransmitter dysregulation across NDDs and APDs. Conclusions: Auditory processing difficulties may represent sensory-level expressions of shared neurochemical vulnerability across neurodevelopmental conditions. Future longitudinal and multimodal studies are needed to clarify causal relationships and to identify clinically useful biomarkers. Full article

Background: The neonatal period involves rapid physiological adaptation and high vulnerability to painful stimuli, especially in NICU-admitted infants. Neonates have the neurophysiological capacity for nociception, and repeated pain exposure may impair neurodevelopment. Non-pharmacological interventions, particularly oral sucrose and breast milk, are widely used as first-line analgesic strategies due to their safety and efficacy. However, heterogeneity in existing studies requires evidence synthesis. Methods: A systematic review following PRISMA guidelines was conducted to assess the effectiveness of sucrose and breast milk in neonatal pain reduction. PubMed, Scopus, CINAHL, and Web of Science were searched for randomized controlled trials published between 2019 and 2024. Studies involving neonates undergoing painful procedures and receiving sucrose, breast milk, or both were included. Data extraction and risk of bias assessment were performed independently. Due to heterogeneity in interventions and outcomes, a narrative synthesis was conducted. Results: Thirteen randomized controlled trials were included. Both sucrose and breast milk consistently reduced neonatal pain scores and physiological indicators such as heart rate and oxygen saturation. Sucrose showed rapid, short-term analgesia mediated by endogenous opioid pathways, while breast milk provided additional sensory, nutritional, and emotional benefits that support mother–infant bonding. Multimodal approaches, including kangaroo care, non-nutritive sucking, and swaddling, enhanced analgesic effects. Heterogeneity in protocols and assessment tools limited comparability across studies. Conclusions: Sucrose and breast milk are safe and effective non-pharmacological interventions for neonatal pain management. Their incorporation into standardized multimodal protocols is recommended to optimize analgesia and promote humanized neonatal care. Further research is needed to standardize dosing and evaluate long-term outcomes. Full article

The way robots represent the environment, make decisions, and express themselves can positively influence human–robot interaction if they clearly communicate their intentions and needs. To improve human–robot communication, biologically inspired models that mimic human communication skills, including task and scenario-specific contextual information, can facilitate mutual understanding and successful task execution. This paper presents a Context-Awareness and Biologically Inspired Behaviour system to generate a more natural human–robot interaction. The architecture combines sensory information processed by a Joint Attention System that prioritises stimuli based on internal processes with task-related motivations to generate context- and goal-adapted verbal and non-verbal interaction. We evaluate the system through a video-based user study that compares two robots with similar appearances but different behaviours, one using the proposed approach and the other not using the internal state and joint attention mechanisms, to make verbal and non-verbal responses. The results show that participants rated the robot endowed with the proposed system as significantly more sociable, agentic, and animated than the robot without it. Additionally, the robot not showing the responses developed in this work was perceived as more disturbing than the robot integrating the proposed system. Full article

Universal Accessibility in Astronomy requires a paradigm shift from visual-centric communication to multisensory data interaction. Because astronomy communication relies inherently on high-resolution imagery and visual metaphors, it creates significant accessibility barriers for blind and low-vision (BLV) audiences. To address this, multimodal encoding offers a feasible and meaningful solution by redistributing information across alternative sensory channels, ensuring that the absence of sight does not preclude the comprehension of spatial data. This article explores the development and evaluation of a low-cost, multimodal tool designed to represent complex astronomical concepts—specifically stellar magnitude and color—through tactile and auditory stimuli. Unlike traditional methods, our approach focuses on the haptic-cognitive link, allowing users to “feel” data through physical relief models. We present a structured impact study involving a heterogeneous group of blind, low-vision, and sighted participants. The methodology followed a mixed-methods approach, including a participatory workshop with 20 individuals and a detailed usability assessment with a core group (n= 6) of blind and low-vision participants. Preliminary results from this pilot phase demonstrate that multimodal integration effectively reduces the perceived mental effort for complex spatial data comprehension. Quantitative and qualitative feedback suggests that tactile-auditory sensory substitution not only improves accessibility but also enhances engagement and information retention across all user groups. These findings highlight the potential of multimodal models in transforming public scientific environments, such as museums and observatories, into inclusive, interactive spaces. Full article

Sensory neurons at barrier tissues were once seen as passive detectors of environmental stimuli. However, in the last five years, increasing evidence has challenged this view, redefining these cells as active immune sentinels that directly affect tissue immunity in the skin, lungs, and gastrointestinal tract. Nociceptors and pruriceptors express various immune-sensing receptors, including Toll-like receptors, cytokine receptors, and alarmin sensors, which allow them to directly detect pathogens, allergens, and tissue damage. When activated, sensory neurons quickly release neuropeptides such as calcitonin gene-related peptide (CGRP), substance P, vasoactive intestinal peptide (VIP), and PACAP (pituitary adenylate cyclase-activating polypeptide), which guide immune cell recruitment, activation, and resolution. Reciprocally, immune-derived mediators, including IL-33, IL-31, thymic stromal lymphopoietin (TSLP), IL-4/IL-13, and TNF-α, modulate neuronal excitability and plasticity, forming bidirectional neuroimmune circuits that control inflammation, host defense, pain, and itch. Landmark studies published in 2024–2025, including neuronal control of gut Treg function and the identification of sensory nerve immune niches, have further refined this framework and revealed tissue-specific circuit specialization. This review synthesizes recent insights from molecular, cellular, and systems levels into the sensory neuroimmune axis, emphasizes its protective versus pathogenic roles, and critically evaluates emerging therapeutic strategies and safety concerns, positioning sensory neuroimmunology as a unifying framework for tissue barrier homeostasis and disease. Full article

Background/Objectives: Burning Mouth Syndrome (BMS) is a chronic condition characterized by recurrent oral burning in the absence of visible mucosal lesions. Although its etiology is multifactorial and not fully understood, recent evidence suggests that alterations in masticatory function and occlusal patterns may contribute to symptom development and persistence. The aim of this review is to explore the association between BMS and alterations in masticatory and occlusal function and perception. Methods: A scoping review was conducted using PubMed, Cochrane, Web of Science, and Scopus databases. The search covered studies published between January 1988 and February 2026. Inclusion criteria included studies in English addressing the relationship between BMS and masticatory or occlusal function and perception. Search strategy included both primary and review studies, and excluded congress abstracts and proceedings, commentaries, letters, theses/dissertations, editorials, animal and preclinical studies. Results: Thirteen studies met the inclusion criteria and were grouped into three categories: occlusal perception and sensory alterations (n = 4), dysfunctional oral habits (n = 6), and prosthetic factors (n = 3). Findings, presented descriptively, suggest that BMS patients may exhibit altered occlusal and sensory perception, increased sensitivity to mechanical or thermal stimuli, and possible central pain dysregulation. Dysfunctional or parafunctional habits may also be associated with symptom persistence. Additionally, prosthetic factors were reported in some studies to be linked with oral discomfort, with symptom improvement following corrective interventions in selected cases. Conclusions: BMS appears to be a complex and multifactorial condition. Altered sensory perception, parafunctional habits, and prosthetic factors may contribute to symptom expression. However, the available evidence is heterogeneous and limited; therefore, further well-designed longitudinal and interventional studies are needed before definitive conclusions can be drawn. Full article

Transfer RNA-derived fragments (tRFs) have been recently recognized for their multiple roles in gene expression, including modulation of translation, mRNA stability, and cellular signaling pathways. Sensory organs, such as the eyes, skin, and oral cavity, are continuously exposed to environmental stressors, including oxidative stress, ultraviolet radiation, microbial challenges, and mechanical stimuli, making them particularly susceptible to dysregulation of RNA-mediated processes. This review comprehensively summarizes current evidence on the role of tRFs in sensory organ physiology and pathology with a focus on their involvement in key processes, such as angiogenesis, inflammation, immune regulation, and fibrosis. tRFs have been shown to influence critical signaling pathways that are central to diseases such as retinal neovascularization, inflammatory skin conditions, wound healing, tissue remodeling, etc. Despite these advances, the field remains limited by a lack of experimentally validated tRF-target interactions, as most available data rely on computational predictions. The findings from the literature emphasize the need for rigorous functional validation in disease-relevant models of tRFs in biofluids, such as saliva and serum, to support their potential as minimally invasive biomarkers. Further translational studies are required to fully elucidate their biological roles and explore their potential in diagnostic and therapeutic applications. Full article

Nasal hyperreactivity (NHR) is a core symptom of allergic rhinitis (AR) and chronic rhinosinusitis (CRS), frequently induced by cold stimuli. Accumulating evidence indicates that NHR is largely mediated by neuroimmune mechanisms rather than classical allergen-driven inflammation alone. Among the molecular sensors involved, the cold-sensitive transient receptor potential channels transient receptor potential ankyrin 1 (TRPA1) and transient receptor potential melastatin 8 (TRPM8) have emerged as key regulators linking environmental cold exposure to sensory nerve activation, neuropeptide release, and immune modulation. This review systematically summarizes the expression, functions, and neuroimmune mechanisms mediated by TRPA1 and TRPM8 in AR and CRS, with a particular focus on their roles in NHR. Furthermore, it discusses the therapeutic potential of targeting these channels to alleviate neurogenic inflammation and refractory nasal symptoms, aiming to provide new perspectives for understanding disease mechanisms and developing precise treatments. Full article

Breathing-controlled electrical stimulation (BreEStim) is an innovative neuromodulation intervention that synchronizes deep voluntary breathing with peripheral electrical stimulation. Prior studies have shown its analgesic effects in healthy adults and spinal cord injury patients with neuropathic pain. The present study used EEG to examine BreEStim’s neural effects on sensory, affective, and cognitive components of pain. Fourteen healthy participants (7 M, 7 F) completed 30 min of BreEStim and conventional electrical stimulation (EStim) interventions in a randomized, crossover within-subject design. Electrical pain thresholds (EPT) and EEG were recorded pre- and post-intervention. Event-related potentials (ERPs) at pre-EPT-level stimuli before and immediately after each intervention were analyzed for early sensory (P30) and affective (P250) processing, while resting-state EEG assessed spectral power across delta, theta, alpha, and beta bands for cognitive processing. Both BreEStim and EStim increased EPT, indicating short-term habituation. There was no change in early ERP responses (P30) after each intervention, suggesting preserved sensory perception. BreEStim selectively reduced P250, reflective of the affective component of pain. BreEStim significantly increased delta and theta band power and reduced alpha band power on resting-state EEG analyses, whereas no significant changes after EStim were observed. Collectively, BreEStim preserves sensory encoding while selectively modulating affective and cognitive dimensions of pain, supporting its potential as a targeted, non-pharmacological neuromodulation strategy. Full article

This prospective, cross-sectional study evaluated reaction time (RT) variations across different sensory stimuli to investigate the efficacy of haptic feedback (HF) in reducing response latency for telesurgical applications. Three healthy-volunteer age cohorts (18–25, 35–45, and 55–65 years) were tested using visual, auditory, superficial, and deep sensations, alongside a multimodal stimulus combining visual and superficial inputs to simulate HF. The findings revealed that combined visual and superficial stimulation yielded a mean RT of 227 ± 27 ms, outperforming visual-only stimulation by 40 ms (95% CI: 32–48 ms) and superficial-only stimulation by 26 ms (95% CI: 20–33 ms) (p = 0.001). While this performance boost was consistent across all age groups, the 55–65 age cohort demonstrated the most pronounced reduction in RT when the combined stimuli were used. These results suggest that integrating tactile sensations with visual cues significantly mitigates latency compared to unimodal inputs, underscoring the potential of haptic feedback to enhance operator performance and safety in latency-sensitive environments like remote surgery. Full article

In the study of sensory processes, the visual system has received the most research compared to other sensory systems. The primary difference between visual and auditory perception lies in the nature of the stimuli and the reception processes: vision perceives electromagnetic radiation, while auditory perception perceives acoustic signals of mechanical origin. This review aims to analyze modern approaches and controversies to the mechanisms of auditory perception related to psychophysics, psychophysiology, psychopathology, modern research on hearing in human–computer interaction (HCI) systems, and machine learning methods. Modern studies of acoustic patterns include a comprehensive assessment of the physical characteristics of perception, complex nonverbal auditory cues, verbalization, perception and memory, as well as individual differences in auditory perception. An analysis of the scientific literature allowed us to conclude that acoustic signals transformed in the brain into auditory images retain (encode) a number of amplitude-temporal parameters of acoustic signals that facilitate auditory discrimination (filtering), but interfere with auditory detection (recognition). Signal processing often, but not necessarily, involves brain regions involved in other forms of perception. It depends on subvocalization, includes semantically interpreted information and expectations, pictorial (visual) and descriptive components, functions as a mnemonic, and is linked to individual musical ability and experience (although the mechanisms of this connection are unclear). Full article