Search Results (23)

This work describes an innovative three-dimensional model of a proton exchange membrane electrolyzer. For the first time, a multi-phase model has captured segregated channel flow together with multiphase flow in a porous medium, as well as heat transfer and phase change employing an Eulerian multiphase model. The novel electrolyzer design investigated employs a symmetrical, interdigitated flow field to facilitate even water distribution. In the current case, a hot spot is predicted with a temperature increase of 7 °C at a current density of 1.0 A/cm${}^2$. The flow field plates are horizontally oriented, and it is shown that gravity plays an important role in the electrolyzer design and orientation. A parametric study shows, for the first time, the effect of operating a PEM electrolyzer at sub-ambient anode pressure to favorably adjust the concentration ratio between water vapor and oxygen in the anode compartment. This ratio is increased by a factor of 5.6 when the pressure is decreased from one bar to 500 mbar. Full article

How to economically and effectively mobilize remaining oil and achieve carbon sequestration after water flooding in low-permeability, high-water-cut reservoirs is an urgent challenge. This study, focusing on Block Y of the Daqing Oilfield, employs numerical simulation to systematically reveal the synergistic influencing mechanisms of CO₂ flooding and geological storage. A three-dimensional compositional model characterizing this reservoir was constructed, with a focus on analyzing the controlling effects of key geological (depth, heterogeneity, physical properties) and engineering (gas injection rate, gas injection volume, bottom-hole flowing pressure) parameters on the displacement and storage processes. Simulation results indicate that the low-permeability characteristics of Block Y effectively suppress gas channeling, enabling a CO₂ flooding enhanced oil recovery (EOR) increment of 15.65%. Increasing reservoir depth significantly improves both oil recovery and storage efficiency by improving the mobility ratio and enhancing gravity segregation. Parameter optimization is key to achieving synergistic benefits: the optimal gas injection rate is 700–900 m³/d, the economically reasonable gas injection volume is 0.4–0.5 PV, and the optimal bottom-hole flowing pressure is 9–10 MPa. This study confirms that for Block Y and similar high-water-cut, low-permeability reservoirs, CO₂ flooding is a highly promising replacement technology; through optimized design, it can simultaneously achieve significant crude oil production increase and efficient CO₂ storage. Full article

This paper presents the detailed comparisons of solute macro-segregation pictures predicted by different meso-macroscopic simulations, based on the single-domain enthalpy–porosity approach coupled with distinct models of flow resistance in the two-phase zone. In the first, the whole zone is treated as a Darcy’s porous medium (EP model); in the other two, the columnar and equiaxed grain structures are distinguished using either the coherency point (EP-CP model) approach or by tracking a virtual surface of columnar dendrite tips (EP-FT model). The simplified 2D model of a solidifying cast in a centrifuge is proposed, and calculations are performed for the Pb-48wt. % Sn cast at various hypergravity levels and rotation angles. It is shown, in the example of Sn-10wt. % Pb alloy, that the predicted macro-segregation strongly depends on the mesoscopic model used, and the EP-FT simulation (validated with the AFRODITE benchmark) provides the most realistic solute inhomogeneity pictures. The EP-FT model is further used to investigate the impact of the hyper-gravity level and the cooling direction on the compositional nonuniformity developing in centrifuge casting. The hyper-gravity level visibly impacts the macro-segregation extent. The region of almost uniform solute distribution in the slurry zone rises with the increased effective gravity, though the solute channeling is more severe for higher gravity and rotation angles. A-channeling and V-channeling were observed for angles between the gravity vector and cooling direction lower than 120° and higher than 120°, respectively. Full article

Metals with a hexagonal close-packed (HCP) structure such as magnesium, titanium and zirconium constitute key structural materials in the aerospace, automotive, biomedical and nuclear energy industries. Their welding and regeneration by conventional methods is hindered due to the limited number of slip systems, high reactivity and susceptibility to the formation of defects. Laser technologies offer precise energy control, minimization of the heat-affected zone and the possibility of producing joints and coatings of high quality. This article constitutes a comprehensive review of the state of knowledge concerning laser welding, cladding and regeneration of HCP metals. The physical mechanisms of laser beam interactions are discussed including the dynamics of the keyhole channel, Marangoni flows and the formation of gas defects. The characteristics of the microstructure of joints are presented including the formation of α′ martensite in titanium, phase segregation in magnesium and hydride formation in zirconium. Particular attention is devoted to residual stresses, techniques of cladding protective coatings for nuclear energy with Accident Tolerant Fuel (ATF) and advanced numerical modeling using artificial intelligence. The perspectives for the development of technology are indicated including the concept of the digital twin and intelligent real-time process control systems. Full article

Fractured-vuggy carbonate reservoirs primarily have pores and caves as their main storage spaces with poor fracture development, resulting in low reservoir connectivity and strong heterogeneity. During nitrogen injection developments, the fluidity of the medium is poor, and gas tends to form dominant flow channels, leading to a short response time. Consequently, the displacement of crude oil in such reservoirs is limited, leaving a large proportion of residual oil trapped within the pore and vug systems. Based on the Tarim fractured-vuggy carbonate reservoir, a two-dimensional visualized physical model of the fractured-vuggy body was designed and constructed to conduct a foam-assisted gas displacement physical experiment. The research shows that foam has good oil recovery efficiency and dominant channel-blocking ability, which can effectively mobilize the residual oil in the fractures and vugs after gas displacement. In the vertical direction, the foam-assisted gas flooding mechanism primarily involves gravity segregation and interfacial tension reduction between oil and water; horizontally, it operates by selectively blocking large fractures and main channels, redirecting gas into smaller and more tortuous pathways, thus enhancing overall sweep efficiency. Once dominant flow channels develop, injecting salt-sensitive foam at a 2:1 gas–liquid ratio and 0.3 pore volume can raise the recovery factor from around 3% to nearly 19%, representing an improvement of about 16%, thereby boosting both gas flooding performance and overall field development efficiency. Full article

This paper addresses the long-standing question of understanding the origin and evolution of low-frequency unsteadiness interactions associated with shock waves impinging on a turbulent boundary layer in transonic flow (Mach: $1.1$ to $1.3$). To that end, high-speed experiments in a blowdown open-channel wind tunnel have been performed across a convergent–divergent nozzle for different expansion ratios (PR = 1.44, 1.6, and 1.81). Quantitative evaluation of the underlying spectral energy content has been obtained by processing time-resolved pressure transducer data and Schlieren images using the following spectral analysis methods: Fast Fourier Transform (FFT), Continuous Wavelet Transform (CWT), as well as coherence and time-lag evaluations. The images demonstrated the presence of increased normal shock-wave impact for PR = 1.44, whereas the latter were linked with increased oblique $\lambda$-foot impact. Hence, significant disparities associated with the overall stability, location, and amplitude of the shock waves, as well as quantitative assertions related to spectral energy segregation, have been inferred. A subsequent detailed spectral analysis revealed the presence of multiple discrete frequency peaks (magnitude and frequency of the peaks increasing with PR), with the lower peaks linked with large-scale shock-wave interactions and higher peaks associated with shear-layer instabilities and turbulence. Wavelet transform using the Morlet function illustrates the presence of varying intermittency, modulation in the temporal and frequency scales for different spectral events, and a pseudo-periodic spectral energy pulsation alternating between two frequency-specific events. Spectral analysis of the pixel densities related to different regions, called spatial FFT, highlights the increased influence of the feedback mechanism and coupled turbulence interactions for higher PR. Collation of the subsequent coherence analysis with the previous results underscores that lower PR is linked with shock-separation dynamics being tightly coupled, whereas at higher PR values, global instabilities, vortex shedding, and high-frequency shear-layer effects govern the overall interactions, redistributing the spectral energy across a wider spectral range. Complementing these experiments, time-resolved numerical simulations based on a transient 3D RANS framework were performed. The simulations successfully reproduced the main features of the shock motion, including the downstream migration of the mean position, the reduction in oscillation amplitude with increasing PR, and the division of the spectra into distinct frequency regions. This confirms that the adopted 3D RANS approach provides a suitable predictive framework for capturing the essential unsteady dynamics of shock–boundary layer interactions across both temporal and spatial scales. This novel combination of synchronized Schlieren imaging with pressure transducer data, followed by application of advanced spectral analysis techniques, FFT, CWT, spatial FFT, coherence analysis, and numerical evaluations, linked image-derived propagation and coherence results directly to wall pressure dynamics, providing critical insights into how PR variation governs the spectral energy content and shock-wave oscillation behavior for nozzles. Thus, for low PR flows dominated by normal shock structure, global instability of the separation zone governs the overall oscillations, whereas higher PR, linked with dominant $\lambda$-foot structure, demonstrates increased feedback from the shear-layer oscillations, separation region breathing, as well as global instabilities. It is envisaged that epistemic understanding related to the spectral dynamics of low-frequency oscillations at different PR values derived from this study could be useful for future nozzle design modifications aimed at achieving optimal nozzle performance. The study could further assist the implementation of appropriate flow control strategies to alleviate these instabilities and improve thrust performance. Full article

The Discrete Element Method (DEM) has become a cornerstone for analysing granular flow and mixing phenomena in static mixers. This review provides a comprehensive synthesis that distinguishes it from previous studies by: (i) covering a broad range of static mixer geometries, including Kenics, SMX, and Sulzer designs; (ii) integrating experimental validation methods, such as particle tracking, high-speed imaging, Particle Image Velocimetry (PIV), and X-ray tomography, to assess DEM predictions; and (iii) systematically analyzing computational strategies, including advanced contact models, hybrid DEM-CFD/FEM frameworks, machine learning surrogates, and GPU-accelerated simulations. Recent advances in contact mechanics—such as improved cohesion, rolling resistance, and nonspherical particle modelling—have enhanced simulation realism, while adaptive time-stepping and coarse-graining improve computational efficiency. DEM studies have revealed several non-obvious relationships between mixer geometry and particle dynamics. Variations in blade pitch, helix angle, and element arrangement significantly affect local velocity fields, mixing uniformity, and energy dissipation. Alternating left–right element orientations promote cross-sectional particle exchange and reduce stagnant regions, whereas higher pitch angles enhance axial transport but can weaken radial mixing. Particle–wall friction and surface roughness strongly govern shear layer formation and segregation intensity, demonstrating the need for geometry-specific optimization. Comparative analyses elucidate how particle–wall interactions and channel structure influence segregation, residence time, and energy dissipation. The review also identifies current limitations, highlights validation and scale-up challenges, and outlines key directions for developing faster, more physically grounded DEM models, providing practical guidance for industrial mixer design and optimization. Full article

Background/Objectives: Long QT Syndrome type 2 (LQT2) is a cardiac channelopathy linked to pathogenic variants in the KCNH2 gene, which encodes the Kv11.1 potassium channel, essential for cardiac repolarization. Variants affecting splice sites disrupt potassium ion flow, prolong QT interval, and increase the risk of arrhythmias and sudden cardiac death (SCD). Understanding genotype–phenotype correlations is key, given the variability of clinical manifestations even within families sharing the same variant. We aimed to evaluate new pathogenic variants by analyzing genotype–phenotype correlations in informative families. Methods: Genetic and clinical assessments were performed on index cases and family members carrying KCNH2 pathogenic variants, referred for genetic testing between 2010 and June 2023. The next-generation sequencing (NGS) of 210 cardiovascular-related genes was conducted. Clinical data, including demographic details, family history, arrhythmic events, electrocardiographic parameters, and treatments, were collected. Results: Among 390 patients (152 probands) tested for LQTS, only 2 KCNH2 variants had over 5 carriers. The detailed clinical information of 22 carriers of this KCNH2 p.Ser261fs. has already been reported by our research group. Moreover, we identified 12 carriers of the KCNH2 c.77-2del variant, predicted to disrupt a splice site and not previously reported. Segregation analysis showed its high penetrance, supporting its classification as pathogenic. Conclusions: The newly identified KCNH2 c.77-2del variant is a pathogenic, as strongly supported by the segregation analysis. Our findings underscore the importance of further research into splice site variants to enhance clinical management and genetic counseling for affected families. Full article

Accurate separation in microfluidic devices is crucial for biomedical applications; however, enhancing their performance remains challenging due to computational and experimental constraints. This study aims to optimize microfluidic devices by systematically refining spiral microchannel configurations for the segregation of circulating tumor cells (CTCs) and red blood cells (RBCs) through detailed variable analysis and resource-efficient techniques. The spiral design was developed into six variations, considering loop numbers (2, 3, and 4), aspect ratios (2.333, 3.333, and 5), spiral radii (5, 6, and 7 mm), flow rates (1.5, 2, and 3 mL/min), surface roughness levels (0, 0.5, and 1 μm), and particle sizes (12, 18, and 24 μm). Simulations were conducted in COMSOL Multiphysics and evaluated using the Taguchi method to determine the optimal configuration, reducing the analysis set from 216 to 27 through an efficient experimental design approach. The results identified the optimal structure as having an aspect ratio of 3.333, four loops, a spiral radius of 6–7 mm, a flow rate of 3 mL/min, a surface roughness of 1 μm, and a particle diameter of 24 μm. Among the evaluated parameters, aspect ratio (61.2%) had the most significant impact, followed by the number of loops (13.9%) and flow rate (9.4%). The optimized design demonstrated high separation efficiency and purity, achieving 97.5% and 97.6%, respectively. The fabrication process involved 3D-printing the channel mold, followed by polydimethylsiloxane (PDMS) casting, validating the durability and scalability of the proposed design. This study integrates simulation and experimental results, providing a robust framework for developing next-generation microfluidic devices and advancing diagnostic and targeted therapeutic applications. Full article

The effect of mixing on coupled heat release and transfer performance of a novel segregated solid motor is numerically evaluated with a transient two-dimensional combustion model. The results show that vortex structures are formed and evolved in the combustion chamber. Quantitative calculation of the mixing effect shows the inhomogeneous distribution of oxidant and fuel species. The well-mixing area is located in a narrow belt-like coupled combustion region near the burning surface of the propellant. Heat transfer coefficient decreases greatly due to lower combustion reaction rate and enlarged flow channel area. Heat transfer coefficients near the two ends of the propellant grain are higher than other parts due to the influence of vortex mixing. Raising the inlet mass flow rate leads to enhanced mixing and heat transfer, which results in a lower temperature and regression rate of the propellant with combustion time. Temperature and oxidation rates of H₂ and CO are unevenly distributed in the boundary layer of coupled combustion. Increasing the mass flux of inlet oxidizer gas leads to a higher combustion heat release rate. Therefore, the gas-phase temperature increases significantly. The heat release rate reaches the maximum near the ends of the propellant grain, where vortex mixing strengthens the coupled combustion process in the motor. Full article

Sinter sensible heat recovery via a vertical cooling furnace is a new type of waste heat recovery process proposed based on coke dry quenching. However, the segregation of the burden in a vertical cooling furnace is serious, resulting in a large amount of cooling gas escaping from the short-circuit channel of the vertical cooling furnace, which seriously affects the uniform gas–solid heat transfer in the furnace. To improve the burden distribution and gas flow in such a furnace, this paper proposes a Venturi-type vertical cooling furnace. Based on the single silo of a vertical cooling furnace in Meishan Steel, a slot model was established, and the improvement effect of the Venturi furnace structure on the burden distribution and gas flow was studied using the DEM–CFD coupling method. The results show that compared with the existing furnace type, the inclined wall of the Venturi furnace changed the direction of the high D_nv (average diameter) channel from vertical to inclined-vertical and reduced the D_nv from >0.033 m to 0.028~0.03 m in the vertical part of the variable-diameter section, thus reducing the influence area of the high D_nv channel. The minimum and average values of the voidage in the contraction part of the variable-diameter section increased from 0.28 and 0.315 to 0.31 and 0.33, respectively, which caused the voidage distribution to change from U-shaped to W-shaped along the longitudinal direction while simultaneously reducing the longitudinal fluctuation range of the voidage from 0.28~0.39 to 0.298~0.37. The gas flow direction changed from vertical-upward to vertical-inclined-upward, which increased the gas–solid contact. The gas velocity increased significantly. In the vertical section, the average gas velocity was 2.34 m/s, which was 30.73% higher than the velocity of 1.79 m/s of the existing furnace type. In the variable-diameter section, the average gas velocity was 3.52 m/s, which was 72.55% higher than the velocity of 2.04 m/s of the existing furnace type. The high-speed gas channel basically only existed in the sidewall area and the center area of the vertical section, and the length was reduced from 3.11 m to 2.52 m, which reduced the influence area. In the variable-diameter section, the high-speed gas channel disappeared, and the uniformity of the gas velocity distribution was greatly improved. The gas pressure drop increased from 4140 Pa to 6410 Pa, with an increase of 54.83%. Therefore, when designing the Venturi furnace type, it was necessary to take into consideration the improvement in the gas velocity distribution and the increase in the pressure drop. The research results of this paper can provide guidance for the structure optimization of the sinter vertical cooling furnace. Full article

Tidal current asymmetry (TCA) often occurs in coastal regions. It can significantly influence bedload sediment transport. Recently, the statistical skewness of the tidal current velocity was calculated to represent the TCA. In archipelagic region, the tidal current directions vary temporally and spatially from channel to channel. This creates complexity in finding the flood–ebb axis about which to discuss the axial dissymmetry of tidal currents. In the present work, a method that involves taking the main flood direction (MFD) as the axis to split the tidal current was suggested. The MFD is the most probable direction of the strongest flood flow during each tidal cycle. The method was applied in an archipelagic region: The Zhoushan Islands. The results show that the calculated skewness well represented the TCA in waters around islands, and the degree of the TCA was mainly determined by the residual current. When the direction of the residual current was the same as the MFD, the skewness was positive, which indicated flood dominance. On the contrary, when the direction of the residual current was opposite to the MFD, the skewness was negative, which indicated ebb dominance. The stronger a residual current is, the more significant the TCA will be. Islands play an important role in forming residual circulations. Large ones force flows to move offshore around headlands or along curved channels, because of centrifugal forcing, while small ones often cause segregated flood/ebb conduits and form residual circulations. In the waterways between the Zhoushan Islands, the ebb current generally carries more sediment than the flood current. Therefore, ebb dominance always means sediment is more likely to be deposited, and vice versa. Further research into sediment transport modeling is suggested. Full article

Segregation defects greatly affect the service performance and working life of castings during the vacuum arc remelting (VAR) process. However, the corresponding research on the prediction of segregation defects is still not comprehensive. Through considering the influence of water-cooled crucible on the electromagnetic field inside an ingot, a full-scale model for the comprehensive prediction of freckles and macrosegregation defects during the VAR process is developed in this paper. The macroscopic solute transport phenomenon and the segregation behavior of Ni-5.8 wt% Al-15.2 wt% Ta alloy are predicted. The results indicate that the freckles are mainly concentrated in the lower region of the ingot. With the growth of the ingot, the solute enrichment channels gradually develop into solute enrichment regions, and the channel segregation evolves into macrosegregation. The Lorentz force mainly affects the flow pattern at the top of the molten pool, while the complex flow of multiple vortices is dominated by thermosolutal buoyancy. The maximum and minimum relative segregation ratio inside the ingot can reach 290% and −90%, respectively, and the positive segregation region accounts for about 79% of the total volume. This paper provides a new perspective for understanding the segregation behavior inside the ingot by studying the segregation evolution during the VAR process. Full article

In the blood flow through microvessels, platelets show high concentrations near the vessel wall. This phenomenon is called margination of platelets and is closely associated with hemostasis and thrombosis. In the present study, we conducted in vitro experiments using platelet-sized fluorescent particles as platelet substitutes to investigate the cross-sectional distribution of these particles in the red blood cell suspension flowing through microchannels with a square cross section. Fluorescence observations were performed to measure the transverse distribution of particles at various heights from the bottom face with the use of a confocal laser scanning microscope system. In downstream cross sections of the channel, particles showed focusing near the four corners rather than uniform margination along the entire circumference of the cross section. The focusing of particles near the corners was more enhanced for higher hematocrits. On the other hand, particles in circular channel flows showed nearly axisymmetric uniform accumulation adjacent to the channel wall. The present result suggests that the segregation of suspended particles in the flow of multicomponent suspensions could have such heterogeneous 2D features of particle distribution in the cross section of channels, especially for rectangular channels often used in microfluidics. Full article

Channel segregation (CS) is the most typical defect during solidification of NbTi alloy. Based on numerical simulation and experimental characterizations, we deeply elucidated its characteristics, formation mechanism, effecting factor and prediction criterion. According to acid etching, industrial X-ray transmission imaging, 3D X-ray microtomography and chemical analysis, it was found that in a casing ingot, by He cooling, finer grain size, weaker segregation and slighter CS can be obtained compared with air-cooled ingot. The simulation results of macrosegregation show that CS is caused by the strong natural convection in the mushy zone triggered by the thermo-solutal gradient. Its formation can be divided into two stages including channel initiation and growth. In addition, due to the stronger cooling effect of the He treatment, the interdendritic flow velocity becomes smaller, consequently lowering the positive segregation and CS and improving the global homogenization of the final ingot. Finally, to predict the formation of CS, the Rayleigh number model was proposed and its critical value was found to be 15 in NbTi alloy for the first time. When it is lower than the threshold, CS disappears. It provides an effective tool to evaluate and optimize the solidification parameters to fabricate the homogenized NbTi ingot in engineering practice. Full article