Search Results (90)

This work presents a numerical investigation of Richtmyer–Meshkov instability (RMI) in shock-driven single-mode stratified heavy fluid layers, with emphasis on the influence of the Atwood number. High-order modal discontinuous Galerkin simulations are carried out for Atwood numbers ranging from $A=0.30$ to $0.72$, allowing a systematic study of interface evolution, vorticity dynamics, and mixing. The analysis considers diagnostic quantities such as interface trajectories, normalized interface length and amplitude, vorticity extrema, circulation, enstrophy, and kinetic energy. The results demonstrate that the Atwood number plays a central role in instability development. At low A, interface deformation remains smooth and coherent, with weaker vorticity deposition and delayed nonlinear roll-up. As A increases, baroclinic torque intensifies, leading to rapid perturbation growth, stronger vortex roll-ups, and earlier onset of secondary instabilities such as Kelvin–Helmholtz vortices. Enstrophy, circulation, and interface measures show systematic amplification with increasing density contrast, while the total kinetic energy exhibits relatively weak sensitivity to A. Overall, the study highlights how the Atwood number governs the transition from linear to nonlinear dynamics, controlling both large-scale interface morphology and the formation of small-scale vortical structures. These findings provide physical insight into shock–interface interactions and contribute to predictive modeling of instability-driven mixing in multicomponent flows. Full article

In order to solve the problem of low thermal efficiency of a 130 t/h industrial circulating fluidized bed boiler, a computational particle fluid dynamic approach was used in this work to study two-phase gas–solid flow, heat transfer, and combustion. The factors influencing coal particle size distributions, air distribution strategies, and operational loads are addressed. The results showed that particle distribution exhibits “core–annulus” flow with a dense-phase bottom region and dilute-phase upper zone. A higher primary air ratio (0.8–1.5) enhances axial gas velocity and bed temperature but reduces secondary air zone (2.5–5.8 m) temperature. A higher primary air ratio also decreases outlet O₂ mole fraction and increases fly ash carbon content, with optimal thermal efficiency at a ratio of 1.0. In addition, as the coal PSD decreases and the load increases, the overall temperature of the furnace increases and the outlet O₂ mole fraction decreases. Full article

Scramjet operation requires a comprehensive understanding of the internal flowfield, encompassing fuel–air mixing and combustion. This study investigates transient flow and flame development within a HIFiRE-2 scramjet engine combustor, which features two opposing cavities and dual sets of fuel injectors—the upstream (primary) and downstream (secondary) injectors. These cavities function as flameholders, creating circulating flows with elevated temperatures and pressures. Shock waves form both ahead of fuel plumes and at the diverging and converging sections of the flowpath. Special attention is given to the interactions among these shock waves and the shear layers along the supersonic core flow as the system progresses towards a quasi-steady state. Driven by increased backpressure, bow shocks and disturbances induced by the normal, secondary fuel injection and the inclined, primary fuel injection move upstream, amplifying the cavity pressure. These shocks generate adverse pressure gradients, causing near-wall flow separation adjacent to both injector sets, which enhances the penetration and dispersion of fuel plumes. Once a quasi-steady state is achieved, a feedback loop is established between dynamic wave motions and combustion processes, resulting in sustained entrainment of reactive mixtures into the cavities. This mechanism facilitates stable combustion in the cavities and near-wall separation zones. Full article

Background and Clinical Significance: Fulminant pulmonary embolism (PE) leading to an out-of-hospital cardiac arrest (OHCA) is associated with a high mortality rate and cardiopulmonary resuscitation (CPR) frequently failing to achieve return of spontaneous circulation (ROSC). Extracorporeal CPR (eCPR) has emerged as a potential life-saving intervention. Case Presentation: A 66-year-old woman suffered an OHCA due to massive PE, presenting with pulseless electrical activity (PEA). After 90 min of pre- and in-hospital CPR without sustained ROSC, venoarterial extracorporeal membrane oxygenation (va-ECMO) was initiated as eCPR upon arrival at the hospital. Even after implantation of the va-ECMO, there was initially a pronounced acidosis (pH 6.9) with a high elevated lactate level (>30 mmol/L); these factors, together with the prolonged low-flow period, indicated a poor prognosis. Further diagnostic tests revealed intracranial hemorrhage (subdural hematoma), and systemic lysis was not possible. With persistent right heart failure, surgical thrombectomy was performed during hospitalization. Intensive multidisciplinary management finally led to successful therapy and weaning from mechanical ventilation, as well as to complete neurological recovery (CPC-Score 1-2). Conclusions: This case illustrates that eCPR can facilitate survival with good favorable neurological outcomes despite initially poor prognostic predictors. It underscores the importance of refining patient selection criteria and optimizing management strategies for eCPR in refractory cardiac arrest secondary to PE. Full article

Under the dual imperatives of air pollution control and energy conservation, this study proposes an enhanced optimization framework for combined heat and power (CHP) district heating systems based on bypass thermal storage (BTS). In contrast to conventional centralized tank-based approaches, this method leverages the dynamic hydraulic characteristics of secondary network bypass pipelines to achieve direct sensible heat storage in circulating water, significantly improving system flexibility and energy efficiency. The core innovation lies in addressing the critical yet under-explored issue of control valve dynamic response, which profoundly impacts system operational stability and economic performance. A quality regulation strategy is systematically implemented to stabilize circulation flow rates through temperature modulation by establishing a supply–demand equilibrium model under bypass conditions. To overcome the limitations of traditional feedback control in handling hydraulic transients and heat transfer dynamics in the plate heat exchanger, a Model Predictive Control (MPC) framework is developed, integrating a data-driven valve impedance-opening degree correlation model. This model is rigorously validated against four flow characteristics (linear, equal percentage, quick-opening, and parabolic) and critical impedance parameters (maximum/minimum controllable impedance). This study provides theoretical foundations and technical guidance for optimizing secondary network heating systems, enhancing overall system performance and stability, and promoting energy-efficient development in the heating sector. Full article

Fontan circulation is a fragile system in which imperfections at any of multiple levels may compromise the quality of life, produce secondary pathophysiology, and shorten life span. Increased inferior vena caval pressure itself may play a role in “Fontan failure”. This study describes a mock flow loop model (MFL) designed to quantitatively estimate pulmonary flow entrainment induced by continuous and pulsed flow injections. A patient generic 3D-printed phantom model of the total cavopulmonary connection (TCPC) with average dimensions matching those of a 2–4-year-old patient was inserted in an MFL derived from a reduced lumped parameter model (LPM) representing cardiovascular circulation. The LPM comprises four 2-element Windkessel compartments (compliance and resistance), approximating the upper and lower systemic circulations and the right and left pulmonary circulations. The prescribed cardiac output is about 2.3 L/min for a body surface area of $0.675{ \mathrm{m}}^2$. The injections originate from an external pump through a 7–9 fr catheter, following a strict protocol suggested by the clinical team, featuring a variation in injection rate (flow rate), injection volume, and injection modality (continuous or pulsed). The key measurements in this study are the flow rates sampled at the distal pulmonary arteries, as well as at the upper and lower body boundaries. These measurements were then used to calculate effective entrainment as the difference between the measured and expected flow rates, as well as jet relaxation (rise and fall time of injection). The results show that for continuous or pulsed injections, varying the total volume injected has no significant influence on the entrainment rate across all injection rates. On the other hand, for both injection modalities, increasing the injection rate results in a reduction in entrainment that is consistent across all injected volumes. This study demonstrates the effectiveness of a high-speed injection jet entraining a slow co-flow while determining the potential for fluid buildup, which could ultimately cause an increase in caval pressure. To avoid the increase in caval pressure due to mass accumulation, we added a fenestration to our proposed injection jet shunt-assisted Fontan models. It was found that for a set of well-defined parameters, the jet not only can be beneficial to the local flow, but any adverse effect can be obviated by careful tuning. These results were also cross-validated with similar in silico findings. Full article

Background. Statins appear to be useful in patients with acute ischemic stroke. Our aim was to evaluate the association between premorbid statin treatment and CT perfusion characteristics of acute ischemic stroke. Methods. A retrospective analysis of patients with acute stroke secondary to occlusion of large vessels in the anterior circulation was performed to assess collateral flow, ischemic core volume, and ischemic penumbra using CT angiography and CT perfusion maps. Fisher’s exact test was used to compare baseline characteristics of patients in the two groups. The Wilcoxon rank-sum test for independent groups was used to compare all variables obtained for the two different groups with and without statin use. Results. We identified 61 patients, including 29 treated with statins and 32 not treated with statins before stroke onset matched by age, gender, and vascular risk factors except for hypercholesterolemia. The statin group showed lower National Institutes of health Stroke Scale scores at onset (14 ± 6.1 vs. 16 ± 4.5; p = 0.04) and lower volumes of brain tissue characterized by impaired cerebral blood flow (CBF), cerebral blood volume (CBV), and ${\mathrm{T}}_{\mathrm{m}\mathrm{a}\mathrm{x}}^{9.5-25\mathrm{s}}$; otherwise, no statistically significant difference was found in the volume of the ${\mathrm{T}}_{\mathrm{m}\mathrm{a}\mathrm{x}}^{16-25\mathrm{s}}$ between the two groups. Conclusions. Premorbid statin treatment is associated with a favorable imaging condition of acute ischemic stroke in terms of ischemic core and ischemic penumbra volume. Full article

The seawater circulation pump represents the pump product with the largest flow rate within nuclear power plants. Its energy consumption accounts for a substantial portion of the energy consumed by nuclear power plants. To investigate the internal flow characteristics of the seawater circulation pump and optimize the performance while reducing energy consumption, taking the seawater circulation pump as the research object, the entropy production of each flow passage component of the pump under different flow conditions are analyzed by employing numerical simulation based on the entropy production theory. Additionally, the entropy production mechanisms of the impeller and volute are specifically analyzed. The results demonstrate that under different flow conditions, the impeller and volute are the main flow components contributing to entropy production losses for the entire pump. The leading and trailing edges of the blade and the shroud are the main locations where entropy production occurs in the impeller. Excessive attack angle and circulation are the main factors leading to entropy production. The throat area of the volute is the main entropy production area of the volute, and the secondary flow and vortex caused by flow separation are the main causes of entropy production. Full article

Theoretical analysis, numerical simulation, and experimental study are used to investigate the ultra-low head bidirectional shaft extension pump, especially near-zero head conditions. The results show that under forward operation, at low flow and design flow conditions, the closer to the shroud, the closer the vortex is to the back of the guide vanes, and the vortex area is becoming smaller. The hydraulic loss of the outlet passage is 15% of the operating head at the minimum flow and 170% of the operating head under near-zero head condition. The peak-to-peak (PTP) value of pressure fluctuation increases with the increase in flow rate. The primary frequency (PF) of vibration is strongly related to the primary and secondary frequencies (PSFs) of pressure fluctuation. Under reverse operation, when the flow rate is less than 0.83Q_r0, the uniformity of axial velocity distribution V_u and the velocity-weighted average angle θ show an approximately exponential declining pattern. The hydraulic loss of the outlet passage at the minimum flow rate is 61% of the operating head and 350% of the operating head under near-zero head condition. The exponential fitting can better describe the relationship between circulation and hydraulic loss. As the flow rate decreases, the PF of vibration decreases to rotational frequency. Full article

Early neurological deterioration is associated with poor functional outcomes in stroke patients, but the underlying mechanisms remain unclear. This study aims to understand the progression of stroke-related brain damage using a rhesus monkey model with ischemic occlusion. Multiparameter MRI was used to monitor the progressive evolution of the brain lesion following stroke. Resting-state functional MRI, dynamic susceptibility contrast perfusion MRI, diffusion tensor imaging, and T1- and T2-weighted scans were acquired prior to surgery and at 4–6 h, 48 h, and 96 h following the stroke. The results revealed a sudden increase in infarction volume after the hyper-acute phase but before 48 h on diffusion-weighted imaging (DWI), with a slight extension by 96 h. Lower relative cerebral blood flow (CBF) and time to maximum (Tmax) prior to the stroke, along with a progressive decrease post-stroke, were observed when compared to other stroke monkeys in the same cohort. Functional connectivity (FC) in the ipsilesional secondary somatosensory cortex (S2) and primary motor cortex (M1) exhibited an immediate decline on Day 0 compared to baseline and followed by a slight increase on Day 2 and a further decrease on Day 4. These findings provide valuable insights into infarction progression, emphasizing the critical role of collateral circulation and its impact on early neurological deterioration during acute stroke. Full article

During slurry shield tunneling in hard rock or cobble strata, the discharge pipes suffer serve wear and damage. However, the effect mechanism of pipe wall wear defects on the flow characteristics of two-phase flow is unclear. In this study, a three-dimensional slurry particle model of pipeline transport was established using the coupled computational fluid dynamics–discrete element method (CFD-DEM) considering the pipe wall wear defect, and the typical pipeline forms of straight pipe and 90° elbow pipe were selected as the research targets. The results indicated that the localized wear defect of pipes can lead to increased inhomogeneity in the velocity distribution, generating localized low-flow zones and resulting in a reduced flow rate or stagnancy in parts of the pipe. Meanwhile, the wear defect of the pipe results in local shape changes, so that the fluid flow path through the pipe is no longer smooth, causing more vortex/turbulence and secondary flow, where an increased vortex promotes localized kinetic energy reduction and creates larger pressure losses at the elbow. In addition, for the elbow pipe without wear defect, the pressure drop of the elbow increases quadratically from an increase of 6.5% to an increase of 16.9%, with the maximum wear depth increasing from 4 mm to 19 mm. For the straight pipe without wear defect, the pressure drop of the elbow increases linearly, from an increase of 2.2% to an increase of 10.2% with the maximum wear depth increasing from 4 mm to 19 mm. The paper investigates the potential mechanism of pipe flow characteristics influenced by wear defect and provides practical guidelines for the efficient operation of a slurry shield circulating system. Full article

In a recent clinical trial, beetroot juice supplementation for 14 days yielded positive effects on systemic inflammation in adults with long COVID. Here, we explored the relationship between circulating markers of mitochondrial quality and inflammation in adults with long COVID as well as the impact of beetroot administration on those markers. We conducted secondary analyses of a placebo-controlled randomized clinical trial testing beetroot juice supplementation as a remedy against long COVID. Analyses were conducted in 25 participants, 10 assigned to placebo (mean age: 40.2 ± 11.5 years, 60% women) and 15 allocated to beetroot juice (mean age: 38.3 ± 7.7 years, 53.3% women). Extracellular vesicles were purified from serum by ultracentrifugation and assayed for components of the electron transport chain and mitochondrial DNA (mtDNA) by Western blot and droplet digital polymerase chain reaction (ddPCR), respectively. Inflammatory markers and circulating cell-free mtDNA were quantified in serum through a multiplex immunoassay and ddPCR, respectively. Beetroot juice administration for 14 days decreased serum levels of interleukin (IL)-1β, IL-8, and tumor necrosis factor alpha, with no effects on circulating markers of mitochondrial quality control. Significant negative associations were observed between vesicular markers of mitochondrial quality control and the performance on the 6 min walk test and flow-mediated dilation irrespective of group allocation. These findings suggest that an amelioration of mitochondrial quality, possibly mediated by mitochondria-derived vesicle recycling, may be among the mechanisms supporting improvements in physical performance and endothelial function during the resolution of long COVID. Full article

The aging process of bourbon within rickhouses is influenced by various environmental factors, including temperature, humidity, air flow, and air quality. Most rickhouses are not climate-controlled, and natural ventilation is a major contributor to airflow. The corrosion of the steel hoops on bourbon barrels occurs due to the presence of ethyl alcohol vapors and has become an issue for the distilling industry. The loss of a barrel or product is the loss of all of the energy and materials that went into the distillation, as well as the removal of the barrel from the secondary market. Despite the large economic and sustainability impact of barrel losses, there is limited published research with respect to corrective actions. This paper investigates airflow patterns within a bourbon rickhouse using a combination of differential pressure surveys and smoke tracing techniques to understand how natural ventilation impacts the aging process and potential for corrosion. A newly constructed rickhouse was surveyed using a micro-manometer to measure differential pressure and a sheet laser with smoke to visualize airflow. This study revealed significant zones of stagnant air and minimal recirculation within the ricks, which are the structures that hold the bourbon barrels. Airflow was found to primarily enter through windows and ground vents, moving along the walkways before exiting through other openings, with minimal penetration into the ricks. Differential pressure measurements generally indicated a lack of significant airflow, while smoke tracing showed that air entering the side of the building does not circulate into the ricks. This lack of airflow promotes the separation of ethyl alcohol vapor due to density, leading to its accumulation on the floor of the ricks. The findings of this study highlight the need to consider how rickhouse design impacts airflow and the potential for the corrosion of metal hoops on barrels due to the presence of ethyl alcohol vapor, and provide insight into optimizing the ventilation of rickhouses for more efficient and sustainable bourbon maturation. Full article

Importance: Although prolonged fasting has become increasingly popular, the favourable biological adaptations and possible adverse effects in humans have yet to be fully elucidated. Objective: To investigate the effects of a three-day water-only fasting, with or without exercise-induced glycogen depletion, on autophagy activation and the molecular pathways involved in cellular damage accumulation and repair in healthy humans. Design: A randomised, single-centre, two-period, two-sequence crossover trial. The primary outcome is autophagic activity, assessed as flux in peripheral blood mononuclear cells (PBMCs) measured in the context of whole blood. Secondary outcomes include changes in body composition, heart rate variability, endothelial function, and genomic, epigenomic, metabolomic, proteomic, and metagenomic adaptations to fasting in plasma, platelets, urine, stools, and PBMCs. Detailed profiling of circulating immune cell populations and their functional states will be assessed by flow cytometry. Setting: All clinical investigations will be undertaken at the Charles Perkins Centre Royal Prince Alfred Hospital clinic, University of Sydney, Australia. Participants: Twenty-four individuals aged 18 to 70 years, with a BMI of 20–40 kg/m², free of major health conditions other than obesity. Discussion: While autophagic flux induction through fasting has garnered interest, there is a notable lack of human studies on this topic. This trial aims to provide the most detailed and integrated analysis of how three days of prolonged water-only fasting, combined with glycogen-depleting exercise, affects autophagy activation and other crucial metabolic and molecular pathways linked to cellular, metabolic, and immune health. Insights from this study may pave the way for safe and effective strategies to induce autophagy, offering potential preventive interventions for a range of chronic conditions. Full article

The burning chamber wall of the ramjet engine is facing an extremely thermal environment during normal conditions. Thermal protection measures must be taken on the wall surface of the combustion chamber. At the same time, the aircraft faces high-power electrical demand problems under high-speed cruising states. To address these issues, a second fluid-closed Brayton cycle system was introduced in this paper. Helium was utilized as the secondary fluid medium, while kerosene was used as the final heat sink. The ramjet engine chamber wall was cooled by the helium cycle system. At the same time, part of the heat absorbed by the helium cycle was transformed into electric power by a generator. This work proposes a new method of thermal management in a closed cycle. Unlike traditional methods, this proposal can regulate the mass flow rate of helium based on the requirement of heat load. A zero-dimensional numerical calculation method was established for thermodynamic analysis. The results show that as the equivalence ratio of 0.8~1.5 for the kerosene flow rate, the system can suffer the thermal load of 200~350 kJ/kg on the combustion chamber wall at the maximum kerosene allowable temperature. To ensure the normal operation of the circulating system, the mass flow ratio between the helium and the air changes from 0.02 to 0.045. Compared with the direct kerosene cooling method, the second fluid circulation method leads to the kerosene equivalent saving ratio by 2% to 14%; at the same time, such a system could generate 160~500 kJ/kg of electrical energy. This new thermal management method can achieve kerosene saving, electric power generating and suffering more thermal loads under the premise of satisfying normal work. Full article