Search Results (365)

Thoracoabdominal aortic aneurysms (TAAAs) are uncommon and usually silent until rupture, causing a substantial burden to the health care system. Aneurysm growth and rupture prediction is mainly based on aneurysm diameter measurement by imaging modalities, meaning that the biology of aneurysm growth is not part of a potentially more adequate surveillance of aortic aneurysm patients. Alternatives or complementary options for aortic aneurysm surveillance are an ongoing, non-addressed open issue of vascular medicine. The application of different biomarkers has been discussed, yet so far, an adequate candidate for aortic aneurysm surveillance, if it comes to the thoracic or thoracoabdominal aorta, preferably without radiation exposure, has not been named. Elastin breakdown, as a component of aortic wall degeneration primarily driven by matrix metalloproteinases (MMPs), is a core element of aneurysm development. Desmosine is an elastin-specific cross-link increasingly studied as a circulating or urinary biomarker of compromised aortic wall integrity and disease activity. Accordingly, this review investigated whether plasma desmosine (pDES), a highly specific marker of elastin degradation, could be used as a non-invasive biomarker for detecting aortic aneurysms and assessing their risk profile. The existing literature of desmosine in fields of aortic pathologies in the acute and chronic setting will be assessed based on the current literature; furthermore, future perspectives of desmosine as a biomarker of aortic pathologies, such as aortic aneurysm dynamics, will be discussed. Full article

Wetting–air-drying cycling significantly alters the internal damage evolution and failure behavior of sandstone, and identifying reliable acoustic-emission (AE) precursors during loading is important for understanding the rupture mechanism of water-affected rock. In this study, uniaxial compression tests with AE monitoring were conducted on green sandstone subjected to different numbers of wetting–air-drying cycles. Ringing counts, RA–AF parameters, b-value evolution, AE spatial localization, and the correlation dimension D₂ were jointly used to characterize mechanical deterioration, failure-mode transition, and fractal dynamic evolution. The results show that increasing cycling causes a progressive decrease in peak stress and elastic modulus, while AE activity evolves from a relatively dispersed state to stronger pre-peak concentration. The RA–AF distributions indicate that the dominant AE population gradually shifts from tensile-feature dominance toward mixed/shear-involved behavior, suggesting increasing shear participation during failure. The b-value captures stage-dependent damage evolution but exhibits relatively strong fluctuations under increasingly nonstationary event distributions. In contrast, D₂ shows a clearer pre-peak turning feature, and the corresponding stress level remains relatively consistent among different cycling groups. These results indicate that wetting–air-drying cycling not only accelerates the mechanical degradation of green sandstone, but also substantially modifies its rupture dynamics. The D₂ feature may therefore serve as a potential precursor parameter for characterizing pre-peak complexity transition in water-affected sandstone. Full article

Rock bursts frequently occur in the fault group area in China, seriously restricting the safe and efficient production of coal mines. Based on field investigation, physical experiments, and numerical simulation, this study investigates the rupture types and spatial evolution of microseismic events during the excavation of working face through fault group areas in the TB Coal Mine, where the hard roof asymmetric is cut by faults. It reveals the cooperative instability mechanism of faults and hard roof, as well as the mechanisms of rock burst. Targeted rock burst prevention measures are proposed, including “roof blasting to cut off dynamic and static load transfer” and “coal blasting to reduce abutment stress”. The results demonstrate the following: (1) during mining in fault group areas, the synchronous activation of faults induces shear-type and high-energy microseismic events and the subsequent movement of hard roof, which has been cut by faults, forms asymmetric parallelograms and symmetric inverted trapezoids, and induces tensile-type and high-energy microseismic events. The synchronous activation of faults and the breaking of the hard roof are identified as the primary reason for high-energy microseismic events. (2) As the fault dip angle approaches 90º, the compressive strength of the fault-segmented hard roof strata decreases. Under synchronous activation of faults, roof failure concentrates in the central, right, and left sections for fault combinations with dip angles of 70° + 70°, 90° + 70°, and 110° + 70°, respectively. (3) Numerical simulations reveal two rock burst mechanisms in faults—hard roof systems: a forward “high dynamic stress and high static stress” type and a rear “low dynamic stress and high static stress “ type, which is consistent with in situ monitoring data. (4) For the three stages in which the 502 working face approaches, passes through, and mines away from the fault group area, a stress relief scheme combining roof blasting and coal blasting is proposed. Compared with the 501 working face, during the mining of the 502 working face, the total microseismic frequency and energy decreased by 71.9% and 87.9%, respectively, and the effectiveness of these measures is verified. Full article

Achieving the EU 2030 target of a 30% CO₂ reduction requires transitioning intercity buses to CNG- or fuel-cell-driven vehicles, and urban buses to electric vehicles. The increasing mass of roof-mounted energy systems, such as battery packs, creates additional loads on the body frame. This study investigates the integration of a welded handrail system into the bus body frame as an additional load-bearing element. A combined approach based on dynamic modeling and finite element analysis was applied to evaluate the structural body response under the UNECE R100 and R110 regulations. The results demonstrate that the structural concept significantly improves the stress–strain state of the body frame. Maximum roof displacements under 5g loading decreased by 34% for the gas-powered model and by 50% for the electric model, enhancing passive safety by reducing window-rack intrusion. Maximum stress decreased by 20%, shifting the stress state below the ultimate strength of S235 steel and preventing rupture. Uniform strength under vertical loading increased significantly (by 58%) due to a more favorable stress distribution within the structure. Overall, the results indicate that integrating a welded handrail truss into the bus body frame can effectively improve structural stiffness and redistribute loads within the frame. Full article

Nuclear mechanics and mechanotransduction are involved in the migration and invasion process, such as those in which the cells need to deform themselves to pass through constrictions. Specifically, properties like nuclear softness, viscoelasticity, plasticity (like nuclear pore complexes) and deformability are critical in cancer and its malignant progression. The nucleus represents a physical barrier for the migration and invasion in dense 3D extracellular matrix (ECM) scaffolds. Therefore, the deformability of the nucleus seems to determine the migration limit in circumstances where the enzymatic remodeling of the surroundings is impaired. There are still significant knowledge gaps regarding effects of nuclear deformation during cancer dissemination. It seems that nuclear deformation can alter gene transcription, induce alternative splicing processes, impact nuclear envelope rupture, nuclear pore complex dilatation, damage the DNA, and increase the genomic instability. These mechanically induced alterations can in turn impact the migratory behavior of the cancer cells. The stiffness of the nucleus relies on the condensation of chromatin, and the nuclear lamina, which consists of a network of intermediate filaments underneath the nuclear envelope. All of this is discussed in the review and it is argued that nuclear deformability is universally found in various cancer types. Another focus is placed on the nuclear envelope proteins like emerin, and the SUN-KASH complex and how they contribute to the Linker of Nucleoskeleton and Cytoskeleton (LINC) complex, which consequently couples the nucleus and the cytoskeleton. It is argued that this connection is crucial for force transmission, which governs nuclear stiffness dynamically, depending on the force applied. In this review, recent findings are described that couple ECM-induced nuclear mechanosensing and mechanotransduction with the migration and invasion of cancer cells. Moreover, it is suspected that changes in the mechanosensory characteristics of the cell nucleus could play a pivotal part in the malignancy of cancer cells and the heterogeneity of tumors. Finally, it is discussed what impact the individual elements of the nucleus offer to mechanically alter cellular migration and invasion in cancer and its malignant progression. Full article

The structural integrity of isolation dams in deep coal mines is critical to preventing underground disasters, particularly those involving water and waste-mixture inrushes. This study presents a forensic root-cause analysis, using reverse-engineering techniques, of a specific isolation-dam rupture to determine the failure mechanism under complex stress conditions and limited data availability. A hybrid investigative methodology was employed, combining sequential post-failure documentation analysis with physical-scale modelling and numerical simulations to reconstruct a deadly disaster for criminal investigation purposes. A 1:5 scale physical model of the excavation and dam was constructed using original construction materials to test the structure’s resistance to hydrostatic pressure. The experimental results demonstrated that the dam maintained integrity under static hydraulic loads representative of real-world conditions, with only minor seepage (“sweating”) and no structural failure over a 7-day monitoring period. To investigate external geomechanical factors, Finite Element Method (FEM) simulations were conducted using ANSYS software. The numerical analysis evaluated the effects of rock mass pressure and convergence on the dam’s stability. The results indicate that while the dam was designed to withstand significant hydraulic head, the failure was precipitated by excessive rock mass pressure at a depth of around 600 m, which induced critical stress concentrations exceeding the masonry’s load-bearing capacity. This study confirms that the dynamic rupture was driven by unforeseen geomechanical forces rather than hydrostatic overload alone, highlighting the necessity of considering rock mass–structure interaction in the safety assessment of underground isolation barriers. This approach enables mutual verification of the results obtained and reduces the ambiguity of interpretation that often accompanies the analysis of accident events in underground mining. It also confirms the application of tested methodology for mining disaster reconstruction as proof at the stage of investigation and in the Court. Full article

This paper examines the evolution of modern Greek Orthodox dogmatic theology, highlighting its transition from early twentieth-century scholasticism to the diverse neo-patristic and existential approaches that shaped its later renewal. It begins with Panagiotes Trembelas, whose comprehensive but manualist synthesis safeguarded doctrinal continuity while limiting historical and experiential depth. After the Second World War, Greek theology encountered Russian émigré thought and rediscovered the Palamite tradition, inspiring a “return to the Fathers” and a search for authentic patristic expression. This movement produced multiple trajectories: John Romanides emphasized historical and experiential purification, Christos Yannaras redefined dogma as personal and relational existence, and John Zizioulas developed a Eucharistic and relational ontology grounded in communion. Rather than representing rupture, these approaches reflect a creative struggle to articulate Orthodox faith within modern intellectual contexts. Overall, this paper presents modern Greek dogmatics as a dynamic field negotiating tradition, modernity, and ecclesial identity. Full article

Background/Objectives: The aim of this study was to report first experiences with dynamic intraligamentary stabilization (DIS) technique for anterior cruciate ligament (ACL) rupture in children and adolescents. Methods: A case series of 22 children and adolescents with a mean age of 13.3 years underwent primary repair of an ACL rupture using the DIS technique as an off-label use in skeletally immature patients. Patients were evaluated for laxity, strength, range of motion (ROM), and functional tests, as well as Tegner, Lysholm, International Knee Documentation Committee (IKDC), and PedsQL scores after 3 years. A follow up after 11 years was conducted to analyze long-term results, rerupture rates and reinterventions. Results: Three years after surgery, there was no significant difference in laxity, strength, ROM, and in the functional tests comparing the injured to the contralateral knee. The Tegner Index after surgery showed a slight drop of 0.8 points, from 7.1 preoperatively to 6.3. Mean IKDC, Lysholm, and peds-QL scores were 91.17 (range 62.64–98.85, median 94.25), 88.27 (range 58–100, median 93), and 88.78 (range 58.15–100, median 91.30). Overall failure rate of the DIS-repaired knees was 55% (12 of 22 patients). In ten patients, reruptures happened at an average time of 3.2 years after initial surgery; additionally, two patients with chronic instability had to undergo revision ACL reconstruction. Conclusions: DIS repair might help ACL healing with satisfactory functional outcomes. However, given the high failure and reintervention rates, further studies need to show non-inferiority of the DIS technique in children and adolescents before being considered a valid treatment option. Full article

Notch wear in austenitic stainless steel turning develops rapidly and remains a key productivity limitation with carbide tools. This work identifies the initiation mechanism of notch wear when turning EN 1.4307 stainless steel using CVD-coated cemented carbide inserts with an Al₂O₃ top layer. Turning tests were performed under dry conditions, followed by optical wear measurements and chip surface analysis. The tool–chip interface chemistry and material transfer were characterized using SEM/EDS, while high-frequency acoustic emissions were recorded to resolve the dynamics of adhesive events. Thermo-mechanical FEM simulations were conducted to map contact pressure and temperature along the cutting edge. The results show that adhesive wear initiates immediately at engagement and governs notch formation: polluted SiO₂ deposits act as an active bonding medium, and repeated bond formation/rupture removes extremely thin flakes of tool and coating material, evidenced by Al₂O₃ and Ti(C,N) fragments on the chip and by characteristic acoustic cluster waves. A new tool–chip contact model is presented, indicating that high pressure and high temperature within the polluted SiO₂ near the chip’s outmost side promote larger, stronger adhesive bonds together with the absence of ceramic particles near the rake in the notch area. Oxidation and diffusion are assumed to be secondary processes that become relevant after local coating loss, while adhesion remains the primary removal mechanism during early and intermediate stages. Full article

On 8 February 2025, an Mw 7.6 strike-slip earthquake ruptured the Swan Islands Transform Fault in the northern Caribbean near its junction with the Mid-Cayman Spreading Center, providing an important offshore case for investigating rupture dynamics along oceanic transform faults. In this study, we jointly apply teleseismic high-frequency back-projection and low-frequency finite-fault full-waveform inversion to image the multi-scale spatiotemporal evolution of the rupture process. Back-projection results reveal a two-stage rupture characterized by an initial sub-shear propagation lasting approximately 20 s, followed by rapid acceleration to supershear velocities of ~5–6 km/s and westward propagation over ~80–100 km. Finite-fault inversion shows that coseismic slip is primarily concentrated within ~20 km west of the epicenter, with a peak slip of ~5.6 m and an overall rupture duration of ~40 s. Comparison between high-frequency radiation and low-frequency slip indicates that the most seismic moment was released during the early slow rupture stage, whereas the later fast-propagating segment produced enhanced high-frequency energy but relatively small slip. These observations reveal a pronounced along-strike complementary relationship between slip amplitude and rupture speed, suggesting a transition in rupture dynamics controlled by variations in fault strength, fracture energy, and/or geometric complexity. By combining high-frequency back-projection with low-frequency finite-fault inversion, we obtain a more complete view of the rupture process of offshore earthquakes, which helps clarify rupture propagation characteristics, including supershear behavior, along oceanic transform faults. Full article

High-entropy alloys (HEAs) provide a broad compositional space for tuning phase stability and surface durability. CoCrFeNiMn_x (x = 0.5, 1.0, 1.5, and 2.0) alloys were fabricated by vacuum arc melting and characterized by X-ray diffraction (XRD), optical microscopy (OM), scanning electron microscopy with energy-dispersive spectroscopy (SEM/EDS), microhardness testing, electrochemical testing in 3.5 wt.% NaCl, and X-ray photoelectron spectroscopy (XPS). Density functional theory (DFT) calculations and first-principles molecular dynamics were further employed to analyze the Mn-dependent electronic structure and oxygen–metal bonding. The XRD results indicate a transition from a single FCC solid solution at x ≤ 1.0 to an FCC + BCC constitution at x ≥ 1.5. With increasing Mn, microstructures evolve from coarse dendrites toward higher fractions of equiaxed grains. Hardness decreases from 163.6 HV (x = 0.5) to 125.1 HV (x = 1.0) and then increases to 162.6 HV (x = 2.0), indicating competing solid-solution and phase/segregation effects. Electrochemical measurements show enhanced corrosion resistance with Mn addition; the x = 2.0 alloy exhibits the lowest fitted corrosion current density (icorr = 0.3482 × 10⁻⁶ μA·cm⁻²) and the most stable passivation response. XPS reveals passive films dominated by Fe₂O₃ together with Mn³⁺ oxides, whose synergistic formation promotes a denser barrier layer. DFT predicts a monotonic decrease in Fermi level and a narrowed conduction band range as Mn increases, consistent with reduced electron transfer activity during anodic dissolution. Interfacial simulations show that O preferentially bonds with Cr and Mn, while Ni–O bonds have the lowest estimated rupture barrier, rationalizing a tendency toward localized corrosion at Ni-associated sites. Full article

Ultra-High-Performance Concrete (UHPC) reinforced with steel fibers has emerged as a promising alternative to conventional concrete, which exhibits limited tensile capacity and a low modulus of rupture and is prone to brittle damage under cyclic loading—a critical drawback in seismic applications. The increasing demand for resilient, damage-tolerant construction materials in seismically active regions worldwide has intensified the need to evaluate the seismic performance of UHPC structural systems at the structural scale. However, the seismic behavior of full structural frames built entirely with cast-in-place UHPC remains largely unexplored. This study presents a full-scale experimental evaluation of single-story UHPC frames with two steel fiber volume fractions (1.0% and 1.5%) subjected to pseudostatic in-plane cyclic loading. A conventional reinforced concrete frame was tested for comparison. Key performance parameters—including hysteretic response, stiffness degradation, and energy dissipation—were assessed. The results suggest that the UHPC frames exhibited enhanced performance in comparison to the conventional frame across the measured parameters. The UHPC frame with 1.5% steel fiber content consistently outperformed both the 1.0% UHPC frame and the conventional reinforced concrete frame in terms of lateral strength, initial stiffness, and energy dissipation capacity, highlighting the critical role of fiber dosage in optimizing seismic performance. The 1.5% fiber UHPC frame reached approximately 59 kN in maximum lateral strength and 6.3 kN/mm in initial stiffness, representing increases of around 59% and 58%, respectively, relative to the conventional frame (~37 kN and 4.0 kN/mm). While stiffness degradation was observed in all specimens, the UHPC frames retained higher stiffness values throughout the test. At 5.5% drift, the 1.5% UHPC frame dissipated approximately 146,000 J, compared to 80,000 J for the conventional frame. These findings indicate that steel fiber-reinforced UHPC may improve the cyclic performance of frame structures and could serve as a viable alternative for earthquake-resistant construction. The results reported here should be interpreted as indicative trends rather than statistically generalizable conclusions. A key limitation of this study is that the experimental program focused solely on single-story frames under quasi-static loading; dynamic effects and multi-story behavior were not addressed. Full article

Fruit spoilage caused by fungal pathogens jeopardizes food safety and inflicts significant economic damage. Cyclic lipopeptides (CLPs) have been applied as biofungicides by disrupting the cell membrane and intracellular components; however, the first target for antifungal action is the fungal cell wall. This study elucidates the molecular mechanism by which CLPs compromise cell wall integrity using molecular dynamics simulation and experimental validation. Among Surfactin C, Iturin A, and Fengycin A, Surfactin C exhibited the strongest binding to β-glucan (ΔE = −1970.536 kcal/mol) and the lowest free volume (7.302%), with enhanced effects at higher concentrations. Key interaction sites were identified at C=O of D-Leu3, -N-H of Leu2, and -COOH of Glu1 by Radial distribution function. In vivo assays with Aspergillus niger confirmed a MIC of 40 µg/mL and Surfactin-induced β-glucan exposure. FTIR and XPS analyses revealed structural reorganization and hydrogen bonding, while SEM/TEM showed spore deformation and wall rupture. These findings demonstrate that Surfactin disrupts fungal cell walls via direct complexation with β-glucan, leading to structural collapse and cell death, supporting its potential as a targeted biofungicide. Full article

Background/Objectives: A1 segment asymmetry, including hypoplasia and aplasia, is a well-recognized anatomical variation associated with altered hemodynamic stress and anterior communicating artery (ACoA) aneurysm formation. However, its influence on subsequent aneurysm rupture risk remains controversial. This study aimed to evaluate the relationship between A1 segment morphology and aneurysm rupture risk, as well as its association with aneurysm size and morphological complexity. Methods: A retrospective single-institution analysis was conducted on 211 patients treated for ACoA aneurysms between June 2016 and March 2025. A1 segment morphology was assessed using digital subtraction angiography and categorized as symmetric, hypoplastic (diameter < 1 mm or <50% of the contralateral vessel), or aplastic. Demographic, clinical, and radiological variables were recorded. Statistical analyses included univariate comparisons with Bonferroni correction for multiple testing and multivariable logistic regression to identify independent predictors of aneurysm rupture. Results: The study population had a mean age of 54.72 ± 10.97 years, with a male-to-female ratio of 1.24:1 (55.5% male, 44.5% female). Symmetric A1 segments were observed in 49.3% of patients, hypoplastic segments in 31.3%, and aplastic segments in 19.4%. No statistically significant association was identified between A1 morphology and aneurysm rupture rates (p = 0.251) or mean aneurysm diameter (p = 0.996). Univariate analysis demonstrated that younger age (p = 0.006), male sex (p = 0.016), and smoking (p = 0.033) were associated with rupture. However, none of these factors, including A1 morphology, remained independent predictors of rupture in the multivariable logistic regression model. Conclusions: Although A1 segment asymmetry is common in patients with ACoA aneurysms, it does not independently influence rupture risk or aneurysm morphology. Our findings suggest that rupture behavior is driven primarily by dynamic hemodynamic factors rather than static anatomical variations. Full article

Conventional assessments of fault rupture propagation in overlying soil layers often rely on static or quasi-static analysis, neglecting the dynamic nature of fault displacement and inertial effects. This study develops a comprehensive simulation method for the entire process from rupture initiation to propagation under dynamic fault displacement. The method integrates a nonlinear elastic constitutive model based on the Hardin backbone curve with a non-uniform input technique for seismic waves on both sides of the fault using viscoelastic artificial boundaries. To demonstrate the distinct capabilities of this dynamic method, we conduct a comparative study on normal and reverse faulting driven by fault displacement time histories of identical magnitude but opposite sense. The simulations reveal that: (1) the fault displacement required for rupture initiation and propagation remains consistent between dynamic and quasi-static analyses; (2) crucially, the proposed method captures the transient dynamic response of fault rupture in the overlying soil. The study confirms that the proposed dynamic simulation framework is essential for resolving transient peak responses, oscillatory behavior, and deformation features associated with different faulting mechanisms, providing a more realistic tool for seismic risk assessment compared to conventional static approaches. Full article